Publications by authors named "Paulin"

The relative accessibility and simplicity of vestibular sensing and vestibular-driven control of head and eye movements has made the vestibular system an attractive subject to experimenters and theoreticians interested in developing realistic quantitative models of how brains gather and interpret sense data and use it to guide behavior. Head stabilization and eye counter-rotation driven by vestibular sensory input in response to rotational perturbations represent natural, ecologically important behaviors that can be reproduced in the laboratory and analyzed using relatively simple mathematical models. Models drawn from dynamical systems and control theory have previously been used to analyze the behavior of vestibular sensory neurons.

View Article and Find Full Text PDF

Purpose: Currently, no comprehensive database detailing topography and axon counts exists. This study aims to review the axon counts and topography of the major peripheral motor nerves of the upper extremity to allow for optimal surgical planning for peripheral nerve reconstruction via neurotization.

Methods: Peer-reviewed journal articles were identified through PubMed, ScienceDirect, Google Scholar, and CENTRAL.

View Article and Find Full Text PDF

Background: Cigarette smoking is an established risk factor for lower health-related quality of life (HRQOL). Studies to date have not used comprehensive measures of tobacco exposures across the life course. We examined the association between a lifetime cigarette smoke exposure index (LCSEI) and HRQOL among older US adults.

View Article and Find Full Text PDF

The bidirectional scattering-surface reflectance distribution function (BSSRDF) is a fundamental scattering quantity that characterizes the appearance of translucent materials. The few existing BSSRDF measurement facilities that ensure traceable results have shown the high complexity of such measurement, while only accounting for light scattered in the reflection hemisphere. We have developed an imaging device for measuring both the reflective and the transmissive part of the spectral BSSRDF.

View Article and Find Full Text PDF

The use of fungal chitosan as an antiseptic in wine appears as a promising alternative to sulfur dioxide for the elimination of sensitive strains. Nevertheless, its utilization raises the question, "how are the treated wines different from the untreated ones?" Chitosan treatment residues were sought in the oligosaccharide and polysaccharide fractions and among 224 low MW ions (<1800 g·mol) in several wines by using liquid chromatography (size exclusion HPLC or LC-MS) and GC-MS. Standard oenological parameters were also examined as well as possible sensory modifications by a panel of tasters composed of experts and non-experts.

View Article and Find Full Text PDF

Objective: The main objective of the study is to explore the potential molecular benefits of Nab-paclitaxel as an effective advanced chemotherapeutic agent for HER2-positive breast cancer patients. Specifically, the study aims to assess Nab-paclitaxel as a potential drug candidate for breast cancer treatment.

Methods: This study used bioinformatics and cheminformatics to analyze the HER2 signaling pathway and its possible interactions with Nab-Paclitaxel.

View Article and Find Full Text PDF

This research explores how variations in laser powder bed fusion (LPBF) parameters-laser power (), scanning speed (), and base plate preheating temperature ()-affect the mechanical properties of the EOS Co-Cr SP2 dental alloy. A central composite design (CCD) was used to optimize the process parameters. Mechanical testing focused on crucial properties for dental applications, including yield strength (), elongation (), toughness (), and flexural strength ().

View Article and Find Full Text PDF

The abundance of Lp(a) protein holds significant implications for the risk of cardiovascular disease (CVD), which is directly impacted by the copy number (CN) of KIV-2, a 5.5 kbp sub-region. KIV-2 is highly polymorphic in the population and accurate analysis is challenging.

View Article and Find Full Text PDF

Background: Violence against Emergency Medical Services (EMS) personnel vary between studies. Current studies are mainly based on self-reporting, thus other designs are needed to provide more perspective. The purpose of this study was to explore the rate and predictors of violent behavior targeted at EMS personnel by exploring the Electronic patient care records (ePCR) documentation by EMS personnel.

View Article and Find Full Text PDF
Article Synopsis
  • Plantar hyperhidrosis (PHH) significantly affects psychosocial well-being, and endoscopic lumbar sympathectomy (ELS) is considered the best treatment option, despite concerns about compensatory sweating and sexual effects, especially in men.
  • A study involving male patients who underwent ELS from 2014-2022 assessed the long-term effectiveness of the procedure and any postoperative side effects through remote interviews and standardized questionnaires.
  • Results showed that 80% of patients achieved significant sweat reduction, with most reporting minimal issues related to compensatory sweating and no cases of erectile dysfunction, leading to improved quality of life and overall satisfaction with the surgery.
View Article and Find Full Text PDF
Article Synopsis
  • - A recent study highlights that adults who started smoking cigarettes before age 15 are at a significantly higher risk for COPD compared to those who began at 15 or older, regardless of their current smoking habits or exposure to second-hand smoke.
  • - In the analysis involving U.S. adults aged 40 and older, 13.4% reported having COPD, with prevalence rates of 29.0% for those who started smoking before 15 and 21.1% for those who started at 15 or older.
  • - The research indicates that those who began smoking early not only had a higher prevalence of COPD but also showed greater intensity in smoking behaviors, highlighting the long-term health risks associated with childhood smoking initiation.
View Article and Find Full Text PDF
Article Synopsis
  • The Long-Read Personalized OncoGenomics (POG) dataset features 189 patient tumors and 41 matched normal samples, sequenced with Oxford Nanopore Technologies, providing a comprehensive resource for cancer research.
  • It highlights the advantages of long-read sequencing in identifying complex structural variants, viral integrations, and specific DNA behaviors, such as prominent methylation patterns associated with various cancers.
  • The findings underscore the potential of this dataset in precision medicine, serving as a tool for advancing analytical techniques in cancer genomics.
View Article and Find Full Text PDF

An 8-year-old neutered male Bengal cat was referred because of a 1-year history of progressive and relapsing generalized muscle weakness and muscle atrophy. Before referral, the cat was treated with immunosuppressive doses of oral prednisolone, intermittently for 6 mo, and had responded well when the immunosuppressive dose was maintained. Generalized paresis, diffuse muscle atrophy, and diminished spinal reflexes were present in all limbs, consistent with a generalized lower motor neuron disease.

View Article and Find Full Text PDF
Article Synopsis
  • The Genome in a Bottle Consortium (GIAB) is creating matched tumor-normal samples that are publicly consented for sharing genomic data and cell lines, focusing on pancreatic ductal adenocarcinoma (PDAC).
  • They provide a comprehensive genomic dataset from the first individual, combining high-depth DNA from tumor and normal cells using advanced whole genome sequencing technologies.
  • This open-access resource aims to help develop benchmarks for detecting genetic variants in cancer, fostering innovation in genome measurement and analysis tools.
View Article and Find Full Text PDF

Objective: To improve health conditions among hypogonadal men ≥70 years of age using testosterone undecanoate (TU) injections, progressive strength training, and oral supplements of vitamin D, calcium, and protein.

Methods: This study is a 1-year follow-up of a double-blind RCT lasting 20 weeks, including 148 older men ≥70 years old with low testosterone levels and mobility problems. During 52 weeks, 4 groups received either testosterone therapy (TU) or progressive resistance training (Training), both (Combo), or no intervention (Controls).

View Article and Find Full Text PDF

Introduction: Cigarette smoking and smoking-related lung disease are more common in rural (vs urban) areas of the United States (US). This study examined relationships between geographical location, cigarette risk perceptions, and current smoking among older adults who are at greatest risk of developing smoking-related lung disease.

Methods: The study was a secondary data analysis of 12126 respondents aged ≥40 years from Wave 5 of the Population Assessment of Tobacco and Health Study.

View Article and Find Full Text PDF

Our objective was to provide expert consensus on best practices for anatomy teaching and training on ultrasound-guided botulinum neurotoxin type A (BoNT-A) injection for specialists involved in treating spasticity and dystonia. Nine experts (three neurologists; six physical medicine and rehabilitation physicians) participated in a three-round modified Delphi process. Over three rounds, experts reached consensus on 15 of 16 statements describing best practices for anatomy and BoNT-A injection training.

View Article and Find Full Text PDF

The human gut microbiome composition has been linked to Parkinson's disease (PD). However, knowledge of the gut microbiota on the genome level is still limited. Here we performed deep metagenomic sequencing and binning to build metagenome-assembled genomes (MAGs) from 136 human fecal microbiomes (68 PD samples and 68 control samples).

View Article and Find Full Text PDF

In recent years, the oak lace bug, Corythucha arcuata, has emerged as a significant threat to European oak forests. This species, native to North America, has in the last two decades rapidly extended its range in Europe, raising concerns about its potential impact on the continent's invaluable oak populations. To address this growing concern, we conducted an extensive study to assess the distribution, colonization patterns, and potential ecological niche of the oak lace bug in Europe.

View Article and Find Full Text PDF

This study sought to investigate if heterosexual-couple parents with adolescent children following identity-release oocyte donation (OD), sperm donation (SD) or standard IVF differed with regard to psychological distress, family functioning, and parent-child relationships. The prospective longitudinal Swedish Study on Gamete Donation consists of couples recruited when starting treatment between 2005 and 2008 from seven Swedish university hospitals providing gamete donation. This study concerns the fifth wave of data collection and included a total of 205 mothers and fathers with adolescent children following OD ( = 73), SD ( = 67), or IVF with own gametes ( = 65).

View Article and Find Full Text PDF

Background: Valid, high-resolution estimates of population-level exposure to air pollutants are necessary for accurate estimation of the association between air pollution and the occurrence or exacerbation of adverse health outcomes such as Chronic Obstructive Pulmonary Disease (COPD).

Objectives: We produced fine-scale individual-level estimates of ambient concentrations of multiple air pollutants (fine particulate matter [PM], NO, NO, and O) at residences of participants in the Subpopulations and Intermediate Outcomes in COPD Air Pollution (SPIROMICS Air) study, located in seven regions in the US. For PM, we additionally integrated modeled estimates of particulate infiltration based on home characteristics and measured total indoor concentrations to provide comprehensive estimates of exposure levels.

View Article and Find Full Text PDF

The duplication-triplication/inverted-duplication (DUP-TRP/INV-DUP) structure is a complex genomic rearrangement (CGR). Although it has been identified as an important pathogenic DNA mutation signature in genomic disorders and cancer genomes, its architecture remains unresolved. Here, we studied the genomic architecture of DUP-TRP/INV-DUP by investigating the DNA of 24 patients identified by array comparative genomic hybridization (aCGH) on whom we found evidence for the existence of 4 out of 4 predicted structural variant (SV) haplotypes.

View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: A non-numeric value encountered

Filename: controllers/Author.php

Line Number: 219

Backtrace:

File: /var/www/html/application/controllers/Author.php
Line: 219
Function: _error_handler

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: A non-numeric value encountered

Filename: libraries/Pagination.php

Line Number: 413

Backtrace:

File: /var/www/html/application/controllers/Author.php
Line: 274
Function: create_links

File: /var/www/html/index.php
Line: 316
Function: require_once