Synthesis and characterization of the Zn(II) and Cu(II) piperidinyl isoeuxanthone complexes: DNA-binding and cytotoxic activity.

Two new complexes ZnL(2)x2H(2)O (1) and CuL(2)x2H(2)O (2) (HL=1-hydroxy-6-(2-(1-piperidinyl)ethoxy)xanthone) have been synthesized and characterized. Their interactions with calf thymus DNA (ct DNA) were investigated by absorption spectroscopy, fluorescence spectroscopy, ethidium bromide (EB) displacement experiments, circular dichroism spectroscopy and viscosity measurements. Experimental results suggested that there were intercalative interactions of the complexes with DNA.

Synthesis, crystal structure, DNA-binding properties and cytotoxic activity of the copper (II) complex involving xanthone.

1, 8-(3, 6, 9-Trioxaundecane-1, 11-diyldioxy)xanthone (L), and its new Cu (II) complex [Cu.L.(CH3CN)2](ClO4)2 have been synthesized and characterized by 1H NMR, electrospray mass spectra (ESI-MS), elemental analyses, infrared spectra (IR) and X-ray single crystal diffraction.

Silane-based poly(ethylene glycol) as a primer for surface modification of nonhydrolytically synthesized nanoparticles using the Stöber method.

This paper describes the use of methoxy-poly(ethylene glycol) silane (MPEG-sil) as a linker molecule for the synthesis of silica-coated nanoparticles by the Stöber method. While short alkane chain-based siloxanes including (acryloxypropyl)trimethoxysilane and 3-methacryloxypropyl-trimethoxysilane are popular molecules used in surface modification, they are not efficient for the silica coating of nanoparticles synthesized from organic solvents containing long carbon chain carboxylic acids or amines as capping agents. Here, we report the utilization of MPEG-sil to bridge this gap.

Selective colorimetric and fluorescent detection of HSO4- with sodium(I), magnesium(II) and aluminium(III) xanthone-crown ether complexes.

Xanthone-crown ether (1) reacts with NaClO(4), Mg(ClO(4))(2) and Al(ClO(4))(3) forming the one-dimensional chain dinuclear polymer [Na(2).1.(ClO(4))(2)] (2), the mononuclear complex [Mg.

Atorvastatin treatment improves survival and effects of implanted mesenchymal stem cells in post-infarct swine hearts.

Aims: To investigate whether Atorvastatin (Ator) treatment improves the cardiac micro-environment that facilitates survival and differentiation of bone-marrow-derived mesenchymal stem cells (MSCs) implanted in the post-infarct myocardium.

Methods And Results: Myocardial infarction was created by coronary ligation and immediately after reperfusion, autologous bone-marrow-derived MSCs were transplanted into the hearts of Chinese swine that were pretreated with or without Ator. Six weeks after transplantation, as evaluated by SPECT and MRI all the animals with Ator showed improved cardiac perfusion and contractility when compared with untreated.

[Clinical application of xenogenic (porcine) acellular dermal atrix (ADM) in scar treatment].

Objective: To investigate the role of xenogenic (porcine) ADM as dermal substitute in scar treatment.

Methods: After scar excision, the wounds were covered with composite grafts of DR procine ADM and autologous thin split-thickness grafts in one stage or in two stages.

Results: 22 out of 47 cases were treated in two-staged procedure.

Effects of Tongxinluo-facilitated cellular cardiomyoplasty with autologous bone marrow-mesenchymal stem cells on postinfarct swine hearts.

Background: Treatment of ischemic heart disease remains an important challenge, though there have been enormous progresses in cardiovascular therapeutics. This study was conducted to evaluate whether Tongxinluo (TXL) treatment around the transplantation of mesenchymal stem cells (MSCs) can improve survival and subsequent activities of implanted cells in swine hearts with acute myocardial infarction (AMI) and reperfusion.

Methods: Twenty-eight Chinese mini-pigs were divided into four groups including a control group (n = 7); group 2, administration of low-dose TXL alone from the 3rd day prior to AMI to the 4th day post transplantation (n = 7); group 3, MSCs alone (n = 7) and group 4, TXL + MSCs (n = 7).

Intracoronary delivery of autologous bone marrow mononuclear cells radiolabeled by 18F-fluoro-deoxy-glucose: tissue distribution and impact on post-infarct swine hearts.

Intracoronary injection of the bone marrow-derived mononuclear cells (MNCs) is emerging as a potentially novel therapy for ischemic heart failure. This study was aimed at assessing the efficacy of intracoronary MNC delivery in the myocardium. The in vivo distribution and myocardial homing of intracoronarily delivered MNCs in experimental Chinese swine with acute myocardial infarction (AMI) created by occlusion of left anterior descending (LAD) coronary artery for 90 min.

The study of inhibiting systematic inflammatory response syndrome by applying xenogenic (porcine) acellular dermal matrix on second-degree burns.

Objective: To investigate the influence of xenogenic (porcine) acellular dermal matrix on the systematic inflammatory reaction syndrome (SIRS), and the reaction of burn patients to tissue damage upon application to second-degree burn wounds.

Method: Seventy-two cases of patients with acute second-degree burns were enrolled in the study. According to the total burn surface area (TBSA) and the treatment methods, we randomly divided the patients into four groups.

[Treatment of deep partial thickness burns by a single dressing of porcine acellular dermal matrix].

Objective: To explore the effect of one dressing of porcine acellular dermal matrix on deep partial thickness burns.

Methods: From January 1997 to January 2004, sixty-seven cases of deep partial thickness total burned surface area (TBSA) from 50% to 90% burn wound were treated by a single dressing of porcine acellular dermal matrix (the porcine acellular dermal matrix group). Ten cases of deep partial thickness burned patients with the same TBSA treated by exposure method served as the exposure method group.

Control of hypertrophic scar from inception by using xenogenic (porcine) acellular dermal matrix (ADM) to cover deep second degree burn.

Objective: We have spent 7 years to investigate the method of applying porcine acellular dermal matrix (ADM) on deep partial thickness burn wound until the wound heals without dressing change. Known as "Feng's pig skin method" by our hospital, the method appears to encourage rapid re-epithilization with minimum scarring.

Method: The deep partial thickness burn wound was rinsed cleanly under anesthesia when the patient admitted.

[Use of lower trapezius musculocutaneous pedicle flap in repairing of maxillofacial region penetrating defect].

Objective: To investigate an safe and effective new technology (treatment) to repair maxillofacial region penetrating defect.

Methods: The lower trapezius musculocutaneous flap is parallel just like as two leaves which is connected to each other, and was folded to provide the liner of oral cavity and external cover.

Results: Totally twelve folding lower trapezius musculocutaneous pedicle flap survived.

[Clinical study and pathological examination on the treatment of deep partial thickness burn wound with negative charge aerosol].

Objective: To investigate the effect of negative charge aerosol (NCA) on the treatment of burn wound.

Methods: Patients with superficial or deep partial thickness burn only were enrolled in the study, and they were randomly divided into trial group (T, including 180 cases of superficial thickness burn and 100 cases of deep partial thickness burn), control group (C, including 30 cases with superficial thickness burn and 30 with deep partial thickness burn), and self control group (SC, including 10 cases with superficial thickness burn and 10 with deep partial thickness burn). The patients in T and SC groups were treated with NCA for 1.

Immobilization of lipase onto micron-size magnetic beads.

A novel and economical magnetic poly(methacrylate-divinylbenzene) microsphere (less than 8 microm in diameter) was synthesized by the modified suspension polymerization of methacrylate and cross-linker divinylbenzene in the presence of magnetic fluid. Then, surface aminolysis was employed to obtain a high content of surface amino groups (0.40-0.

[Experimental study of pharmaceutic stress myocardial perfusion imaging with higenamine].

Objective: To evaluate the applicative value of higenamine used as a new agent for pharmaceutical stress test in detection of coronary artery disease by radionuclide myocardial perfusion imaging.

Methods: Thirteen pigs with chronic coronary artery stenosis by placement of the Ameroid constrictor in the middle section of left anterior descending artery were included in this study. Rest, higenamine and dobutamine stress radionuclide myocardial perfusion imaging was performed with Tc-99m-sestamibi.

[Observation by color Doppler ultrasound on endothelium-dependent dilation of congestive heart failure treated with Kanli Decoction].

Objective: To observe the changes of endothelium-dependent dilation (EDD) of patients with congestive heart failure (CHF) before and after Kanli Decoction treatment.

Methods: Thirty-five CHF patients were treated with Kanli Decoction. We used color Doppler ultrasound to monitor the flow-mediated dilation (FMD), pulsatile index (PI), resistance index (RI), baseline blood flow (BF), ejection fraction (EF) before and after the treatment.

Direct imaging of exercise-induced myocardial ischemia with fluorine-18-labeled deoxyglucose and Tc-99m-sestamibi in coronary artery disease.

Background: Scintigraphic myocardial perfusion imaging is the most widely used noninvasive modality for the detection of coronary artery disease (CAD). A technique for direct imaging of exercise-induced myocardial ischemia is highly desirable and preferable over perfusion imaging but is presently unavailable. We evaluated the feasibility and diagnostic accuracy of direct imaging of exercise-induced myocardial ischemia with fluorine-18-2-deoxyglucose (18FDG).

[An investigation of bacterial epidemiology and an analysis of bacterial resistance to antibiotics in a burn unit from 1993 to 1999].

Objective: To investigate the bacterial epidemiology in our department in recent years, so as to provide assistance to the clinical management of burn patients.

Methods: A retrospective analysis was carried out with 345 bacterial cultures from burn wound and drug-sensitivity results in 784 burn patients during 1993 to 1999 in our department.

Results: (1) Among all the bacteria, gram negative (G(-)) bacilli accounted for 56.