Design considerations for medicinal cannabis clinical trials in people receiving palliative care.

Context: Evaluating medicinal cannabis in clinical trials is important for informing its efficacy and safety in clinical care. Alongside the inherent practical challenges of conducting clinical trials in people receiving palliative care, operationalising clinical trials with a medicinal cannabis product requires additional consideration of legal, regulatory, ethical, feasibility, pharmacological and product requirements.

Objective: This manuscript aims to explore these considerations when operationalising medicinal cannabis clinical trials in people receiving palliative care.