Co, Cu, Ni, and Zn complexes of N-[(3-phenoxy phenyl)methylidene]-l-valine as α-glycosidase and α-amylase inhibitors: Synthesis, molecular docking & antimicrobial evaluation.

The ligand N-[(3-phenoxyphenyl)methylidene]-l-valine (HL) and its Co, Ni, Cu, and Zn derivatives (1-4) were synthesized and characterized. These compounds were tested for α-glucosidase and α-amylase inhibition activity, showing IC values of 10.51-51.

A Retrospective Study of the Profiles of Outpatients Attending the State Adolescent Friendly Health Resource Center, Andhra Pradesh, South India.

Background: Adolescents compose a significantly large age group, and attention to their health needs is lacking due to insufficient data and policy implementation globally and in India. India, having 268 million adolescents, faces the world's largest adolescent population, which highlights the importance of addressing their health requirements. The aim of this study was to describe the morbidity profiles of adolescent patients attending the State Adolescent Friendly Health Resource Centre at a tertiary-level healthcare institution in South India.

Heterojunction semiconductor nanocatalysts as cancer theranostics.

Cancer nanotechnology is a promising area of cross-disciplinary research aiming to develop facile, effective, and noninvasive strategies to improve cancer diagnosis and treatment. Catalytic therapy based on exogenous stimulus-responsive semiconductor nanomaterials has shown its potential to address the challenges under the most global medical needs. Semiconductor nanocatalytic therapy is usually triggered by the catalytic action of hot electrons and holes during local redox reactions within the tumor, which represent the response of nontoxic semiconductor nanocatalysts to pertinent internal or external stimuli.

Bacillus thuringiensis (Bt)-based biopesticide: Navigating success, challenges, and future horizons in sustainable pest control.

The global demand for food production is escalating, necessitating innovative approaches to mitigate pest-related crop losses. Conventional pest management using synthetic pesticides has several drawbacks, promoting the search for eco-friendly alternatives such as biopesticides. Among these, Bacillus thuringiensis (Bt)-based biopesticides have emerged as a promising option due to their specificity, sustainability, and safety.

Salivary Calprotectin Levels and Bone Mineral Density in Post-Menopausal Women With and Without Chronic Periodontitis - An Evaluative Study.

Introduction: Menopause is a normal developmental stage in a woman's life marking the permanent cessation of menstruation. Periodontitis and osteoporosis are noteworthy health concerns in post-menopausal women. Calprotectin is an inflammatory biomarker for precise diagnosis of periodontal disease.

Magnetic stirring with iron oxide nanospinners accretes neurotoxic Aβ oligomers into phagocytic clearable plaques for Alzheimer's disease treatment.

An increasing number of medications have been explored to treat the progressive and irreversible Alzheimer's disease (AD) that stands as the predominant form of dementia among neurodegenerative ailments. However, assertions about toxic side effects of these drugs are a significant hurdle to overcome, calling for drug-free nanotherapeutics. Herein, a new therapeutic strategy devoid of conventional drugs or other cytotoxic species was developed.

Acceptability of Prenatal Screening Tests Among Expectant Mothers in India: Insights and Implications for Public Health.

Introduction: Prenatal screening tests are essential for preventing common genetic disorders, yet their acceptability among pregnant women in India remains unexplored. This study aims to investigate the acceptability of prenatal screening tests and their correlation with demographic characteristics among pregnant women in India.

Methods: A cross-sectional study was conducted at a tertiary care, public hospital, involving 200 pregnant women.

A Refashioned Head Cover Device of Personal Protective Equipment to Facilitate Conventional Auscultation.

Conventional stethoscope is a useful clinical examination tool to aid evaluation of the underlying clinical condition, especially respiratory and cardiac illnesses, even before definitive imaging studies are performed. Auscultation with a stethoscope becomes highly challenging when wearing personal protective equipment (PPE) because the hood of the PPE covers both the ears. Herein, we describe an innovation that involves refashioning of the head cover device of the PPE suit to facilitate conventional auscultation using a stethoscope.

Unveiling the mysteries: Functional insights into hypothetical proteins from 638R.

Humans benefit from a vast community of microorganisms in their gastrointestinal tract, known as the gut microbiota, numbering in the tens of trillions. An imbalance in the gut microbiota known as dysbiosis, can lead to changes in the metabolite profile, elevating the levels of toxins like toxin (BFT), colibactin, and cytolethal distending toxin. These toxins are implicated in the process of oncogenesis.

In-silico insights of ESBL variants and tracking the probable sources of ESBL-producing Escherichia coli in a small-scale poultry farm.

Commercial broiler farms face challenges of extended spectrum beta-lactamase (ESBL)-producing Escherichia coli transmitted from both vertical and horizontal routes. Understanding the dynamics of ESBL-E. coli transmission in compromised biosecurity settings of small-scale rural poultry farms is essential.

Combined Application of Biochar and Plant Growth-Promoting Rhizobacteria Improves Heavy Metal and Drought Stress Tolerance in .

Plants are often exposed to multiple stresses, including heavy metals (HM) and drought, which limit the plant growth and productivity. Though biochar or plant growth-promoting rhizobacteria (PGPR) have been widely used for alleviating HM or drought stress in plants, the study of the effects of combined treatment with biochar and PGPR under simultaneous HM and drought stress is limited. This study investigated individual and combined effects of groundnut shell biochar (GS-BC) and PGPR strain ARN7 on growth, physiology, and HM accumulation, along with their impact on soil enzymes under HM (Ni and Zn), drought, or HM+drought stress.

Understanding the Awareness of Prenatal Genetic Screening Tests Among Pregnant Women in India: A Cross-Sectional Study.

Introduction Genetic disorders pose a significant health challenge in India, with chromosomal abnormalities ranking second only to congenital anomalies in terms of disease burden. Prenatal testing offers a crucial strategy for identifying and managing these disorders. However, the awareness and understanding of prenatal screening tests among pregnant women in India remain understudied.

Prevalence of Physical Nicotine Dependence and its Determinants among Tobacco users in the Rural Field Practice Area of a Tertiary Care Hospital in Tamil Nadu, India.

Background: Tobacco is the major cause of preventable death globally, which kills one person prematurely every six seconds. In India, around 46.9% of men and women aged 15 years and above use any kind of tobacco, according to NFHS-5.

Menstrual pattern and anthropometric characteristics of women with primary and secondary infertility in comparison with age-matched controls.

Background: The incidence of infertility has increased significantly due to lifestyle changes and the presence of diverse environmental stress. Body mass index (BMI) and waist circumference (WC) are two common anthropometric measures of obesity. Factors such as differences in race, sex, and age influence BMI, and recent studies have reported limitations in the use of BMI to determine obesity.

Utility of telemedicine for providing Obstetrics and Gynecology services during the COVID-19 pandemic-A single center experience from a tertiary care teaching hospital located in South India.

Background: The COVID-19 pandemic greatly impeded the provision of public healthcare within a healthcare system that was already under considerable strain. Routine patient care services were impacted during that time, leading to the promotion of telemedicine as a means of maintaining uninterrupted healthcare services. Telemedicine involves the utilization of electronic technology and communication to provide health-related information and medical care to individuals who are physically separated from healthcare professionals.

Psychometric Measurement of Fertility-related Quality of Life across Gender in Primary Infertile Couples.

Background: Infertility is a crucial global public health issue that affects millions of people of reproductive age. Fertility-related stress can negatively impact infertile couples' quality of life (QoL).

Aims: This study aimed to assess and compare the psychometric properties of fertility QoL between primary infertile couples' male and female partners.

Management of symptomatic irreversible pulpitis using irrigation agitation techniques in anterior teeth.

Endodontic pain, a common complication after root canal treatment, affects 2.5% to 60% of patients. Therefore, it is of interest to compare apical negative pressure irrigation (EndoVac) with conventional needle irrigation to assess their impact on postoperative pain in permanent anterior teeth with symptomatic irreversible pulpitis.

Influence of COVID-19 over seasonal influenza activity in southern India.

Basic epidemiological data is urgently needed in order to ascertain the changes brought about by COVID-19 pandemic, and help researchers, clinicians, and policy makers in addressing these issues. Data on influenza positivity from 2009 to 2019 was collected from Regional Influenza laboratory, JIPMER. Being COVID testing centre we tested samples (2020-2023) from Tamilnadu and Pondicherry.

A comprehensive review on antibacterial analysis of natural extract-based metal and metal oxide nanoparticles.

Pharmaceutical, food packing, cosmetics, agriculture, energy storage devices widely utilize metal and metal oxide nanoparticles prepared via different physical and chemical methods. It resulted in the release of several dangerous compounds and solvents as the nanoparticles were being formed. Currently, Researchers interested in preparing nanoparticles (NPs) via biological approach due to their unique physiochemical properties which took part in reducing the environmental risks.

Thermoluminescence properties of copper-doped TiO2 nanoparticles synthesised using co-precipitation method for high-dose gamma dosimetry.

In this work, copper (Cu)-doped titanium dioxide (TiO2) nanoparticles were prepared by co-precipitation. For studying the morphological properties, the copper doped titanium dioxide (TiO2:Cu) nanocrystalline structures were characterised through powder X-ray diffraction and field emission scanning electron microscopy. The prepared TiO2:Cu nanoparticles were annealed at two temperatures, namely, copper doped titanium dioxide annealed at 723 K temperayure (TC1) and copper doped titanium dioxide annealed at 1073 K temperayure (TC2).