Differentiation of lesions caused by mycotoxin T-2 from autolytic morphologic change in CD-1 mice.

Experiments with topically applied T-2 trichothecene mycotoxin were undertaken to determine whether lesions caused by this toxin could be differentiated from autolysis. Two pathologists, who had previously seen lesions caused by T-2 toxin, graded lesions without knowledge of treatment group and stated whether the animal had received the toxin or not. Both pathologists differentiated T-2 toxin-treated mice up to 6 h post-mortem.

Erythrocyte osmotic fragility testing and the prediction of canine malignant hyperthermia susceptibility.

A Doberman-German Shepherd cross-bred male dog, previously diagnosed as malignant hyperthermia susceptible, was mated to an unrelated nonsusceptible German Shepherd cross-bred female. The resultant litter was subjected to hematological, biochemical and erythrocyte osmotic fragility testing in an endeavor to predict the susceptibility of individuals to malignant hyperthermia. Laboratory evaluations were repeated at one year of age and the litter subjected to the halothane challenge test.

Canine malignant hyperthermia: diagnosis of susceptibility in a breeding colony.

Fifteen related dogs were studied for susceptibility to malignant hyperthermia using halothane challenge and caffeine contracture tests. These dogs had hypertrophied muscles, were of a nervous temperament and had rectal temperatures at the upper limit of the normal range. Clinical pathology findings were mild elevations of serum aspartate transaminase and mean corpuscular hemoglobin.

Abortion in mice associated with Pasteurella pneumotropica.

Pasteurella pneumotropica was isolated from the uteri, fetuses, lungs, and spleens of aborting Swiss Carworth mice. Male mice in the colony carried P. pneumotropica in pharynges, testes, and seminal vesicles.

Morphologic effects of dietary plant and animal lipids rich in docosenoic acids on heart and skeletal muscle of cynomolgus monkeys.

Cynomolgi (Macaca fascicularis) were fed diets containing 25% rapeseed oil (RSO), partially hydrogenated herring oil (PHHO), or a 3:1 mixture of lard and corn oil as control for 4 months. The RSO contained approximately 25% of the fatty acids as erucic acid; the PHHO contained a similar concentration of mainly cetoleic acid. The control diet did not include such fatty acids.

Effects of plant and animal lipids rich in docosenoic acids on the myocardium of Cynomolgus monkeys.

Cynomolgus monkeys (Macaca fascicularis) were fed diets containing 25% rapeseed oil (RSO), partially-hydrogenated herring oil (PHHO) or a 3:1 mixture of lard/corn oil as control (CON) for 4 months. The RSO contained approximately 25% of the fatty acids as erucic acid (cis-docos-13-enoic, 22:1w9) while the PHHO contained a similar concentration of mainly cetoleic acid (cis-docos-11-enoic, 22:1w11). The CON contained no 22:1 acids.

Thiamin status of laboratory rabbits.

Measurements of blood thiamin concentration, erythrocyte transketolase (TK) activity, and stomach and cecal thiamin concentration were made in 10 normal New Zealand white rabbits consuming a commercial pelleted rabbit diet. The concentration of the vitamin was somewhat higher in stomach content (57.2 +/- 11.

Salmonella typhimurium infection in guinea pigs: observations on monitoring and control.

A spontaneous outbreak of salmonellosis in a guinea pig colony was caused by Salmonella typhimurium. A simple, comprehensive monitoring procedure, consisting of mass fecal sampling, was developed. Using the monitoring system described, the disease was eliminated by: 1) removal of animals in pens in contact with Salmonella, and 2) strict hygienic procedures.