Inhibition of nitric oxide production in RAW 264.7 cells and cytokines IL-1β in osteoarthritis rat models of 70 % ethanol extract of (L.) merr stems.

Introduction: One of the most frequent types of arthritis is osteoarthritis, also referred to as a degenerative joint disease. Interleukin-1β (IL-1β) and nitric oxide (NO) are essential factors in the pain response; IL-1β and NO are responsible for increasing the production of matrix metalloproteinases (MMP) and a disintegrin-like and metalloproteinases with thrombospondin motifs (ADAMS) in chondrocytes. (L.

Effects of (mill.) urb. bulb extract on mice glucocorticoid-induced osteoporosis models.

Background: Low bone mass accompanied by microarchitectural alterations in the bone that cause fragility fractures is known as secondary osteoporosis and occurs when there is an underlying condition or medication present. Eleutherine bulbosa bulb extract has been shown to affect bone because of its content, which can help osteoblast differentiation and inhibit osteoclast differentiation.

Objective: This study aimed to assess the effects of 70% ethanol extract of Bulbs (EBE) from Pasuruan-East Java on blood calcium levels, osteoblast cell count, and bone density of trabecular femur in osteoporosis rats.

Antiosteoarthritis activities of 70% ethanol extract of (mill.) urb. bulb on rats monosodium iodoacetate-induced osteoarthritis.

Background: Osteoarthritis (OA) is a common degenerative joint situation that induces pain and disability in the elderly. Traditionally, bulb from Pasuruan, East Java, is used to treat many diseases, also as an anti-inflammatory.

Objective: In this research, we employed an model to examine the effects of 70% ethanol extracts of (EBE) on the progression and development of OA.

estrogen receptor alpha antagonist studies and toxicity prediction of leaves bioactive ethyl acetate fraction.

The estrogen hormone dependent accounts for a major cause in the incidence of women breast cancer. Thus, their receptor, especially the estrogen receptor α (ER-α), is becoming a target in endocrine treatment. These ligand-inducible nuclear functions are regulated by an array of phytochemical and synthetic compounds, such as 17 β-estradiol and tamoxifen (4-hydroxytamoxifen [4OHT]).

The coronavirus disease 2019 main protease inhibitor from (Burm. f) Ness.

The coronavirus disease 2019 (COVID-19) pandemic has attracted worldwide attention. (Burm. f) Ness (AP) is naturally used to treat various diseases, including infectious diseases.

The recent use of (L.) Jacq. as antidiabetes type 2 phytomedicine: A systematic review.

Background: Natural resources provide more efficient and safer alternatives in managing diabetes compare to the synthetic oral anti diabetes (OAD). The plants not only have hypoglycemic effect, but also prevent its complications; in which no synthetic drugs provide of both properties. Among antidiabetes plants, mahogany seed () has been used as traditional medicine in Indonesia and India, though most popular utilized as timber wood.

Bio-selective hormonal breast cancer cytotoxic and antioxidant potencies of L. wild type leaves.

L. is used widely in traditional medicine for local or systemic ailments. Although studies exist on phytochemicals and potencies of Chinese and Indian cultivars of , the present study investigated antioxidant properties of wild type and its cytotoxicity against T47D cell.

Calotroposid A: a Glycosides Terpenoids from Calotropis gigantea Induces Apoptosis of Colon Cancer WiDr Cells through Cell Cycle Arrest G2/M and Caspase 8 Expression.

Objective: This study aims to isolate the active anticancer compound from ethyl acetate fraction extracted from the roots of Calotropis gigantea and to determine the operating mechanism of the isolates towards WiDr colon cancer cells. Methods: the isolation was conducted by using bioassay guided isolation approach method. The cytotoxic potential was determined by using MTT method.

New Isolinariins C, D and E, Flavonoid Glycosides from Linaria japonica.

Three new flavonoid glycosides named isolinariins C, D and E (1-3), two known flavonoid glycosides (4, 5) and three known flavonoids (6-8) were isolated from the whole plant of Linaria japonica. The structures of these compounds were determined mainly by spectroscopic analyses. The bioactivities of these isolated compounds were evaluated for their inhibitory activities against human cell line A549, collagenase, and advanced glycation end product (AGE) formation.

Apoptosis inducing effect of andrographolide on TD-47 human breast cancer cell line.

Andrographolide isolated from Andrographis paniculata Ness (Acanthaceae) at 0.35 mM, 0.70 mM and 1.

Cytotoxic mechanism of flavonoid from Temu Kunci (Kaempferia pandurata) in cell culture of human mammary carcinoma.

The cytotoxic activity of flavonoid from Temu Kunci (Kaempferia pandurata) was tested by brine shrimp lethality test and cell culture of human mammary carcinoma. This compound is pinostrobin, and has antitumor activity. However, the critical biochemical target of these pinostrobin has not been identified.