Factors influencing intraoperative conversion from double- to single-incision mastectomy with free nipple grafts in 352 transgender and non-binary patients.

Background: Double-incision mastectomy (DIM) with free nipple grafts (FNG) is a common technique employed in gender-affirming mastectomy (GAM), but is associated with a high scar burden. Intraoperatively, the surgeon may opt for a single-incision mastectomy (SIM) along the inframammary folds (IMF) to optimize aesthetic outcomes. This study sought to identify factors predictive of intraoperative conversion.

Arterialized Vein Bypass Graft Recipient Vessel in Free Tissue Transfer Covering Diabetic Foot Ulcers Complicated by Critical Limb Ischemia.

Limb salvage options are limited in diabetic patients with critical limb ischemia. Soft tissue coverage remains technically demanding with limited recipient vessels for free tissue transfer. These factors make revascularization alone challenging.

A single-cell map of antisense oligonucleotide activity in the brain.

Antisense oligonucleotides (ASOs) dosed into cerebrospinal fluid (CSF) distribute broadly throughout the central nervous system (CNS). By modulating RNA, they hold the promise of targeting root molecular causes of disease and hold potential to treat myriad CNS disorders. Realization of this potential requires that ASOs must be active in the disease-relevant cells, and ideally, that monitorable biomarkers also reflect ASO activity in these cells.

A single-cell map of antisense oligonucleotide activity in the brain.

Antisense oligonucleotides (ASOs) dosed into cerebrospinal fluid (CSF) distribute broadly throughout the brain and hold the promise of treating myriad brain diseases by modulating RNA. CNS tissue is not routinely biopsied in living individuals, leading to reliance on CSF biomarkers to inform on drug target engagement. Animal models can link CSF biomarkers to brain parenchyma, but our understanding of how individual cells contribute to bulk tissue signal is limited.

Trends in Fellowship Training across United States Plastic and Reconstructive Surgery Academic Faculty.

Unlabelled: Plastic and reconstructive surgery (PRS) academic positions are more coveted each year. We aim to determine the requirement of fellowship training before PRS academic appointments.

Methods: PRS faculty at U.

Incorporating the Osseous Genioplasty Into Rejuvenation of the Lower Face.

Background: The chin plays a critical role in the shape, projection, and soft tissue support of the lower face. Osseous genioplasty is a powerful tool in facial rejuvenation as it allows for optimal control of the resulting chin dimensions and improvement in submental and submandibular laxity. Osseous genioplasty can be used alone or in combination with other facial rejuvenation procedures to achieve an optimal result.

Bounds for metric dimensions of generalized neighborhood corona graphs.

In this paper, the authors analysed metric dimensions of arbitrary graphs in which graphs are non-trivial, is connected, and denotes generalized neighborhood corona operation. We found lower bounds of as function of where denotes adjacency metric dimensions of . We also found upper bounds of when does not contain pair of false twin vertices.

The reflexive edge strength on some almost regular graphs.

A function with domain and range are respectively the edge set of graph and natural number up to , and a function with domain and range are respectively the vertex set of graph and the even natural number up to are called a total -labeling where . The total -labeling of graph by the condition that every two different edges have different weight is called an edge irregular reflexive -labeling, where for any edge , the weight is . The reflexive edge strength of the graph , denoted by is the minimum for graph which has an edge irregular reflexive -labelling.

The dominant metric dimension of graphs.

The be a connected graph with vertex set and edge set . A subset is called a dominating set of if for every vertex in , there exists at least one vertex in such that is adjacent to . An ordered set is called a resolving set of , if every pair of vertices and in have distinct representation with respect to .

Correlation of bioimpedance changes after compressive loading of murine tissues in vivo.

Objective: Rises in the incidence of pressure ulcers are increasingly prevalent in an aging population. Pressure ulcers are painful, are associated with increased morbidity and mortality, increase the risk for secondary infections and inpatient stay, and adds $26.8 billion annually to the healthcare costs of the USA.

Increasing Fat Graft Retention in Irradiated Tissue after Preconditioning with External Volume Expansion.

Background: Fat grafting is an adjuvant that may improve the quality of radiation-damaged tissue. However, fat grafting for volume restoration in irradiated sites may be less effective because of a poorly vascularized fibrotic recipient bed. External volume expansion has emerged as a potential technique to prepare the recipient sites for improved survival of grafted fat.

Wireless Pressure Ulcer Sensor: Validation in an Animal Model.

Pressure ulcers are increasingly prevalent in an aging population. The most commonly used method of pressure ulcer prevention is pressure off-loading achieved by physically turning bedbound patients or by using expensive, single application devices such as wheelchair cushions. Our aim is to approach the problem of pressure ulcer prevention in a new way: a wireless sensor worn by the patient at locations susceptible to pressure injury.

Generation of Functional Human Adipose Tissue in Mice from Primed Progenitor Cells.

This research describes the use of human mesenchymal progenitor cells for generating functional adipose tissue in a nude mouse model. Further preclinical development of the methods and insights described in this article can lead to therapeutic use of these cells in regenerative and reconstructive medicine.

Evolution of customization design for total knee arthroplasty.

Total Knee Arthroplasty (TKA) is a highly successful surgical procedure with more than 600,000 TKA's performed annually in the US. Interest in improving surgical outcomes has led to improvements in surgical technique, instrumentation, and implant design. Computer navigation and robotic systems were introduced to further refine the mechanical alignment of joint replacement procedures.

Unicompartmental knee resurfacing: enlarged tibio-femoral contact area and reduced contact stress using novel patient-derived geometries.

Advances in imaging technology and computer-assisted design (CAD) have recently enabled the introduction of patient-specific knee implant designs that hold the potential to improve functional performance on the basis of patient-specific geometries, namely a patient-specific sagittal and coronal curvature, as well as enhanced bone preservation. The objective of this study was to investigate the use of a novel implant design utilizing a patient specific sagittal J-curve on the femoral component combined with a novel constant, patient-derived femoral coronal curvature and to assess tibio-femoral contact area and contact stress on a femur matched curved tibial polyethylene insert. Mean contact area and standard deviations were 81+/-5, 96+/-5 and 74+/-4 mm(2) for the heel strike, toe off and mid-stance positions, respectively.

Osteolysis after total knee arthroplasty.

Osteolysis ranks as the most significant cause of revision surgery in both total hip arthroplasty and total knee arthroplasty (TKA). The factors leading to osteolysis in TKA are unique and sometimes preventable. Changes in polyethylene manufacturing and implant design are striving to improve overall wear.

Patellar crepitation in the P.F.C. sigma total knee system.

Painless and painful patellar crepitation and patellar clunk syndrome represent a spectrum of peripatellar scar formation particular to posterior-stabilized knee components, although it may occur with cruciate-retaining designs as well. The formation of peripatellar inflammatory scar tissue is related to implant design and surgical technique, with microscopic and gross findings indicating varying degrees of inflammatory fibrous hyperplasia. These well recognized clinical entities have an incidence ranging between 1% and 5% in different series.

Tibial forces measured in vivo after total knee arthroplasty.

An instrumented tibial prosthesis was developed to measure forces in vivo after total tibial arthroplasty. This prosthesis was implanted in a 67-kg, 80-year-old man. The prosthesis measured forces at the 4 quadrants of the tibial tray.

The Chitranjan Ranawat Award: in vivo knee forces after total knee arthroplasty.

Tibial forces were measured in vivo during the first year after total knee arthroplasty in a 66 kg, 80-year-old man. Forces were measured during activities of daily living, rehabilitation, and exercise. Peak tibial forces recorded during walking increased up to 12 months postoperatively (2.