Inter-annual and spatial variations of air-sea CO fluxes and acidification mechanism in the coastal waters of Qingdao, China during 2011-2019.

The interplay of global climate change and anthropogenic activities has significantly affected the carbon cycle in coastal ocean environments. Consequently, further investigation into the carbonate system, carbon source and sink processes, and acidification mechanisms is essential. This study examined the surface carbonate system offshore of Qingdao, utilizing data from nine spring cruises in 2011-2019.

Magneto-optical metasurfaces for high-Q perfect absorption with quasi-bound states in the continuum.

We present a novel, to the best of our knowledge, magneto-optical (MO) metasurface composed of a bismuth iron garnet (BIG) nanocube array, designed to achieve near-perfect absorption through quasi-bound states in the continuum (QBICs). This metasurface supports a stable QBIC mode induced by MO-induced permittivity terms that break the symmetry of the permittivity tensors, corresponding to a longitudinal electric dipole (ED) mode. By integrating graphene to introduce material loss, the absorption reaches 99.

Dual-band high-Q near-perfect absorption by tilted Si-assisted metasurfaces.

All-dielectric metasurface perfect absorbers (MPAs) based on quasibound states in the continuum (QBICs) play a crucial role in optical and photonic devices as they can excite high-Q resonances. These structures require adding back reflectors or placing at least two asymmetric elements in each unit to break the absorption limit of 50%, which will increase the design complexity. In this work, we propose a high-Q monolayer MPA (MMPA) composed of a tilted Si nanocube array.

BECN1 regulates FADD/RIPK1/Caspase-8 complex formation via RIPK1 ubiquitination by downregulating OTUD1 in MI/R induced myocyte apoptosis.

Background: Cardiomyocyte apoptosis plays a vital role in myocardial ischemia-reperfusion (MI/R) injury; however, the role of beclin1 (BECN1) remains unclear. This study aimed at revealing the function of BECN1 during cardiomyocyte apoptosis after MI/R injury.

Methods: In vivo, TTC and Evan's blue double staining was applied to verify the gross morphological alteration in both wild type (WT) mice and BECN1 transgene mice (BECN1-TG), and TUNEL staining and western blot were adopted to evaluate the cardiomyocyte apoptosis.

Achieving bi-anisotropic coupling through uniform temporal modulations without inversion symmetry disruption.

Temporal modulations provide a new approach for realizing metamaterials. In this study, through the imposition of uniform temporal modulations, we achieve two types of reciprocal bi-anisotropic metamaterials. Notably, these achievements do not rely on any spatial modulation, preserving inversion symmetry at any instantaneous time.

Inferior vena cava hemangioma resected using a novel Toumai robotic surgical platform.

This study aims to investigate the significance of using the Toumai robotic platform for the resection of inferior vena cava (IVC) hemangiomas. Our objective is to provide information on the potential benefits of this innovative approach in managing these uncommon vascular tumors and to contribute to the growing body of knowledge in the field of surgical oncology and vascular surgery. A 37-year-old female patient with an incidental finding of a right retroperitoneal mass underwent contrast-enhanced magnetic resonance imaging, which confirmed the diagnosis of an IVC hemangioma.

Broadband frequency translation by space-time interface with weak permittivity temporal change.

Breaking spatial and temporal homogeneities simultaneously incurs the combination of wavenumber and frequency translations. In this work, broadband frequency translations with both redshifts and blueshifts triggered by a single photonic space-time interface (PSTI) with weak temporal change of permittivity across which a homogeneous medium suddenly becomes a one-dimensional photonic crystal is proposed. Mode conversions induced by the PSTI are analyzed, according to which the frequency translation amplitudes are independent of the change of permittivity and the initial frequency but are given by the product of the phase speed of the homogeneous medium and the spatial modulation frequency of the photonic crystal.

Kerker-type positional disorder immune metasurfaces.

Metasurfaces that can operate without a strictly periodic arrangement of meta-atoms are highly desirable for practical optical micro-nano devices. In this paper, we propose two kinds of Kerker-type metasurfaces that exhibit immunity to positional disorder. These metasurfaces consist of two distinct core-shell cylinders that satisfy the first and second Kerker conditions, respectively.

Patterns of antibiotic use, pathogens, and prediction of mortality in hospitalized neonates and young infants with sepsis: A global neonatal sepsis observational cohort study (NeoOBS).

Background: There is limited data on antibiotic treatment in hospitalized neonates in low- and middle-income countries (LMICs). We aimed to describe patterns of antibiotic use, pathogens, and clinical outcomes, and to develop a severity score predicting mortality in neonatal sepsis to inform future clinical trial design.

Methods And Findings: Hospitalized infants <60 days with clinical sepsis were enrolled during 2018 to 2020 by 19 sites in 11 countries (mainly Asia and Africa).

Association of psoriasis with chronic kidney disease and end-stage renal disease: a systematic review and meta-analysis.

Background And Objective: Previous studies have shown that patients with psoriasis are at higher risk of developing chronic kidney disease (CKD) and end-stage renal disease (ESRD) compared with general population; however, data on the differences in the occurrence of CKD and ESRD between patients with psoriasis and non-psoriatic controls are limited and inconsistent. The aim of this study was to carry out a comparison of the probability of suffering CKD and ESRD in patients with or without psoriasis by conducting a meta-analysis of cohort studies.

Methods: Cohort studies on PubMed, Web of Science, Embase and Cochrane Library by March, 2023 were searched for.

Challenges in the Implementation of the NeoOBS Study, a Global Pragmatic Observational Cohort Study, to Investigate the Aetiology and Management of Neonatal Sepsis in the Hospital Setting.

Neonatal sepsis is a significant cause of mortality and morbidity in low- and middle-income countries. To deliver high-quality data studies and inform future trials, it is crucial to understand the challenges encountered when managing global multi-centre research studies and to identify solutions that can feasibly be implemented in these settings. This paper provides an overview of the complexities faced by diverse research teams in different countries and regions, together with actions implemented to achieve pragmatic study management of a large multi-centre observational study of neonatal sepsis.

Therapeutic mechanisms of integrated traditional Chinese and conventional medicine underlying its treatment of precancerous lesions of gastric cancer.

China has a high incidence of gastric cancer. Secondary prevention of gastric cancer is a major public health problem that must be solved urgently. Modern medicine focuses on the pathogenesis of precancerous lesions of gastric cancer (PLGC), and it has been found that there are a variety of abnormal gene expression patterns in PLGC.

A predictive model of macrosomic birth based upon real-world clinical data from pregnant women.

Background: Fetal macrosomia is associated with an increased risk of several maternal and newborn complications. Antenatal predication of fetal macrosomia remains challenging. We aimed to develop a nomogram model for the prediction of macrosomia using real-world clinical data to improve the sensitivity and specificity of macrosomia prediction.

The Association Between Diabetic Retinopathy and the Prevalence of Age-Related Macular Degeneration-The Kailuan Eye Study.

This study aimed to investigate the prevalence of age-related macular degeneration (AMD) in patients with diabetes mellitus (DM) and diabetic retinopathy (DR) and analyze whether DR is a risk factor for AMD. This population-based epidemiological study included 14,440 people from the Kailuan Eye Study in 2016, of whom 1,618 were patients with type 2 DM aged over 50 years, and 409 had DM with DR. We analyzed whether there were differences in the prevalence of AMD between DM with DR and DM without DR, and conducted a hierarchical statistical analysis according to different stages of DR.

Sevoflurane ameliorates LPS-induced inflammatory injury of HK-2 cells through Sirtuin1/NF-κB pathway.

The anesthetic sevoflurane (SEV) has been shown to protect against organ's injury during sepsis. The present study intended to uncover the protective effects of SEV on sepsis-induced acute kidney injury (SI-AKI) and its possible mechanism. Human renal tubular epithelial cell HK-2 was treated with 10 μg/mL lipopolysaccharide (LPS) to construct SI-AKI cell model.

Management of Cervical Spondylotic Radiculopathy: A Systematic review.

Objective: (1) To evaluate the effects of surgery and conservative treatments for cervical spondylotic radiculopathy and (2) provide reference for choosing the time and method of treatment.

Methods: A literature search was performed using PubMed, EMbase, The Cochrane Library, Web of Science, and ClinicalTrials from inception to September 2021. Randomized controlled trials (RCTs) on the use of surgery or conservative Treatments in Cervical Spondylotic Radiculopathy (CSR) were selected.

Management and Prognosis of Interstitial Lung Disease With Lung Cancer (ILD-LC): A Real-World Cohort From Three Medical Centers in China.

Background And Objective: Interstitial lung disease with lung cancer (ILD-LC) is rare and its management has not been fully described. This study aimed to investigate the management and prognosis of ILD-LC patients in China.

Methods: The present analysis is a retrospective real-world cohort study.

[Research progress on chemical constituents, pharmacological action and quality control of Scutellaria barbata].

Scutellaria barbata is a recognized anti-cancer traditional Chinese medicine, with the effects of clearing heat and detoxi-fication, dispelling blood stasis and stopping bleeding, diuresis and detumescence. At present, terpenoids, flavonoids, polysaccharides and volatile oils have been isolated from S. barbata, which have many pharmacological effects, such as resisting tumor, virus, bacteria and oxidation, and immunomodulation.

A bearing fault diagnosis scheme with statistical-enhanced covariance matrix and Riemannian maximum margin flexible convex hull classifier.

To achieve more appropriate fault feature representation for bearing, a statistical-enhanced covariance matrix (SECM) is proposed to extract the global-local features and the interaction of them. Besides, three statistical parameters are introduced to SECM to enhance its statistical characteristics. For fully mining the Riemannian geometric information embedded in SECMs, a Riemannian maximum margin flexible convex hull (RMMFCH) classifier with Log-Euclidean metric (LEM) is designed, where a set of Riemannian kernel mapping functions map SECMs to a higher-dimensional Hilbert space.

Changes in serum inflammatory cytokine levels and intestinal flora in a self-healing dextran sodium sulfate-induced ulcerative colitis murine model.

Aims: Whether dextran sodium sulfate (DSS)-induced ulcerative colitis (UC) animal models undergo self-healing remains unclear. Therefore, the study aim was to determine if these models have self-healing ability.

Main Methods: UC was induced using 4% DSS in male KM mice.

Efficacy of sex hormone-binding globulin on predicting metabolic syndrome in newly diagnosed and untreated patients with polycystic ovary syndrome.

Purpose: The aims of this study were to investigate the correlation of sex hormone-binding globulin (SHBG) and the components of metabolic syndrome (MetS) and explore the ability of SHBG to predict MetS in newly diagnosed and untreated patients with polycystic ovary syndrome (PCOS).

Methods: Ninety-eight newly diagnosed and untreated patients with PCOS and 37 healthy volunteers were recruited. A receiver operating characteristic (ROC) curve was used to explore the best cutoff values of SHBG for predicting that the patients with PCOS would fulfill at least one abnormal index of MetS components, at least two abnormal indexes of MetS components, or MetS.