Multimode Miniature Polarization-Sensitive Metamaterial Absorber with Ultra-Wide Bandwidth in the K Band.

Metamaterial absorbers have gained widespread applications in fields such as sensing, imaging, and electromagnetic cloaking due to their unique absorption characteristics. This paper presents the design and fabrication of a novel K-band polarization-sensitive metamaterial absorber, which operates in the frequency range of 20.76 to 24.

Next-Generation Sequencing of Chinese Children with Congenital Hearing Loss Reveals Rare and Novel Variants in Known and Candidate Genes.

Hearing loss (HL) is the most common disorder in newborns with a highly heterogeneous genetic background. Despite significant progress in screening and identifying genes related to congenital hearing loss, there are still candidate genes implicated in HL that remain undiscovered. We investigated HL in 43 Chinese families by segregating bilateral sensorineural HL via whole-exome sequencing (WES) and Sanger sequencing.

A non-linear association of low-density lipoprotein cholesterol with all-cause and cardiovascular mortality among patients with hypertension.

Background: Although a few studies have examined the correlation between low-density lipoprotein cholesterol (LDL-C) and mortality, no study has explored these associations in hypertensive populations. This study aims to investigate the relationship between low-density lipoprotein cholesterol and cardiovascular and all-cause mortality in adults with hypertension.

Methods: Hypertensive participants aged ≥18 years from the National Health and Nutrition Examination Survey 1999-2018 with blood lipid testing data and complete follow-up data until 31 December 2019 were enrolled in the analysis.

Constructing coral reef-like imprinted structure on molecularly imprinted nanocomposite membranes based on nanospheres with hydrophilic multicores for selective separation of acteoside.

Molecularly imprinted nanocomposite membranes (MINMs) have shown great superiority in selective separation of acteoside (ACT) from phenylethanoid glycosides in Cistanche tubulosa. Herein, ACT-based MINMs (A-MINMs) with coral reef-like imprinted structure were proposed and developed for specifically separating ACT molecules. The nanospheres with hydrophilic multicores (NHMs) were introduced into polyvinylidene fluoride (PVDF) powders to obtain NHMs@PVDF membranes by a phase inversion method.

Latent epigenetic programs in Müller glia contribute to stress and disease response in the retina.

Previous studies have demonstrated the dynamic changes in chromatin structure during retinal development correlate with changes in gene expression. However, those studies lack cellular resolution. Here, we integrate single-cell RNA sequencing (scRNA-seq) and single-cell assay for transposase-accessible chromatin sequencing (scATAC-seq) with bulk data to identify cell-type-specific changes in chromatin structure during human and murine development.

Mitochondrial SO-Activated NIR Photodiagnostic Agent Harnessing Hydroxyl Radicals for Efficient Inflammation Eradication and Tumor Suppression.

At present, some progress has been made in developing NIR light-responsive free radical generators. However, the efficacy of theranostics continues to be hindered by tumor-associated inflammatory reactions. Hence, fulfilling the in situ release of free radicals upon NIR light excitation specifically activated by the inflammation microenvironment would be an ideal strategy for efficient inflammation eradication and tumor suppression but remains a challenge.

Research on short-term precipitation forecasting method based on CEEMDAN-GRU algorithm.

Precipitation forecasting is vital for managing disasters, urban traffic, and agriculture. This study develops an improved model for short-term precipitation forecasting by combining Complete Ensemble Empirical Mode Decomposition with Adaptive Noise (CEEMDAN) and Gated Recurrent Unit (GRU). Using precipitation data from January 1, 2019, to December 31, 2022, as a sample, the model capitalizes on CEEMDAN's superior signal decomposition capabilities and GRU's ability to capture nonlinear dynamic patterns in time series.

PABPC1 Silencing Inhibits Gastric Cancer Cell Proliferation, Metastasis, and EMT Via the PI3K/AKT Pathway.

Unlabelled: Gastric cancer is associated with high morbidity and mortality rates and seriously threatens human life. Our research aimed to explore the effects of poly (A) binding protein cytoplasmic 1 (PABPC1) on gastric cancer cells and elucidate the underlying mechanisms.

Methods: PABPC1 levels in gastric cancer cell lines were assessed by western blotting and RT-qPCR.

Menisoxoisoaporphine A, a novel oxoisoaporphine alkaloid from Menispermi Rhizoma, inhibits inflammation by targeting PDE4B.

Background: Dysregulated and excessive inflammatory reactions can lead to tissue damage, which is the underlying cause of most human diseases. Menisoxoisoaporphine A (MA), a novel oxoisoaporphine alkaloid, was obtained from Menispermi Rhizoma, a traditional Chinese medicinal herb used in the treatment of inflammatory conditions in clinical practice. This suggests that MA has very promising potential for the development of anti-inflammatory therapeutics.

Correction: A biotin-stabilized HKUST-1/ADM scaffold for facilitating MSC endothelial differentiation and vascularization in diabetic wound healing.

Correction for 'A biotin-stabilized HKUST-1/ADM scaffold for facilitating MSC endothelial differentiation and vascularization in diabetic wound healing' by Qiong Zhang , , 2023, , 854-872, https://doi.org/10.1039/D2BM01443B.

Compound 21 Attenuates Isoflurane-Induced Injury in Neonatal Rat Hippocampal Neurons and Primary Rat Neuronal Cells by Upregulating METTL3.

Background: Isoflurane, as an anesthetic drug, has a neurotoxic effect on the developing brain tissue. Compound 21 (C21) has been reported to be neuroprotective and ameliorate stroke effects. However, the mechanism by which C21 protects against nerve damage remains unclear.

The Therapeutic Potential of Pristimerin in Osteoarthritis: Mechanistic Insights from in vitro and in vivo Studies.

Objective: Osteoarthritis (OA), a degenerative disease marked by cartilage erosion and synovial proliferation, has led to an increased interest in natural plant-based compounds to slow its progression. Pristimerin(Pri), a triterpenoid compound derived from Tripterygium wilfordii, has demonstrated anti-inflammatory and antioxidant characteristics. This study explores the protective effects of Pri on OA and its potential mechanisms.

Biomechanical evaluation of percutaneous compression plate and femoral neck system in Pauwels type III femoral neck fractures.

Background: The optimal treatment for Pauwels type III femoral neck fractures remains contentious. We aim to compare the biomechanical properties of three inverted cannulated compression screw (ICCS), femoral neck system (FNS), and percutaneous compression plate (PCCP) to determine which offers superior stability for unstable femoral neck fractures.

Materials And Methods: Finite element analysis and artificial bone models were used to establish Pauwels III femoral neck fracture models.

Pilot-scale implementation of mainstream anammox for municipal wastewater treatment against cold temperature.

Applying anammox to municipal wastewater treatment promises enormous energy and resource savings; however, seasonally cold conditions pose a considerable challenge, impeding its future applications towards non-tropical regions. In this study, we establish a pilot-scale wastewater treatment plant (50 m/d) in northern China and implement the partial denitrification coupling anammox process on actual municipal wastewater. Despite seasonal cooling, the nitrogen removal efficiency remains high, ranging from 75.

Marein ameliorates the progression of osteoarthritis: An in vitro and in vivo studies.

Osteoarthritis (OA) is a prevalent, degenerative joint disease that requires effective treatments to prevent its progression. Therefore, the development of novel therapeutic strategies to address this unmet clinical challenge is paramount. Marein (MA), the principal active compound of Coreopsis tinctoria Nutt, exhibits anti-inflammatory and anti-oxidant properties in various diseases, indicating its potential as a therapeutic agent for OA.

Tocilizumab for the management of corticosteroid-resistant GO combined with OMG: a case series.

Purpose: To highlight the safety and efficacy of tocilizumab (TCZ) in Graves' ophthalmopathy (GO) combined with ocular myasthenia gravis (OMG) patients refractory to steroids and cholinesterase inhibitor (CEI).

Methods: This was retrospective case series. We reviewed the health records of patients with GO combined with OMG, ten of whom were refractory to corticosteroids and CEI treatment and received intravenous injection of TCZ.

Modulating Aggregation and Deaggregation Based on Assembling Strategy to Switch on NIR-II Light-Excited Fluorescence for Self-Reporting Viability of Eliminating Cancer Cell.

The fabrication of self-reporting photosensitizers (PSs), enabling real-time evaluation of the extent of elimination of cancer cells, holds significant scientific importance in the photodynamic therapy (PDT) process. To address the intrinsic challenge of the short-wavelength light source, this work proposed an innovative approach of rational design second near-infrared (NIR-II, 1000-1700 nm) light-excited fluorescent PS systems (named , , and , respectively) through modulating aggregation and deaggregation based on assembling strategy. Therein, the suitable interplanar distance of adjacent linked with C-H···π interactions was an idea for relieving compact π···π packing for fluorescent imaging as well as elevating the spin-orbit coupling for reactive oxygen species (ROS) generation.

A Rare Case of an Infant With Mutation Presenting With Direct Hyperbilirubinemia and Hepatomegaly.

Translocations within the TFE gene resulting in oncogenic fusion proteins have been associated with multiple neoplasms. De novo mutations in the X-linked gene TFE3 in exons 3 and 4 are considered to contribute to lysosomal storage disorder-like features. However, the histologic findings within the livers of patients with TFE3 mutations are not well characterized.

Predictive value of percutaneous peripheral arterial compliance T in left ventricular diastolic function with coronary artery disease.

Background: Diastolic dysfunction emerges early in patients with cardiac insufficiency and is prevalent, underscoring the importance of its early identification and intervention in the prevention of heart failure. The study leverages the convenience and accuracy of measuring peripheral arterial sclerosis to facilitate the early detection of diastolic dysfunction, which is instrumental in mitigating and delaying the onset and progression of heart failure, holding significant clinical relevance.

Methods: This research enrolled 556 patients suspected of experiencing Acute Coronary Syndrome (ACS) and stratified them into Groups A, B, C, and D according to the severity of coronary artery stenosis.

Progress of systematic psychological interventions in elderly patients with femoral fractures: A comprehensive review.

This review aims to gain a deeper understanding of the psychological state of elderly patients with femoral fractures and provide more theoretical and practical support for clinical treatment and care. Through a literature analysis, we found that elderly patients with femoral fractures face various psychological issues such as anxiety, depression, sleep disorders, and social isolation. The application of systematic nursing interventions in clinical practice, including cognitive-behavioral therapy, mindfulness therapy, family therapy, art therapy, interpersonal therapy, emotion-focused therapy, and relaxation training, has yielded significant results.