Proposed biosensor for the detection of Bovine Serum Albumin using 7CB liquid crystals: A preliminary study.

Liquid crystal (LC) based biosensors offer a sensitive platform for detecting biomolecules due to their ability to respond to molecular interactions through changes in LC orientations. In this paper, we introduce a novel LC biosensor using 4-heptyl-4-biphenyl carbonitrile (7CB) to detect Bovine Serum Albumin (BSA). The interaction between BSA and 7CB was investigated using polarising optical microscopy (POM), molecular docking (MD), and Raman spectroscopy.

Efficacy and safety of microneedling radiofrequency in acne scars.

Objectives: To study the efficacy and safety of microneedling radiofrequency (MNRF) in the treatment of acne scars.

Material And Methods: This is a hospital-based and prospective interventional study. A total of 44 patients (18- 55 years old), skin types III-V, with acne scars, were enrolled.

Microplastic pollution: A global perspective in surface waters, microbial degradation, and corresponding mechanism.

Plastics are incredibly useful materials that have many benefits for both society and individual daily lives. However, the extensive utilization of plastic and plastic-derived products has led to plastic pollution in various environmental compartments across the world at alarming levels. Due to different biogeochemical processes, this plastic waste is broken down into tiny, omnipresent, and long-lasting fragments known as microplastics (<5 mm), which are causing great concern among scientists.

Developing a biosensing prototype utilising a 7CB liquid crystal for human insulin detection.

This paper presents a novel prototype for human insulin detection using a 4-heptyl-4-biphenylcarbonitrile liquid crystal (7CB-LC). Human insulin is essential for regulating blood glucose levels and facilitating the metabolism of carbohydrates, lipids, and proteins. Insufficient insulin can lead to hyperglycemia, where cells cannot utilise glucose effectively for energy production.

Role of the Surgical Approach in the Treatment of Eagle Syndrome.

 Eagle syndrome is a rare and an often misdiagnosed entity in otorhinolaryngology.  To determine the efficacy of the surgical treatment for Eagle syndrome.  The present prospective study included 25 patients who presented with complaints of pain in the throat, ear, and neck, as well as difficulty and/or pain while swallowing; they were assessed for Eagle syndrome.

Medicinal applications of vanadium complexes with Schiff bases.

Many transition metal complexes have been explored for their therapeutic properties after the discovery of cisplatin. Schiff bases have an efficient complexation tendency with the transition metals and several medicinal properties have been reported. However, fewer studies have reported the medicinal utility of vanadium and its Schiff base complexes.

Feasibility and preliminary clinical tolerability of low-field MRI-guided prostate biopsy.

Objective: We evaluate the clinical feasibility of a portable, low-field magnetic resonance imaging (MRI) system for prostate cancer (PCa) biopsy.

Methods: A retrospective analysis of men who underwent a 12-core systematic transrectal ultrasound-guided prostate biopsy (SB) and a low-field MRI guided transperineal targeted biopsy (MRI-TB). Comparison of the detection of clinically significant PCa (csPCa) (Gleason Grade [GG] ≥ 2) by SB and low field MRI-TB, stratified by Prostate Imaging Reporting & Data System (PI-RADS) score, prostate volume, and prostate serum antigen (PSA) was performed.

Acquired Reactive Perforating Collagenosis: Case Series.

Acquired reactive perforating collagenosis (ARPC) is one of the four acquired perforating dermatoses. The condition is characterized by transepidermal elimination of altered collagen. These are rare and underdiagnosed clinical entities and a few studies are available in the Indian literature.

Advantageous Detection of Significant Prostate Cancer Using a Low-Field, Office-Based MRI System.

Background Methods to diagnose prostate cancer (PCa), a highly prevalent disease, remain inadequate in terms of accuracy, cost, and logistical constraints for both patients and providers. Early and accurate detection of PCa is crucial to patient management, most notably in increasing quality of life and lowering cost burdens when considering the associated treatment and follow-up pathways. This article aims to discuss the impact to care pathways for nine patients whose PCa was detected by a novel Food and Drug Administration-cleared low-field magnetic resonance imager (MRI) for transperineal PCa interventions but was missed by standard-of-care systematic transrectal ultrasound (TRUS).

Outdoor Inclined Plastic Column Photobioreactor: Growth, and Biochemicals Response of Culture on Daily Solar Irradiance in a Tropical Place.

Implementation of outdoor photobioreactors has been challenged by an extremely oversaturated daily peak of solar irradiance. This study aims to understand the role of column size and paranet shading as well as to investigate the most convenient light control in outdoor cyanobacterial culture. The photobioreactor (PBR) consisted of plastic columns with a diameter of 12.

Progress on microalgae cultivation in wastewater for bioremediation and circular bioeconomy.

Water usage increased alongside its competitiveness due to its finite amount. Yet, many industries still rely on this finite resource thus recalling the need to recirculate their water for production. Circular bioeconomy is presently the new approach emphasizing on the 'end-of-life' concept with reusing, recycling, and recovering materials.

Changing Trends in COVID-19 Symptomatology: A Survey-Based Analysis.

India currently ranks the highest in the world with over 3.86 lakhs new COVID-19 cases per day. With a spike in the number of cases in the second wave of COVID-19 in 2021 compared to the first wave of the outbreak in 2020, there have been varied clinical manifestations among masses.

Optimization of alkali pretreatment and enzymatic saccharification of jute (Corchorus olitorius L.) biomass using response surface methodology.

Reduction of inherent structural recalcitrance and improved saccharification efficiency are two important facets to enhance fermentable sugar yield for bioethanol production from lignocellulosic biomass. This study optimized alkaline pretreatment and saccharification conditions employing response surface methodology to improve saccharification yield of jute (Corchorus olitorius cv. JROB-2) biomass.

COVID-19 Associated Mucormycosis with Newly Diagnosed Diabetes Mellitus in Young Males - A Tertiary Care Experience.

 Patients with a history of or active COVID-19 infection are predisposed to the development of opportunist bacterial and fungal infections. A rising incidence of a rare occurring fungal infection earlier, called mucormycosis, has been reported in abundance across the globe since March 2021, especially in India just as the second wave of COVID-19 began, caused by the trifecta of hyperglycemia (new-onset or exacerbation of pre-existing diabetes), oxygen therapy (invasive or noninvasive ventilation), and prolonged intake of steroids.  The present study aimed at assessing the prevalence of post-COVID mucormycosis in males of younger age group and spread of rhino-orbital-cerebral mucormycosis (ROCM).

Office-Based, Single-Sided, Low-Field MRI-Guided Prostate Biopsy.

This paper describes the workflow of transperineal prostate biopsy (TBx) using the single-sided, low-field Promaxo MRI system (Promaxo Inc., Oakland, California, United States) operating at a field strength ranging between 58 and 74 millitesla (mT). Prostate cancer (PCa) is the leading cause of cancer-related death and the second most frequently diagnosed cancer in men.

Effect of leaves extracts on thermo-lipid oxidation and Maillard pathway born food toxicant acrylamide in Indian staple food.

Unlabelled: Deep frying of food is a common practice that leads to the formation of lipid oxidation products. These lipid oxidation products have a role in the Maillard reaction, which ultimately leads to the formation of cancer-causing and neurotoxic substance acrylamide. In this regard, the leaves extract-treated sunflower oil on oxidative stability and acrylamide content in  a popular deep-fried staple food in India were studied and compared with synthetic antioxidant butylated hydroxytoluene (BHT) till four frying cycles.

Longitudinal follow-up and performance validation of an mRNA-based urine test (Xpert Bladder Cancer Monitor ) for surveillance in patients with non-muscle-invasive bladder cancer.

Objective: To evaluate the performance of the Xpert Bladder Cancer Monitor (Xpert; Cepheid, Sunnyvale, CA, USA) test as a predictor of tumour recurrence in patients with non-muscle-invasive bladder cancer (NMIBC).

Patients And Methods: Patients (n = 429) undergoing surveillance for NMIBC underwent Xpert, cytology, and UroVysion testing. Patients with a positive Xpert and a negative cystoscopy result (positive-negative [PN] group, n = 66) and a control group of double negative patients (negative Xpert and cystoscopy results [NN] group) were followed for 12 months (±90 days).

An Updated Review of Secondary Metabolites from Marine Fungi.

Marine fungi are valuable and richest sources of novel natural products for medicinal and pharmaceutical industries. Nutrient depletion, competition or any other type of metabolic stress which limits marine fungal growth promotes the formation and secretion of secondary metabolites. Generally secondary metabolites can be produced by many different metabolic pathways and include antibiotics, cytotoxic and cyto-stimulatory compounds.

Role of Cresp in the management of chemotherapy-induced anemia in cancer patients: A real-world clinical practice audit.

Introduction: Anemia is a common, underestimated problem in cancer patients receiving myelosuppressive chemotherapy and has significant adverse effect on the quality of life and outcome. Darbepoetin has been shown to be effective in this setting, but controversy surrounds it actual use.

Methods: We analyzed prospectively collected clinical practice data of patients receiving darbepoetin in a real-world setting for this retrospective audit.