Synthesis and Evaluation of 3,5-Disubstituted-1,2,4-Oxadiazolyl Benzamides as Potential Anti-Breast Cancer Agents: In Vitro and In Silico Studies.

Herein, the synthesis, anti-cancer evaluation, and in silico studies of a series of 1,2,4-oxadiazole compounds (8-15) are disclosed. The synthesized molecules were tested in vitro for anti-cancer activity against MCF-7, MDA-MB-231, HeLa, Ishikawa cell lines and human embryonic kidney (HEK-293) cell lines. Among the synthesized compounds, 9 and 15 exhibited significant cytotoxicity, with IC values of 7.

Wound-healing and cytokine-modulating potential of medicinal oil formulation comprising leaf extract of Murraya koenigii and olive oil.

The study investigated the wound healing effect of medicinal oil (MO) formulation prepared from Murraya koenigii leaves extract (methanolic) incorporated in olive oil. The MO was visually transparent, homogenous, smooth in texture, the viscosity grade was observed as 140 cP and easily spreadable. Pro-inflammatory cytokines IL-1β, IL-6, and TNF-α were significantly reduced to 82.

Investigating the Viral Suppressor HC-Pro Inhibiting Small RNA Methylation through Functional Comparison of HEN1 in Angiosperm and Bryophyte.

In plants, HEN1-facilitated methylation at 3' end ribose is a critical step of small-RNA (sRNA) biogenesis. A mutant of well-studied Arabidopsis HEN1 (AtHEN1), , showed a defective developmental phenotype, indicating the importance of sRNA methylation. Moreover, has been identified to have a ortholog gene (Mp); however, its function remained unfathomed.

Spectral analysis, in vitro cytotoxicity and antibacterial studies of bioactive principles from the leaves of Conocarpus lancifolius, a common tree of Jazan, Saudi Arabia.

The objective of the present study was to analyse the bioactive compounds of the leaves of Conocarpus lancifolius (C. lancifolius). The GC-MS analysis of the hot methanolic extract of the leaves (HMEL) of C.

Trends in mandibular fracture patterns in central Telangana - A retrospective overview and analysis.

Background/aim: Socio-economic, environmental and cultural influences may lead to discrepancies in the distribution and occurrence of orofacial injuries. The aim of this study was to analyze the patient demographics and current patterns of mandibular fractures within a geographic population.

Material And Methods: The medical records of patients with facial trauma treated over a period of 3 years were retrieved and reviewed.

Phytochemical and spectral analysis of the methanolic extracts of leaves of of Jazan, Saudi Arabia.

The present study aimed to explore the biocomponents of leaves through hot continuous percolation method using methanol as solvent. The spectral analysis by GC-MS and FTIR study demonstrated the presence of alkaloids, tannins, fatty acids, and steroids. The extract was characterized by the presence of unique compounds such as epiyangambin, stigmasterol, α-terpineol, eucalyptol, ethyl cinnamate, fatty acids, and other steroids.

Solvent extraction, spectral analysis and antibacterial activity of the bioactive crystals of (Turner) C.Agardh from Red Sea.

The purpose of this study was to investigate the chemical composition and anti-bacterial properties of the bioactive principles of (Turner) C.Agardh, a brown seaweed in Red sea of Jazan province, Kingdom of Saudi Arabia. Crystals were obtained from the petroleum ether extract of and subjected to chemical tests, FTIR spectroscopic analysis and NMR analysis to identify their chemical composition, and to study their antibacterial properties against selected human pathogenic bacteria.