Publications by authors named "Sohaib Peerzada"
Evaluation and Comparison of Seed Extract for Its Anti-inflammatory Effect.
J Pharm Bioallied Sci
November 2020
Article Synopsis
- The study aimed to evaluate the anti-inflammatory effects of different seed extracts at various doses using a method called Soxhlet extraction with n-hexane, chloroform, and methanol.
- Wistar rats were tested with varying doses of the extracts to measure their anti-inflammatory activity, with a standard drug (diclofenac sodium) used as a comparison.
- Results showed that the n-hexane extract had the strongest anti-inflammatory effect, while all tested extracts worked by enhancing GABA neurotransmission and suppressing glutamate receptors.
A halophytic plant, Haloxylon stocksii, is used to treat various inflammatory disorders traditionally. The present study was carried out to investigate the phytochemical parameters, anti-inflammatory, analgesic and cytotoxic potential of the whole plant extracts of H. stocksii.
View Article and Find Full Text PDFHerbal medicines frequently suffer with quality controversies because of similar species or varieties. This often leads to sophistication or admixture of the crude drug as they share various look alike physical features. Commercially, stalks of Caralluma edulis are commonly adulterated with other species because of their analogous morphology.
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- Fumaria officinalis, part of the Papaveraceae family, has traditional uses in treating hypertension, hepatitis, and diabetes, prompting a study on its antidiabetic properties.
- The study involved extracting the plant’s aerial parts with different solvents and analyzing their phytochemical and antioxidant activities, showing the methanolic extract had the highest inhibition rates for both DPPH and alpha-amylase.
- In vivo tests on diabetic rats demonstrated that aqueous and methanolic extracts significantly lowered blood glucose levels, improved body weight, and enhanced kidney and liver functions, suggesting the plant's herbal potential in diabetes management due to its antioxidant effects.
Pistacia khinjuk is one of the fifteen known species of Pistacia belonging to Anacardiaceae family. Keeping in view the possible therapeutic utility of this genus and the lack of literature on this plant, this study involves phytochemical investigation of P. khinjuk and its antioxidant activity.
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- A study assessed the safety of herbal medicines, focusing on the genotoxic and mutagenic effects of two extracts from a medicinal plant using the Ames and MTT assays.
- The aqua-methanolic extract showed significant mutagenicity with a high mutagenic index when tested on specific bacterial strains, while the n-hexane extract was found to be mutagenic but less pronounced.
- Both extracts exhibited cytotoxicity, indicating potential risks for human health, and the study recommends further investigation in animal models to evaluate the safety of the plant.
Article Synopsis
- Many herbal medicines in alternative medicine are not well-researched for safety, potentially putting users at risk.
- This study tested the genotoxic (mutagenicity) and cytotoxic (cell toxicity) effects of various fruit extracts traditionally used in folk medicine using specific bacteria and cell lines.
- Results indicated that both aqueous and ethanolic extracts showed significant mutagenicity and cytotoxicity, suggesting that these fruit extracts may not be safe for use, highlighting the need for more thorough safety evaluations.
Viral hepatitis, an inflammatory liver disease, is caused by various genotypes of hepatitis C viruses (HCV). Hepatitis C slowly sprouts into fibrosis, which progresses to cirrhosis. Over a prolonged period of time compensated cirrhosis can advance to decompensated cirrhosis culminating in hepatic failure and death.
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