Isolation of a Novel Bacterium Isolate Capable of Utilizing Crude Oil and Diesel Oil Spills as a Biological Bioremediation Agent.

Background: Contamination with crude oil and hydrocarbons has become a global threat. Such threats have urged us to invent solutions to deal with this dilemma. However, chemical treatment comes with limited benefits.

A rare presentation of glycogenic acanthosis on the lips: A case report.

Glycogenic acanthosis (GA) is a benign, asymptomatic condition commonly found in the lower third of the esophagus. This case report presents a unique occurrence of GA on the lips of a 55-year-old male smoker, who exhibited asymptomatic white lesions on his upper and lower lips for many years. Physical examination revealed multiple white papules on the wet-dry vermilion border of the lips.

Inflammatory protein levels in asthmatic bronchitis: A study in the Duhok population, Iraq.

Objectives: This study aims to determine the levels of TNF-α, IGF-1, IL-6, and IL-10 protein in blood samples and their potential link to bronchitis-asthma diseases in the Iraq Duhok population, highlighting the prevalence of these long-term inflammatory diseases.

Methods: Sixty blood samples were used and separated into patients (n = 43) and control (n = 17) groups. Serum samples were separated for each individual.

Identification of Nontuberculous Mycobacterium and Mycobacterium tuberculosis Complex in Sputum Patients with Suspected Tuberculosis.

Background: Pulmonary tuberculosis (TB) is predominantly caused by Mycobacterium tuberculosis complex (MTBC) and can also involve nontuberculous mycobacteria (NTM). These pathogens pose significant global health challenges, particularly in developing countries. Differentiating between MTBC and NTM in clinical specimens is often difficult using conventional acid-fast staining methods, leading to an underestimation of NTM prevalence in TB-endemic regions.

Amaurosis Post-Bilateral Neck Dissection: A Systematic Review.

To discuss the prevalence of amaurosis post-bilateral radical neck dissections; and to provide a management algorithm that highlights the approaches undertaken in available literature to minimize incidence and maximally improve outcomes. This objective will be achieved by systematically reviewing and highlighting current literature. We systematically reviewed Pubmed, EMBASE, and Web of Science for articles pertaining to the management of amaurosis post-bilateral neck dissection.

Double Twist and Shout: An Emergency Caused by Torsion of the Ovary and the Wandering Spleen.

Intermittent severe abdominal pain is a medical emergency with multiple possible underlying causes. This case report describes a 30-year-old female experiencing severe pelvic pain alternating between the left and right lower abdomen. The pain was periodic and very intense.

Network pharmacology and bioinformatic integrative analysis reveals candidate gene targets and potential therapeutic of East Kalimantan propolis against hepatocellular carcinoma.

Introduction: Hepatocellular Carcinoma (HCC) is commonly treated with surgery, liver transplantation, and chemotherapy, but recurrence and metastasis remain challenges. Natural complementary therapies like propolis, known for its hepatoprotective properties, are gaining interest due to limited efficacy and toxicity of conventional chemotherapy. This study aims to identify core targets for HCC, assess the therapeutic potential of East Kalimantan propolis (EKP) from stingless bees, and analyze the molecular interactions.

-amyrin heptadecanoate, a new oleanane triterpenoid with -glucosidase inhibitory and cytotoxic activities from the leaves of L.

A previously unreported oleanane triterpenoid, -amyrin heptadecanoate (), was isolated from the leaves of Thai (Oxalidaceae), along with five known compounds, -amyrin (), -sitosterol (), -sitosterol-D-glucoside (), -sitosteryl oleate (), and -tocopherol (). Their structures were elucidated through spectroscopic analysis, including extensive NMR and HRESIMS, and by comparison with the previous literature. All isolated compounds were evaluated for their -glucosidase inhibitory and cytotoxic activities.

Cost-effectiveness of the single-surgeon approach in microvascular decompression for trigeminal neuralgia.

Background: Centralizing surgical cases to a dedicated surgeon (single-surgeon approach) has shown improved outcomes in various neurosurgical procedures, including microvascular decompression (MVD) for trigeminal neuralgia (TN). However, the cost-effectiveness of this approach in MVD for TN has not been conclusively demonstrated. This study aims to investigate the cost-effectiveness of the single-surgeon approach in MVD for TN compared to the conventional multi-surgeon approach.

Antifungal combinations in paediatric invasive fungal infections: a protocol for systematic review and meta-analysis.

Background: Invasive fungal infections (IFIs) significantly impact immunocompromised paediatric patients, contributing to high rates of morbidity and mortality. Despite the evolution of antifungal therapy, the efficacy and safety of combination antifungal therapies in paediatric patients, especially those with haematological malignancies, remain controversial. This systematic review and meta-analysis seeks to critically evaluate the efficacy and safety of antifungal combinations in paediatric IFIs.

Long COVID or Post-Acute Sequelae of COVID-19 (PASC) in Children and Adolescents.

Few studies of children with long COVID (post-COVID-19 condition) or post-acute sequelae of SARS CoV-2 (PASC) have been reported. Those terms describe symptoms that persist for weeks or months or as new symptoms that develop after SARS-CoV-2 infection. This condition might be found to various degrees in the severity of COVID-19.

Comparative Analysis of Holmium Laser Enucleation of the Prostate (HoLEP) and Robotic-Assisted Simple Prostatectomy (RASP) in BPH Management: A Systematic Review and Meta-Analysis.

Purpose: As the prevalence of benign prostatic hyperplasia (BPH) increases, the demand for surgical interventions that optimize patient outcomes while minimizing complications grows. This systematic review compares the efficacy, efficiency, and safety of holmium laser enucleation of the prostate (HoLEP) with robotic-assisted simple prostatectomy (RASP), providing insights for evidence-based surgical decision-making in BPH treatment.

Materials And Methods: Adhering to PRISMA guidelines, the study protocol was registered with Prospero [CRD42024509627].

Analysis of angiotensin II type 1 receptor and osteoprotegerin gene polymorphism on the risk of cardiovascular mortality risk and progressivity of chronic kidney disease.

Background: Chronic kidney disease (CKD) is a significant global public health issue with increased risk of atherosclerotic cardiovascular disease (ASCVD) and cardiovascular mortality. Single nucleotide polymorphisms (SNPs) on angiotensin II type 1 receptor (AT1R) A1166C and osteoprotegerin (OPG) C950T gene have received significant attention as a genetic risk factor for cardiovascular disease and CKD.

Methods: This was a cross-sectional study involving 75 adults with CKD recruited from Nephrology Outpatient Clinics of Universitas Airlangga Hospital, Surabaya, Indonesia.

Identifying Potential Human Monoacylglycerol Lipase Inhibitors from the Phytoconstituents of L. Fruits by in silico Pharmacology and in vitro Study.

Background: Human monoacylglycerol lipase (MGL) is accountable for the hydrolysis of 2-arachidonoylglycerol (2-AG), thus contributing pivotally to neuroprotection because 2-AG is the main source of arachidonic acid, the precursor of prostaglandins production. Inhibiting MGL reduces inflammatory damage in the ischemic brain and enhances cerebral blood flow. Plants have been reported for their neuroprotective effect, such as on pentylenetetrazol (PTZ)-induced kindling seizures in mice, by reducing the seizures and restoring behavioral and biochemical changes, although the mechanism is not described.

The Possible Role of Progesterone Receptors in Prostate Cancer Incidences in the Iraqi Population.

Background: Prostate cancer (PCa) is one of the leading diseases causing mortality. It comes in the third rank of common cancer types. It is considered extremely a complicated cancer type since it occurs in highly steroid-responsive and dependent tissues.

Dataset on the chemical composition and bioactive compound of estuarine seaweed from four different cultivation area in Java and Lombok Island, Indonesia.

The data examines the evaluation of the quality of seaweed as the main raw material of various industrial products. , a red seaweed, serves as the primary ingredient in the agar industry and is subsequently utilized in food, biotechnological fields, nutraceuticals, and pharmaceutical applications due to its rich nutritional and bioactive compounds beneficial for human health. In fact, this seaweed has been cultivated in many regions and countries, especially in Indonesia.

Impacts of digital social media detox for mental health: A systematic review and meta-analysis.

The impact of social media has been significant on various aspects of life, particularly mental health. Growing concerns about the adverse effects of social media use have prompted the exploration of experimental interventions, defined as digital detox interventions. However, it remains unclear whether digital detox interventions are effective for mental health outcomes.

Effect of black garlic () on gonadosomatic index, follicle-stimulating hormone level and spermatozoa quality: A study in monosodium glutamate-exposed rat model.

Infertility rates have risen significantly, one of which is due to monosodium glutamate (MSG) consumption. Recent studies have shown that flavonoids in black garlic () act as antioxidants. The aim of this study was to assess the effect of black garlic extract (BGE) on gonadosomatic index, follicle-stimulating hormone (FSH) levels, and spermatozoa quality in rats exposed to MSG.

CO trapping dynamics in tight sandstone: Insights into trapping mechanisms in Mae Moh's reservoir.

The reliance on fossil fuels is a major contributor to increased anthropogenic CO emissions, driving global challenges such as climate change through the greenhouse effect. Carbon capture and storage (CCS) is a promising interdisciplinary technology aimed at mitigating these emissions by securely sequestering gigatons of CO. This study focuses on the feasibility of storing point-source CO emissions in saline formations, with a particular emphasis on the Mae Moh coal-fired power plant in Lampang, Thailand, which is located near its associated coal mine.

A road to surgical success: a case report of huge retroperitoneal idiopathic non-pancreatic cyst in a 6-year-old child at tertiary hospital, Muhimbili National Hospital.

In most reported cases, pancreatic pseudocysts are the most commonly reported cases and mostly occur in adults. Idiopathic non-pancreatic pseudocyst is rarely reported among children. We are reporting a rare case of retroperitoneal pseudocyst in a 6-year-old male with a 4-week history of abdominal swelling.

Unveiling the anti-obesity potential of Kemuning (Murraya paniculata): A network pharmacology approach.

Obesity has become a global issue that affects the emergence of various chronic diseases such as diabetes mellitus, dysplasia, heart disorders, and cancer. In this study, an integration method was developed between the metabolite profile of the active compound of Murraya paniculata and the exploration of the targeting mechanism of adipose tissue using network pharmacology, molecular docking, molecular dynamics simulation, and in vitro tests. Network pharmacology results obtained with the skyline query technique using a block-nested loop (BNL) showed that histone acetyltransferase p300 (EP300), peroxisome proliferator-activated receptor gamma (PPARG), and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A) are potential targets for treating obesity.