Performance evaluation of a low-cost Ti-Mo-Fe (TMF8) as a replacement for Ti-6Al-4V for internal fixation implants used in mandibular angular fractures: a finite element analysis study.

Stainless steel and titanium-based alloys have been the gold standard when it comes to permanent implants and magnesium-based alloys have been the best option for bioresorbable alloys. Ti-6Al-4V, Ti-64, with its 110 GPa Young's Modulus is the most commonly employed alloy to manufacture biomedical implants used for treatment of fractures of skeleton. Recently, researchers have developed a new low-cost and toxic Vanadium-free alternative to this alloy, Ti-3Mo-0.

Pattern of rapidly growing mycobacteria (RGM) species isolated from clinical samples: A 10-year retrospective study in a tertiary care hospital of Bangladesh.

Purpose: Infections caused by rapidly growing mycobacteria (RGM) are increasing worldwide. The study was conducted in a microbiological laboratory of Bangladesh to determine the pattern of detection of RGM from clinical samples.

Methods: All laboratory culture records of RGM from 2012 to 2022 were collected retrospectively and analyzed.

Design, synthesis, and biological evaluation of tetrahydropyrimidine analogue as GSK-3β/Aβ aggregation inhibitor and anti-Alzheimer's agent.

The complex nature of Alzheimer's disease (AD) etiopathology is among the principal hurdles to developing effective anti-Alzheimer agents. Tau pathology and Amyloid-β (Aβ) accumulation are hallmarks and validated therapeutic strategies of AD. GSK-3β is a serine/threonine kinase involved in tau phosphorylation.

Synergistic Effect of 3D/2D Vanadium Diselenide/Tungsten Diselenide Hybrid Materials: Electrochemical Detection of 5-Nitroquinoline a Hazard to the Aquatic Environment.

The development of multidimensional structured electrode materials with simple synthetic methods and their electrochemical sensing ability against environmental pollution is still a challenge. In this article, we propose a hybrid formed using multidimensional (3D/2D) vanadium diselenide microspheres and tungsten diselenide nanosheets (VSe/WSe) for the electrochemical detection of 5-nitroquinoline (5-NQ), a highly toxic and hazardous substance that is polluting aquatic life due to increasing industrial activities. The 3D/2D VSe/WSe hybrids were prepared by a simple solvothermal method and their morphological and structural analysis was confirmed by various spectroscopy and analytical techniques such as powder X-ray diffraction, X-ray photoelectron spectroscopy, field emission scanning electron microscopy-energy dispersive X-ray spectroscopy, transmission electron microscopy, cyclic voltammetry, and differential pulse voltammetry.

TiCT Filled in EMIMBF Semi-Solid Polymer Electrolytes for the Zinc-Metal Battery.

Zinc-ion batteries (ZIBs) are promising candidates for safe energy storage applications. However, undesirable parasitic reactions such as dendrite growth, gas evaluation, anode corrosion, and structural damage to the cathode under an acidic microenvironment severely affected cell performance. To resolve these issues, an MXene entrapped in an ionic liquid semi-solid gel polymer electrolyte (GPE) composite was explored.

Electrochemical detection of sulfanilamide using tannic acid exfoliated MoS nanosheets combined with reduced graphene oxide/graphite.

Sulfonamides are a family of synthetic drugs with a broad-spectrum of antimicrobial activity. Like other antimicrobials, they have been found in aquatic environments, making their detection important. Herein, an electrochemical sensor was designed using tannic acid exfoliated few-layered MoS sheets, which were combined with a mixture of reduced graphene oxide (rGO) and graphite flakes (G).

Management of post-implant inferior alveolar neuropathy, utilizing autologous fibrin glue, concentrated growth factors and enriched bone graft matrix-A case report with 5 years follow-up.

This case report explains meticulous management of 5 year old, inferior alveolar nerve neuropathy, following placement of dental implants in the mandible. The imperative situation was that 'implants placed were not in contact with the nerve, but triggered neuralgic pain'. The objective of the treatment was to identify, and eliminate the causative factor, and to promote nerve regeneration, with pain relief.

Synthesis of novel 5-[3-(4-chlorophenyl)-substituted-1,3-dimethylpyrimidine-2,4,6(1,3,5)-trione derivatives as potential anti-diabetic and anticancer agents.

In this work, we developed a series of novel 5-[3-(4-chlorophenyl)-substituted-1,3-dimethylpyrimidine-2,4,6(1,3,5)-trione derivatives a one-pot multicomponent reaction. The structures of the compounds were confirmed using analytical and spectroscopic techniques. Also, the synthesized compounds were screened for their anti-diabetic activity, cytotoxicity and studies.

Intravenous Dexmedetomidine-Ketamine Versus Ketamine-Propofol for Procedural Sedation in Adults Undergoing Short Surgical Procedures: A Randomized Controlled Trial.

Background and objective Moderate to deep sedation is a prerequisite during total intravenous anesthesia for short-duration surgeries, and it can be achieved by using individual drugs or in combination. Our study compared dexmedetomidine-ketamine (DK) versus ketamine-propofol (KP) in terms of sedation, procedural interference, hemodynamics, and incidence of side effects in patients undergoing short surgical procedures. Methods A total of 194 patients scheduled for short-duration elective surgeries were randomly allocated into two groups.

A novel, extreme low-cost poly (Erythrosine) modified pencil graphite electrode for determination of Adrenaline.

A simple, novel, and less cost yellow (Erythrosine) modified pencil graphite electrode (Po-ERY/MGPE) was successfully fabricated via electropolymerization method using cyclic voltammetric techniques. The fabricated Po-ERY/MGPE opted as a sensor for the detection of Adrenaline (ADR) in 0.2 M PBS (7.

Development of an Amorphous Nickel Boride/Manganese Molybdate Heterostructure as an Efficient Electrode Material for a High-Performance Asymmetric Supercapacitor.

The exploration of heterostructure materials with unique electronic properties is considered a desirable platform for fabricating electrode/surface interface relationships for constructing asymmetric supercapacitors (ASCs) with high energy density. In this work, a heterostructure based on amorphous nickel boride (NiB) and crystalline square bar-like manganese molybdate (MnMoO) was prepared by a simple synthesis strategy. The formation of the NiB/MnMoO hybrid was confirmed by powder X-ray diffraction (p-XRD), field emission scanning electron microscopy (FE-SEM), field-emission transmission electron microscopy (FE-TEM), Brunauer-Emmett-Teller (BET), Raman, and X-ray photoelectron spectroscopy (XPS).

Interaction of sugar stabilised silver nanoparticles with Momordica charantia seed lectin, a type II ribosome inactivating protein.

Sugar-stabilised nanomaterials have received a lot of attention in cancer therapy in recent years due to their pronounced application as specific targeting agents and maximizing their therapeutic potential while bypassing off-target effects. Lectins, the carbohydrate-binding proteins, are capable of binding to receptors present on the target cell/tissue and interact with transformed glycans better than normal cells. Besides some of the lectins exhibit anticancer activity.

Synthesis of active-site rich molybdenum-doped manganese tungstate nanocubes for effective electrochemical sensing of the antiviral drug (COVID-19) nitazoxanide.

Nitazoxanide (NTZ), a promising antiviral agent, is currently being tested in clinical trials as a potential treatment for novel coronavirus disease 2019 (COVID -19). This paper describes a one-pot hydrothermal synthesis to prepare molybdenum (Mo)-doped manganese tungstate nanocubes (Mo-MnWO NCs) for the electrochemical sensing of NTZ. The as-prepared Mo-MnWO NCs were characterized using various techniques such as XRD, Raman, FE-SEM, FE-TEM, and XPS to confirm the crystal structure, morphology, and elemental composition.

Determination of Effectiveness of Photobiomodulation in the Treatment of Oral Submucous Fibrosis.

Context: Oral submucous fibrosis (OSMF) is chronic, scarring disease of the oral cavity. Cytokines and growth factors produced by inflammatory cells play a major role in its pathogenesis. Low-level laser therapy (LLLT) application, which has an anti-inflammatory, was used to determine the improvement in mouth opening.

SARS-CoV-2 main protease (3CL) interaction with acyclovir antiviral drug/methyl-β-cyclodextrin complex: Physiochemical characterization and molecular docking.

During the current outbreak of the novel coronavirus disease 2019 (COVID-19), researchers have examined several antiviral drugs with the potential to inhibit the proliferation of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The antiviral drug acyclovir (AVR), which is used to treat COVID-19, in complex with methyl-β-cyclodextrin (Mβ-CD) was examined in the solution and solid phases. UV-visible and fluorescence spectroscopic analyses confirmed that the guest (AVR) was included inside the host (Mβ-CD) cavity.

Is Age a Limitation for Organ Donation? A Comparison of Elderly and Non-elderly Donors in a Deceased Donor Organ Transplantation Program from South India.

To bridge the gap between demand and supply of organs, deceased donors with extreme ages can be utilized. The object of this study was to compare elderly with non-elderly donors and to assess the predictors of organ utilization or wastage. This was a retrospective chart analysis.

Microfluidic Biosensor-Based Devices for Rapid Diagnosis and Effective Anti-cancer Therapeutic Monitoring for Breast Cancer Metastasis.

Breast cancer with unpredictable metastatic recurrence is the leading cause of cancer-related mortality. Early cancer detection and optimized therapy are the principal determining factors for increased survival rate. Worldwide, researchers and clinicians are in search of efficient strategies for the timely management of cancer progression.

Application of radon (Rn) as an environmental tracer in hydrogeological and geological investigations: An overview.

Radon (Rn) is a colourless, odourless, inert, and radioactive noble gas (t = 3.8 days) that emanates from rocks and soils as a result of the alpha decay of its parent, radium (Ra) in the decay series of uranium-238, is the focus of this study. Radon is produced in the crystal lattice of the minerals and emanates out through alpha recoil.

Structure-Based Virtual Screening and in vitro and in vivo Analyses Revealed Potent Methyltransferase G9a Inhibitors as Prospective Anti-Alzheimer's Agents.

G9a is a lysine methyltransferase able to di-methylate lysine 9 of histone H3, promoting the repression of genes involved in learning and memory. Novel strategies based on synthesizing epigenetic drugs could regulate gene expression through histone post-translational modifications and effectively treat neurodegenerative diseases, like Alzheimer's disease (AD). Here, potential G9a inhibitors were identified using a structure-based virtual screening against G9a, followed by in vitro and in vivo screenings.

Facile synthesis of neodymium stannate nanoparticles an effective electrocatalyst for the selective detection of dimetridazole in biological samples.

In this work, pyrochlore neodymium stannate nanoparticles (NdSnO NP) have been synthesized by a facile co-precipitation technique and employed as an electrode material on GCE for the determination of dimetridazole (DM) drug. The physical properties and texture of the NdSnO NP were characterized by PXRD, Raman spectroscopy, FE-SEM, EDX mapping, XPS, and HR-TEM analytical studies. The electrocatalytic investigation of NdSnO NP/GCE was carried out by CV, and DPV techniques.