A network pharmacology approach to elucidate the anti-inflammatory and antioxidant effects of bitter leaf ( Del.).

The therapeutic potential of bitter leaf ( Del.) has been established both empirically and in various scientific investigations. However, the molecular pathways related to its possible anti-inflammatory and antioxidant properties remain unclear.

Intravenous administration of iron dextran as a potential inducer for hemochromatosis: Development of an iron overload animal model.

Iron overload in transfusion-dependent thalassemia patients represents a significant public health challenge due to its high mortality rate and risks of severe complications. Therefore, developing safe and effective therapeutic modalities for managing iron overload is critical, as current animal models inadequately replicate human conditions. The aim of this study was to investigate the effects of intravenous iron dextran on hepatocyte morphology, liver iron concentration, and serum iron profile changes as a model for hemochromatosis.

Gynura procumbensin vitro adventitious root nanohydrogel improves inflammation-proliferation transition in second-degree burn healing.

Inflammation-proliferation transition plays a key role in the successful healing of a common burn type, second-degree burn. Gynura procumbens in vitro adventitious root nanohydrogel is currently being studied for its immunomodulatory to improve reparative environment. Root production and nanohydrogel preparation was done respectively by in vitro propagation and emulsion/ solvent diffusion with carbomer as a polymer.

Analysis of Circulating Plasma MicroRNA Profile in Low-Grade and High-Grade Glioma - A Cross-Sectional Study.

Background: Glioma is the second most common type of brain tumor, accounting for 24% of all brain tumor cases. The current diagnostic procedure is through an invasive tissue sampling to obtain histopathological analysis, however, not all patients are able to undergo a high-risk procedure. Circulating microRNAs (miRNAs) are considered as promising biomarkers for glioma due to their sensitivity, specificity, and non-invasive properties.

Bovine trichomoniasis: A hidden threat to reproductive efficiency.

Bovine trichomoniasis is a reproductive illness that affects cattle causing pyometra, early to mid-pregnancy miscarriages, and lower birth rates. is a flagellated protozoan which first discovered in France in 1888 and composts three phases during its lifecycle including trophozoite, cyst, and pseudocyst. In addition, several factors contributed to the prevalence of trichomoniasis and fall into three categories are management, cow, and bull-related factors.

Public exposure from inhalation of radon and thoron around the tin mine and smelter areas in Bangka, Indonesia.

Radon (Rn) and thoron (Rn) were reported as the highest contributors to natural radiation received by humans. Furthermore, radon has been stated as the second-highest cause of lung cancer. The concentrations of U and Th (the parent nuclide of radon and thoron, respectively) in nature vary with geological conditions and can be enhanced by human activities.

Evaluation of hepatoprotective and nephroprotective activities of extract in rats.

The liver and kidneys are important organs for body homeostasis but susceptible to damage or injury caused by different factors. A number of medicinal plants, such as have been proven effective in protecting the liver and kidneys from damage. Therefore, the present study aimed to examine the effect of extract (CcE) on paracetamol-induced hepatotoxicity and gentamicin-induced nephrotoxicity in rat model.

Isolation of Thermophilic Bacteria From Mount Tangkuban Perahu and the Novelty as a Candidate for Anti-Biofilm.

Thermophilic bacteria living in extreme areas with high temperatures are capable of producing secondary metabolites, such as antimicrobial peptides (AMPs). AMPs are stable at high temperatures and show good antibacterial activity. Therefore, this study aimed to identify thermophilic bacteria from the crater of Mount Tangkuban Perahu around West Java and assess antibacterial effectiveness of AMPs against , which contribute to oral biofilm formation.

The role of the Ki-67 labelling index as an independent prognostic factor in indonesian glioma patients.

Introduction: Gliomas are the most common type of brain tumor. However, interpreting glioma morphology is subjective, and identifying mitosis can be challenging. This can impact the determination of the patient's tumor grade, therapy, and prognosis.

Comparison of Food Safety Hazards in Pigs and Broilers from Intensive and Extensive Production Systems: A Literature Review.

Consumer demand for meat from extensive production (e.g., organic, free-range, and antimicrobial-free) is increasing, partly due to consumers' perception that these types are safer than conventional meats.

Improvement of Growth Rate in Culture of M. W. Wood & P. Taylor and J. J. Smith using Banana Enrichment Media.

and have unique labellum colour and shaped like lady's slippers. These orchids are from the Cochlopetalum section, which is exclusively found in Sumatra and Java. There are so many people that desire to collect these plants illegally.

Recurrent Acute Upper Limb Ischemia in a Young Male: Case Report.

Although acute upper limb ischemia (AULI) is less prevalent than lower acute limb ischemia, AULI may lead to severe morbidity if not well-treated. To manage AULI appropriately, evaluation of the etiologies, risk factors, and revascularization is of importance. Here we present a case of recurrent AULI and its appropriate diagnostic and management approaches.

Generic Food Safety Assessment: A Framework to Evaluate Food Safety Hazards Emerging from Change(s) in the Primary Production System - A Case Study Involving Intercropping.

Food safety is a shared responsibility of all actors along the food supply chain. Changes in the primary production system can affect food safety hazards along the supply chain. This highlights the need for a framework that enables primary producers (i.

Comparative Analysis of Different Natural Polymers as Coating Agents for Freeze-Dried Microencapsulation of Kunth Compounds.

The flavonoid compounds in K., known for their various benefits, are prone to quick degradation, leading to reduced biological activity. This research aimed to evaluate the types of coatings: gum Arabic (GA), maltodextrin (MD), and a combination of both (MDGA) in K.

The lipoteichoic acid of Lactobacillus plantarum effect on lymphocyte, VEGF-A and TGF-β expression in male rat dental pulp.

Objective: Lipoteichoic acid from Lactobacillus plantarum (L. plantarum) is a significant virulence factor that exacerbates pulp inflammation. Lipoteichoic acid plays a role in modulating the inflammatory to proliferative phase transition is crucial in determining the outcome of pulp healing or necrosis.

Antioxidant and cytotoxicity screenings of ethyl acetate extract from leaves and its fractions.

Leaves of have medicinal potential which has gained attention from researchers around the world. This study has an objective to screen the antioxidant and cytotoxicity of ethyl acetate extract from leaves and its fraction. The fine powder of was macerated in methanol and further partitioned using two different solvents, namely n-hexane and ethyl acetate.

Effectiveness of Using Gum Arabic for Co-Microencapsulation of L. and Extracts as Encapsulating Agent and Release Studies.

This study used a combination of leaves extracts from L. and plants encapsulated using gum Arabic. The selection of leaves in medicinal plants because they are rich in bioactive compounds that provide health benefits.

Priorities for health outcomes in glaucoma in an ethnically diverse UK cohort: an observational study.

Objectives: To assess whether patients from minority ethnic groups have different perceptions about the quality-of-life outcomes that matter most to them.

Design: Cross-sectional observational study.

Setting: High volume eye centres serving the most ethnically diverse region in the UK, recruiting from July 2021 to February 2022.

The utilization of three-dimensional imaging and three-dimensional-printed model in autologous microtia reconstruction.

Background: The use of three-dimensional (3D) technology helps surgeons in performing autologous microtia reconstruction due to more accurate measurements and a better precision template model. However, the technical aspects of using a 3D imaging and 3D-printed model and the difference in outcomes postoperatively remain poorly reviewed.

Purpose: This systematic review aimed to provide the current evidence of the benefit and technical aspects of using 3D technology in autologous microtia reconstruction.

Immunogenicity studies of recombinant RBD SARS-CoV-2 as a COVID-19 vaccine candidate produced in .

The severe acute respiratory syndrome coronavirus 2 -related global COVID-19 pandemic has been impacting millions of people since its outbreak in 2020. COVID-19 vaccination has proven highly efficient in reducing illness severity and preventing infection-related fatalities. The World Health Organization has granted emergency use approval to multiple, including protein subunit technology-based, COVID-19 vaccines.