Exploring the freshness biomarker and volatiles formation in stored pork by means of lipidomics and volatilomics.

Raw pork is prone to oxidation and rancidity as it contains a high level of unsaturated lipid molecules. Reliable biomarkers to benchmark pork freshness and their formation have not been systematically investigated. The results indicated that the peroxide values, TVB-N and rancid volatiles dramatically increased in pork during the storage period (4 °C, 0-9 d).

Current status and strategies for controlling hexachlorobutadiene from multiple perspectives of emission, occurrence, and disposal.

Hexachlorobutadiene (HCBD), as an emerging persistent organic pollutant, poses a pressing global environmental issue concerning its reduction and control. However, the lack of systematic studies on the sources and occurrence of HCBD hinders the development of effective disposal technologies. This study addresses HCBD prevention and treatment from multiple perspectives, including source emissions, environmental contamination distribution, and control technologies.

Nanobody-assisted nanoluciferase fragment complementation for in situ measurement and visualization of endogenous protein-protein interaction.

Here, we developed nanobody-assisted nanoluciferase fragment complementation for in situ measurement and visualization of endogenous protein-protein interaction (NanaPPI). When an interaction occurs, primary antibodies for two proteins bring the proximity of secondary nanobody-fused small/large fragment to reassemble into an intact NanoLuc variant, thus transforming interaction events to luminescent signals in situ with high sensitivity. Compared to proximity ligation assay, NanaPPI has a similar signal-to-background ratio, but it is more convenient with faster procedures, easier readout and lower cost.

Designing Carbon-Foam Composites via Molten-State Reduction for Multifunctional Electromagnetic Interference Shielding.

Advanced electromagnetic interference (EMI) shielding materials are in great demand because of the severe electromagnetic population problem caused by the explosive growth of advanced electronics. Besides superior EMI shielding properties, the mechanical strength of the shielding materials is also critical for some specific application scenarios (e.g.

Whole-Cell Vaccine Preparation Through Prussian Blue Nanoparticles-Elicited Immunogenic Cell Death and Loading in Gel Microneedles Patches.

Tumor whole-cell vaccines are designed to introduce a wide range of tumor-associated antigens into the body to counteract the immunosuppression caused by tumors. In cases of lymphoma of which the specific antigen is not yet determined, the tumor whole-cell vaccine offers distinct advantages. However, there is still a lack of research on an effective preparation method for the lymphoma whole-cell vaccine.

Promoting Photocatalytic Hydrogen Evolution by Stabilization of Excited Triplet States and Enhancement of Internal Electric Field at Dye/PCN Interface.

The heterojunction photocatalysts composed of organic dyes and polymeric carbon nitride (PCN) have great potential for photocatalytic hydrogen evolution (PHE). However, serious charge recombination exists at the dye/PCN interface for the large gaps in time scales and the poor driving force of charge transfer process. Herein, both the excited triplet states of organic dyes with long lifetimes and strong internal electric fields (IEF) as charge transfer driving forces are achieved by the construction of high dipole moments with aromatic-core engineering, and modulation of dye aggregates by alkyl modification.

HClO-Activated Near-Infrared Chemiluminescent Probes with a Malononitrile Group for In-Vivo Imaging.

Chemiluminescence (CL) imaging has emerged as a powerful approach to molecular imaging that allows exceptional sensitivity with virtually no background interference because of its unique capacity to emit photons without an external excitation source. Despite its high potential, the application of this nascent technique faces challenges because the current chemiluminescent agents have limited reactive sites, require complex synthesis, are insufficiently bright, and lack near-infrared emission. Herein, a series of HClO-activated chemiluminescent probes that exhibit robust near-infrared emission are studied.

Safety and efficacy of GLP-1/FGF21 dual agonist HEC88473 in MASLD and T2DM: a randomized, double-blind, placebo-controlled study.

Background And Aims: Glucagon-like peptide-1 (GLP-1) and fibroblast growth factor 21 (FGF21) are key regulators of glucose and lipid metabolism. In the present study, we assessed the safety and efficacy of a novel GLP-1/FGF21 dual agonist HEC88473 for the treatment of metabolic dysfunction-associated steatotic liver disease (MASLD) combined with type 2 diabetes mellitus (T2DM).

Methods: This was a randomized, double-blind, placebo-controlled, multiple-ascending-dose phase 1b/2a trial.

Comparison of the Effects of Ciprofol and Propofol on Postoperative Nausea and Vomiting in Patients Undergoing Outpatient Hysteroscopy.

Purpose: To evaluate and compare the effects of ciprofol and propofol on postoperative nausea and vomiting (PONV) in patients undergoing outpatient hysteroscopy.

Design: Double-blind randomized controlled trial.

Methods: This study included 1104 patients scheduled for elective outpatient hysteroscopy.

Mendelian randomization analyses support causal relationships between systemic lupus erythematosus and brain imaging-derived phenotypes.

Background: Neuropsychiatric disorders in systemic lupus erythematosus (NPSLE) are often accompanied by alterations in brain structure and function. Subtle changes in brain structure also can be observed in non-NPSLE patients. MRI can be used as a non-invasive tool to determine nervous system involvement in SLE.

Discovery of four new Chinese species of Jacobsonina Hebard, 1929 and Blattella Caudell, 1903 (Blaberoidea: Blattellidae).

In this study, specimens of Blattellidae collected in China in recent years are analyzed by combining molecular data and morphological characters, and four new species of Jacobsonina and Blattella are described, Jacobsonina plicata Yao & Che, sp. nov., Jacobsonina subapiculata Yao & Che, sp.

The ATAC complex represses the transcriptional program of the autophagy-lysosome pathway via its E3 ubiquitin ligase activity.

The Ada two A-containing (ATAC) complex, containing histone acetyltransferases general control non-derepressible 5 (GCN5) or p300/CBP-associated factor (PCAF), has gained recognition as a prominent transcriptional coactivator. Recent revelations unveiled E3 ligase activity present in both GCN5 and PCAF; however, how the dual enzymatic activities of the ATAC complex orchestrate distinct transcriptional programs and signaling networks remains largely elusive. Our study unveils the function of the ATAC complex as a negative regulator of the autophagy-lysosome pathway's transcriptional program by modulating the stability of transcription factors TFE3 and TFEB.

Heat-Processed Diet Rich in Advanced Glycation End Products Induced the Onset and Progression of NAFLD via Disrupting Gut Homeostasis and Hepatic Lipid Metabolism.

Epidemiologic studies have suggested an association between the consumption of dietary advanced glycation end products (dAGEs) and the incidence of nonalcoholic fatty liver disease (NAFLD). However, the precise mechanism by which dAGEs induce NAFLD development, particularly the pathogenic role of the gut-liver axis, remains poorly understood. In this study, by establishing a high-AGE diet (HAD)-fed C57BL/6 mouse model, we employed multiomics approaches combined with a series of biological analyses to investigate the effect of HAD on NAFLD .

Mendelian randomization reveals predictive, preventive, and personalized insights into inflammatory bowel disease: the role of gut microbiome and circulating inflammatory proteins.

Background: A chronic illness with increasing global frequency, inflammatory bowel disease (IBD), which includes ulcerative colitis (UC) and Crohn's disease (CD), profoundly affects patients' quality of life and healthcare systems. IBD pathogenesis consists of changes in gut microbiota, immune system dysregulation, and genetic predisposition. Although emerging data suggests that gut microbiota and circulating inflammatory proteins play critical roles in IBD, their utility as biomarkers for predictive, preventive, and personalized medicine (PPPM) remains incompletely understood.

Case report: CD7-targeted autologous CAR-T therapy for the treatment of T-cell acute lymphoblastic leukemia undergoing allogeneic peripheral blood stem cell transplantation in the long-term follow-up.

Introduction: Chimeric antigen receptor T-cell (CAR-T) therapy has emerged as a promising approach for treating relapsed/refractory (r/r) T-cell acute lymphoblastic leukemia (T-ALL). However, it is mostly used as a bridging therapy for allogeneic hematopoietic stem cell transplantation (allo-HSCT). Furthermore, secondary allo-HSCT is costly and associated with significantly high treatment-related mortality rate than the primary transplants.

Sex-specific difference for melanoma from immunotherapy advancement.

Background: The evaluation of melanoma incidence and mortality trends based on population characteristics, with a particular focus on sex differences, is of utmost importance.

Methods: The gender-stratified analysis of melanoma mortality across various calendar years was conducted. Utilizing the Joinpoint software, we detected alterations in the incidence rates and delineated the mortality trends.

Glycated albumin levels in the third trimester of women with gestational diabetes mellitus are associated with adverse pregnancy-related outcomes.

Background: Glycated albumin (GA) levels have been considered as a promising biomarker for estimating glycemic control during pregnancy, but the relationship between GA levels and the incidence of adverse pregnancy outcomes in women with gestational diabetes mellitus (GDM) remains unclear. Our study aimed to investigate the relationship between GA levels during the third trimester and 13 different adverse pregnancy-related outcomes among women with GDM in China.

Methods: We retrospectively extracted clinical data from the medical records of 819 pregnant women with GDM who underwent prenatal examinations and child delivery at the Affiliated Hospital of Qingdao University between January 2022 and October 2022.

Biomimetic Microstructure with Anti-Slip and Anti-Adhesion for Efficient Handling of Brittle Material Surfaces in High-Temperature Environments.

Non-destructive handling such as wafer handling usually requires a high-temperature environment, however, most bionic materials fail in high temperatures due to material decomposition. In this study, inspired by the unique microstructure of locust toe pads with low adhesion and high friction, bionic high-temperature friction pads are designed and fabricated, selecting high-temperature-resistant silicone rubber as the material. The interfacial mechanical properties at high temperatures are analyzed.

Enhanced lutein and protein production with improved organoleptic properties in a novel yellow strain of Auxenochlorella pyrenoidosa mutant through atmospheric and room temperature plasma mutagenesis and norflurazon-based screening.

To achieve the triple purpose of enhancing lutein and protein contents as well as improving organoleptic properties in biomass of Auxenochlorella pyrenoidosa mutant as raw material of future food, a novel yellow mutant, CX41 strain, was successfully selected through atmospheric and room temperature plasma (ARTP) mutagenesis and norflurazon-based screening. CX41 strain exhibited a significantly increased lutein (0.86 mg/g) and protein (49.

Vaccine and therapeutic agents against the respiratory syncytial virus: resolved and unresolved issue.

Respiratory syncytial virus (RSV) is a predominant pathogen responsible for respiratory tract infections among infants, the elderly, and immunocompromised individuals. In recent years, significant progress has been made in innovative vaccines and therapeutic agents targeting RSV. Nevertheless, numerous challenges and bottlenecks persist in the prevention and treatment of RSV infections.

A Key R2R3-MYB Transcription Factor Activates Anthocyanin Biosynthesis and Leads to Leaf Reddening in Poplar Mutants.

Colorful woody plants are highly valued for their ornamental qualities, and are commonly used in garden landscape design. We previously cultivated several ornamental poplar varieties from bud mutants of Populus sp. Linn.