Evaluating Choroidal Vascular Changes in Young Adults With High Myopia Utilizing Swept source optical coherence tomography angiography.

Purpose: Utilizing Swept source optical coherence tomography angiography (SS-OCTA) investigates the changes in the vascular characteristics of the choriocapillaris and larger vascular layers, including Sattler's and Haller's layers, in the macular region of young myopia patients, in order to to Enhance our comprehension of the underlying mechanisms of the pathogenesis of myopia.

Methods: A retrospective analysis was performed on 103 young adults (154 eyes) that underwent SS-OCTA. Axial lengths (AL) were measured, 64 eyes with AL < 26.

Scraping therapy for knee osteoarthritis: a systematic review and Meta-analysis.

Objective: To systematically evaluate the efficacy of scraping therapy on knee osteoarthritis (KOA).

Methods: A computerized search was conducted in several databases, including PubMed, Web of Science, Cochrane Library, China National Knowledge Infrastructure Database, China Science and Technology Journal Database, Wanfang, and Chinese BioMedical Literature Database, from the establishment date of these databases to April 9, 2023. Randomized controlled trials (RCTs) on scraping therapy for KOA were collected in accordance with the "Participants-Intervention-Control-Outcome-Study design" criteria.

The French multicentric molecular analysis platforms and personalized medicine trials MOST, MOST Plus and MEGAMOST.

Background And Purpose: In this manuscript we describe the academic French multicentric molecular analysis platforms including PROFILER, promoted by Centre Léon Berard, and the multicentric personalized medicine trials MOST, MOST Plus and MEGAMOST.

Patients/material And Methods: MOST, MOST Plus and MEGAMOST comprise 14 cohorts with different targeted agents and immunotherapies.

Results And Interpretation: PROFILER has recruited 5,991 patients in 10 years, MOST and MOST Plus 875 patients since 2014 and MEGAMOST 172 patients since 2020, and are still ongoing.

Rational resistance amidst gentle breeze and mild rain: Examining online collective behavior among the Chinese public using the elaborated social identity model.

This research examines internet collective behavior in mainland China during the COVID-19 pandemic, focusing on the factors and characteristics that drive such behavior. The Chinese government initially implemented a conservative and biased policy to contain the spread of the virus, but the sudden lifting of lockdown measures in late 2022 resulted in a surge in infections and scarcity of medical resources. This policy shift led many Chinese internet users to perceive the government's actions as hasty and harsh, prompting them to engage in collective online behavior.

Uniformly dispersed ruthenium nanoparticles on porous carbon from coffee waste outperform platinum for hydrogen evolution reaction in alkaline media.

Biowaste-derived carbon materials are a sustainable, environmentally friendly, and cost-effective way to create valuable materials. Activated carbon can be a supporting material for electrocatalysts because of its large specific surface area and porosity. However, activated carbon has low catalytic activity and needs to be functionalized with heteroatoms, metals, and combinations to improve conductivity and catalytic activity.

Effectiveness and Safety of Different Postoperative Adjuvant Regimens in Patients with Low-Grade Gliomas: A Network Meta-Analysis.

Objective: This study aimed to investigate the effectiveness and safety of various adjuvant regimens in patients with low-grade gliomas and to further explore the optimal adjuvant treatment for patients with low-grade gliomas and the differences in the efficacy of each treatment regimens in different tumor types.

Methods: A comprehensive search of the PubMed, Cochrane Library, Ovid, Embase, and Web of Science databases was conducted to screen randomized and nonrandomized controlled trials related to adjuvant therapy in patients with low-grade gliomas. The Cochrane quality assessment method and the Newcastle-Ottawa Scale were used to assess the quality of the included randomized and nonrandomized controlled trials, respectively.

Study of the effect of minerals on the pyrolysis of oil shale in Fushun, China.

Herein, the effect of Fushun oil shale minerals on its kerogen has been investigated. The samples were obtained under non-isothermal conditions at different final temperatures. Scanning electron microscope (SEM) analysis revealed that the silicates were layered and the carbonates were tightly bound to each other.

Effect Western Medicines Combined With Nao-Xue-Shu in Patients With Hypertensive Intracerebral Hemorrhage: A Network Meta-Analysis.

To explore the efficacy of nimodipine, nifedipine, and edaravone (EDA) combined with Nao-Xue-Shu in patients with hypertensive intracerebral hemorrhage (HICH) and to determine the best western medicine combined with Nao-Xue-Shu for treating HICH patients using a ranking method. After a comprehensive search of the China National Knowledge Infrastructure (CNKI), Wanfang Database, VIP information database, Chinese Biomedical Database (CBM), PubMed, Embase, and Cochrane Library database from the database establishment 31 December 2021, data extraction and quality assessment were conducted for the included articles. The primary outcome measure was the effectiveness after treatment.

Effects of electroacupuncture on the expression of hypothalamic neuropeptide Y and ghrelin in pubertal rats with polycystic ovary syndrome.

Background: Polycystic ovary syndrome often starts in puberty, and its pathogenesis is not clear. This study aimed to explore the pathogenesis of pubertal polycystic ovary syndrome (PCOS) and assess the therapeutic effect of electroacupuncture on pubertal PCOS.

Methods: Dihydrotestosterone (DHT) was used to induce rat models of pubertal PCOS.

Clinical Implications of Plasma Galectin-3 in Heart Failure With Preserved Ejection Fraction: A Meta-Analysis.

Background: Heart failure with preserved ejection fraction (HFpEF) is an increasing public health concern. Currently, data regarding the clinical application value of plasma Galectin-3 (Gal-3) in HFpEF are contradictory. Therefore, we performed the following meta-analysis to appraise the clinical implications of serum Gal-3 in HFpEF, including its capacity to predict new-onset disease, long-term unfavorable endpoints, and the degree of cardiac structural abnormality and left ventricular diastolic dysfunction (LVDD).

Efficacy and safety of different drug treatments in patients with spinal-cord injury-related neuropathic pain: a network meta-analysis.

Study Design: Systematic review with network meta-analysis.

Objective: We explored the efficacy and safety of different drug treatments in patients with spinal-cord injury (SCI)-related neuropathic pain. We investigated which treatment is most suitable for such patients by judging the efficacy and safety of these drugs.

Efficacy and Safety of Bevacizumab Combined with Other Therapeutic Regimens for Treatment of Recurrent Glioblastoma: A Network Meta-analysis.

Background: Despite the fact that bevacizumab (Bev) has been approved to treat recurrent glioblastoma, patients have failed to demonstrate a significant overall survival (OS) advantage. In recent years, the advent of more Bev combination regimens seems to bring new hope for patients; nevertheless, there is still a lack of intuitive comparison among these therapies.

Objective: To explore the efficacy and safety of various Bev combination regimens in patients with recurrent glioblastoma and to further explore the differences in the efficacy of each treatment in randomized controlled trials (RCTs) and nonrandomized controlled trials (non-RCTs).

Physical perspective forward-inverse learning for ultrasonic sensing diagnosis in small diameter and thin-wall tube.

The ultrasonic testing method is a well-known non-destructive testing technique which has been applied to the tube inspection for guarantying the quality of the production. However, there exist several challenges to detect the defects of tubes with small diameter and thin-wall due to the complex of multiple reflections and waveform conversion. Parameters selection of the transducer takes key role to enhance the detection sensitivity such as frequency, size, refraction angle, distance offset, and focal point distance.

Rapid Room-Temperature Synthesis of Mesoporous TiO Sub-Microspheres and Their Enhanced Light Harvesting in Dye-Sensitized Solar Cells.

Submicron sized mesoporous spheres of TiO have been a potential alternative to overcome the light scattering limitations of TiO nanoparticles in dye-sensitized solar cells (DSSCs). Currently available methods for the growth of mesoporous TiO sub-microspheres involve long and relatively high temperature multi-stage protocols. In this work, TiO mesoporous sub-microspheres composed of ~5 nm anatase nanocrystallites were successfully synthesized using a rapid one-pot room-temperature CTAB-based solvothermal synthesis.

Preliminary exploration of atmospheric water vapor, liquid water and ice water by ultraviolet Raman lidar.

Water is the only atmospheric component with three phases. In this work, ultraviolet Raman lidar is developed for synchronous measurements of water vapor, liquid water and ice water in Xi'an (34.233°N, 108.

In-depth transcriptomic and proteomic analyses of the hippocampus and cortex in a rat model after cerebral ischemic injury and repair by Shuxuetong (SXT) injection.

Background: There is a lack of systematic descriptions and characterization of strokes and their effects in both the cerebral hippocampus and cortex. Shuxuetong (SXT) injection was reported to have good therapeutic effects in the clinic; therefore, it was selected as a drug intervention method for cerebral ischemia repair in rat models. The aim of this study was to understand the features of molecules and pathways and to reveal key processes of SXT repair.

[Imported malaria in Hefei City: a case report].

Objective: To perform epidemiological survey and laboratory diagnosis of a malaria case imported into Hefei City, so as to provide scientific evidence for the prevention and control of imported malaria in the future.

Methods: The epidemiological history and clinical data of the imported malaria case were collected and analyzed.

Results: The patient returned to China from Mozambique, and was admitted to the hospital due to repeated fever several months after returning to China.

Development of epidermal growth factor receptor targeted therapy in pancreatic cancer.

The epidermal growth factor receptor (EGFR) family is a series of important cancer therapeutic targets involved in cancer biology. These genes play an important role in tumor biological characteristics including angiogenesis, cell survival, invasion and glucose metabolism. In recent years, progress has been achieved on the cellular and molecular biological characteristics of EGFR and its role in cancer development based on the study of tumor specimens and experimental animal model.

CHOP induces apoptosis by affecting brain iron metabolism in rats with subarachnoid hemorrhage.

The endoplasmic reticulum stress-related factor CCAAT/enhancer binding protein (C/EBP) homologous protein (CHOP) aggravates early brain injury (EBI) in rats after subarachnoid hemorrhage (SAH). Our research aims to investigate the role of CHOP-mediated iron metabolism in EBI after SAH and the underlying mechanism. Male Sprague-Dawley rats were used to establish SAH models.

Inhibitory effect of Zanthoxylum bungeanum essential oil (ZBEO) on Escherichia coli and intestinal dysfunction.

The inhibitory effects of Zanthoxylum bungeanum essential oil (ZBEO) on Escherichia coli (E. coli) in vitro and in vivo were investigated, as well as its function of improvement of intestinal health. The results of in vitro studies, such as minimal inhibitory concentration (MIC) analysis, agar disc diffusion test and growth curve analysis of E.

Evaluating photographic scales of facial pores and diagnostic agreement of tests using latent class models.

Background: Ordinal severity scales illustrated by photographs have been widely developed to help dermatologists in evaluating skin problems or improvements. Numerous scales have been published, and none of them were used for assessing facial pores.

Methods: A five-point photographic scale of facial pores was formulated, and photographs of pores on nasal ala from 128 female volunteers were acquired.

A Novel Method for Detection the Deafness-Associated Mitochondrial A1555G and C1494T Mutations.

Background: To develop a novel method for molecular detection of deafness-associated mitochondrial A1555G and C1494T mutations.

Methods: We designed four primers that specifically bind to human mitochondrial 12S rRNA. PCR amplification of DNA samples including the A1555G, C1494T, and healthy controls is performed.

Size of the semicircular canals measured by multidetector computed tomography in different age groups.

Purpose: The purpose of the study was to obtain reference values for the sizes of the semicircular canals (SCCs) on multidetector computed tomographic (CT) images in different age groups.

Methods: Computed tomographic images of the temporal bone of 210 patients, a total of 420 ears without inner ear pathology, have been evaluated. These patients were divided into 4 groups by age: young children (<7 years), older children and adolescents (8-17 years), adults (18-59 years), and the elderly patients (>60 years).

The osteogenic study of tissue engineering bone with BMP2 and BMP7 gene-modified rat adipose-derived stem cell.

To evaluate the feasibility and advantages of constructing a novel tissue engineering bone, using β-tricalcium phosphate (β-TCP) and rat adipose-derived stem cells (ADSCs), modified with BMP2 and BMP7 by lentivirus. In the present study, ADSCs transfected with Lv-BMP2 and Lv-BMP7, alone or together, were seeded on β-TCP scaffold and cultured in vitro. Based on the results of DNA assay, alkaline phosphatase (ALP) activity, alizarin red staining and osteogenic marker genes expression analysis, the BMP2 and BMP7 genes cotransfection group exhibited a higher degree of osteogenic differentiation in vitro.