Publications by authors named "Shashidhar"

Introduction: Neonatal intensive care unit (NICU) graduates are at risk of sudden death at home after discharge. Many of these deaths can be prevented if parents can identify warning signs and provide immediate resuscitation.

Objectives: The primary objective of this study was to assess the feasibility of training parents of high-risk neonates in low- and middle-income countries (LMICs) to deliver infant resuscitation effectively.

View Article and Find Full Text PDF

Purpose: Arachnoid cysts constitute approximately 1 % of intracranial mass lesions, with quadrigeminal cistern arachnoid cysts being 5-18 % of those. This study presents a series of 31 cases of quadrigeminal cistern arachnoid cysts, constituting the most extensive series reported to date.

Methods: A retrospective analysis was conducted on 31 patients diagnosed with quadrigeminal cistern arachnoid cysts, focusing on clinical presentation, demographics, treatment approaches, and outcomes.

View Article and Find Full Text PDF

The mungbean yellow mosaic India virus (MYMIV, Begomovirus vignaradiataindiaense) causes Yellow Mosaic Disease (YMD) in mungbean (Vigna radiata L.). The biochemical assays including total phenol content (TPC), total flavonoid content (TFC), ascorbic acid (AA), DPPH (2,2-diphenyl-1-picrylhydrazyl), and FRAP (Ferric Reducing Antioxidant Power) were used to study the mungbean plants defense response to MYMIV infection.

View Article and Find Full Text PDF
Article Synopsis
  • - Forkhead box (Fox) transcription factors (TFs) are crucial for heart development in mammals, influencing cardiac progenitor cell roles and positions.
  • - Researchers found that the Jumu gene plays a key regulatory role, with many downstream targets linked to cell division in cardiac progenitor cells.
  • - The study highlights Jumu as a central hub in a network that controls cardiac progenitor cell division, supported by the interactions of identified gene targets.
View Article and Find Full Text PDF
Article Synopsis
  • * A case study reports a 14-year-old boy diagnosed with diabetes insipidus, initially thought to have a high-grade glioma in the left frontal region, but was later confirmed to have a germinoma through histopathology.
  • * Post-surgery, the patient experienced improvement in his hypernatremia and successfully managed his condition with a small dose of desmopressin, highlighting the unique presentation of this germinoma without typical involvement in key brain regions.
View Article and Find Full Text PDF
Article Synopsis
  • The study investigated how COVID-19 disruptions affected neuroscience research projects and young researchers in India through an online survey targeting medical trainees, post-docs, PhD students, and early career faculty.
  • A total of 504 valid responses revealed that over 83% of participants experienced negative impacts on their research, with one-third noting delays and many adapting their methodologies due to the pandemic.
  • The findings highlighted significant challenges, particularly for those involved in prospective studies, emphasizing the need for focused support for neuroscience research in the post-pandemic landscape.
View Article and Find Full Text PDF

The SARS-CoV-2 virus responsible for the COVID-19 pandemic has profoundly impacted global health, economics, and society. This review seeks to encompass an overview of current knowledge on COVID-19, including its transmission, pathogenesis, and clinical presentation related to various systems within the human body. COVID-19 is a highly contagious illness that has rapidly spread worldwide.

View Article and Find Full Text PDF

Introduction: Meningiomas in children are rare, constituting less than 5% of all paediatric brain tumours and less than 2% of all meningiomas. Multiple meningiomas (synchronous or metachronous) are even more uncommon, typically occurring due to radiation exposure or in patients with phacomatoses like Neurofibromatosis II. This report presents the case of a child with metachronous meningiomas without dural attachment in unusual locations, along with their management.

View Article and Find Full Text PDF

Introduction: Meningiomas located in the posterior fossa and involving the sinodural angle at the junction of the transverse and sigmoid sinuses are uncommon and present unique challenges due to their complex anatomical location. Despite their distinctive features, they are frequently categorized with tentorial meningiomas in the literature.

Materials And Methods: This retrospective study conducted at a tertiary care center involved 64 patients with sinodural meningiomas who underwent surgical treatment between 2010 and 2023.

View Article and Find Full Text PDF

Hyperventilation-induced intracranial pressure reduction might be impaired in cerebral venous thrombosis (CVT) patients. Using transcranial Doppler, we assessed carbon dioxide-vasomotor reactivity (CO-VMR) within 24 hours of admission in CVT patients and studied its correlation with patient outcomes. Adult moderate-severe CVT patients (participants of another large observational study) were included.

View Article and Find Full Text PDF

Context: Diabetic eyes suffer from variety of complications including macular edema. Cataract surgery is the most commonly done procedure throughout the world and majority would be diabetics. As pseudophakic-cystoid macular edema (CME) is a known complication following cataract surgery, our study concentrated on finding the role of prophylactic topical nonsteroidal anti-inflammatory drugs (NSAIDs) on change in total macular volume (TMV) postcataract surgery in diabetic eyes.

View Article and Find Full Text PDF

Exploring the Role of Cap Grafts in tracheocutaneous fistula Closure. A tracheocutaneous fistula (TCF) is an abnormal connection that forms between the trachea (windpipe) and the skin of the neck. If spontaneous closure does not occur, fibrosis of the surrounding tissue may result in a persistent TCF and in some cases, iatrogenic laryngotracheal stenosis at the level of tracheostoma, the so-called A-frame deformity.

View Article and Find Full Text PDF

Catabolite repression is a mechanism of selectively utilizing preferred nutrient sources by redirecting the metabolic pathways. Therefore, it prevents non-essential energy expenditure by repressing the genes and proteins involved in the metabolism of other less favored nutrient sources. Catabolite repressor protein (CRP) is a chief mediator of catabolite repression in microorganisms.

View Article and Find Full Text PDF

Background And Objectives: Stereotactic biopsies are a relatively safe and reliable way of tissue diagnosis and characterization of eloquent area lesions/neoplasm. However, predicting the accuracy of the site of biopsy with the desired/planned site is not always possible. We describe a technique to identify the precise location of the biopsy site in the post-operative computed tomography (CT) scan using the injection of a low volume of air into the biopsy cannula.

View Article and Find Full Text PDF

Purpose: This study aims to discuss the management challenges of huge hydrocephalus (HH), a severe subset of hydrocephalus, presenting predominantly in underprivileged backgrounds. Insights into the condition's characteristics, factors affecting outcomes, and associated morbidity are discussed.

Methods: A retrospective review of all operated cases of hydrocephalus with head circumference greater than body length (HC>L) was conducted (January 2019-January 2023).

View Article and Find Full Text PDF

The study's objective was to evaluate the status of converted degraded land into productive agricultural models by improving the physicochemical properties of the soil, soil organic matter (SOM), soil organic carbon (SOC) fractions (active and passive), and microbial biomass carbon (MBC), while also generating carbon (C) credit for additional farmers' income. Six models were analyzed, namely: (1) Arjun forest-based agroecosystems (AFBAE); (2) Lemon grass-based agroecosystems (LGBAE); (3) Legume-cereal-moong-based agroecosystems (LCMBAE); (4) Bael-black mustard-based agroecosystems (BMBAE); (5) Guava-wheat-based agroecosystems (GWBAE), and (6) Custard apple -lentil -based agroecosystems (CALBAE). These models were replicated three times in a randomized block design (RBD).

View Article and Find Full Text PDF

Mirror movements, characterized by involuntary symmetrical movements in contralateral body parts during intentional movements, have been associated with various neurological conditions. Limited dorsal myeloschisis (LDM), a rare form of spinal dysraphism, is defined by a focal closed midline defect and a fibro-neural stalk connecting the skin lesion to the underlying cord. We present a unique case of a 4-year-old girl with cervical LDM exhibiting mirror movements.

View Article and Find Full Text PDF

Non-invasive methods for haemoglobin estimation hold enormous potential for early detection and treatment of anaemia, especially in limited resource settings. We sought to validate the diagnostic accuracy of ToucHb, a non-invasive haemoglobin estimation device available in the Indian market. We prospectively evaluated the diagnostic performance of the ToucHb device using the Automated complete blood count (CBC) method as the gold standard.

View Article and Find Full Text PDF

Lumpy skin disease virus (LSDV) belongs to the genus Capripoxvirus and family Poxviridae. LSDV was endemic in most of Africa, the Middle East and Turkey, but since 2015, several outbreaks have been reported in other countries. In this study, we used whole genome sequencing approach to investigate the origin of the outbreak and understand the genomic landscape of the virus.

View Article and Find Full Text PDF

Introduction: Resection of meningiomas (THMs) at the torcular Herophili poses challenges to surgeons due to complex regional anatomy. The current study aims to evaluate factors affecting the extent of resections, progression-free survival, and the role of radiation.

Methods: We did a retrospective study of all the THM patients treated at our institute between May 1987 and June 2022.

View Article and Find Full Text PDF

Embedded system technologies are increasingly being incorporated into manufacturing, smart grid, industrial control systems, and transportation systems. However, the vast majority of today's embedded platforms lack the support of built-in security features which makes such systems highly vulnerable to a wide range of cyber-attacks. Specifically, they are vulnerable to malware injection code that targets the power distribution system of an ARM Cortex-M-based microcontroller chipset (ARM, Cambridge, UK).

View Article and Find Full Text PDF

Dermatoglyphics is the study of various dermal configurations on the fingers, palms, and soles. These appear during the 12th week of intrauterine life and develop completely by the 24th week. It is said that they remain constant thereafter.

View Article and Find Full Text PDF

Introduction: The mandibular buccal shelf area is an extra-alveolar anchorage site that has high quality and quantity of bone, provides biomechanical benefits and has low failure rates. It is essential to place the implant in the region of bone with optimal thickness. The aim of this study was to determine the suitable site of the mandibular buccal shelf for bone screw insertion at 90 degrees and 30 degrees angles of insertion and various heights, angulations, areas of the buccal shelf in prognathic and retrognathic mandibles, and vertical and horizontal growth patterns.

View Article and Find Full Text PDF

Objective: Symptomatic developmental venous anomalies (DVAs) are rare. Here, we illustrate the varied clinicoradiologic profiles of symptomatic DVAs and contemplate the mechanisms that render these (allegedly) benign entities symptomatic supported by a review of literature.

Methods: Institutional databases were searched to identify cases of symptomatic DVAs.

View Article and Find Full Text PDF