Sea Hare Hydrolysate Reduces PD-L1 Levels in Cancer Cells and Mitigates Rheumatoid Arthritis Ina Collagen-Induced Arthritis Mouse Model.

Our previous study highlighted the anticancer potential of sea hare hydrolysate (SHH), particularly its role in regulating macrophage polarization and inducing pyroptotic death in lung cancer cells through the inhibition of signal transducer and activator of transcription 3 (STAT3). These findings prompted us to investigate additional features of immune-oncology (I-O) agents or adjuvants, such as programmed cell death protein 1 (PD-1)/programmed death ligand 1 (PD-L1) inhibition and their association with rheumatoid arthritis (RA) risk, to explore the potential of SHH as an I-O agent or adjuvant. In this study, we investigated the effects of SHH on PD-L1 levels in various cancer cell types and assessed its effectiveness in treating RA, a common side effect of I-O agents.

Effectiveness of strengthening social protection and security programs in alleviating poverty in rural areas through multi-sector partnerships.

The effectiveness of strengthening social protection and security has proven to alleviate poverty in rural communities in the Garut Regency area, West Java Province, Indonesia, due in particular to excellent multi-sectoral cooperation. The social protection and security programs that the Indonesian Government provides are mainly targeted at the poor, as recorded in the social welfare data (DTKS). Poor people who are not registered with the DTKS cannot obtain social assistance programs.

Assessment of brand awareness and marketing techniques of health services by users of primary health centres in Indonesia.

Community health centres are of great importance in the context of disease prevention and health promotion. Nevertheless, the number of individuals who utilise health centres for preventive care is significantly lower than those who seek treatment for existing illnesses. The objective of this study was to provide insights into innovative marketing strategies and brand awareness to enhance the utilisation of primary health services.

Strengthening Indonesia's health system through community and technological engagements in public health interventions.

The 7th International Symposium on Public Health (ISoPH 2023), was held on October 2-3, 2023, in Surabaya, Indonesia, which brought together a diverse array of public health professionals, researchers, and policymakers from around the globe. The purpose of the symposium was to facilitate the exchange of the latest information and ideas within the realm of public health. The symposium aspired to foster discussions and the exchange of insights regarding scientific issues in the field of public health globally and within the context of Indonesia.

Anti-Inflammatory Effects of Fermented and Aged Mountain-Cultivated Ginseng Sprouts via Suppression of MAPK-NF-κB Pathway in Lipopolysaccharide-Stimulated RAW264.7 Macrophages.

Fermented and aged mountain-cultivated ginseng sprouts (FAMCGS) exhibit superior antioxidant and anti-inflammatory properties compared to mountain-cultivated ginseng sprouts (MCGS). However, the mechanisms behind these properties of FAMCGSE remain unclear. This study explores the anti-inflammatory effects of FAMCGS extract (FAMCGSE) on LPS-stimulated RAW 264.

Ash characteristics investigation from co-firing of Calliandra calothyrsus and Gliricidia sepium with a high-sulfur and -iron coal in drop tube furnace.

Calliandra calothyrsus and Gliricidia sepium ash characteristics as co-firing fuel to high-sulfur and -iron coal were investigated through theoretical prediction, FactSage modelling, and combustion experiment in drop tube furnace. The results show that the addition of Calliandra and Gliricidia were able to mitigate the slagging risk according to theoretical prediction and FactSage modelling. Slag formations were predicted to occur at higher combustion temperature compared to coal which was reflected in higher ash fusion temperature.

Plants with Anti-Ulcer Activity and Mechanism: A Review of Preclinical and Clinical Studies.

Ulcer disorders including the oral mucosa, large intestine, and stomach mucosa, cause significant global health burdens. Conventional treatments such as non-steroid anti-inflammatory drugs (NSAIDs), proton pump inhibitors (PPIs), histamine H receptor antagonists (HRAs), and cytoprotective agents have drawbacks like mucosal injury, diminish gastric acid secretion, and interact with concurrent medications. Therefore, alternative therapeutic approaches are needed to tackle this health concern.

Investigation on combustion characteristics and ash-related issues of Calliandra calothyrsus and Gliricidia sepium using thermogravimetric analysis and drop tube furnace.

Calliandra calothyrsus and Gliricidia sepium are developed as wood energy forest plantations in degraded land. They have good survivability, are fast to be harvested, and have good calorific value to be utilized as biomass fuel. This study aims to investigate their combustion characteristics by thermogravimetric analysis and their ash-related issues by combustion experiments in drop tube furnace and ash observation.

Prediction of self-efficacy in recognizing deepfakes based on personality traits .

While deepfake technology is still relatively new, concerns are increasing as they are getting harder to spot. The first question we need to ask is how good humans are at recognizing deepfakes - the realistic-looking videos or images that show people doing or saying things that they never actually did or said generated by an artificial intelligence-based technology. Research has shown that an individual's self-efficacy correlates with their ability to detect deepfakes.

Immunogenicity of Oral Rabies Vaccine Strain SPBN GASGAS in Local Dogs in Bali, Indonesia.

Dog-mediated rabies is endemic in much of Indonesia, including Bali. Most dogs in Bali are free-roaming and often inaccessible for parenteral vaccination without special effort. Oral rabies vaccination (ORV) is considered a promising alternative to increase vaccination coverage in these dogs.

Case Report: Severe Plasmodium vivax Malaria after Splenectomy.

Severe malaria after splenectomy has been reported with infections with Plasmodium falciparum, Plasmodium knowlesi, and Plasmodium malariae, but is less well-characterized with Plasmodium vivax. We describe a case of severe P. vivax malaria with hypotension, prostration, and acute kidney injury occurring 2 months after splenectomy in Papua, Indonesia.

Microclimate investigation of vehicular traffic on the urban heat island through IoT-Based device.

Anthropogenic is defined as one of the influencing factors of the climatic phenomenon, called Urban Heat Island (UHI), in which urban areas have higher air temperatures than their rural surroundings. Analyzing the impact of anthropogenic factors, such as vehicular traffic, has implications for the potential benefits of health monitoring systems; however, the spatiotemporal impact of anthropogenic factors, as well as vehicle mobility, has not been thoroughly investigated. This study incorporates vehicle mobility data by leveraging two different sensors; fixed station sensor instruments designed to integrate with the Internet of Things (IoT), and the camera of an area traffic control system (ATCS) that uses CCTV visualization with object detection.

Prognosticating 2-Year Survival Rate of Breast Cancer Patients Through Plasma miRNA-21 and Other Associating Factors.

Background: miRNA-21, one of breast cancer (BC) predictive markers, is now gaining cardinal attention from researchers worldwide to evaluate BC patients' survival rate. However, cancer staging, hormonal status, and other BC markers still have to be discussed. We aim to determine the relationship between miRNA-21 and associating factors such as BC staging, other tumor markers, and hormonal status to predict the 2-year survival rate of BC patients.

How Everyday Counterfeit Behavior That Disrupts Self Authenticity Might Lead to Corruption Tendencies.

Background: In the field of moral psychology, researchers have strived to understand the complex dynamics of corruption psychology. This study contributes to this area by presenting a theoretical model for sequential behavior, placing counterfeit behavior (CB) as a predictor and corruption tendencies (proneness to moral emotions, ie, guilt and shame/GASP) as the criterion. In addition, two bridging variables are assigned, ie, inauthenticity/counterfeit self (CS) and moral disengagement (MD).

Additional Blue LED during Cultivation Induces Cold Tolerance in Tomato Fruit but Only to an Optimum.

Tomato is a chilling-sensitive fruit. The aim of this study is to examine the role of preharvest blue LED lighting (BL) to induce cold tolerance in 'Foundation' tomatoes. Blue and red supplemental LED light was applied to achieve either 0, 12 or 24% additional BL (0B, 12B and 24B).

The Association between Plasma miRNA-21 Levels with Overall 1-year Survival Rate of Breast Cancer Patients at Various Stages.

Background: miRNA 21 exhibits an increased expression in breast cancer (BC). However, its relationship with the 1-year survival of breast cancer patients is still disputable and under serious discussion.

Methods: Cohort prospective study involving 49 breast cancer patients was done, comprising 26 in early stage and 23 in end-stage.

Brief dataset on chemical and mechanical properties of Corypha utan leaf fiber-reinforced composite with alkaline and silane treatment.

This paper presents the chemical and mechanical properties of Corypha utan leaf fiber (CULF) subjected to different chemical treatments for reinforced composite materials. Natural fibers are currently considered as an alternative constituent for composite reinforcement due to their friendly environment character. The CULF were chemically treated during a pre-fabrication process using NaOH, and 3-(Trimethoxysilyl) propyl methacrylate was introduced at three different concentrations of 0%, 5%, and 10%, respectively.

Antimicrobial and antihemolytic properties of a CNF/AgNP-chitosan film: A potential wound dressing material.

Cellulose nanofibers (CNFs), chitosan, and silver nanoparticles (AgNPs) are widely used to enhance the active functions and antibacterial properties of wound dressings. This study was conducted to prepare CNF/AgNP-chitosan using a straight incorporation method and to assess its antimicrobial activity. CNFs were isolated from oil palm empty fruit bunches (OPEFBs) using the pulping method and acid hydrolysis.

Tracking Fecal Bacterial Dispersion from Municipal Wastewater to Peri-Urban Farms during Monsoon Rains in Hue City, Vietnam.

Disease outbreaks attributed to monsoon flood-induced pathogen exposure are frequently reported, especially in developing cities with poor sanitation. Contamination levels have been monitored in past studies, yet the sources, routes, and extents of contamination are not always clear. We evaluated pollution from municipal wastewater (MWW) discharge and investigated fecal contamination by () in three agricultural fields on the outskirts of Hue City, Vietnam.

Longitudinal ex vivo and molecular trends of chloroquine and piperaquine activity against Plasmodium falciparum and P. vivax before and after introduction of artemisinin-based combination therapy in Papua, Indonesia.

Drug resistant Plasmodium parasites are a major threat to malaria control and elimination. After reports of high levels of multidrug resistant P. falciparum and P.