P-N bond hydrolysis assisted formation of a pseudo-trigonal antiprismatic Co(II) complex with strong easy-axis anisotropy : A magneto-structural and theoretical study.

The reaction of a hydrated cobalt(II) perchlorate salt with the rigid tripodal ligand, tris(3,5-dimethylpyrazolyl) phosphine oxide, (O)P(3,5-DMPz)3, results in selective in situ hydrolysis of a P‒N bond affording a neutral mononuclear Co(II) complex, [Co{(O)P(O)(3,5-DMP)2}2] (1Co(II)). The X-ray crystal structure of 1Co(II) shows that it is formed by the coordination of two N2O-tripodal (O)P(O)(3,5-DMPz)2 ligands, leading to a CoIIN4O2 coordination sphere with an elongated pseudo-trigonal antiprismatic geometry. The analysis of the dc magnetic data revealed that this compound shows a strong easy-axis magnetic anisotropy with D = ‒45.

Choroid and Retinal Pigmented Epithelium in Pigs: A Comprehensive Light and Ultrastructural Study.

This study was conducted on 12 adult pigs of a local mixed breed to examine the histology, histochemistry and ultrastructure of the choroid and retinal pigmented epithelium (RPE). The tissues were fixed in Davidson's Fluid for light microscopy and Karnovsky's fluid for electron microscopy. Due to the physiological, anatomical and metabolic similarities between pigs and humans, pigs are a suitable animal model for various ophthalmic studies.

Atomic scale determination of magnetism and stoichiometry at the LaSrMnO/SrTiO interface: investigation of inverse hysteresis.

Controlling the correlations and electronic reconstruction at the interface of transition metal oxide heterostructures provides a new pathway for tuning their unique physical properties. Here, we investigate the effects of interfacial nonstoichiometry and vertical phase separation on the magnetic properties and proximity-induced magnetism of epitaxial LaSrMnO (LSMO)/SrTiO(001) oxide heterostructures. We also reinvestigate the recently observed inverse hysteresis behavior reported for this system, which we find emanates from the remanent field of the superconducting solenoid and not from antiferromagnetic intra-layer exchange coupling in low coercivity LSMO thin films.

Structural, microstructural, dielectric, mechanical properties of PVDF/HAP nanocomposite films for bone regeneration applications.

Poly(vinylidene fluoride) (PVDF)/hydroxyapatite (HAP) nanocomposite films, incorporating HAP nanoparticles as filler within a PVDF matrix, were successfully synthesized by solution casting method. Increasing the HAP concentration in the nanocomposite significantly enhances its electroactive properties, with synergistic effects on surface, electrical and biological characteristics are investigated comprehensively. Improvements in topographical and mechanical parameters reveal the nanocomposite films for biomimetic suitability.

Time-course RNA-seq analysis of upland cotton (Gossypium hirsutum L.) responses to Southern root-knot nematode (Meloidogyne incognita) during compatible and incompatible interactions.

Background: The Southern root-knot nematode (Meloidogyne incognita) poses a substantial threat to cotton (Gossypium hirsutum L.) by causing significant agricultural losses. Host plant resistance is the most plausible approach for minimizing these losses.

Exceptional Seizure-Like Presentation of Torsades De Pointes.

We present a rare case of a 40-year-old male who experienced a seizure-like episode, later diagnosed as torsades de pointes (TDP), following an R-on-T phenomenon feature on ECG. This case underscores the importance of considering cardiac arrhythmias in the differential diagnosis of atypical seizure presentations. The patient underwent successful treatment with antiarrhythmics and coronary stenting for underlying coronary artery stenosis, emphasizing a comprehensive approach to managing such complex cases.

Design, synthesis, and biological evaluation of quinazolinone-dihydropyrimidinone as a potential anti-diabetic agent via GLUT4 translocation stimulation.

A library of 30 novel quinazolinone-dihydropyrimidinone derivatives was synthesized employing a diversity-oriented approach for the identification of potential anti-diabetic therapeutic lead. In vitro evaluation revealed that seven compounds (5d, 5e, 5i, 5j, 5l, 5m and 5s) significantly enhanced the rate of GLUT4 translocation to the cell surface in L6-GLUT4myc myotubes. Out of these, compound, 5m exhibited promising potency to stimulate GLUT4 translocation in skeletal muscle cells via activating AMPK-dependent pathway, but independent to PI-3-K/AKT signaling.

A Study of Body Composition in Children Suffering From Infantile Vitamin B12 Deficiency.

Background: Infantile tremor syndrome (ITS), or neurocutaneous infantile vitamin B12 deficiency syndrome (NIBS), is characterised by tremors, developmental delay, anaemia and skin hyperpigmentation. This study aimed to assess the body composition and serum lipids in children with ITS.

Methods: Children under 2 years of age with a clinical diagnosis of ITS were enrolled.

Factors influencing -pharmacy adoption in India: A study of user experiences through interpretative phenomenological analysis.

The rapid growth of e-commerce has led to the emergence of e-pharmacies, which enable consumers to purchase prescription medications online. This study aims to explore the factors influencing the adoption of e-pharmacies in India through an interpretative phenomenological analysis (IPA) approach. Twelve in-depth interviews were conducted with individuals who had experience ordering prescription medicines through e-pharmacies.

Screening of Coulombic Interactions To Achieve a Higher Power Factor in Conjugated Polymers.

Thermoelectric properties of conducting polymers typically suffer from molecular chain disordering, as charge transport is predominantly controlled by morphology. This is especially more problematic when counterions are introduced to tune the carrier concentration for optimal thermoelectric performance, which disturbs the morphology further. In this work, we introduce a new avenue for enhancing thermoelectric properties without needing to regulate the morphology, namely, by controlling the coulombic interaction between polarons and counterions.

Microplastics influencing aquatic environment and human health: A review of source, determination, distribution, removal, degradation, management strategy and future perspective.

Microplastics (MPs) are produced from various primary and secondary sources and pose multifaceted environmental problems. They are of non-biodegradable nature and may stay in aquatic environments for a long time period. The present review has covered novel aspects pertaining to MPs that were not covered in earlier studies.

Expression of concern: Photo-induced reduction of CO using a magnetically separable Ru-CoPc@TiO@SiO@FeO catalyst under visible light irradiation.

Expression of Concern for 'Photo-induced reduction of CO using a magnetically separable Ru-CoPc@TiO@SiO@FeO catalyst under visible light irradiation' by Pawan Kumar , ., 2015, , 4546-4553, https://doi.org/10.

Deciphering the endomicrobiome of Podophyllum hexandrum to reveal the endophytic bacterial-association of in-planta podophyllotoxin biosynthesis.

Understanding the change in plant-associated microbial diversity and secondary metabolite biosynthesis in medicinal plants due to their cultivation in non-natural habitat (NNH) is important to maintain their therapeutic importance. Here, the bacterial endomicrobiome of Podophyllum hexandrum plants of natural habitat (NH; Kardang and Triloknath locations) and NNH (Palampur location) was identified and its association with the biosynthesis of podophyllotoxin (PTOX) was revealed. Rhizomes (source of PTOX) of plants of NH had highest endophytic bacterial diversity compared to NNH-plants.

Silica Nanoparticles: A Promising Vehicle for Anti-Cancer Drugs Delivery.

The prevalence and death due to cancer have been rising over the past few decades, and eliminating tumour cells without sacrificing healthy cells remains a difficult task. Due to the low specificity and solubility of drug molecules, patients often require high dosages to achieve the desired therapeutic effects. Silica nanoparticles (SiNPs) can effectively deliver therapeutic agents to targeted sites in the body, addressing these challenges.

Elucidating the binding specificity of interactive compounds targeting ATP-binding cassette subfamily G member 2 (ABCG2).

The ATP-binding cassette transporter superfamily plays a pivotal role in cellular detoxification and drug efflux. ATP-binding cassette subfamily G member 2 (ABCG2) referred to as the Breast cancer resistance protein has emerged as a key member involved in multidrug resistance displayed by cancer cells. Understanding the molecular basis of substrate and inhibitor recognition, and binding within the transmembrane domain of ABCG2 is crucial for the development of effective therapeutic strategies.

A Cross-Sectional Study on the Presence of Mamelons in Northeastern India.

Introduction Dental anthropology plays a pivotal role in human evolution and forensic sciences. This study explores a unique method for age estimation-analyzing mamelons on incisors. Mamelons are small projections on the incisal edge of permanent incisors, exhibiting age-related changes.

Hydroxyethylamine based analog targets microtubule assembly: an in silico study for anti-cancerous drug development.

Microtubules are dynamic cytoskeletal structures essential for cell architecture, cellular transport, cell motility, and cell division. Due to their dynamic nature, known as dynamic instability, microtubules can spontaneously switch between phases of growth and shortening. Disruptions in microtubule functions have been implicated in several diseases, including cancer, neurodegenerative disorders such as Alzheimer's and Parkinson's disease, and birth defects.

Adsorption-Enhanced Sensitivity for Electrochemical Sensing of Diclofenac by Poly(ether sulfone)-Based Laser-Induced Graphene.

Emerging contaminants are a matter of growing concern for environmental and human health and safety, requiring efficient and affordable sensing platforms. Laser-induced graphene (LIG) is a novel material with a 3D porous graphene structure that can be fabricated in a simple one-step fabrication process. However, most LIG-based works in electrochemical sensors are limited to polyimide (PI)-based platforms, thus limiting the purview of properties of LIG dependent on the substrate-laser interaction.

Bilateral Traumatic Rupture of the Quadriceps Tendon - A Case Report.

Introduction: Quadriceps tendon rupture is a traumatic injury where the quadriceps detaches from the patella, disrupting the knee's extensor mechanism. Bilateral ruptures, first documented in 1949, are rare, with an incidence of 0.17-2.

Development of a minimum data set for long COVID: a Delphi study protocol.

Introduction: Previous consensus-based long COVID research has focused on establishing research priorities, developing clinical definitions, core outcomes and a list of recommendations of patient-reported outcome measures that can be used to assess and characterise long COVID. Complementing and extending this work, the proposed study will bring together diverse knowledge users to prioritise concepts of care, quality of life and symptoms to inform a national patient registry on long COVID.

Methods And Analysis: We will conduct a Delphi process involving Canadians with lived experiences and/or professional expertise with long COVID (including clinicians, policymakers, caregivers and community leaders).

Pancreatic Leiomyosarcoma With Multi-organ Metastases: A Rare Case.

This case report describes the diagnosis, treatment, and progression of a 50-year-old male patient diagnosed with stage IV pancreatic leiomyosarcoma with metastases to the liver, lungs, and brain, representing the only case involving both the pancreas and brain documented in the hospital registry with a histopathological diagnosis of leiomyosarcoma. The patient initially presented with chronic abdominal pain, constipation, and weight loss, and subsequent CT scans revealed a large pancreatic mass with metastases to the liver, lungs, and brain. A biopsy confirmed the diagnosis of leiomyosarcoma, and the patient underwent eight cycles of palliative chemotherapy with cisplatin and docetaxel, along with palliative radiotherapy targeting the brain metastases.