Pharmacological effects of osimertinib on a chicken chorioallantoic membrane xenograft model with the EGFR exon-19-deleted advanced NSCLC mutation.

Non-small cell lung cancer (NSCLC) affects 10-50% of patients with epidermal growth factor receptor (EGFR) mutations. Osimertinib is a third-generation EGFR tyrosine kinase inhibitor (TKI) that radically changes the outcome of patients with tumors bearing EGFR sensitizing or EGFR T790M resistance mutations. However, resistance usually occurs, and new therapeutic combinations need to be explored.

TIR signaling activates caspase-like immunity in bacteria.

Caspase family proteases and Toll/interleukin-1 receptor (TIR)-domain proteins have central roles in innate immunity and regulated cell death in humans. We describe a bacterial immune system comprising both a caspase-like protease and a TIR-domain protein. We found that the TIR protein, once it recognizes phage invasion, produces the previously unknown immune signaling molecule adenosine 5'-diphosphate-cyclo[N7:1'']-ribose (N7-cADPR).

Unravelling impacts of the insecticide deltamethrin on neuronal sodium channels in honey bees: Molecular insights and behavioural outcomes.

The current risk assessment framework for insecticides suffers from certain shortcomings in adequately addressing the effects of low doses on off-target species. To remedy this gap, a combination of behavioural assays and in vitro cellular approaches are required to refine the precision of toxicity assessment. The domestic honey bee has long been standing as an emblematic pollinator in ecotoxicology, and once more, it provides us with a practical testing model for this purpose.

Assessing the Host Range of for the Biological Control of in France.

is a well-known invasive species in Europe, causing health issues with its extremely allergenic pollen and yield loss through competition in agriculture. One potential biological control agent is , accidentally introduced in Europe in 2013. This species was discovered in France in 2023, but before planning further mass releases for biological control, it is necessary to assess its safety for agricultural crops and local plant biodiversity.

Heritability of Alzheimer's disease plasma biomarkers: A nuclear twin family design.

Introduction: Alzheimer's disease (AD) is a highly heritable disease (60%-80%). Amyloid beta (Aβ) 42/40, neurofilament light chain (NfL), and glial fibrillary acidic protein (GFAP) are plasma biomarkers for AD. Clinical biomarker research would be served by an understanding of the sources of variance in these markers.

Performance of plasma p-tau217 and NfL in an unselected memory clinic setting.

Introduction: Plasma phosphorylated tau-217 (p-tau217) and neurofilament light (NfL) can differentiate between different dementias in selected cohorts. We aim to test the discrimination potential of these markers in a real-world cohort.

Methods: We measured p-tau217 (ALZpath) and NfL (Quanterix) in 415 (unselected) consecutive memory clinic patients.

Unifying the roll waves.

Free surface flows down a slope occur in various real-life scenarios, such as civil engineering, industry, and natural hazards. Unstable waves can develop at the free surface when inertia is sufficiently strong, indicated by the Reynolds number exceeding a critical value. Although this instability has been investigated for specific fluids with different rheologies, a common framework is still lacking to facilitate comparison among the various models.

Severe uterine haemorrhagic complications from gestational trophoblastic neoplasia.

Objective: Gestational trophoblastic neoplasia are highly vascularized infiltrating lesions that can lead to severe haemorrhagic complications. The aim of this study was to describe the characteristics of patients with gestational trophoblastic neoplasia who experienced uterine haemorrhagic complications, and their management.

Study Design: This retrospective study analysed the histories of 2099 patients with gestational trophoblastic neoplasia registered at the French Reference Centre for Trophoblastic Disease between 1999 and 2023.

Experimental characterization of an isoplanatic patch in mouse cortex using adaptive optics.

Optical microscopy techniques have become essential tools for studying normal and pathological biological systems. However, in many situations, image quality deteriorates rapidly in the field of view due to optical aberrations and scattering induced by thick tissues. To compensate for these aberrations and restore the microscope's image quality, adaptive optics (AO) techniques have been proposed for the past 15 years.

Phages reconstitute NAD to counter bacterial immunity.

Bacteria defend against phage infection through a variety of antiphage defence systems. Many defence systems were recently shown to deplete cellular nicotinamide adenine dinucleotide (NAD) in response to infection, by cleaving NAD into ADP-ribose (ADPR) and nicotinamide. It was demonstrated that NAD depletion during infection deprives the phage of this essential molecule and impedes phage replication.

Impact of Previous Abdominal Surgery and Timing of Peritoneal Metastases on Accuracy of Imaging in Predicting the Surgical PCI: A Report From the PRECINCT Study.

Background And Aim: In this report from Phase 1 of the prospective, observational, PRECINCT (Pattern of peritoneal dissemination and REsponse to systemic Chemotherapy IN Common and uncommon peritoneal Tumours) study, a correlation was performed between the radiological PCI (peritoneal cancer index; rPCI) and surgical PCI (sPCI). The impact of timing of peritoneal malignancy (PM) and previous abdominal surgery was also studied.

Methods: The rPCI and sPCI were considered the 'same' if they differed by ≤ 3 points.

Nineteen years of radiographic screening: Impact of sepsis and evolution of osteochondrosis dissecans prevalence in Walloon sport horses born between 2004 and 2022.

Osteochondrosis dissecans is a particularly common developmental orthopaedic disorder in equines. Among its causes, the hereditary component is no longer a matter of debate, and, for several decades, the various studbooks for sport horses have been selecting stallions in order to limit the prevalence of this condition in the population. However, to our knowledge, no study has evaluated changes in the prevalence of osteochondrosis dissecans over time through longitudinal monitoring of a population of sport horses.

Surprising minimisation of CO emissions from a sandy loam soil over a rye growing period achieved by liming (CaCO).

Agricultural liming improves acidic soils productivity and is considered a lever for mitigating nitrous oxide (NO) emissions from soils. However, the benefit of liming in reducing soil greenhouse gas (GHG) emissions depends on the evolution of carbon from the calcium carbonate (CaCO), and on the evolution of soil organic carbon (SOC) after CaCO application. The literature, based on limited field data, presents contrasting effects of liming on inorganic- and SOC-derived CO emissions, raising concerns that the reduction in NO emissions could be offset by increased CO emissions.

Ingestion of Bacillus cereus spores dampens the immune response to favor bacterial persistence.

Strains of the Bacillus cereus (Bc) group are sporulating bacteria commonly associated with foodborne outbreaks. Spores are dormant cells highly resistant to extreme conditions. Nevertheless, the pathological processes associated with the ingestion of either vegetative cells or spores remain poorly understood.

Re-Emergence of DENV-3 in French Guiana: Retrospective Analysis of Cases That Circulated in the French Territories of the Americas from the 2000s to the 2023-2024 Outbreak.

French Guiana experienced an unprecedented dengue epidemic during 2023-2024. Prior to the 2023-2024 outbreak in French Guiana, DENV-3 had not circulated in an epidemic manner since 2005. We therefore studied retrospectively the strains circulating in the French Territories of the Americas (FTA)-French Guiana, Guadeloupe, and Martinique-from the 2000s to the current epidemic.

What evidence exists relating the impact of different grassland management practices to soil carbon in livestock systems? A systematic map protocol.

Background: Grasslands are essential for providing vital resources in the livestock sector and delivering invaluable ecosystem services such as biodiversity and soil carbon (C) sequestration. Despite their critical importance, these ecosystems face escalating threats from human disturbances, human degradation, and climate change, compromising their ability to effectively stock C. Restoring degraded grasslands emerges as a pragmatic and cost-effective approach to tackling climate change.