HIV clinic-based buprenorphine plus naloxone versus referral for methadone maintenance therapy for treatment of opioid use disorder in HIV clinics in Vietnam (BRAVO): an open-label, randomised, non-inferiority trial.

Background: UNAIDS recommends integrating methadone or buprenorphine treatment of opioid use disorder with HIV care to improve HIV outcomes, but buprenorphine adoption remains limited in many countries. We aimed to assess whether HIV clinic-based buprenorphine plus naloxone treatment for opioid use disorder was non-inferior to referral for methadone maintenance therapy in achieving HIV viral suppression in Vietnam.

Methods: In an open-label, non-inferiority trial (BRAVO), we randomly assigned people with HIV and opioid use disorder (1:1) by computer-generated random number sequence, in blocks of ten and stratified by site, to receive HIV clinic-based buprenorphine plus naloxone treatment or referral for methadone maintenance therapy in six HIV clinics in Vietnam.

Synthesis of Porous Biochar Containing Graphitic Carbon Derived From Lignin Content of Forestry Biomass and Its Application for the Removal of Diclofenac Sodium From Aqueous Solution.

Porous biochar containing graphitic carbon materials have received great attention from various disciplines, especially for environmental pollutant treatment, due to their cost-effective and specific textural properties. This study exhibited a two-step strategy to compose lignin-porous biochar containing graphitic carbon (LPGC) from pitch pine sawdust and investigated its adsorptive removal for diclofenac sodium (DCF) from an aqueous solution. Sulfuric acid (HSO) was utilized to obtain lignin content from biomass and potassium ferrate (KFeO) and was adopted to fulfill the synchronous carbonization and graphitization of LPGC.

Efficient Removal of Diclofenac from Aqueous Solution by Potassium Ferrate-Activated Porous Graphitic Biochar: Ambient Condition Influences and Adsorption Mechanism.

Porous graphitic biochar was synthesized by one-step treatment biomass using potassium ferrate (KFeO) as activator for both carbonization and graphitization processes. The modified biochar (Fe@BC) was applied for the removal of diclofenac sodium (DCF) in an aqueous solution. The as-prepared material possesses a well-developed micro/mesoporous and graphitic structure, which can strengthen its adsorption capacity towards DCF.

Impact of a methadone maintenance therapy pilot in Vietnam and its role in a scaled-up response.

Background: As a dual response to the HIV epidemic and the high level of injecting drug use in Vietnam, the Ministry of Health (MOH) initiated a pilot methadone maintenance therapy (MMT) program in Hai Phong and Ho Chi Minh City (HCMC) in early 2009. The objectives of the pilot were to provide evidence on whether MMT could be successfully implemented in Vietnam and scaled up to other localities.

Methods: A prospective study was conducted among 965 opiate drug users admitted to the pilot.

[Preformulation study of controlled release nitrofurantoin preparations. 2].

In their previous publications the authors rendered account of preparation and stability test of products containing controlled release nitrofurantoin in circumstances of preparing and storing. Following previous publications in vitro active principle release of developed product has been investigated by rotating basket method and by applying Sartorius Dissolution tester. Absorptions of active principle and coated pharmacon have been determined by means of Sartorius Membrane transport tester.