Characterisation and serodiagnostic evaluation of a recombinant 22.6-kDa tegument protein of .

Schistosomosis in animals due to significantly burdens India's livestock economy because of high prevalence and morbidity and is mostly underdiagnosed from the lack of sensitive tools for field-level detection. This study aimed to clone, express the 22.6-kDa tegument protein of (rSs22.

Thiamine-responsive megaloblastic anaemia.

We report a 26-year-old girl who was diagnosed with diabetes mellitus in her childhood and was treated with insulin. With a history of visual disturbances during her childhood and anaemia, which was partially evaluated; the possibility of syndromic diabetes was considered. Genetic analysis was done and revealed a mutation in the SLC19A2 gene, confirming the diagnosis of thiamine-responsive megaloblastic anaemia.

Photodegradation of rhodamine-B in aqueous environment using visible-active gCN@CS-MoS nanocomposite.

Rapid industrial expansion leads to environmental pollution especially in an aqueous environment. Photocatalytic degradation is one of the most efficient and environmentally friendly techniques used to treat industrial pollution due to its complete degradation capability of a variety of water contaminants to their non-toxic state. Graphitic carbon nitride (gCN) and molybdenum disulfide (MoS) provide efficient dye degradation, but MoS has few disadvantages.

Water Quality Analysis Using Physicochemical Parameters and Estimation of Pesticides in Water from Various Sources of Tirupati, Andhra Pradesh, India.

Tirupati is one of the famous tourist places in India. So, safe drinking water is a priority. Therefore, to handle ground water contamination and to make aware the people in the area of Tirupati, in the present paper, research was conducted with the goal to estimate water quality by using physico-chemical parameters and to analyse pesticides with analytical technique Gas Chromatography-Mass Spectrometry (GC-MS) of ground water in and around Tirumala, Tirupati, located in Andhra Pradesh State of India.

Immunogenicity and safety of homologous and heterologous booster vaccination of ChAdOx1 nCoV-19 (COVISHIELD™) and BBV152 (COVAXIN®): a non-inferiority phase 4, participant and observer-blinded, randomised study.

Background: Primary SARS-CoV-2 vaccination has been shown to wane with time and provide lower protection from disease with new viral variants, prompting the WHO to recommend the administration of booster doses. We determined the safety and immunogenicity of homologous or heterologous boosters with ChAdOx1 nCoV-19 (COVISHIELD™) or BBV152 (COVAXIN®), the two vaccines used widely for primary immunization in India, in participants who had already received two primary doses of these vaccines.

Methods: Participants primed with two doses each of COVISHIELD™ or COVAXIN® 12-36 weeks previously, were randomised to receive either COVISHIELD™ or COVAXIN® booster in a 1:1 ratio.

The Need for Continuum of Care in Control of Hypertension in Primary Health-care Setting.

The hypertension care continuum is a public health model that outlines the steps or stages that people with hypertension go through from diagnosis to achieving and maintaining blood pressure (BP) under control through care and treatment. Despite diagnosis being straightforward and treatments widely available and relatively inexpensive, there are significant gaps in delivery at the level of awareness, treatment, adherence, and control of hypertension. This article reviews the correlates of client acquisition and retention at the primary care level for hypertension management along the continuum of care context of the public health system in India.

Total Dystrophic Onychomycosis of All the Nails Caused by Non-dermatophyte Fungal Species: A Case Report.

Onychomycosis (OM) is a common disease of nails. It is a major public health issue worldwide due to its increasing prevalence. Moreover, OM is associated with substantial consequences including physical and psychological outcomes.

Ni/Ni(OH)-rGO nanocomposites sensor for the detection of long forgotten mycotoxin, xanthomegnin.

Xanthomegnin, a known fungal toxin, secondary metabolite, and pigment diffuses from the dermatophytes has gained attention as local virulence factor because of the mutagenicity, toxicity, cytocidal, and immunosuppressive properties. Not only as a dermatophyte in skin related disorders, the production of xanthomegnin is implicated as a powerful diagnostic marker in patients suffering from ocular mycoses. Incidentally also attributed to death in livestock's majorly by exposing themselves to food-borne fungi like Aspergillus and Penicillium.

Effect of Thermocycling on Shear Bond Strength of PEEK-A Comparative Study of Resin Luting Cements: An In-Vitro Study.

Introduction: Thermocycling is an process; it may affect the bonding strength between tooth and resin which is depending upon the adhesive system.

Aim And Objectives: To evaluate and compare the thermocycling effect on shear bond strength of RelyX Unicem and G-CEM Linkace to polyether ether ketone (PEEK) surface.

Materials And Methods: A total of 40 PEEK disk-shaped specimens were fabricated with dimensions of 10 × 3 mm and randomly allocated into two groups.

Evaluation of the Toxicity of Human Dental Pulp-Derived Mesenchymal Stem Cells on Animal Models: An Animal Study.

Introduction: Dental pulp remains one of the important sources of mesenchymal stem cells for most preclinical and clinical studies.

Aim And Objectives: To assess the safety after injecting human dental pulp-derived mesenchymal stem cells by intramucosal and intrabony routes in rabbits for clinical application.

Materials And Methods: Animal studies were carried out among 30 New Zealand male white rabbits (3-5 months old), weighing 1.

Autonomous service for managing real time notification in detection of COVID-19 virus.

In today's world, the most prominent public issue in the field of medicine is the rapid spread of viral sickness. The seriousness of the disease lies in its fast spreading nature. The main aim of the study is the proposal of a framework for the earlier detection and forecasting of the COVID-19 virus infection amongst the people to avoid the spread of the disease across the world by undertaking the precautionary measures.

Study of Infections in Type 2 Diabetes Mellitus.

Unlabelled: Diabetes mellitus (DM) is a clinical syndrome associated with deficiency of insulin secretion or action. It is considered one of the largest emerging threats to health in the 21st century. Besides the classical complications of the disease, DM has been associated with reduced response of T cells, neutrophil function, and disorders of humoral immunity.

A cross-sectional and histological analysis to understand the cytological effects of cell phone radiation on buccal mucosa of children.

Context: The ongoing pandemic has affected all the spheres of life and one of the severely affected avenues is the education of a child. The online education has seen an upward curve since the start of COVID-19 pandemic. Schools globally have adopted online class tutorials as the main method to impart education and directly increasing the screen time for a child.

Impurity Profiling and Identification of 2,6-Diisopropylphenol by HPLC Method and Raman Spectroscopy Method.

Identification of 2,6-diisopropylphenol by Raman spectroscopy using the TruScan Raman spectrum is validated by specificity test and robustness. HPLC assay method is developed to detect the 2,6-diisopropylphenol and its impurities A = determination of 2,6-diisopropylphenol; its main impurities related compound A = 2,6-diisopropylphenyl isopropyl ether, related compound B = 2,6-diisopropylquinone, and related compound C = 3,3'-5,5'-tetraisopropyl diphenol; and unknown impurities done by HPLC method. Related compound A and C determination has been developed by normal phase HPLC; good resolution peak shapes have resulted from the peak results.

Synthesis and Biological Evaluation of Substituted Thiophene Derivatives.

A novel series of pyrazolines were synthesized by cycloaddition of various chalcones (prepared by a Claisen-Schmidt condensation of 3-acetyl-2,5-dimethyl thiophene and various aromatic aldehydes) with the phenyl hydrazines in the presence of pyridine and subjected to molecular property prediction by Molinspiration, MolSoft, and Osiris software. The structures of new compounds were established by HNMR, IR, and mass spectral data. Most of the synthesized compounds (1A-E) were found to be in conformity with Lipinski's "rule of five" and other parameters, for their screening for antimicrobial and antifungal activity as oral active leads/drugs.

Phospholipid Fatty Acid Profile of Spirulina platensis.

Phospholipid fatty acid (PLFA) analysis is used to measure the microbial biomass and the phospholipids present in the environmental samples. Microalgae spirulina is found to be a rich source of very-long-chain polyunsaturated fatty acids (VLCPUFAs) and has been used as a neutraceutical and regenerative medicine in the biotechnological industries as PUFAs are not synthesized in the human body due to the lack of enzymes for their bioconversion and must be supplied through the diet. Eicosapentanoic acid (EPA) and docosahexanoic acid (DHA) are the two most important long-chain omega-3 (ω-3) polyunsaturated fatty acids involved in the human physiology, and their precursors stearic acid (ω-9), linoleic acid (ω-6), and gamma linolenic acid (ω-6) were found to be in higher concentrations in Spirulina platensis.

Evaluation of HiCrome KPC Agar for the Screening of Carbapenem-Resistant Enterobacterales Colonization in the ICU Setting of a Tertiary Care Hospital.

Spread of carbapenem-resistant (CRE) is a significant concern in intensive care unit (ICU) settings. Approaches to routine screening for CRE colonization in all ICU patients vary depending on institutional epidemiology and resources. The present study was aimed to evaluate the performance of HiCrome carbapenemase (KPC) agar for the detection of CRE colonization in ICU settings taking the Centers for Disease Control and Prevention (CDC) recommended method as reference.

Client Satisfaction of Antiretroviral Therapy Service Delivery: A Cross-Sectional Study at an Antiretroviral Therapy Center.

Context: People living with HIV (PLHIV)/AIDS are faced with the task of maintaining optimal health status despite an increasing insult to their immune status. Antiretroviral therapy (ART) centers provide comprehensive services to all PLHIV enrolled under the program. Patients with higher satisfaction levels may also have improved health outcomes.

Repurposing antiviral drugs on recently emerged viral infections: A review article.

Finer understandings of drugs, for newly emerged diseases are becoming difficult nowadays. The contemporary approach is Drug Repurposing. Drug repurposing implies the exploration of surviving drugs for new restorative motive.

Clinical Profiling of a Bilingual Client with Anomic Aphasia.

Background: Aphasia is an acquired condition affecting auditory comprehension, verbal expression, reading, writing and word-finding abilities along with sensory-motor impairments. Anomia refers to difficulty in word retrieval or naming which is seen irrespective of the type of aphasia. However, if a patient shows word-finding difficulty, in specific, a diagnosis of Anomic aphasia is made.

Immobilization of MIL-88(Fe) anchored TiO-chitosan(2D/2D) hybrid nanocomposite for the degradation of organophosphate pesticide: Characterization, mechanism and degradation intermediates.

In this study, we have rationally designed and grafted a bio-assisted 2D/2D TiO/MIL-88(Fe) (TCS@MOF) heterojunction by growing granular TiO on the surface of MIL-88(Fe) nanosheet, as hybrid photocatalyst. The hierarchical TCS@MOF composite was prepared via the one-pot solvothermal process and employed for monocrotophos (MCP) degradation under visible light region, since its persistent nature on soil and water causes major threat to the environment. The TCS@MOF promotes a number of packed high-speed nano-tunnels in the (p-n) heterojunctions, which significantly enhance the migration of photo-induced electrons (e) and holes (h), respectively and thus limits the charge recombination of es.

Properties of South-Indian rice cultivars: physicochemical, functional, thermal and cooking characterisation.

Physicochemical, functional, thermal, pasting and cooking properties of five Indian rice cultivars, ADT 36, 43, 39, IW PONNI and CR1009 were investigated. The starch, protein and fat contents varied from 1.321 to 2.