Publications by authors named "Nesma Hussein Abdel Hay"
Article Synopsis
- Renal fibrosis is a major issue in chronic kidney disease, and recent studies suggest that protein prenylation plays a role in its progression.
- The research explored the protective effects of zoledronic acid (ZA) on kidney function in rats with chemically induced renal fibrosis, measuring several health indicators and protein levels.
- Results showed that ZA significantly improved blood pressure, reduced markers of kidney damage and fibrosis, and preserved renal function by inhibiting a specific protein involved in the fibrosis process.
The potential role of SNHG16/ miRNA-146a/ TRAF6 signaling pathway in the protective effect of zoledronate against colorectal cancer and associated osteoporosis in mouse model.
Int Immunopharmacol
May 2024
Bone fracture as a consequence of colorectal cancer (CRC) and associated osteoporosis (OP) is considered a risk factor for increasing the mortality rate among CRC patients. SNHG16/ miRNA-146a/ TRAF6 signaling pathway is a substantial contributor to neoplastic evolution, progression, and metastasis. Here, we investigated the effect of zoledronate (ZOL) on the growth of CRC and associated OP in a mouse model.
View Article and Find Full Text PDFMiRNA 200-c-3p has varying functions in different tumor types, whether tumor suppression or promotion. Comprehensive assessment of its function in non-small cell lung cancer (NSCLC) together with its effect on antitumor immune response have not been declared before. We aimed to explore the effect of replacement and suppression of miRNA 200-c-3p on non-small cell lung cancer and its impact on immune checkpoint function and subsequently antitumor immunity.
View Article and Find Full Text PDFBackground: Rho kinase (ROCK) pathway plays a critical role in post-COVID-19 pulmonary fibrosis (PCPF) and its intervention with angiotensin-converting enzyme 2 (ACE2) and vascular endothelial growth factor (VEGF) will be a potential therapeutic target.
Objectives: The present study was conducted to investigate the efficacy of zoledronate (ZA) on carbon tetrachloride (CCl4) induced pulmonary fibrosis (PF) in rats through targeting ACE2, ROCK, and VEGF signaling pathways.
Methods: Fifty male Wistar rats were divided into five groups: control, vehicle-treated, PF, PF-ZA 50, and PF-ZA 100 groups.