Publications by authors named "Saigal"

Background: During the COVID-19 pandemic, it has been observed that acute kidney injury (AKI) especially requiring intervention support of hemodialysis has notably increased mortality rates among COVID-19-positive critically ill patients; however, comprehensive data regarding this from India, especially the eastern territory, remains sparse. This study aims to outline the demographic, clinical, and biochemical characteristics, along with the outcomes, of these patients.

Methods: A retrospective study was performed at the All India Institute of Medical Sciences (AIIMS), Patna, from March 1, 2020, to March 31, 2021.

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  • Knee pain often involves varus deformity and unicompartmental osteoarthritis, where high tibial valgus osteotomy (HTO) has emerged as an effective treatment option to delay joint replacement.
  • A case report highlighted two patients with bilateral knee arthritis who underwent medial opening-wedge high tibial osteotomy using Dr. Saigal's plate, both achieving good range of motion and minimal complications post-surgery.
  • Comprehensive evaluations, including radiological assessments and specific surgical techniques like the Miniaci Method, were employed to ensure successful outcomes, with both patients showing significant improvement after one year.
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Preface.

Best Pract Res Clin Gastroenterol

December 2024

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Miliary tuberculosis (TB) is an uncommon yet severe condition that can pose substantial risks to pregnant women and their unborn child. This case study describes a 22-year-old pregnant female at 23 weeks of gestation presented with breathlessness, fever accompanied by chills, dry cough, and loss of appetite. With no significant comorbidities, her initial symptoms were inconclusive, leading to her initial diagnosis as a case of pyrexia of unknown origin.

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A 62-year-old man, previously treated for oral cavity carcinoma, presented with new-onset cognitive-motor symptoms. Brain MRI revealed a periventricular, avidly enhancing lesion in the right anterior basal ganglia and hypothalamus suspicious for a brain tumor, particularly CNS lymphoma. 18F-FDG brain PET/CT showed corresponding uptake suggestive of primary brain tumor, lymphoma, or metastasis.

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Purpose: In this prospective study incidence of Mycoplasma pneumoniae (M. pneumoniae) infection was investigated in children with community-aquired lower respiratory tract infections (LRTIs) using methods such as serology, nested PCR (polymerase chain reaction), and multiplex PCR analysis.

Methods: M.

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Vein of Galen malformations (VOGMs) are rare and complex congenital vascular anomalies that can lead to severe morbidity and mortality. Management predominantly focuses on postnatal endovascular interventions. However, these may not be feasible for fetuses with hemodynamic instability and high-output cardiac failure and may fail to prevent irreversible brain damage induced by prolonged compression by the venous varix, hemodynamic alterations and resultant potential ischemic injury.

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  • Intra and inter-pathologist variability complicates the evaluation of metabolic dysfunction-associated steatohepatitis (MASH) biopsy results, hindering patient selection and assessment quality in clinical trials.
  • A study analyzed 120 histology slides with and without AI assistance to evaluate its impact on pathologists' reliability in fibrosis staging, especially for early fibrosis stages.
  • Results showed that AI assistance significantly improved concordance among pathologists, increasing agreement rates for clinical trial inclusion and exclusion, which could enhance the overall efficiency and reliability of MASH-related clinical research.
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  • Phlyctenular keratoconjunctivitis is an inflammatory eye condition caused by a type IV hypersensitivity reaction, characterized by inflamed nodules, and can progress to more severe issues like nodular scleritis, particularly in patients with underlying infections like HSV-2.
  • A 66-year-old woman initially diagnosed with keratoconjunctivitis displayed symptoms that progressed to conjunctival phlyctenule, where HSV-2 was identified as a contributing factor, and her condition improved significantly with oral antiviral treatment.
  • This case emphasizes the need for proper diagnosis and treatment options for ocular inflammatory diseases, advocating for thorough testing and close follow-up to ensure effective management and personalized care for patients.
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Introduction: Ethnicity can influence susceptibility to SARS-CoV-2 infection, hospitalisation and death. Its association with ongoing symptomatic COVID-19 is unclear. We assessed if, among a population followed up after discharge from hospital with COVID-19, adults from Asian, black, mixed and other backgrounds are at increased risk of physical and mental health symptoms.

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  • - The study investigates how the timing of radiotherapy (RT) after radical prostatectomy influences long-term health-related quality of life (HRQOL) in men with prostate cancer, focusing on sexual, urinary, and bowel health.
  • - Researchers analyzed data from two cohorts, comparing outcomes between three groups: men who had just prostatectomy, those who received early RT (within 12 months), and those who had late RT (12 months or later).
  • - Findings revealed that men who underwent RT after prostatectomy experienced greater declines in aspects of HRQOL compared to those who did not receive RT, highlighting the potential negative effects of post-surgery radiation timing.
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It is sobering that many liver failure patients die in the absence of liver transplantation (LT), and reducing its morbidity and mortality urgently needs more non-transplant treatment options. Among the several artificial liver support devices available, therapeutic plasma exchange (TPE) is the only one that improves survival in acute liver failure (ALF) patients. In many other disorders, data on survival benefits and successful bridging to transplant is encouraging.

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  • Giant cell tumors (GCT) of bone are rare, slow-growing tumors that mostly affect young adults and are usually found in long bones, while their occurrence in the clivus is even rarer, especially in children.
  • A 13-year-old patient with a large GCT in the clivus had initial clinical and radiographic findings that raised suspicion for this tumor, though other common types were also considered.
  • Key imaging features, such as low T2 signal on MRI and a T2 hypointense rim on CT, helped confirm the diagnosis via an endoscopic biopsy, emphasizing the importance of imaging in identifying and treating such rare tumors effectively.
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A 44-year-old patient presented with hoarseness of voice and a polypoidal lesion on the left vocal cord. Complete excision was done. To our knowledge, this is the second reported case of molluscum contagiosum of the vocal cords.

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Background and aims Optimal postoperative care and analgesia are the key factors in the management of cases of lumbosacral spine surgery. The erector spinae plane (ESP) block is a recently evolving entity and has a dynamic role in postoperative pain management. However, its role in the management of pain in lumber spinal surgeries is still not clear, and the literature remains anecdotal.

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  • - The study aimed to compare the motor examinations done by the clinical neurosurgery team with the ISNCSCI assessments, since the latter can be time-consuming and impractical during acute spinal cord injuries.
  • - Researchers analyzed data from the TRACK-SCI registry, which included 72 pairs of motor examinations from 63 patients, and found strong correlations between the two methods, indicating that neurosurgery motor examinations can effectively substitute for ISNCSCI exams.
  • - The results showed a very high agreement between the scores from both types of examinations with low bias, suggesting that clinical neurosurgery evaluations are reliable for assessing neurological function after spinal cord injuries.
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  • The study aimed to explore the connection between lip and tongue print patterns and blood types among participants.
  • A total of 154 individuals (103 females and 51 males) participated in the research after consenting to the study's objectives.
  • Although the research identified gender differences in lip and tongue patterns related to blood groups, no statistically significant links were found between these variables.
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The global decline of shark populations, largely driven by overfishing to supply the shark fin trade, poses a significant threat to marine ecosystems. Southeast Asia, and particularly Singapore, is a key hub for the transit and trade of shark fins that contribute to the exploitation of these apex predators. Through the use of DNA barcoding techniques, this study aimed to determine what species of shark are involved in the Singapore shark fin trade.

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Few studies have investigated the acceptability of wearable technology in patients with long-term respiratory disease. We conducted a 24-item cross-sectional survey (September 2022-February 2023), developed using four common themes universal to previously described models of technology acceptance and social behavioural therapy, to explore the acceptability of wearable technology spanning the breadth of chronic respiratory disease. A total of 74 valid survey responses were analysed with 50 % aged 51-70years; 72 % female; 63 % white British ethnicity; 79 % having an income less than £50,000, and 93 % having at least obstructive airways disease.

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  • The study evaluated the effectiveness and safety of intravenous golimumab for treating anterior uveitis in patients with juvenile idiopathic arthritis (JIA).
  • A retrospective analysis of 13 patients revealed significant improvements in anterior chamber reaction and flare-ups after 12 months of treatment compared to the year prior.
  • Most patients (84.6%) responded positively to the medication, although there were some adverse effects, highlighting the need for more extensive research to confirm the results.
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  • Recurrence of high-grade gliomas is common even after the best treatment, and current imaging methods can't effectively predict when it will happen.
  • A new whole-brain magnetic resonance spectroscopy (WB-MRS) method was tested, focusing on tumor microenvironments to improve understanding of glioma progression and assist in treatment decisions.
  • By analyzing tumor metabolites and using machine learning techniques on data from 16 patients, researchers were able to predict glioma progression, particularly identifying key features that indicate future growth.
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To investigate the diagnostic and therapeutic potential of nanoparticle (NP)-based immunosensors in the field of oral cancer. PubMed, Embase, Scopus, Web of Science, and Google Scholar databases were explored for NP applications in oral cancer. Data extraction in terms and quality assessment of all the articles were done.

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Background: Ventilator-associated pneumonia (VAP) is a major cause of morbidity and mortality in patients receiving mechanical ventilation in India. Surveillance of VAP is essential to implement data-based preventive measures. Implementation of ventilator-associated events (VAE) criteria for surveillance has major constraints for low resource settings, which can lead to significant underreporting.

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We establish low-temperature resonant inelastic light scattering (RILS) spectroscopy as a tool to probe the formation of a series of moiré bands in twisted WSe_{2} bilayers by accessing collective inter-moiré-band excitations (IMBEs). We observe resonances in RILS spectra at energies in agreement with inter-moiré-band transitions obtained from an ab initio based continuum model. Transitions between the first and second moiré band for a twist angle of about 8° are reported and between the first and the third, and higher bands for a twist of about 3°.

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Introduction: NIV (Non-invasive ventilation) and HFNC (High Flow nasal cannula) are being used in patients with acute respiratory failure. HACOR score has been exclusively calculated for patients on NIV, on other hand ROX index is being used for patients on HFNC. This is first study where ROX index has been used in patients on NIV to predict failure.

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