570 nm/770 nm light-excited deep-red fluorescence switch based on dithienylethene derived from BF-curcuminoid.

Developing dithienylethene (DTE)-based fluorescence switches triggered by biocompatible visible light has always been a long-term goal in view of their potential in numerous biological scenarios. However, their practical availability is severely limited by the short visible light (generally less than 500 nm) required for photocyclization, their inability to achieve red or near-infrared emission, and their short fluorescence lifetimes. Herein, we present a novel DTE derivative featuring a dimethylamine-functionalized BF-curcuminoid moiety (NBDC) by using an "acceptor synergistic conjugation system" strategy.

Deduced Conservation Strategy of the Macaques in China from their Evolutionary Development.

Understanding how climate, ecological and environmental changes, and anthropogenic activities have driven animals' development and predicting their prospective distribution profiles are essential to making a tangible conservation strategy. Macaques () distributed in China provide an ideal research model for such an effort. We reconstruct their geographic distribution profiles from the last inter-glaciation (LIG, 120,000-140,000 years BP), the Last Glacial Maximum (LGM, 22,000 years BP), and the present (1970-2000), based on which we deduce their distribution perspective in the 2050s.

Aerobic Ammoxidation of Cyclic Ketones to Dinitrile Products with Copper-Based Catalysts.

Adiponitrile (ADN) has wide applications, especially in the polymer industry. With the substantial and increasing global demand for ADN, effective production of ADN using safe and abundant starting materials is highly desirable but very challenging. Herein, we discovered that CuBr, combined with 1,10-phenanthroline (phen), could effectively promote the ammoxidation reaction of cyclohexanone to ADN with a yield of >99% using aqueous ammonia as the nitrogen source and O as the terminal oxidant under mild reaction conditions (80 °C, 5 atm O).

Microbiome-proteome analysis of gastrointestinal microbiota and longissimus thoracis muscle proteins in cattle with high and low grades of marbling.

Marbling is a key indicator of the meat quality of ruminants. Gastrointestinal microbiota may regulate the formation of marbling by influencing the nutritional metabolism of animals. This study analyzed the composition and functional differences of microbiota in the rumen and cecum, the differences in volatile fatty acids (VFAs) content in the longissimus thoracis muscle, and the differences in protein abundance in the longissimus thoracis muscle of ruminants with different marbling grades through microbiome-proteome analysis.

Identification of BRCA new prognostic targets and neoantigen candidates from fusion genes.

Cancer-associated gene fusions serve as a potential source of highly immunogenic neoantigens. In this study, we identified fusion proteins from fusion genes and extracted fusion peptides to accurately predict Breast cancer (BRCA) neo-antigen candidates by high-throughput artificial intelligence computation. Firstly, Deepsurv was used to evaluate the prognosis of patients, providing a landscape of prognostic fusion genes in BRCA.

Morphometric Study on the Mandible of Colobine Fossil (Mesopithecus pentelicus) Found in East Asia, a Comparison With Extant Taxa.

A tooth-bearing mandible fossil of a colobine monkey discovered at Shuitangba, Zhaotong, Yunnan, China, was morphometrically analyzed and compared with extant Asian colobines. Our previous qualitative and quantitative descriptions indicate that it can be safely attributed to Mesopithecus pentelicus, a Miocene fossil colobine widely found in Europe and South Asia. The present research aims to explore fossil association with extant colobines and functionally propose its dietary preferences based on multivariate morphometric analyses of mandibular morphology.

Cholesterol: The driving force behind the remodeling of tumor microenvironment in colorectal cancer.

Essential membrane components and metabolites with a wide range of biological roles are both produced by cholesterol metabolism. Cell-intrinsic and cell-extrinsic stimuli alter cholesterol metabolism in the tumor microenvironment (TME), which in turn encourages colorectal carcinogenesis. Metabolites produced from cholesterol play intricate roles in promoting the development of colorectal cancer (CRC) and stifling immunological responses.

Association of different inflammatory indices with risk of early natural menopause: a cross-sectional analysis of the NHANES 2013-2018.

Background: Early natural menopause, characterized by the cessation of ovarian function before the age of 45, has been a subject of prior research indicating that inflammation may predict the onset of menopause. However, the specific relationship between peripheral blood inflammatory parameters and early natural menopause remains ambiguous.

Methods: This observational study utilized data from the National Health and Nutrition Examination Survey (NHANES) spanning the years 2013-2018.

Step forward: Implementation and evaluation of STEPS program to optimize postpartum hemorrhage management in vaginal deliveries.

Background: Postpartum hemorrhage (PPH) is a leading cause of maternal mortality worldwide, particularly in resource-limited settings. Enhancing maternal safety in relation to PPH requires optimizing care protocols, continuous monitoring, and timely interventions. However, integrating these methodologies into vaginal delivery practices remains underexplored.

Health and economic evaluation of herbal medicines for heart failure: A population-based cohort study.

Background: Heart failure (HF) represents an advanced stage of various cardiovascular disorders, with its elevated admission rates and resultant health economic burden posing an ongoing global concern.

Purpose: To evaluate the health and economic benefits of herbal medicine (HM) for patients with HF.

Study Design: Population-based cohort study.

FHL1 Inhibition by Mir-1301-3p Promotes Uterine Corpus Endometrial Carcinoma Cell Proliferation and Migration: A Prognostic Insight.

Background: The impact of microRNA-1301-3p (miR-1301-3p) on various cancer subtypes is noteworthy. However, its specific role within the framework of uterine corpus endometrial carcinoma (UCEC) is yet to be clearly defined.

Objective: The objective of this research was to investigate and clarify the function of miR-1301-3p in relation to UCEC.

Role of COX6C and NDUFB3 in septic shock and stroke.

Background: Septic shock is a clinical syndrome characterized by acute circulatory disturbance. Stroke is an acute cerebrovascular disease caused by brain tissue damage. However, the relationship of COX6C and NDUFB3 to them is unclear.

Identification of PANoptosis-Related Genes in Community-Acquired Pneumonia Diagnosis.

Background: This study aimed to identify and characterize novel PANoptosis biomarkers for community-acquired pneumonia (CAP) diagnosis.

Methods: Transcriptomic data from training set GSE196399 and validation sets GSE94916 and GSE202947 were utilized. A PANoptosis gene set was identified by intersecting DEGs linked to CAP, WGCNA hub genes, and PANoptosis-related genes.

Alzheimer's disease-like pathology induced by in middle-aged mice is mediated by NLRP3 inflammasome via the microbiota-gut-brain axis.

Background: () has been found to enter the brain and induce inflammation, contributing to Alzheimer's disease (AD). is also closely linked to gut dysbiosis. However, does induce AD-like pathology through the microbiota-gut-brain axis? There is limited literature on this topic.

Crohn's disease after multiple doses of rituximab treatment in a child with refractory nephrotic syndrome and an mutation: a case report.

inflammatory bowel disease (IBD) in response to rituximab (RTX) has been documented on multiple occasions as a severe adverse effect. However, none of these reports mentioned any genetic variation associated with this complication. We describe the case of a 16-year-old patient with refractory nephrotic syndrome (NS) diagnosed at the age of 6 years, notably with a heterozygous mutation of the gene, who developed Crohn's disease (CD) following ten administrations of RTX.

Influencing factors on nutritional knowledge, attitudes, and practices among nursing assistants in nursing homes.

Background: The nutritional status of older adults requires focused attention. In Chinese nursing homes, nursing assistants are often the primary caregivers responsible for the daily care of older adults, and their knowledge and attitudes toward nutrition play a fundamental role in providing adequate nutritional care. However, research on the knowledge and attitudes of nursing assistants is limited, despite the fact that these factors play a fundamental role in providing adequate nutritional practices.

Enhanced Gelation Properties and Saltiness Perception of Low-Salt Surimi Gel with Psyllium Husk Powder.

Reducing salt intake is an effective strategy for preventing and managing hypertension and cardiovascular diseases. In this study, psyllium husk powder (PHP) was incorporated into surimi to address the challenges of diminished saltiness and texture in low-salt surimi products. PHP promoted the conversion of α-helix structures into β-sheet and strengthening intermolecular interactions, such as ionic bonds, hydrogen bonds, hydrophobic interactions, and disulfide bonds.

Physiological characteristics during the formation of aromatic components in xylem of induced by exogenous substances.

An inductive combination of plant growth regulators, inorganic salts, and fungi is essential for the formation of aromatic components in the xylem of . However, the dynamics of xylem physiology and the relationships between physiological properties and aromatic components after artificial induction remain unclear. In this study, the changes in physiological properties of .

Effect of corneal cross-linking on biomechanical properties of swollen rabbit corneas.

Corneal cross-linking (CXL) is an effective method to prevent the progression of keratoconus. CXL combined with hypotonic riboflavin solution is a modified treatment for thin corneas, which are deemed to be below the safe thickness threshold. In this study, rabbit corneas were subjected to different hydration levels using different osmolarity of riboflavin dextran solutions before CXL.

The diagnosis and treatment progress of infectious endophthalmitis.

Endophthalmitis is a blinding disease that may lead to permanent vision loss. The diagnosis of endophthalmitis relies on clinical findings. It is crucial to identify causative microorganisms in time for subsequent treatment and saving vision.

Prognostic role of tumor-infiltrating lymphocytes in gastric cancer: A systematic review and meta-analysis.

Background: To analyze the relationship between tumor-infiltrating lymphocytes (TILs) subtypes and infiltration locations and the prognosis of gastric cancer (GC) patients.

Methods: Eligible articles were obtained through systematic retrieval and rigorous screening, collecting study information and extracting hazard ratio (HR), 95 % confidence interval (CI) for pooled analyses of disease-free survival (DFS) and overall survival (OS).

Results: Higher CD4 TILs were correlated with favorable OS (HR=0.

Hydrogel Fibers-Based Biointerfacing.

The unique 1D structure of fibers offers intriguing attributes, including a high length-to-diameter ratio, miniatured size, light-weight, and flexibility, making them suitable for various biomedical applications, such as health monitoring, disease treatment, and minimally invasive surgeries. However, traditional fiber devices, typically composed of rigid, dry, and non-living materials, are intrinsically different from the soft, wet, and living essence of biological tissues, thereby posing grand challenges for long-term, reliable, and seamless interfacing with biological systems. Hydrogel fibers have recently emerged as a promising candidate, in light of their similarity to biological tissues in mechanical, chemical and biological aspects, as well as distinct fiber geometry.

Witnessing Quantum Incompatibility Structures in High-Dimensional Multimeasurement Systems.

Quantum incompatibility, referred as the phenomenon that some quantum measurements cannot be performed simultaneously, is necessary for various quantum information processing tasks, such as nonlocality and steering. When these applications come to high-dimensional multimeasurement scenarios, it is crucial and challenging to witness the incompatibility of measurements with complex structures. To address this problem, we propose a modified quantum state discrimination protocol that decomposes complex compatibility structures into pairwise ones and employs noise robustness to bound incompatibility structures.