Bond Strength Evaluation of Ceramic Restorations with Immediate Dentin Sealing: A Systematic Review and Meta-Analysis.

Statement Of The Problem: Immediate dentin sealing (IDS) was introduced to overcome the disadvantages of delayed dentin sealing like pollution of dentin tubules, microleakage, and bond strength destruction over time. The effect of IDS on the bond strength of indirect restorations is still debatable.

Purpose: This study was conducted to determine the effect of IDS on the bond strength of ceramic restorations to dentin.

Increasing membrane polyunsaturated fatty acids sensitizes non-small cell lung cancer to anti-PD-1/PD-L1 immunotherapy.

Immune checkpoints inhibitors (ICIs) as anti-PD-1/anti-PD-L1 have been approved as first-line treatment in patients with non-small cell lung cancer (NSCLC), but only 25 % of patients achieve durable response. We previously unveiled that estrogen receptor α transcriptionally up-regulates PD-L1 and aromatase inhibitors such as letrozole increase the efficacy of pembrolizumab. Here we investigated if letrozole may have additional immune-sensitizing mechanisms.

Investigating the anticancer effects of chitosan-NLC-folate nanohybrid loaded with auraptene on A2780 ovarian cancer cells.

The significant fatality rate associated with ovarian cancer underscores the urgent need for novel therapeutic interventions in this area. The focus of this study was to assess the cytotoxic impact of auraptene nanohybrid chitosan folate on A2780 ovarian cancer cells. A combination of liquid and solid lipids were used to create auraptene-nanostructured lipid carriers.

TFEB controls sensitivity to chemotherapy and immuno-killing in non-small cell lung cancer.

Background: In non-small cell lung cancer (NSCLC) the efficacy of chemo-immunotherapy is affected by the high expression of drug efflux transporters as ABCC1 and by the low expression of ABCA1, mediating the isopentenyl pyrophosphate (IPP)-dependent anti-tumor activation of Vγ9Vδ2 T-lymphocytes. In endothelial cells ABCA1 is a predicted target of the transcription factor EB (TFEB), but no data exists on the correlation between TFEB and ABC transporters involved in the chemo-immuno-resistance in NSCLC.

Methods: The impact of TFEB/ABCC1/ABCA1 expression on NSCLC patients' survival was analyzed in the TCGA-LUAD cohort and in a retrospective cohort of our institution.

The Efficacy of Different Antibiotic Compounds in Regenerative Treatment of Immature Necrotic Teeth.

Endodontic treatment of immature teeth poses a significant challenge, especially in achieving a proper seal using traditional obturation methods. Revascularization presents itself as an alternative approach to this problem, and the application of triple antibiotic paste (TAP) has been suggested as a means to achieve disinfection during the procedure. This study aims to compare the antibacterial properties of three different antibiotic combinations to assess their effectiveness on root canal disinfection.

Evaluation of the Fracture Resistance of Conservative and Ultraconservative Access Cavity Designs with Different Treatment Modalities: An In Vitro Study.

Introduction: The aim of this study was to evaluate the fracture resistance of endodontically treated mandibular molars using traditional and conservative access cavity preparation.

Materials And Methods: In this in vitro study, 100 extracted healthy human mandibular molars were selected and divided into 10 groups ( = 10). Healthy teeth in one group were considered the control group.

The effect of silver diamine fluoride on the bond strength of glass ionomer to the enamel of primary teeth.

Background: Dental caries is a disease which is caused by the acidic by-products of the metabolic processes of dental plaque. Silver components are one of the clinical solutions to prevent caries. This study aimed to investigate the effect of silver diamine fluoride (SDF) application on the shear bond strength of glass ionomer to primary teeth enamel.

Comparison of antibacterial activity and fluoride release in tooth-colored restorative materials: Resin-modified glass ionomer, zirconomer, giomer, and cention N.

Background: Considering the important role of fluoride in preventing caries by reducing the number and activity of cariogenic bacteria and introducing new fluoride-releasing tooth-colored restorative materials, this study was performed to compare and evaluate fluoride ion release and antibacterial activity of resin-modified GI, zirconomer, giomer (Beautifil), and Cention N.

Materials And Methods: In this experimental study, eighty samples (20 samples in each group) were prepared, 10 samples for fluoride testing and 10 samples for antibacterial activity. To evaluate the release of fluoride (PPM), fluoride ion-selective electrode was used on days 1, 3, 7, 14, and 21; and antibacterial activities against were examined using direct contact test by absorption of light hourly once every 5 h and days 1, 2, and 7 using an ELISA reader with a microplate reader of 800 TS at a wavelength of 630 nm.

The effect of air pollution on systemic lupus erythematosus: A systematic review and meta-analysis.

Background: Systemic lupus erythematosus (SLE) is an autoimmune disease resulting from impaired inflammatory responses. Given the role of air pollution on increasing inflammatory mediators, thus, we aimed to systematically review and meta-analyze evidence regarding an association between short-term exposure to air pollution and SLE onset, activity, and hospitalization.

Methods: Electronic databases including Web of Science, PubMed, Scopus, and Embase were searched for all published articles until July 5, 2021.

Evaluation of microleakage in Class II composite restorations: Bonded-base and bulk-fill techniques.

Background: This study compared microleakage of Class II cavities restored using bonded-base and bulk-fill techniques with different bases.

Materials And Methods: In this study, in 60 extracted human molars, standardized (4 mm × 2 mm × 8 mm) Class II cavities were prepared, such that the gingival floor was located 1 mm below the CEJ. The teeth were randomly divided into five groups and filled with: (1) Fuji II LC + x-tra fil, (2) Ionoseal + x-tra fil, (3) x-tra base + x-tra fil, (4) Grandio Flow + x-tra fil, and (5) x-tra fil only [control group]; in open-sandwich technique, the base thickness was 1 mm.

Programmed cell death 1 as prognostic marker and therapeutic target in upper gastrointestinal cancers.

Gastrointestinal (GIs) cancers are among the most common causes of cancer related death, and hence the importance for the identification of novel prognostic/predictive biomarkers for detection of patients at an early stage, and for using these to identify novel targeted therapies to improve the efficacy of existing chemotherapeutic regimens. Programmed cell death 1 has been reported as a potential target in several malignancies, and targeting agents are being developed, some already approved by FDA, such as: pembrolizumab, Atezolizumab, Nivolumab. Pembrolizumab that have been approved for the treatment of metastatic non-small cell lung cancer.

The therapeutic potential of renin-angiotensin system inhibitors in the treatment of pancreatic cancer.

Pancreatic cancer is among the most lethal malignancies with poor prognosis and patients become chemoresistant to current therapies, supporting further investigations to identify new therapeutic regimens in the treatment of this condition. Preclinical and clinical studies now appear to support the role of the renin-angiotensin system (RAS) in the regulation of tumor growth, angiogenesis, and metastasis in different malignancies including pancreatic cancer. These studies suggest that RAS blockers; Angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs); could have anti-carcinogenic effects and improve clinical outcomes in the management of pancreatic cancer.

Effect of play therapy on behavioral problems of maladjusted preschool children.

Objective: The present research was conducted to study the effect of play therapy on reducing behavioral problems of children with oppositional defiant disorder.

Method: Using multistage cluster sampling, regions 6, 7, and 8 in Tehran were selected. Among kindergartens of these areas, 3 kindergartens which were supported by the welfare organization were randomly selected.