Chitosan-Biotin-Conjugated pH-Responsive Ru(II) Glucose Nanogel: A Dual Pathway of Targeting Cancer Cells and Self-Drug Delivery.

The current study paves the way for improved chemotherapy by creating pH-responsive nanogels (NGs) ( and ) loaded with synthetic ruthenium(II) arene complexes to increase biological potency. NGs are fabricated by the conjugation of chitosan (CTS)-biotin biopolymers that selectively target the cancer cells as CTS has the pH-responsive property, which helps in releasing the drug in cancer cells having pH ∼ 5.5, and biotin provides the way to target the cancer cells selectively due to the overexpression of integrin.

Fabrication of a paper-based facile and low-cost microfluidic device and digital imaging technique for point-of-need monitoring of hypochlorite.

Lab-on-a-paper-based devices are promising alternatives to the existing arduous techniques for point-of-need monitoring. The present work reports an instant and facile method to produce a microfluidic paper-based analytical device (μPAD). The fabricated μPAD has been used to detect hypochlorite (OCl) by incorporating newly synthesized chromo-fluorogenic ratiometric probes 1 and 2 into the sample reception zone.

Studies on anticancer properties with varying co-ligands in a Ru(II) arene benzimidazole system.

Recently in the field of chemotherapeutics, to combat the side effects of cisplatin, ruthenium complexes have been investigated extensively. In this work, a bidentate benzimidazole-based ligand, HL [HL = 2-(1-benzo[]imidazol-2-yl)-6-methoxyphenol], was utilized to obtain three Ru(II) arene complexes having a generalized formula [Ru(η--cym)(L)(X)] or [Ru(η--cym)(L)(X)] (where -cym = -cymene). The co-ligand X (X = (i) Cl, (ii) PPh = triphenyl phosphine, and (iii) PTA = 1,3,5-triaza-7-phosphaadamantane) was varied in order to study the effect it has on the antitumor activity of the compounds.

Pyrene-based fluorescent Ru(II)-arene complexes for significant biological applications: catalytic potential, DNA/protein binding, two photon cell imaging and cytotoxicity.

Ruthenium complexes are being studied extensively as anticancer drugs following the inclusion of NAMI-A and KP1019 in phase II clinical trials for the treatment of metastatic phase and primary tumors. Herein, we designed and synthesized four organometallic Ru(II)-arene complexes [Ru(η--cymene)(L)Cl] (1), [Ru(η-benzene)(L)Cl] (2), [Ru(η--cymene)(L)N] (3) and [Ru(η-benzene)(L)N] (4) [HL = ()-'-(pyren-1-ylmethylene)thiopene-2-carbohydrazide] that have anticancer, antimetastatic and two-photon cell imaging abilities. Moreover, in the transfer hydrogenation of NADH to NAD, these compounds also display good catalytic activity.

Cancer-Targeted Chitosan-Biotin-Conjugated Mesoporous Silica Nanoparticles as Carriers of Zinc Complexes to Achieve Enhanced Chemotherapy and .

Despite being the most common component of numerous metalloenzymes in the human body, zinc complexes are still under-rated as chemotherapeutic agents. Herein, the present study opens up a key route toward enhanced chemotherapy with the help of two Zn complexes (ZnMBC) synthesized alongside Mannich base ligands to upsurge biological potency. Further, well-established mesoporous silica nanoparticles (MSNs) have been chosen as carriers of the titled metallodrugs in order to achieve anticancer drug delivery.

Unveiling the urease like intrinsic catalytic activities of two dinuclear nickel complexes towards the in situ syntheses of aminocyanopyridines.

Designing metal complexes as functional models for metalloenzymes remains one of the main targets in synthetic bioinorganic chemistry. Furthermore, the utilization of the product(s) derived from the catalytic reaction for subsequent organic transformation that occurs in biological systems is an even more difficult challenge for biochemists. Urease, the most efficient enzyme known, catalyzes the hydrolysis of urea and it contains an essential dinuclear Ni cluster in the active site.

Studies on the influence of the nuclearity of zinc(ii) hemi-salen complexes on some pivotal biological applications.

Though a large amount of literature has been reported on outlining the biological significance of zinc(ii) Schiff base complexes, yet none of them have explored the influence of nuclearity on their properties. This report elaborates the targeted syntheses of two different hemi-salen ligands for their ability to produce Zn(ii)-complexes with different nuclearity. Herein, one dimeric, [ZnL(N)] (1) and one trimeric [ZnL(N)] (2) [HL = (2-(((2-(diethylamino)ethyl)imino)methyl)phenol, HL = 2-(((3-(dimethylamino)-2,2-dimethylpropyl)imino)methyl)-6-methoxyphenol] complexes of hemi-salen ligands have been thoroughly screened for various biological studies including cytotoxic assay, DNA/protein-complex interplay, fluorescence imaging, and antibacterial pathogen tests.