Comprehensive Review on Low-Level Laser Therapy in Dentistry.

Low-level laser therapy (LLLT) has broad applications in dentistry, enhancing patient outcomes through its anti-inflammatory, analgesic, and biostimulatory effects. It is used for reducing pain and swelling, accelerating wound healing, and promoting tissue regeneration. LLLT is effective in managing conditions, such as temporomandibular disorders (TMDs), oral mucositis, and postoperative discomfort.

Analyzing Pooled Microarray Gene Expression Data to Uncover Common Pathways in Periodontitis and Oral Squamous Cell Carcinoma from the Gene Expression Omnibus.

Periodontitis and oral squamous cell carcinoma (OSCC) are prevalent oral diseases with distinct etiologies, yet they share certain molecular and biological characteristics. Gene expression datasets from the gene expression omnibus (GEO) repository (GSE30784 for OSCC and GSE10334 for periodontitis) were analyzed. Data preprocessing and differential gene expression analysis using GEO2R identified common differentially expressed genes (DEGs), and FunRich software facilitated the construction of a protein-protein interaction (PPI) network on the STRING database.

Role of F-FDG-PET/CT in an AML-M5a Subtype Patient with Rare Constellation of Hemophagocytic Lymphohistiocytosis & Bilateral Multiple Breast Chloromas.

We report a treated case of acute myeloid leukemia (AML-M5a subtype) with monocytic differentiation (AMoL) presenting with fever and body pains. Initial F-FDG-PET/CT ( F-flurodeoxyglucose positron emission tomography/computed tomography) identified multiple lymph nodal, and marrow lesions. Biopsy confirmed hemophagocytic lymphohistiocytosis (HLH).

District-Wise Treatment Gaps and Hospitalizations in Under-Five Children With Diarrhea in India.

India bears greatest under-5 diarrheal burden and mortality. We studied geographical variation in under-5 diarrhea prevalence, oral rehydration solution (ORS) and zinc supplementation treatment gaps and hospitalization rates. We point to treatment gap in western Maharashtra, Andhra Pradesh and Gujarat.

Antimicrobial Efficacy of Three Different Mouthwashes on Periodontal Pathogens-An Study.

Aim: The aim of this research was to identify the antimicrobial effectiveness of three different mouthwashes on periodontal pathogenic microorganisms.

Materials And Methods: 2 periodontal disease-causing microorganisms, i.e.

Predictive Equation for Construction of Anatomic Porion with Machine Porion as Reference Point.

Aim: The aim of the study was to find a relationship between anatomic porion (PoA) and machine porion (PoM) and to construct PoA with the help of machine porion.

Methodology: About 200 pretreatment lateral roentgenic cephalograms were used for the study. Perpendicular distances of PoA and PoM were measured from Sella-Nasion (SN) plane and SN perpendicular plane.

A model for organization and regulation of nuclear condensates by gene activity.

Condensation by phase separation has recently emerged as a mechanism underlying many nuclear compartments essential for cellular functions. Nuclear condensates enrich nucleic acids and proteins, localize to specific genomic regions, and often promote gene expression. How diverse properties of nuclear condensates are shaped by gene organization and activity is poorly understood.

A model for cis-regulation of transcriptional condensates and gene expression by proximal lncRNAs.

Long noncoding RNAs (lncRNAs) perform several important functions in cells including cis-regulation of transcription. Barring a few specific cases, the mechanisms underlying transcriptional regulation by lncRNAs remain poorly understood. Transcriptional proteins can form condensates via phase separation at protein-binding loci (BL) on the genome (e.

The phosphatidylinositol-transfer protein Nir3 promotes PI(4,5)P replenishment in response to TCR signaling during T cell development and survival.

Hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP) by phospholipase C-γ (PLCγ1) represents a critical step in T cell antigen receptor (TCR) signaling and subsequent thymocyte and T cell responses. PIP replenishment following its depletion in the plasma membrane (PM) is dependent on delivery of its precursor phosphatidylinositol (PI) from the endoplasmic reticulum (ER) to the PM. We show that a PI transfer protein (PITP), Nir3 (Pitpnm2), promotes PIP replenishment following TCR stimulation and is important for T cell development.

The importance of wage loss in the financial burden of illness: Longitudinal evidence from India.

Background: A key aim of Universal Health Coverage (UHC) is to protect individuals and households against the financial risk of illness, and large-scale health insurance expansions are a central focus of the UHC agenda. Importantly, however, health insurance does not protect against a key dimension of financial risk associated with illness: forgone wage income. In this paper, we quantify the economic burden of illness in India attributable - separately - to wage loss and to medical care spending, as well as differences in them across the socio-economic distribution.

Comparative Evaluation of Intrathecal Bupivacaine 0.5% With Intrathecal Bupivacaine 0.5% and 60-µg Buprenorphine for Postoperative Analgesia in Elective Cesarean Section Patients.

Introduction: The analgesia after the C-section is a very challenging condition to the anesthetist. Various combinations of the agents have been proposed for a successful analgesia. Hence, in our study, we aimed to compare the intrathecal bupivacaine 0.

Diclofenac versus tramadol for mucositis related pain in head and neck cancer patients undergoing concurrent chemoradiation-a phase 3 study.

Background: Oral mucositis related pain during CTRT in head and neck cancers is a common problem. Unfortunately, in spite of it being common, there is limited evidence for selection of systemic analgesic in this situation. Hence, this study was designed to compare the analgesic effect of a non-steroidal anti-inflammatory drug (diclofenac) versus a weak opioid (tramadol).

Geometry of Implant Abutment Surface Improving Cement Effectiveness: An Study.

Aim: The aim of the study was to investigate whether the surface geometry or topography of implant abutments affects the retentive strength of prosthesis cemented with zinc phosphate on standard machined, sandblasted, and grooved implant abutments and to compare the results between them.

Materials And Methods: Fifteen similarly shaped implant abutments (MDcpk61; MIS Implant Technologies Ltd.,) (height 6.

Case of the Very Rare Gallbladder Paraganglioma.

Gallbladder paraganglioma is a very rare condition, and only a few cases have been reported in the literature. Herein, we present and discuss the clinical and radiological findings of a 72-year-old woman who complained of heaviness, pain, and on and off watery discharge from the left ear for 1 year and reduced hearing in both ears. She was thoroughly investigated radiologically where multiple paragangliomas were found with the discovery of the very rare gallbladder paraganglioma.

Phase separation in fluids with many interacting components.

Fluids in natural systems, like the cytoplasm of a cell, often contain thousands of molecular species that are organized into multiple coexisting phases that enable diverse and specific functions. How interactions between numerous molecular species encode for various emergent phases is not well understood. Here, we leverage approaches from random-matrix theory and statistical physics to describe the emergent phase behavior of fluid mixtures with many species whose interactions are drawn randomly from an underlying distribution.

Comparison of Tru-Cut Biopsy and Incisional Biopsy in Achieving Prompt Diagnosis of Maxillofacial Pathology.

Tru-cut (core needle) biopsy has many advantages over open biopsy. It is quick and easy to perform, may be carried out in the outpatient department, avoids incision through previously irradiated skin and has few complications. The purpose of this study is to compare the two available biopsy techniques that are Tru-cut biopsy and incisional biopsy in achieving prompt diagnosis of maxillofacial pathology.

Awareness among anesthesia residents pertaining to various intubation techniques in craniofacial surgery: A questionnaire study.

Aim: This study was intended to evaluate the knowledge and clinical skill of anesthesia residents pertaining to various intubation techniques employed in craniofacial surgery.

Materials And Methods: A cross-sectional survey research design was employed in this study. A self-administered questionnaire survey was used to validate the knowledge and clinical skill of anesthesia residents pertaining to various intubation techniques employed in craniofacial surgery.

RNA-Mediated Feedback Control of Transcriptional Condensates.

Regulation of biological processes typically incorporates mechanisms that initiate and terminate the process and, where understood, these mechanisms often involve feedback control. Regulation of transcription is a fundamental cellular process where the mechanisms involved in initiation have been studied extensively, but those involved in arresting the process are poorly understood. Modeling of the potential roles of RNA in transcriptional control suggested a non-equilibrium feedback control mechanism where low levels of RNA promote condensates formed by electrostatic interactions whereas relatively high levels promote dissolution of these condensates.

Prevalence of oromucosal lesions in HIV positive patients receiving haart-A prospective clinical study.

Aim: To determine the preponderance of oral mucosal lesions and conditions in patients receiving highly active antiretroviral therapy (HAART) for Human Immunodeficiency virus (HIV).

Material And Methods: Patient tested Seropositive for HIV and on HAART therapy were clinically examined to evaluate prevalence of oral lesions.

Results: In the pool of 152 HIV positive patients in the study, age ranged from 7 to 71 years, 67 were males and 85 females.

Simultaneous determination of colchicine and febuxostat in rat plasma: Application in a rat pharmacokinetic study.

A selective, sensitive and rapid LC-MS/MS method has been developed and validated as per US Food and Drug Administration regulatory guidelines for the simultaneous quantitation of colchicine and febuxostat in rat plasma. Colchicine and febuxostat were extracted from the rat plasma using 10% tert-butyl methyl ether in ethyl acetate using colchicine-d as an internal standard (IS). The chromatographic separation of colchicine, febuxostat and the IS was achieved using a mobile phase comprising 5 mm ammonium formate and 0.

Partitioning of cancer therapeutics in nuclear condensates.

The nucleus contains diverse phase-separated condensates that compartmentalize and concentrate biomolecules with distinct physicochemical properties. Here, we investigated whether condensates concentrate small-molecule cancer therapeutics such that their pharmacodynamic properties are altered. We found that antineoplastic drugs become concentrated in specific protein condensates in vitro and that this occurs through physicochemical properties independent of the drug target.

Enhancer Features that Drive Formation of Transcriptional Condensates.

Enhancers are DNA elements that are bound by transcription factors (TFs), which recruit coactivators and the transcriptional machinery to genes. Phase-separated condensates of TFs and coactivators have been implicated in assembling the transcription machinery at particular enhancers, yet the role of DNA sequence in this process has not been explored. We show that DNA sequences encoding TF binding site number, density, and affinity above sharply defined thresholds drive condensation of TFs and coactivators.