Publications by authors named "Praveen-Kumar"

Food packaging industries are growing to meet consumer demand and prevent pollution by adopting significant biopolymer advancements. Therefore, this study aimed to develop functionally active chitosan (CS)/polyvinyl alcohol (PVA)-based biopolymer films and evaluate the effect of Justicia Adhatoda extract (JAE), pure quercetin (Q), and CS-capped quercetin nanoparticles ((Q) NPs) on sustainable bread packaging. CS was successfully loaded onto (Q) by the one-pot method, which was confirmed by light absorption spectroscopy (UV), Fourier transform infrared spectroscopy (FTIR), and X-ray diffraction (XRD).

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Introduction: Ralstonia pickettii is a non-fermenting gram-negative bacillus rarely associated with hospital-acquired infections. The study aimed to characterise the clinical profile and outcomes of R. pickettii bacteremia cases.

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The present circumstances of Asian expatriates' wives residing in the United States and the effects of acculturation stress, parenthood stress, and depression on the distress disclosure intention have been examined this study. The nature of this investigation is exploratory. 611 married women with children who reside in the United States provided data, which was then processed with a measurement model, structural analysis, mediating analysis, moderating analysis, and regression analysis.

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Article Synopsis
  • Alzheimer's disease (AD) is a progressive neurodegenerative condition that leads to significant cognitive decline and motor dysfunction due to the loss of cholinergic neurons, with current medications only providing temporary relief of symptoms.
  • Novel compounds based on rivastigmine (such as 3q and 6e) were developed and shown to effectively inhibit key enzymes involved in AD, exhibit antioxidant properties, and prevent the aggregation of tau and Aβ proteins.
  • These compounds also reduced inflammation in brain cells and restored memory function in animal models, showing increased expression of neuroprotection markers, indicating their potential for treating AD more effectively than existing medications.
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Background: Cancer is a leading cause of death globally and in the US, prompting research into medicinal plants with anticancer properties. , or Ashwagandha, is one such plants, known for its diverse pharmacological effects. Withaferin A and Viscosalactone B are two compounds found in Ashwagandha with known anticancer activity.

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We use a 16-month-long, 20 Hz wind data from a mooring deployed in the Bay of Bengal (BoB) to study the characteristics of turbulent wind stress ( events in the marine atmospheric boundary layer (MABL). Quadrant analysis of the motion-corrected and suggests that sweep and ejections, representing downward stress transfer into the ocean, dominate the (~ 140%). In comparison, outward and inward interactions representing an upward stress transfer into the atmosphere provide the counter-contribution (~ 40%).

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Unlabelled: Antimicrobial resistance (AMR) poses a foremost threat to global health, necessitating innovative strategies for discovering antimicrobial agents. This review explores the role and recent advances of techniques in identifying novel antimicrobial agents and combating AMR giving few briefings of recent case studies of AMR. techniques, such as homology modeling, virtual screening, molecular docking, pharmacophore modeling, molecular dynamics simulation, density functional theory, integrated machine learning, and artificial intelligence, are systematically reviewed for their utility in discovering antimicrobial agents.

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The visible light-promoted -alkenylation of phenols and naphthols with terminal alkynes is achieved using 2,4,6-tris(4-fluorophenyl)pyrylium tetrafluoroborate (T(-F)PPT) as a photocatalyst at room temperature without the need of any external ligand or additive. Apart from its excellent functional group tolerance, the protocol described herein represents an appealing alternative strategy to classical transition-metal catalysed hydroarylation reactions. Mechanistic investigations revealed that the reaction involves a radical pathway.

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Non-alcoholic fatty acid liver disease (NAFLD), non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC) are the fatal liver diseases which encompass a spectrum of disease severity associated with increased risk of type 2 diabetes mellitus (T2DM), a metabolic disorder. Heat shock proteins serve as markers in early prognosis and diagnosis of early stages of liver diseases associated with metabolic disorder. This review aims to comprehensively investigate the significance of HSP90 isoforms in T2DM and liver diseases.

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Article Synopsis
  • - The study investigated the potential of khellin (KL) to counteract the effects of Parkinson's disease (PD) induced by rotenone in zebrafish, using various analyses including drug assessments, molecular docking, and dynamics studies which indicated strong binding affinity of KL to monoamine oxidase B (MAO-B).
  • - KL demonstrated significant antioxidant properties in vitro, suggesting it can help maintain redox balance, and further in vivo analysis revealed that KL treatment improved locomotor activity and social interactions in zebrafish models of PD while also reducing various oxidative stress markers.
  • - Histopathological examinations showed that KL treatment effectively alleviated brain abnormalities associated with PD, highlighting its potential therapeutic benefits for PD symptoms.
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Biodegradable and sustainable food preservation materials have gained immense global importance to mitigate plastic pollution and environmental impact. Biopolymers like cellulose offer significant advantages for food preservation, including biodegradability and the ability to extend shelf life. Therefore, the present study aims to prepare gallic acid (GA) and zinc oxide nanoparticles (ZnO NPs) incorporated methylcellulose (MC) composite films by employing a solvent casting technique.

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Biomass resources are often disposed of inefficiently and it causes environmental degradation. These wastes can be turned into bio-products using effective conversion techniques. The synthesis of high-value bio-products from biomass adheres to the principles of a sustainable circular economy in a variety of industries, including agriculture.

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Article Synopsis
  • Breast cancer is the most common type of cancer and a major cause of death in women, with some types being harder to treat than others.
  • The study looked at the differences between a difficult-to-treat type of breast cancer (DTBC) and a more common type (Luminal A) to find out what makes them different.
  • Researchers used advanced techniques to analyze tumor samples and found that DTBC tumors have different gene mutations and characteristics, which could help identify ways to improve treatment and predict patient outcomes.
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Methylcellulose, a prominent polysaccharide prevalent in the food sector, was considered to fabricate the active films with glutaraldehyde as a crosslinker and Noni (Morinda citrifolia) Leaf Extract (NLE) as an active agent. FTIR analysis confirms the intermolecular -OH bonding, and SEM micrograms demonstrate methylcellulose active films' homogeneous, dense morphologic appearance. Due to the crosslinking effect of glutaraldehyde and noni leaf extract, tensile strength (41.

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  • - Hepatocellular Carcinoma (HCC) is the main type of liver cancer that results from issues with cell cycle regulation, with higher expression of Heat Shock Protein 90 (HSP90) and mitochondrial HSP90 (TRAP1) noted in patients.
  • - The review highlights the significance of HSP90 and TRAP1 inhibitors and their targeted delivery for potential early diagnosis and treatment of HCC.
  • - It emphasizes the role of protein-protein interactions involving HSP90 and TRAP1 in HCC pathways, while exploring systems and computational biology to study the effects of herbal plant molecules on these proteins.
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In the present research, we have developed a model-based crisp logic function statistical classifier decision support system supplemented with treatment planning systems for radiation oncologists in the treatment of glioblastoma multiforme (GBM). This system is based on Monte Carlo radiation transport simulation and it recreates visualization of treatment environments on mathematical anthropomorphic brain (MAB) phantoms. Energy deposition within tumour tissue and normal tissues are graded by quality audit factors which ensure planned dose delivery to tumour site thereby minimising damages to healthy tissues.

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Introduction: Viridans Group of Streptococci (VGS) are heterogeneous alpha hemolytic Streptococci that form commensal flora in the oral cavity, upper respiratory tract, gastrointestinal tract and female genital tract and are potential pathogens that can cause serious infections like infective endocarditis and bacteremia. Penicillin or Ceftriaxone is the recommended first line agent for definitive therapy of VGS endocarditis. Alteration in penicillin binding proteins can decrease the susceptibility of VGS to penicillin and other beta-lactam agents and complicate antimicrobial therapy for serious VGS infections like Infective endocarditis.

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Purpose: To explore the association of clinicopathologic and molecular factors with the occurrence of positive margins after first surgery in breast cancer.

Methods: The clinical and RNA-Seq data for 951 (75 positive and 876 negative margins) primary breast cancer patients from The Cancer Genome Atlas (TCGA) were used. The role of each clinicopathologic factor for margin prediction and also their impact on survival were evaluated using logistic regression, Fisher's exact test, and Cox proportional hazards regression models.

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Objective: Dedifferentiated endometrial cancer (DDEC) is an uncommon and clinically highly aggressive subtype of endometrial cancer characterized by genomic inactivation of SWItch/Sucrose Non-Fermentable (SWI/SNF) complex protein. It responds poorly to conventional systemic treatment and its rapidly progressive clinical course limits the therapeutic windows to trial additional lines of therapies. This underscores a pressing need for biologically accurate preclinical tumor models to accelerate therapeutic development.

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Objective This study aimed to investigate the knowledge, attitude, and practices (KAP) of intentional replantation among postgraduate students and endodontists in India, the United States of America, and the United Kingdom. Materials and methods The sample size was estimated using G*Power. Based on the pilot study done before with 60 participants, a sample size of 928 was obtained.

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Constructing stable heterostructures with appropriate active site architectures in covalent organic frameworks (COFs) can improve the active site accessibility and facilitate charge transfer, thereby increasing the catalytic efficiency. Herein, a pore-wall modification strategy is proposed to achieve regularly arranged TiO nanodots (≈1.82 nm) in the pores of COFs via site-specific nucleation.

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The depletion of fossil fuels and increasing demand for energy are encountered by generating renewable biogas. Anaerobic digestion (AD) produces not only biogas, also other value-added products from the digestate using various organic, municipal and industrial wastes which have several benefits like remediating waste, reduces greenhouse gas emissions, renewable energy generation and securing socio-economic status of bio-based industries. This review work critically analyzes the biorefinery approaches on AD process for the production of biogas and digestate, and their direct and indirect utilization.

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The development of aluminium composite with the inclusion of advanced materials is a continuous research process due to the increasing industrial demand for advanced hybrid materials. To cater for this need, this research work focuses on the development of Al 7075 alloy reinforced with TiB and graphene and on the evaluation of its strengthening mechanism. Two different modes of improving the strength of the hybrid composite have been followed; one is by the inclusion of graphene at three levels of 0.

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