Functionalization of Graphene by Interfacial Engineering in Thermally Conductive Nanofibrillated Cellulose Films.

Flexible nanocomposites incorporating nanofibrillated cellulose (NFC) hold significant promise for thermal management applications. However, their heat dissipation performance is primarily constrained by the interfacial thermal resistance (). In this work, 1-pyrenemethylamine hydrochloride (PyNH) noncovalent functionalized graphene subsequently self-assembled with NFC through a vacuum-assisted filtration technique.

Itaconate transporter SLC13A3 confers immunotherapy resistance via alkylation-mediated stabilization of PD-L1.

Itaconate is a metabolite catalyzed by cis-aconitate decarboxylase (ACOD1), which is mainly produced by activated macrophages and secreted into the extracellular environment to exert complex bioactivity. In the tumor microenvironment, itaconate is concentrated and induces an immunosuppressive response. However, whether itaconate can be taken up by tumor cells and its mechanism of action remain largely unclear.

Data on hydrodynamic flow and aspiration mechanisms in a patient-specific pharyngolaryngeal model with variable epiglottis angles.

This dataset comprises a comprehensive collection of videos and images illustrating the fluid dynamics of swallowing and aspiration in a patient-specific pharyngolaryngeal model with varying epiglottis angles. The data also includes the physical properties of the fluids used, comprising dynamic viscosity, surface tension, and contact angle. Videos under varying swallowing conditions were collected to investigate the mechanisms underlying aspiration.

Efficacy of wearable transcutaneous electrical acupoint stimulation bracelet on moderate-to-severe postoperative nausea and vomiting in patients after general anesthesia: a study protocol for a multicenter randomized controlled trial.

Background: Postoperative nausea and vomiting (PONV) is the most common complication following general anesthesia. Currently, pharmaceutical therapy is the primary method of treatment, but it has reached a plateau, and it is accompanied by inherent adverse reactions and high costs. Stimulation of the wrist acupuncture point PC6 is recommended as an effective means of preventing PONV.

A review of ethical considerations for the medical applications of brain-computer interfaces.

The development and potential applications of brain-computer interfaces (BCIs) are directly related to the human brain and may have adverse effects on the users' physical and mental health. Ethical issues, particularly those associated with BCIs, including both non-medical and medical applications, have captured societal attention. This article initially reviews the application of three ethical frameworks in BCI technology: consequentialism, deontology, and virtue ethics.

Risk of nasal septal perforation following nasal packing for epistaxis in the emergency department.

Introduction: Nasal packing is commonly employed in the emergency department (ED) to manage epistaxis that does not respond to conservative treatments. However, this intervention may increase the risk of nasal septal perforation (NSP) due to reduced blood flow to the nasal septum. No prior study has explored the relationship between nasal packing and risk of NSP.

Real Effect or Bias? Good Practices for Evaluating the Robustness of Evidence From Comparative Observational Studies Through Quantitative Sensitivity Analysis for Unmeasured Confounding.

The assumption of "no unmeasured confounders" is a critical but unverifiable assumption required for causal inference yet quantitative sensitivity analyses to assess robustness of real-world evidence remains under-utilized. The lack of use is likely in part due to complexity of implementation and often specific and restrictive data requirements for application of each method. With the advent of methods that are broadly applicable in that they do not require identification of a specific unmeasured confounder-along with publicly available code for implementation-roadblocks toward broader use of sensitivity analyses are decreasing.

The application of neuroprosthesis in restoration of unilateral facial nerve paralysis: A scoping review.

Facial nerve palsy can pose functional, psychosocial, and cosmetic issues for patients. Although various surgical techniques can improve facial functions and appearance for patients who do not fully recover following conservative management, they can be extensively invasive with limited restoration of facial movement and symmetry. Functional electrical stimulation (FES) is a technology that has been developed to stimulate paralyzed nerves or muscles and has 2 different applications in facial nerve palsy treatment: facial rehabilitation and neuroprosthesis.

The effects of PstR, a PadR family transcriptional regulatory factor, in Plesiomonas shigelloides are revealed by transcriptomics.

Background: Plesiomonas shigelloides is a gram-negative opportunistic pathogen associated with gastrointestinal and extraintestinal diseases in humans. There have been reports of specific functional genes in the study of P. shigelloides, but there are also many unknown genes that may play a role in P.

Super Astragalus polysaccharide in specific gut microbiota metabolism alleviates chronic unpredictable mild stress-induced cognitive deficits mice.

Chronic stress affects intestinal microbiota. Astragaloside IV (AS), called super Astragalus polysaccharide, is a monomer component of traditional herbs Astragalus membranaceus which belongs to medicinal food homology (MFH), exerts a neuroprotection effect, but the underlying mechanism has not yet been elucidated. Intestinal flora is also involved in the biotransformation of the active ingredients of MFH species, thus affecting their physiological and pharmacological properties.

Case Report: PROS1 (c.76+2_76+3del) pathogenic mutation causes pulmonary embolism.

Background: Genetic variation plays an extremely important pathogenic role in the development of venous thromboembolism (VTE). Genetic protein S (PS) deficiency caused by PROS1 gene mutation is an important risk factor for hereditary thrombophilia.

Case Introduction: In this case, we report a 28-year-old male patient who developed a severe pulmonary embolism during his visit.

Fabrication and Properties of Hydrogel Dressings Based on Genipin Crosslinked Chondroitin Sulfate and Chitosan.

Multifunctional hydrogel dressings remain highly sought after for the promotion of skin wound regeneration. In the present study, multifunctional CHS-DA/HACC (CH) hydrogels with an interpenetrated network were constructed using hydroxypropyl trimethyl ammonium chloride modified chitosan (HACC) and dopamine-modified chondroitin sulfate (CHS-DA), using genipin as crosslinker. The synthesis of HACC and CHS-DA was effectively confirmed using Fourier transform infrared (FT-IR) analysis and H nuclear magnetic resonance (H NMR) spectroscopy.

Association between salivary microbiota and tacrolimus pharmacokinetic variability in kidney transplant.

Kidney transplantation (KT) serves as a highly effective treatment for end-stage renal disease (ESRD). Nonetheless, the administration of tacrolimus, a commonly used immunosuppressant in KT, faces challenges due to the lack of dependable biomarkers for its efficacy and the considerable variability in tacrolimus pharmacokinetics (TacIPV). In this study, 183 saliva samples from 48 KT recipients under tacrolimus therapy, alongside 9 healthy control samples, were subjected to 16S rRNA sequencing.

Bioinformatics analysis of immune infiltration in human diabetic retinopathy and identification of immune-related hub genes and their ceRNA networks.

Diabetic retinopathy (DR) is the most common microvascular complication in diabetic patients, and recent studies have shown that immune regulatory mechanisms are closely associated with retinal damage in DR. Therefore, this study focused on exploring immune cells and immune-related genes (IRGs) in DR and gaining insight into the ceRNA mechanisms by which IRGs regulate DR progression. Four datasets from human DR model retinal tissues were obtained from the Gene Expression Omnibus (GEO) database.

Application of antithrombotic drugs and risk factor analysis in ICU patients with lower gastrointestinal bleeding from MIMIC-IV.

Objective: This study aims to assess the effects of antithrombotic therapy on the outcomes of lower gastrointestinal bleeding (LGIB) in ICU patients, focusing on in-hospital mortality, rebleeding, and length of hospital and ICU stays.

Method: This retrospective observational study utilized the MIMIC-IV 2.2 database, which includes 513 ICU patients with LGIB.