Barks and leaves of Lauraceae plants as anti-acne.

Acne vulgaris is an inflammatory skin disease caused by several factors, including an imbalance of microorganisms compared to the normal microbial distribution in healthy tissue. The Lauraceae family which have been reported from antiseptic. This research was conducted to assayed the compounds, the biological activity of the Lauraceae plant essential oil (EO) could against microbes.

Activity of isoflavone in managing polycystic ovary syndrome symptoms (Review).

Polycystic ovary syndrome (PCOS), a hormonal and metabolic disorder manifested in women of reproductive age, is still being treated using drugs with side effects. As an alternative to these drugs, isoflavone, also identified as phytoestrogen, has anti-PCOS activity. Isoflavone can help relieve PCOS symptoms by lowering the level of testosterone, which causes hyperandrogenism, thereby normalizing the menstrual cycle and restoring normal ovarian morphology.

Diving into paclitaxel: isolation and screening content from at Singgalang Conservation Center, West Sumatra.

The report features the first isolation of paclitaxel from wood of conservated . The is a nationally protected endemic plant that has been successfully cultivated outside its natural habitat at the Singgalang Conservation Centre in West Sumatra. The paclitaxel was utilised as a reference standard for evaluating its presence in different parts of .

Inhibitory activity of xanthoangelol isolated from Ashitaba ( Koidzumi) towards α-glucosidase and dipeptidyl peptidase-IV: and studies.

In Indonesia, the sap Koidzumi has been utilized traditionally as a blood-sugar reducer, nonetheless, its molecular mechanism still needs to be studied. This study aimed to isolate xanthoangelol (XA) from the yellow sap of planted in Mount Rinjani, Indonesia, and to investigate its mechanism by and methods towards α-glucosidase and dipeptidyl peptidase-IV (DPP-IV). The dried yellow sap was macerated using ethanol, subjected to liquid-liquid extraction using a different polarity of solvents, further gradient-eluted with column chromatography.

Micropropagation and Secondary Metabolites Content of White-Purple Varieties of Blume Miq.

<b>Background and Objective:</b> The cat whiskers plant (<i>Orthosiphon aristatus</i> Blume Miq) is a plant that has been widely used as raw material for traditional medicine. The population of white-purple varieties of <i>O. aristatus</i> is decreasing efforts to maintain the white-purple <i>O.

Molecular Docking, Synthesis And Biological Evaluation Of Ergosteryl-Ferulate As A Hmg-Coa Reductase Inhibitor.

In the present study, ergosteryl-ferulate (5), oryzanol analog was evaluated for its possibility as the inhibitor of hmg-coa reductase (hmgr), through in silico and in vitro approach. firstly, the study was conducted through molecular docking simulation using autodock tools software to predict the interaction of 5 in complexes with hmgr. in addition, four major compounds of oryzanol (1-4) were employed as a comparison.

Positioning Bacillus subtilis as terpenoid cell factory.

Increasing demands for bioactive compounds have motivated researchers to employ micro-organisms to produce complex natural products. Currently, Bacillus subtilis has been attracting lots of attention to be developed into terpenoids cell factories due to its generally recognized safe status and high isoprene precursor biosynthesis capacity by endogenous methylerythritol phosphate (MEP) pathway. In this review, we describe the up-to-date knowledge of each enzyme in MEP pathway and the subsequent steps of isomerization and condensation of C5 isoprene precursors.

Antioxidant and antibacterial activities of multiflora honey extracts from the Indonesian bee.

Objectives: Honey is an apiary product with various medicinal properties resulting from its bioactive compounds. Here, we aimed to determine the antioxidant and antibacterial properties of the Indonesian honey extracts and their correlation with total phenolic content (TPC) and total flavonoid content (TFC).

Methods: We extracted ethyl acetate-n-hexane and two types of ethanolic extracts from crude honey.

Constituents of Indonesian medicinal plant Averrhoa bilimbi and their cytochrome P450 3A4 and 2D6 inhibitory activities.

As constituents of Averrhoa bilimbi leaves we identified three new compounds (1-3) together with 12 known ones (4-15); their inhibitory activities on cytochrome P450 3A4 (CYP3A4) and 2D6 (CYP2D6) were examined. Among the isolated compounds, the mixture of 1 and 2, and compounds 4 and 9 showed strong inhibition on CYP3A4, but mild or no inhibition on CYP2D6. These compounds revealed the characteristics of 1) time- and concentration-dependent inhibition, 2) requirement of NADPH for the inhibition, 3) no protection by nucleophiles, and 4) suppression of the inhibition by competitive inhibitor.

Immunostimulating effect of pule (Alstonia scholaris L. R.Br., Apocynaceae) bark extracts.

The immunostimulating effect of "Pule" (Alstonia scholaris (L.) R.Br.