Effects of wet cupping in a rat model of primary dysmenorrhea.

Background: Primary dysmenorrhea (PD) is characterized by discomfort with no organic etiology (no pelvic disease), recurring pain, or lower abdominal cramps that start between the first 8-72 h of menstruation. Cupping therapy uses a tool to form a vacuum at certain points on the skin.

Objectives: We investigated the mechanism of pain relief caused by cupping therapy in primary dysmenorrhea that is played by cupping therapy in PD.

Synergistic therapeutic approach for hemorrhoids: integrating mesenchymal stem cells with diosmin-hesperidin to target tissue edema and inflammation.

Introduction: Mesenchymal stem cells (MSCs) have promising regenerative properties in tissue repair and anti-inflammatory responses. This study aimed to investigate the effects of MSCs and their combination with micronized purified flavonoid fraction (MPFF) in a croton oil-induced hemorrhoids model on tissue edema, inflammation, and underlying molecular mechanisms.

Material And Methods: MSCs were isolated and characterized for their adherence, differentiation capacity, and immunophenotyping.

Evaluation of placental bed uterine in L-NAME-induced early-onset preeclampsia (EO-PE) like the rat model.

Objective: Preeclampsia (PE) is the leading cause of maternal death worldwide and is associated with long-term morbidity in both mothers and newborns. Animal modeling is considered a functional source for understanding PE pathogenesis, diagnostic standards, and therapeutic approaches.

Materials And Methods: This study aimed to demonstrate and evaluate the use of N-nitro-L-arginine methyl ester (L-NAME) in a Wistar rat model under conditions similar to PE.

Correlation between circulating fibrosis biomarkers with left atrial function and left atrial volume index in rheumatic mitral stenosis.

Mitral stenosis is the most common rheumatic heart disease (RHD) disorder worldwide, including in Indonesia. This pathological condition causes left atrial pressure, leading to left atrial fibrosis that affects the structure and function of the left atrial as well as the clinical condition. The aim of this study was to assess the correlation between circulating fibrosis biomarkers with net atrioventricular compliance (Cn) as a parameter of left atrial function, and left atrial volume index (LAVI) as a parameter left atrium structure of changes.

A minimal colloid model of solution crystallization nucleates crystals classically.

A fundamental assumption of the classical theories of crystal nucleation is that the individual molecules from the "old" phase associate to an emerging nucleus individually and sequentially. Numerous recent studies of crystal nucleation in solution have revealed nonclassical pathways, whereby crystal nuclei are hosted and fed by amorphous clusters pre-formed in the solution. A sizable knowledge gap has persisted, however, in the definition of the molecular-level parameters that direct a solute towards classical or nonclassical nucleation.

Improvement of renal functions in mice with septic acute kidney injury using secretome of mesenchymal stem cells.

Background: A potentially fatal complication of sepsis is septic acute kidney injury. Stem cell therapy is a potential new method of treating sepsis and has been applied to treat some human diseases.

Objectives: This study investigated the effects of secretome-MSCs on NGAL, CRP, NF-κB, and MMP-9 proteins, and histopathology in mice with septic AKI.

Dose-response effect of L-citrulline on skeletal muscle damage after acute eccentric exercise: an study in mice.

Background: Eccentric exercise may trigger mechanical stress, resulting in muscle damage that may decrease athletic performance. L-citrulline potentially prevents skeletal muscle damage after acute eccentric exercise. This study aimed to assess the dose-response effect of L-citrulline as a preventive therapy for skeletal muscle damage in mice after acute eccentric exercise.

Effect of Dapagliflozin on Patients with Rheumatic Heart Disease Mitral Stenosis.

(1) Background: Mitral stenosis is the most common rheumatic heart disease (RHD). Inflammation and fibrosis are the primary pathophysiology, resulting in left atrial stress and dysfunction. Dapagliflozin is a new heart failure treatment with anti-inflammation and anti-fibrosis effects from previous studies.

Factors Affecting Village Apparatus, Integrated Service Post and Early Childhood Education in Stunting Prevention.

Background: The study aimed to identify the achievement of stunting prevention based on the contribution of the Village Apparatus, Integrated Health Services Post and Early Childhood Education. Moreover, it determined the effect of the personnel factors of each agency on the achievement of stunting prevention.

Methods: A cross-sectional study was conducted on 175 respondents in Surakarta residences covering Klaten, Boyolali, Karanganyar, Surakarta, Sukoharjo, and Sragen districts from August to October 2021.

The Role of Asiatic Acid in Preventing Dental Pulp Inflammation: An in-vivo Study.

Purpose: Acute dental pulp inflammation necessitates early treatment to alleviate inflammation and pain. In the inflammatory phase, a substance is required to lower the inflammatory mediators and reactive oxygen species that play a crucial role in that phase. Asiatic acid is a natural triterpene obtained from the plant with a high antioxidant value.

Effects of Polymer Molecular Weight on Structure and Dynamics of Colloid-Polymer Bridging Systems.

We investigate the effects of polymer molecular weight on the structure and dynamics of a model colloid-polymer bridging system using confocal microscopy. Polymer-induced bridging interactions between trifluoroethyl methacrylate---butyl methacrylate (TtMA) copolymer particles and poly(acrylic acid) (PAA) polymers of molecular weight of 130, 450, 3000, or 4000 kDa and normalized concentrations /* ranging from 0.05 to 2 are driven by hydrogen bonding of PAA to one of the particle stabilizers.

Association between carotid intima media thickness and acute ischemic stroke at an Indonesian tertiary referral hospital.

Objectives: A high prevalence of tobacco smoking contributes to a high incidence of acute ischemic stroke (AIS) in Indonesia. Large-artery atherosclerosis is known to be a significant cause of AIS. The present study was aimed at evaluating the association between AIS and atherosclerosis on the basis of carotid intima-media thickness (CIMT) measurements in a tertiary care hospital in Indonesia.

Detection of carrier Booroola (Fec) allele in BMPR1B gene of MEGA (Merino × Garut) sheep and its association with growth traits.

Background: Bone morphogenetic protein receptor 1B (BMPR1B) gene is one of candidate genes for reproductive and growth traits in sheep. The present study was aimed to detect the Booroola (Fec) allele in BMPR1B gene and its association with growth traits in MEGA (Merino × Garut) sheep. A total of 82DNA samples collected from individual lamb (mixed-sex) blood were genotyped for allelic polymorphism using a PCR-RFLP method.

Modulation effects of Etlingera elatior ethanol extract as anti-inflammatory on chronic kidney disease in mice with hypertension and diabetes.

The incidence of diabetes increased significantly around the world in accordance with lifestyle and change in eating behaviour. (STZ-NA) is capable of inducing Diabetes Mellitus type 2 in experimental animals for insulin resistance. In this research, we inspect the therapeutic potential of ethanol extract (EEEE) on diabetes associated with diabetic nephropathy and hypertension complications in mice models.

Aggregation and gelation in a tunable aqueous colloid-polymer bridging system.

We report a colloid-polymer model system with tunable bridging interactions for microscopic studies of structure and dynamics using confocal imaging. The interactions between trifluoroethyl methacrylate-co-tert-butyl methacrylate copolymer particles and poly(acrylic acid) (PAA) polymers were controllable via polymer concentration and pH. The strength of adsorption of PAA on the particles, driven by pH-dependent interactions with polymer brush stabilizers on the particle surfaces, was tuned via solution pH.

Exosomes Derived from Secretome Human Umbilical Vein Endothelial Cells (Exo-HUVEC) Ameliorate the Photo-Aging of Skin Fibroblast.

Purpose: This is an in-vitro experimental study to analyze the effect of Exo-HUVEC on endothelial cell (CD31), cell proliferation, matrix metalloproteinase 1 (MMP-1) and collagen type 1 on irradiated fibroblast with UVB as photo-aging model.

Patients And Methods: Fibroblast cultures were divided into 5 groups, namely without UVB exposure, UVB exposure 600mJ/cm for 80 seconds as photo-aging model, and UVB exposure +Exo-HUVEC exposure 0.1%, 0.

Proteomic analysis of hypoxia and non-hypoxia secretome mesenchymal stem-like cells from human breastmilk.

Introduction: Breastmilk contains proteins and cells which have stem cell properties. The human breastmilk stem cell mimick mesenchymal stem cells and expresses pluripotency genes. The protein level of breastmilk is high in colostrum and gradually subsides in the first year of lactation.

Chronic exposure to heavy metals from informal e-waste recycling plants and children's attention, executive function and academic performance.

E-waste contains valuable metals that require appropriate waste management plans. However, rudimentary e-waste processing methods are a source of heavy metals environmental pollution. This study has characterised concentrations of heavy metals in soil (n = 10), water (n = 10) and hair (n = 44) of children in areas surrounding Jakarta (Indonesia), where e-waste is being or has been conducted in the past, and in a reference unexposed site.

The effect of logotherapy on the expressions of cortisol, HSP70, Beck Depression Inventory (BDI), and pain scales in advanced cervical cancer patients.

This study aims to analyze the effect of logotherapy on the expression of cortisol, HSP70, and the Beck Depression Inventory (BDI) and to conduct pain assessments in advanced cervical cancer patients. We carried out this research through pretest-posttest control-group design on the expression of cortisol, HSP70, the BDI, and pain scales after a patient receives logotherapy treatment. Based on a comparative test conducted with the two groups before the treatment, there is no significant difference (p > .

Implantation of nerve stump inside a vein and a muscle: comparing neuroma formation in rat.

Among many techniques independently reported to manage neuroma formation, manipulation of the nerve stump inside muscle and vein is the most advantageous technique. This study aimed to enrich the basic data of macroscopic appearance and histo-pathology regarding which technique generates less neuroma: nerve stump implantation inside vein or inside muscle. An experimental study with posttest-only control-group design was conducted in 24 rats that were randomly arranged into 3 groups.

Prevalence and clinical profile of diabetes mellitus in productive aged urban Indonesians.

Aims/introduction: To estimate the prevalence and clinical profile of diabetes mellitus in productive aged urban Indonesians based on the National Basic Health Research 2007.

Materials And Methods: The statistical analyses of a cross-sectional survey included the data of 15,332 adults, aged 18-55 years, living in an urban area. Blood glucose was measured by an automatic clinical chemistry analyzer by 2-h, 75-g post glucose load after an overnight fast.

The plausibility and promptness of some pathological aspects of breast cancer. "DHARMAIS" NCCH.

Breast Cancer (BC) still interest to be discussed, comparison studies from several investigators still in controversial, especially on risk factors of BC, otherwise BC morbidity and mortality were stationary, infact, had a tendency increasing. Epidemiology studies on BC, daily observation for a long period explored that some Indonesian BC cases from different areas were young, plenty of the Indonesian BC cases were admission to hospital in a late stage (TNM III-IV). Western style of life influences on diet, cooking, breast feeding, smoking, etc.

Pathological aspects of brain tumors.

Brain tumors based on their histogenesis, consist of all tumors, derive from the entirely tissue in the intracranial space, both from the neuro-ectodermal/neuro-epithelial tissue and the mesenchymal tissue. By their location they can be divided into infratentorial or supratentorial, and further into deep vs. superficial.

Fat intake and breast cancer risk in an area where fat intake is low: a case-control study in Indonesia.

Background: Associations of fat and other macronutrients with breast cancer risk are not clear in areas where fat intake is low.

Methods: We conducted a hospital-based case-control study from 1992 to 1995 in Jakarta, Indonesia.

Results: The study, based on 226 cases and 452 age and socioeconomic status matched controls, provided the following findings.