Publications by authors named "Stephania Assimopoulos"

Article Synopsis
  • Individuals with congenital heart disease (CHD) face a heightened risk for neurodevelopmental impairments, and understanding this relationship could benefit from data-driven approaches.
  • Utilizing data from the Pediatric Cardiac Genomics Consortium, researchers analyzed brain structure using MRI to identify subgroups of individuals with CHD, focusing on variations related to cardiac lesions and language ability.
  • The study also examined white matter connectivity through diffusion MRI, revealing that rare genetic variants significantly influence visual-motor functions, highlighting the intricate links between cardiac conditions, genomic differences, and brain development in CHD patients.
View Article and Find Full Text PDF

Non-human primates are extensively used in neuroscience research as models of the human brain, with the rhesus macaque being a prominent example. We have previously introduced a set of tractography protocols (XTRACT) for reconstructing 42 corresponding white matter (WM) bundles in the human and the macaque brain and have shown cross-species comparisons using such bundles as WM landmarks. Our original XTRACT protocols were developed using the F99 macaque brain template.

View Article and Find Full Text PDF

Background And Aim: We investigated the incidence rate of perioperative complications following major vascular surgery, as well as identified the risk factors and preoperative clinical, electrocardiographic and echocardiographic determinants, related to these complications.

Methods: We studied 241 patients with asymptomatic intact abdominal aortic aneurysm (AAA) subjected to open surgical repair, 182 with critical carotid stenosis subjected to endarterectomy (CEA), and 158 with severe symptomatic occlusive peripheral artery disease subjected to aortofemoral bypass (AFB). Preoperatively, all subjects provided a medical history and underwent physical, laboratory examinations, a standard ECG, and transthoracic echocardiography.

View Article and Find Full Text PDF

Autism spectrum disorder (ASD) and congenital heart disease (CHD) are linked on a functional and genetic level. Most work has investigated CHD-related neurodevelopmental abnormalities. Cardiac abnormalities in ASD have been less studied.

View Article and Find Full Text PDF

Hemorrhage is recognized as a new independent predictor of adverse outcomes following acute myocardial infarction. However, the mechanisms of its effects are less understood. The aim of our study was to probe the downstream impact of hemorrhage towards chronic remodeling, including inflammation, vasodilator function and matrix alterations in an experimental model of hemorrhage.

View Article and Find Full Text PDF

Objectives: We investigated the clinical, electrocardiographic, and echocardiographic determinants of the cardiac status in nonagenarian patients.

Methods: We consecutively examined 654 Caucasian patients (232 males and 422 females) aged ≥90 years. All patients underwent clinical examination, ECG, and transthoracic echocardiography.

View Article and Find Full Text PDF

We aimed to depict the electrocardiographic and echocardiographic aspects in patients before elective major vascular surgery. We evaluated through standard 12 lead electrocardiography and transthoracic echocardiography 469 patients with asymptomatic large abdominal aortic aneurysm (AAA), 334 with critical carotid stenosis (CAS), and 238 with advanced peripheral artery disease (PAD) before surgical revascularization. Patients with AAA were predominantly males ( < .

View Article and Find Full Text PDF