[Factors associated with venous thromboembolism in tuberculosis patients in Burkina Faso: A case control study].

Introduction: The mortality caused by tuberculosis is partially explained by co-morbidities such as venous thromboembolic disease. Our study was aimed at identifying the factors associated with venous thromboembolism in tuberculosis patients.

Methods: This was a case-control study of patients with pulmonary tuberculosis with or without venous thromboembolic disease.

Insecticide resistant Anopheles from Ethiopia but not Burkina Faso show a microbiota composition shift upon insecticide exposure.

Background: Malaria remains a key contributor to mortality and morbidity across Africa, with the highest burden in children under 5. Insecticide-based vector control tools, which target the adult Anopheles mosquitoes, are the most efficacious tool in disease prevention. Due to the widespread use of these interventions, insecticide resistance to the most used classes of insecticides is now pervasive across Africa.

Assessing customer satisfaction: the case of test prescribers at the clinical biology laboratory of Centre Muraz/ Institut National de Santé Publique, Burkina Faso.

Context: Assessing customer satisfaction with a product or service is one technique for evaluating the quality of a product or service given by a company. One of the instruments used to gauge customer satisfaction is the satisfaction survey. The Clinical Biology Laboratory of Centre Muraz employed this method to determine how satisfied its test prescribers were to improve.

Tracking acute flaccid paralysis in Niger: a half-decade epidemiological portrait (2016-2021).

Background: Recently, a total of 74 circulating vaccine-derived poliovirus (cVDPV) outbreaks were detected in 39 countries, with 672 confirmed Acute Flaccid Paralysis (AFP) cases identified in 27 countries. Despite progress, Niger experienced cVDPV outbreaks in 2018, highlighting the importance of maintaining AFP surveillance as a tool for polio eradication. This analysis aims to comprehensively assess AFP surveillance trends, patterns, and challenges in Niger, offering insights for public health initiatives in conflict-affected contexts.

Can microbiota gut-brain axis reverse neurodegenerative disorders in human?

The trillions of microbial populations residing in the gut have recently shown that they can be used as a remedy for various diseases. The gut microbiota-brain-axis interface is one unique pathway that the microbiota demonstrates its medicinal value. This medicinal value is further seen when there is a decline in gut microbial diversity (dysbiosis).

Evaluation of a novel malaria anti-sporozoite vaccine candidate, R21 in Matrix-M adjuvant, in the UK and Burkina Faso: two phase 1, first-in-human trials.

Background: Malaria remains a substantial public health burden among young children in sub-Saharan Africa and a highly efficacious vaccine eliciting a durable immune response would be a useful tool for controlling malaria. R21 is a malaria vaccine comprising nanoparticles, formed from a circumsporozoite protein and hepatitis B surface antigen (HBsAg) fusion protein, without any unfused HBsAg, and is administered with the saponin-based Matrix-M adjuvant. This study aimed to assess the safety and immunogenicity of the malaria vaccine candidate, R21, administered with or without adjuvant Matrix-M in adults naïve to malaria infection and in healthy adults from malaria endemic areas.

Optimization and Standardization of the Extraction Method of Del. Seeds (Zygophyllaceae) Used in the Formulation of an Antiparasitic Phytomedicine.

Del. (Zygophyllaceae) is widely used in traditional medicine, both human and veterinary, throughout Africa for its many properties, including antiparasitic properties. This experimental study aims to optimize the extraction conditions of the seeds of Del.

Perspectives on integrating family planning and nutrition: a qualitative study of stakeholders.

Background: Limited information is available on the value of integrating family planning and nutrition services to improve related outcomes among women of reproductive age and effective approaches to achieve this. This study aimed to ascertain the perspectives and experiences of global and regional stakeholders about integrating family planning and nutrition services, examine facilitators and barriers and identify opportunities and considerations for integration.

Methods: We conducted semistructured interviews with 34 global and regional stakeholders in family planning, nutrition and related domains.

Prevalence and Antibiotic Susceptibility of Pathogenic Enterobacteria Strains from Three Biotopes in the City of Ouagadougou (Burkina Faso).

Purpose: The emergence of antibiotic resistance in pathogenic is a public health problem in tropical countries such as Burkina Faso. Antibiotic resistance could be identified using a variety of approaches. This study aimed to estimate the prevalence of pathogenic enterobacteria strains from three sources, as well as their antibiotic resistance profile to biotope and climatic season.

Influence of pH on the release of nickel ions from fixed orthodontic appliances in artificial saliva.

Aim: The aim of this study was to make a laboratory assessment of pH influence on the kinetics of the release of nickel ions in artificial saliva.

Methods And Material: In this study, 15 basic orthodontic appliances are immersed in 15 polyethylene tubes each containing 40 ml of artificial saliva. Tubes were divided into three sub-groups of 5 tubes depending on the pH: pH 5, pH 7 and pH 8.

[Occupational asthma in a laboratory technician].

This observation reports the case of an occupational allergic asthma in a laboratory technician, caused by exposure to formaldehyde. She experienced feelings of discomfort during low exposure, below the regulatory exposure thresholds. Sent to occupational medicine, signs of an asthma attack were noted by the doctor.

[The ambient air and (peanut) oil dressing in severe burns in children under 15 years of age at the regional hospital center of dédougou].

The dressing is an important element in the management of severe burns. The aim of this study was to present the results of the dressing in room air and peanut oil. This was a descriptive retrospective study conducted from January 1, 2014 to December 31, 2020 in the surgery department of the Dédougou regional hospital center.

Salivary extracellular vesicles isolation methods impact the robustness of downstream biomarkers detection.

Extracellular vesicles (EVs), crucial mediators in cell-to-cell communication, are implicated in both homeostatic and pathological processes. Their detectability in easily accessible peripheral fluids like saliva positions them as promising candidates for non-invasive biomarker discovery. However, the lack of standardized methods for salivary EVs isolation greatly limits our ability to study them.

A descriptive summary of the WHO availability assessments of medical abortion medicines in eight African countries.

Background: The use of medical abortion using either a combination of mifepristone and misoprostol, or misoprostol alone has contributed to increased safety and decreased mortality and morbidity. The availability of quality medical abortion medicines is an essential component in the provision of quality abortion care. Understanding the factors that influence the availability of medical abortion medicines is important to help in-country policymakers, program planners, and providers improve availability and use of medical abortion.

A mathematical model of plasmin-mediated fibrinolysis of single fibrin fibers.

Fibrinolysis, the plasmin-mediated degradation of the fibrin mesh that stabilizes blood clots, is an important physiological process, and understanding mechanisms underlying lysis is critical for improved stroke treatment. Experimentalists are now able to study lysis on the scale of single fibrin fibers, but mathematical models of lysis continue to focus mostly on fibrin network degradation. Experiments have shown that while some degradation occurs along the length of a fiber, ultimately the fiber is cleaved at a single location.

Evaluating artesunate monotherapy and dihydroartemisinin-piperaquine as potential antimalarial options for prevaccination radical cures during future malaria vaccine field efficacy trials.

Background: In malaria vaccine clinical trials, immune responses after vaccination may be compromised due to immunosuppression caused by concurrent Plasmodium falciparum infection. This has a direct effect on the protective efficacy of the vaccine being evaluated. Therefore, parasite clearance prior to vaccination is being considered.

HPV vaccine hesitancy among parents and caregivers of adolescents in Northern Nigeria.

Background: The recent introduction of the HPV vaccine into Nigeria's routine immunization schedule has brought parental vaccine hesitancy to the forefront. This cross-sectional study, conducted in Kano State, a region with historically low immunization rates, is crucial in assessing the level of parental hesitancy and uncovering its determinants, potentially informing future public health policies.

Methods: The participants were a representative sample of parents or caregivers of children aged 9-14 years ( = 1071) in Kano State and were selected via a multi-stage sampling method.

Describing Biological Vulnerability in Small, Vulnerable Newborns in Urban Burkina Faso (DenBalo): Gut Microbiota, Immune System, and Breastmilk Assembly.

: Small vulnerable newborns (SVNs), including those born preterm, small for gestational age, or with low birth weight, are at higher risk of neonatal mortality and long-term health complications. Early exposure to maternal vaginal microbiota and breastfeeding plays a critical role in the development of the neonatal microbiota and immune system, especially in low-resource settings like Burkina Faso, where neonatal mortality rates remain high. : The DenBalo study aims to investigate the role of maternal and neonatal factors, such as vaginal and gut microbiota, immune development, and early nutrition, in shaping health outcomes in SVNs and healthy infants.

Assessment of salivary microRNA by RT-qPCR: Facing challenges in data interpretation for clinical diagnosis.

Salivary microRNAs (miRNAs) have been recently revealed as the next generation of non-invasive biomarkers for the diagnostics of diverse diseases. However, their short and highly homologous sequences make their quantification by RT-qPCR technique highly heterogeneous and study dependent, thus limiting their implementation for clinical applications. In this study, we evaluated the use of a widely used commercial RT-qPCR kit for quantification of salivary miRNAs for clinical diagnostics.

Safety and efficacy of the blood-stage malaria vaccine RH5.1/Matrix-M in Burkina Faso: interim results of a double-blind, randomised, controlled, phase 2b trial in children.

Background: Two pre-erythrocytic vaccines (R21/Matrix-M and RTS,S/AS01) are now approved for Plasmodium falciparum malaria. However, neither induces blood-stage immunity against parasites that break through from the liver. RH5.

Exploring sexual and reproductive health needs, barriers, and coping strategies of internally displaced women of reproductive ages in north-central Nigeria: A qualitative analysis.

Context: Women and girls form a substantial proportion of the population of internally displaced people (IDP) in Nigeria, these vulnerable populations are at risk of sexual and reproductive health (SRH) rights violations and greater risk of unsafe abortion and high maternal deaths. IDP women's living conditions are often precarious, exposing them to health risks, challenges are often faced due to lack of finance and other related factors to access health care services leading to them improvising health care services which is considered dangerous to their health. There is a gap in the study regarding the SRH needs of the IDP women and the alternative they opt for in meeting their sexual needs.

Immune response to GeneVac-B (rDNA I.P. hepatitis B vaccine) in vaccinated persons with a standard schedule in Bobo-Dioulasso, Burkina Faso.

Objective: This study aimed to evaluate the immune response in people fully vaccinated against hepatitis B with the GeneVac-B vaccine in Burkina Faso under actual conditions of use.

Methods: This cross-sectional study included individuals fully vaccinated with GeneVac-B. For each consenting participant, sociodemographic and clinical data were collected using a structured questionnaire.

Health and eHealth Literacy of Patients With Diabetes in Low-Income Countries: Perspective From Guinea and Burkina Faso.

Background: Diabetes is a significant health concern in sub-Saharan Africa, emphasizing the importance of assessing the health literacy and eHealth skills of hospitalized patients with diabetes. This study evaluated the health literacy and eHealth literacy of patients with diabetes at Donka Hospital in Guinea and Sanou Sourou Hospital in Burkina Faso, providing insights for targeted interventions and mobile health (mHealth) solutions to improve self-management and treatment outcomes.

Objective: The aim of this study is to evaluate the levels of health literacy and eHealth literacy among patients at Sanou Sourou Hospital in Burkina Faso and Donka Hospital in Guinea.

Correction: Assessment of the transmission blocking activity of antimalarial compounds by membrane feeding assays using natural Plasmodium falciparum gametocyte isolates from West-Africa.

[This corrects the article DOI: 10.1371/journal.pone.