Upgraded space and time resolved visible spectroscopic diagnostic on ADITYA-U tokamak.

Poloidal asymmetries in neutral and impurity ion temperatures and particle and impurity transports have been observed in many tokamaks. To investigate these asymmetries, space-resolved visible spectroscopic diagnostic of the ADTIYA-U tokamak has been upgraded to measure the spatial profile of Hα and impurities spectral line profile, ion temperature, and plasma rotation from both low and high field sides of the plasma, simultaneously with a better spatial resolution. This has been done by developing a linear array of 15 optical fibers as compared to the present linear array of nine fibers having a core diameter of 400 μm and coupling it to the entrance slit of a 1 m long high-resolution spectrometer of the existing diagnostic.

A COMPARATIVE STUDY OF VICRYL RAPIDE SUTURE VERSUS CHROMIC CATGUT SUTURE FOR EPISIOTOMY REPAIR.

Background: An episiotomy is a perineal incision performed to facilitate childbirth by enlarging the diameter of the vulvae outflow. This study used vicryl rapide suture, a polyglactin analogue that causes less tissue reactivity and is removed through hydrolysis (as opposed to chromic catgut suture), because long-term complications after episiotomy repair are common. Made of collagen, chromic catgut is broken down by proteolytic enzymes and phagocytosis, which causes an inflammatory response in the tissues.

Reorganization of circadian activity and the pacemaker circuit under novel light regimes.

Many environmental features are cyclic, with predictable changes across the day, seasons and latitudes. Additionally, anthropogenic, artificial-light-induced changes in photoperiod or shiftwork-driven novel light/dark cycles also occur. Endogenous timekeepers or circadian clocks help organisms cope with such changes.

Drosophila melanogaster Neuromuscular Junction as a Model to Study Synaptopathies and Neuronal Autophagy.

Neuronal synapse dysfunction is a key characteristic of several neurodegenerative disorders, such as Alzheimer's disease, spinocerebellar ataxias, and Huntington's disease. Modeling these disorders to study synaptic dysfunction requires a robust and reproducible method for assaying the subtle changes associated with synaptopathies in terms of structure and function of the synapses. Drosophila melanogaster neuromuscular junctions (NMJs) serve as good models to study such alterations.

Assessing the synergistic effectiveness of intermittent theta burst stimulation and the vestibular ocular reflex rehabilitation protocol in the treatment of Mal de Debarquement Syndrome: a randomised controlled trial.

Introduction: Mal de Debarquement Syndrome (MdDS) is a rare central vestibular disorder characterised by a constant sensation of motion (rocking, swaying, bobbing), which typically arises after motion experiences (e.g. sea, air, and road travel), though can be triggered by non-motion events.

Knowledge and awareness of clinical trials among trial participants in India: A multicentric questionnaire-based cross-sectional study.

Purpose: The knowledge and attitude of participants toward clinical trials (CTs) are a key determinant in successful recruitment and retention. This study aimed to evaluate knowledge and awareness-attitude among the recruited CT participants about CTs.

Methods: This was a cross-sectional face-to-face survey comprising CT participants involved in the past or currently a part of a CT during this study within the Indian Ophthalmology Clinical Trial Network (IOCTN).

Examining the physico-chemical, structural and thermo-mechanical properties of naturally occurring Acacia pennata fibres treated with KMnO.

Natural fiber is a viable and possible option when looking for a material with high specific strength and high specific modulus that is lightweight, affordable, biodegradable, recyclable, and eco-friendly to reinforce polymer composites. There are many methods in which natural fibres can be incorporated into composite materials. The purpose of this research was to evaluate the physico-chemical, structural, thermal, and mechanical properties of Acacia pennata fibres (APFs).

Changing human hair fibre colour and shape from the follicle.

Introduction: Natural hair curvature and colour are genetically determined human traits, that we intentionally change by applying thermal and chemical treatments to the fibre. Presently, those cosmetic methodologies act externally and their recurrent use is quite detrimental to hair fibre quality and even to our health.

Objectives: This work represents a disruptive concept to modify natural hair colour and curvature.

Effect on the Resistome of Dual vs Monotherapy for the Treatment of : Results From a Randomized Controlled Trial (ResistAZM Trial).

Background: No randomized controlled trial (RCT) has compared the impact on the resistome of ceftriaxone (CRO) plus azithromycin (AZM) vs CRO for the treatment of (NG).

Methods: This was an open-label, single-center, RCT comparing the effect on the resistome of CRO plus AZM vs CRO for the treatment of NG. Men who have sex with men (MSM) with genital, anorectal, or pharyngeal NG infection were randomized into the CRO/AZM and CRO arms.

Investigation on the removal of contaminants from washing machine discharge using (clearing nut) - A potential purifying agent.

The objective of the present study is to develop eco-friendly purifying agents from natural materials, (SP) - a coagulant. The seeds of SP were used for wastewater treatment (washing machine effluent). Physico-chemical parameters like turbidity, total dissolved solids (TDS), electrical conductivity (EC), pH, calcium (Ca), magnesium (Mg) and phosphate (PO) were tested and the data obtained were compared with BIS standards.

Attitude and perception toward clinical trials in India among patients and patient bystanders visiting the Indian Ophthalmology Clinical Trial Network: A multi-centric, cross-sectional survey.

Purpose: Advances in patient treatment depend heavily on clinical trials (CTs). Patient volunteers for CT are tougher to recruit and retain. In order to administer CTs effectively, it is necessary to comprehend how the public views and perceives participating in them.

Safety and efficacy of anti-BCMA CAR-T cell therapy in older adults with multiple myeloma: A systematic review and meta-analysis.

Introduction: Anti-B-cell maturation antigen (BCMA) chimeric antigen receptor T-cell (CAR-T) therapy is transforming the care of patients with relapsed/refractory multiple myeloma (MM). Unfortunately, despite being a disease of older adults these patients remain under-represented in most pivotal clinical trials. We performed a systematic review and proportion meta-analysis of prospective clinical trials and observational studies of anti-BCMA CAR-T therapy in patients with MM with the aim to determine the efficacy and safety of this therapy in older adults (≥65 years).

Knowledge and perception of health-care professionals on clinical trials in India: A pan-Indian cross-sectional survey.

Purpose: The purpose of the study was to evaluate the knowledge and perception of health-care professionals (HCPs), such as doctors/surgeons, pharmacists, nurses, optometrists, and lab technicians, on clinical trials (CTs) in India.

Methods: The study was a pan-Indian cross-sectional survey initiated by the Indian Ophthalmology Clinical Trial Network (IOCTN) by using a previously validated questionnaire for three months of data collection. An online survey was used to record information regarding demographics, CT knowledge, and CT perception among HCPs.

Physico-chemical and extraction properties on alkali-treated Acacia pennata fiber.

The production of reinforced composite materials can generally benefit greatly from the use of natural cellulosic woody fibers as good sustainable resources. Natural plants like hemp, cotton, and bamboo are great options for knitters and crocheters looking to make eco-friendly goods. The current study examines the properties of natural fiber obtained from the stem of the Acacia pennata (AP) plant, as well as its basic physico-chemical, structural, thermal, and mechanical characteristics.

Restoration of Sleep and Circadian Behavior by Autophagy Modulation in Huntington's Disease.

Circadian and sleep defects are well documented in Huntington's disease (HD). Modulation of the autophagy pathway has been shown to mitigate toxic effects of mutant Huntingtin (HTT) protein. However, it is not clear whether autophagy induction can also rescue circadian and sleep defects.

Characterisation of Sodium Acetate Treatment on Natural Fibres.

The present study concerns the physico-chemical, structural, mechanical and thermal characterization of Acacia pennata, a natural and almost inexpensive fibre, as a potential reinforcement in polymer composites. The effect of treating the fibre with sodium acetate to increase its qualities has been seen through the use of thermogravimetric analysis, scanning electron microscope (SEM) analysis, X-ray diffraction (XRD), mechanical property tester, and Fourier transform infrared spectroscopy (FTIR). According to XRD analysis, the elimination of lignin and wax-like impurities resulted in an increase in the AP fibre's crystalline index (79.

A Subset of Circadian Neurons Expressing Enables Appropriate Phasing of Activity Rhythms in Under Warm Temperatures.

Under conditions of prolonged durations of warmth, flies counter potential temperature stress by shifting their locomotor activity from day into night when the conditions are likely to be less harsh. Modulation of a rhythmic behavior such as this in response to the environment would require interaction between at least 2 neuronal systems: (1) a system to receive input from the environment, and (2) the to correctly time rhythmic activity in response to this thermosensory input. Our previous studies found that a thermosensory mutant of the ion channel Transient Receptor Potential-A1 () failed to shift activity into the dark like control flies do and also identified the role of a specific cluster of the -expressing neurons, the neurons necessary for this.

Effectiveness of non-pharmacological treatments for vestibular and oculomotor dysfunction in patients with persistent post-concussive symptoms: protocol for a systematic review and meta-analysis.

Introduction: Concussion is a form of mild traumatic brain injury that disrupts brain function. Although symptoms are mostly transient, recovery can be delayed and result in persistent postconcussive symptoms (PPCS). Vestibular and oculomotor dysfunction are among the most debilitating impairments associated with PPCS.

A new player in circadian networks: Role of electrical synapses in regulating functions of the circadian clock.

Several studies have indicated that coherent circadian rhythms in behaviour can be manifested only when the underlying circadian oscillators function as a well-coupled network. The current literature suggests that circadian pacemaker neuronal networks rely heavily on communication mediated by chemical synapses comprising neuropeptides and neurotransmitters to regulate several behaviours and physiological processes. It has become increasingly clear that chemical synapses closely interact with electrical synapses and function together in the neuronal networks of most organisms.

Visual disorders and mal de debarquement syndrome: a potential comorbidity questionnaire-based study.

Aim: Mal de debarquement syndrome (MdDS) is a neurological condition characterized by a constant sensation of self-motion; onset may be motion-triggered (MT) or non-motion-triggered/spontaneous (NMT/SO). People with MdDS experience similar symptoms to those with vertical heterophoria, a subset of binocular visual dysfunction. Hence, we aimed to explore potential visual symptom overlaps.

Effects of Food Availability Cycles on Phase and Period of Activity-rest Rhythm in .

Foraging and feeding are indispensable for survival and their timing depends not only on the metabolic state of the animal but also on the availability of food resources in their environment. Since both these aspects are subject to change over time, these behaviors exhibit rhythmicity in occurrence. As the locomotor activity of an organism is related to its disposition to acquire food, and peak feeding in fruit flies has been shown to occur at a particular time of the day, we asked if cyclic food availability can entrain their rhythmic activity.

Identification of cyber harassment and intention of target users on social media platforms.

Due to Coronavirus diseases in 2020, all the countries departed into lockdown to combat the spread of the pandemic situation. Schools and institutions remain closed and students' screen time surged. The classes for the students are moved to the digital platform which leads to an increase in social media usage.

Populations Reared Under Tropical Semi-natural Conditions Evolve Season-dependent Differences in Timing of Eclosion.

Circadian clocks are considered an evolutionary adaptation to environmental cycles, helping organisms to adapt to daily and seasonal changes. However, most studies on the evolution of circadian rhythms have been carried out in controlled laboratory conditions; hence evolution of circadian clocks and rhythms in organisms reared under the influence of naturally varying time cues is not well understood. To address this, we reared large outbred fly populations in an outdoor enclosure on our institutional grounds in Bengaluru, southern India for about 150 generations, at the same time maintaining their ancestral control populations under standard laboratory conditions.

Glutamatergic Synapse Dysfunction in Neuromuscular Junctions Can Be Rescued by Proteostasis Modulation.

Glutamate is the major excitatory neurotransmitter in the nervous system, and the glutamatergic neuromuscular junctions (NMJs) offer a tractable platform to understand excitatory synapse biology both in health and disease. Synaptopathies are neurodegenerative diseases that are associated with synaptic dysfunction and often display compromised proteostasis. One such rare, progressive neurodegenerative condition, Spinocerebellar Ataxia Type 3 (SCA3) or Machado-Joseph Disease (MJD), is characterized by cerebellar ataxia, Parkinsonism, and degeneration of motor neuron synapses.