Synthesis of Nano-Selenium from Polypeptide and Exploring Its Antioxidant and Skin Whitening Ability.

To increase the stability of selenium in nano state and further improve its antioxidant and skin whitening ability, polypeptide (BBPP) was prepared. The optimum synthesis conditions of polypeptide nano-selenium (BBPP-SeNPs) were determined by a double-peak method. BBPP-SeNPs were characterized by transmission electron microscope (TEM), Fourier transform infrared spectroscopy (FT-IR), and particle size analysis (PSS).

The Effectiveness of Digital Animation-Based Multistage Education for Patients With Atrial Fibrillation Catheter Ablation: Randomized Clinical Trial.

Background: Digital education for outpatient patients with atrial fibrillation (AF) has gradually increased. However, research on digital education for patients undergoing atrial fibrillation catheter ablation (AFCA) is limited.

Objective: This study aimed to develop a novel digital animation-based multistage education system and evaluate its quality-of-life benefits for patients with AFCA.

Comorbidity Pattern in Patients with Moderate-to-Severe Plaque Psoriasis: Network Analysis of a Hospitalized Database in China.

Introduction: Psoriasis is a chronic systemic inflammatory disorder characterized by a high prevalence of comorbid conditions, profoundly affecting patient quality of life and complicating treatment strategies. This study aims to analyze demographic characteristics, prevalence, age distribution, and gender differences of psoriatic comorbidities in hospitalized patients with moderate-to-severe psoriasis at a single center. Additionally, we explore the correlation between comorbidities and psoriasis through network analysis.

Elbow Joint Classification for Total Elbow Arthroplasty.

Current elbow prosthesis design and fabrication is not catering for the target population, leading to a prevalent occurrence of prosthesis mismatch in total elbow arthroplasty (TEA) surgeries. To address this challenge, it is crucial to develop an efficient elbow joint classification method that accurately captures specific morphological variations, advancing the design of diverse prostheses for optimal matching. In this paper, we introduce two classification algorithms utilizing shape features extracted from the Riemannian manifold and anatomical features derived from three-dimensional (3D) measurements.

Data-Driven Event-Triggered Sliding Mode Secure Control for Autonomous Vehicles Under Actuator Attacks.

This article investigates a comprehensive data-driven event-triggered secure lateral control of autonomous vehicles under actuator attacks. We consider stabilization issues of autonomous vehicles subject to modeling difficulties, limited communication resources, and actuator attacks. The dynamic model decomposition (DMD) from data is exploited to characterize the inherent lateral dynamics model of autonomous vehicles, the event-triggered transmission scheme is utilized to alleviate communication burden for limited bandwidth network, and the sliding mode control scheme is designed to ensure the security of autonomous vehicles under actuator attacks.

Targeting amino acid metabolism to inhibit gastric cancer progression and promote anti-tumor immunity: a review.

The incidence of gastric cancer remains high and poses a serious threat to human health. Recent comprehensive investigations into amino acid metabolism and immune system components within the tumor microenvironment have elucidated the functional interactions between tumor cells, immune cells, and amino acid metabolism. This study reviews the characteristics of amino acid metabolism in gastric cancer, with a particular focus on the metabolism of methionine, cysteine, glutamic acid, serine, taurine, and other amino acids.

Orbital Apex Syndrome Caused by Herpes Zoster Ophthalmicus Following Nasal Endoscopic Surgery: A Case Report.

Orbital apex syndrome (OAS) is a severe orbital condition caused by impairment of cranial nerves after inflammation or local compression. The report details an uncommon case of OAS caused by herpes zoster ophthalmicus (HZO) following endoscopic sinus surgery. A 52-year-old male exhibited symptoms of OAS in the postoperative phase; however, imaging examination and endoscopic evaluations failed to support that surgical damage and bacterial infection were the cause.

Inhibition of Polo-Like Kinase 1 Dampens the Replication of Vaccinia Virus in Mammalian Cells.

Since the eradication of smallpox, zoonotic poxviruses, such as the mpox virus (MPXV), continue to pose a threat to public health. Identifying drugs that reduce poxvirus infection and replication, as well as understanding their molecular mechanisms, is essential for epidemic control. Polo-like kinase 1 (PLK1) has been shown to facilitate vaccinia virus (VACV) infection and replication.

Selective Electrochemical CO Reduction to Ethylene or Ethanol via Tuning *OH Adsorption.

Selective electrocatalytic reduction of carbon dioxide (CORR) into ethylene (CH) or ethanol (CHOH) is a high challenge. In this study, the rational manipulation of Cu defect sites was realized for the selective formation of CHOH and CH. Low-coordination amorphous and medium-coordination grain-boundary Cu defect sites with different *OH affinity were found to play a decisive role in the selective protonation of CHCHO*.

PMA1-containing extracellular vesicles of triggers immune responses and colitis progression.

() exhibits aberrant changes in patients with colitis, and it has been reported to dominate the colonic mucosal immune response. Here, we found that PMA1 expression was significantly increased in from patients with IBD compared to that in healthy controls. A Crispr-Cas9-based fungal strain editing system was then used to knock out PMA1 expression in .

Decomposition based neural dynamics for portfolio management with tradeoffs of risks and profits under transaction costs.

Real-time online optimisation plays a crucial role in high-frequency trading (HFT) strategies. The Markowitz model, as a Nobel Prize-winning framework, is widely used for portfolio management optimisation by framing the problem as a constrained quadratic programming task. While conventional analytical methods are typically effective for solving quadratic programming problems with linear constraints, the introduction of both linear equality and inequality constraints in the Markowitz model necessitates the use of numerical methods.

The iPhylo suite: an interactive platform for building and annotating biological and chemical taxonomic trees.

Accurate and rapid taxonomic classifications are essential for systematically exploring organisms and metabolites in diverse environments. Many tools have been developed for biological taxonomic trees, but limitations apply, and a streamlined method for constructing chemical taxonomic trees is notably absent. We present the iPhylo suite (https://www.

Modified Vaccinia Virus Ankara Selectively Targets Human Cancer Cells With Low Expression of the Zinc-Finger Antiviral Protein.

Oncolytic viruses are emerging as promising cancer therapeutic agents, with several poxviruses, including vaccinia virus (VACV) and myxoma virus, showing significant potential in preclinical and clinical trials. Modified vaccinia virus Ankara (MVA), a laboratory-derived VACV strain approved by the FDA for mpox and smallpox vaccination, has been shown to be incapable of replicating in human cells unless zinc finger antiviral protein (ZAP) is repressed. Notably, ZAP deficiency is prevalent in various cancer types.

Hydrological transport and endosperm weakening mechanisms during dormancy release in Tilia henryana seeds.

Seed germination is a pivotal stage in the plant life cycle, with endosperm weakening and radicle elongation serving as crucial prerequisites for successful endospermic seed germination. Tilia henryana seeds exhibit deep dormancy, necessitating a period of 2-3 years to germinate in a natural environment, and the germination rate is extremely low. This study employed morphological and physiological approaches to dynamically analyzing the hydrological mechanism and the endosperm weakening process during the dormancy release of T.

MugenNet: A Novel Combined Convolution Neural Network and Transformer Network with Application in Colonic Polyp Image Segmentation.

Accurate polyp image segmentation is of great significance, because it can help in the detection of polyps. Convolutional neural network (CNN) is a common automatic segmentation method, but its main disadvantage is the long training time. Transformer is another method that can be adapted to the automatic segmentation method by employing a self-attention mechanism, which essentially assigns different importance weights to each piece of information, thus achieving high computational efficiency during segmentation.

Genomic insights into demographic history, structural variation landscape, and complex traits from 514 Hu sheep genomes.

Hu sheep is an indigenous breed from the Taihu Lake Plain in China, known for its high fertility. Although Hu sheep belong to the Mongolian group, their demographic history and genetic architecture remain inconclusive. Here, we analyze 697 sheep genomes from representatives of Mongolian sheep breeds.

Zwitterionic Polymer Lipid Nanoparticles Enabling Selective Organ Targeting Delivery of Small Interfering RNA for the Treatment of Hepatic and Pulmonary Inflammation.

Lipid nanoparticles (LNPs) are clinically advanced small interfering RNA (siRNA) carriers, which can prevent the breakdown of siRNA during delivery and deliver siRNA into the cytoplasm to down-regulate the target gene. However, clinical LNPs are limited to the liver, and enhancing extrahepatic targeting is vital to expand the application of LNPs in vivo. Here, zwitterionic polymer LNPs (ZP-LNPs) are assembled with the zwitterionic polymer polycarboxybetaine (PCB) modified 1,2-dimyristoylglycerol (DMG) lipid DMG-PCB can selectively deliver siRNA to liver and lung, respectively.

Isolation and Identification of Lumpy Skin Disease Virus.

Lumpy skin disease virus (LSDV), a member of the capripoxvirus genus, induces lumpy skin disease (LSD) in cattle and buffalo populations. The initial documentation of LSD dates back to 1929 in Zambia, with subsequent rapid dissemination within the cattle community in Africa and Asia. Described as the "smallpox" equivalent in cattle, LSD manifests through clinical features such as fever, extensive cutaneous nodules, body wasting, lymph node enlargement, and skin edema.

Nicotine-Induced Transient Activation of Monocytes Facilitates Immunosuppressive Macrophage Polarization that Restrains T Helper 17 Cell Expansion.

Macrophages in smoking environment exhibit a distinct immunosuppressive phenotype, but the mechanisms that allow nicotine to "educate" macrophages are incompletely understood. Here, we identified that nicotine transiently activates and subsequently deactivates monocytes, leading to reduced anti-infective capability of macrophages. This deactivation results in a suppression of IL-17-producing cell expansion through decreased IL-1β production.

Design of optimal concentrations for in vitro cytotoxicity experiments.

Concentration-dependent cytotoxicity experiments are frequently used in toxicology. Although it has been reported that an adequate choice of concentrations improves the quality of the statistical inference substantially, a recent literature review of three major toxicological journals has shown that the corresponding methods are rarely used in toxicological practice. In this study the performance of different sets of concentrations, also called designs, are analyzed, while the overall goal is to promote the advantages of optimal design procedures and to present a user-friendly guideline for planning new cytotoxicity concentration-response experiments.

Host species-specific activity of the poxvirus PKR inhibitors E3 and K3 mediate host range function.

The antiviral protein kinase R (PKR) is activated by viral double-stranded RNA and phosphorylates translation initiation factor eIF2α, thereby inhibiting translation and virus replication. Most poxviruses contain two PKR inhibitors, called E3 and K3 in vaccinia virus (VACV), which are determinants of viral host range. The prevailing model for E3 function is that it inhibits PKR through the non-specific sequestration of double-stranded (ds) RNA.

Early Effects of the ESRD Treatment Choices Model on Kidney Transplant Waitlist Additions.

Key Points: The ESRD Treatment Choices model did not lead to an increase in kidney transplant waitlisting. The COVID-19 pandemic had a substantial impact on kidney transplant waitlist additions. Financial incentives alone, in the short term, did not lead to a substantial effect on kidney transplant waitlisting practices.

Input-to-state stabilization of discrete-time delayed fuzzy systems via aperiodically intermittent control.

This paper studies input-to-state stabilization of delayed discrete-time Takagi-Sugeno (T-S) fuzzy systems via aperiodically intermittent control. We first consider aperiodically intermittent time-triggered control, where we present sufficient conditions via the mathematical induction under the hypotheses of the quasiperiodicity condition. Based on the derived sufficient conditions, we apply a Lyapunov-Krasovskii (L-K) method together with the descriptor method to derive the explicit linear matrix inequalities (LMIs) that ensure the exponential stability and input-to-state stability (ISS), and show the existence of the aperiodically intermittent time-triggered controller that leads to efficient results with much less numerical complexity.

User comfort and naturalness of automated driving: The effect of vehicle kinematic and proxemic factors on subjective response.

User comfort in higher-level Automated Vehicles (AVs, SAE Level 4+) is crucial for public acceptance. AV driving styles, characterised by vehicle kinematic and proxemic factors, affect user comfort, with "human-like" driving styles expected to provide natural feelings. We investigated a) how the kinematic and proxemic factors of an AV's driving style affect users' evaluation of comfort and naturalness, and b) how the similarities between automated and users' manual driving styles affect user evaluation.

Stealthy Measurement-Aided Pole-Dynamics Attacks With Nominal Models.

When traditional pole-dynamics attacks (TPDAs) are implemented with nominal models, model mismatch between exact and nominal models often affects their stealthiness, or even makes the stealthiness lost. To solve this problem, this article presents a novel stealthy measurement-aided pole-dynamics attacks (MAPDAs) method with model mismatch. First, the limitations of TPDAs using exact models are revealed.