Modulating Charge Transfer Kinetics along Poly Adenine: Chemical Modifications, Temperature, and Conformational Effects.

The charge transfer (CT) reactions in nucleic acids are crucial for genome damage and repair and nanoelectronics using DNA as a molecular conductor. Previous experimental and theoretical works underlined the significance of nucleic acid structural dynamics on CT kinetics, requiring models that incorporate the dynamics of the nucleic acid, solvents, and counterions. Here, we investigated hole transfer kinetics in poly adenine single and double strands at various temperatures and the rate enhancement due to adenine-to-7-deazaadenine mutation by means of a QM/MM approach.

Are parents with bipolar disorder at higher risk of having offspring with ADHD? A systematic review.

Background: The offspring of parents with bipolar disorder (BD) and with attention deficit hyperactivity disorder (ADHD) have a higher risk of having the same condition. Both disorders also share psychopathological symptoms; however, little is known about their genetic overlap. To examine whether the offspring of parents with BD have a greater chance of being affected by ADHD, we conducted a systematic review.

From Hippocrates to the Ages of Technology: A Narrative Review of the Evolution of the doctor-patient Relationship.

Objectives: Thus, through a narrative review, this article analyzes how the advancement of technology, the use of digital resources, and social media have impacted the doctor-patient relationship.

Methods: We conducted a scoping review on the relationship between Digital Health Equity and Telemedicine and e-health via Scopus and Pubmed electronic databases. The following inclusion criteria were established: papers on the relationship between digital health equity and telemedicine and e-health, written in English and with no time limits.

Adrenal lymphangioma: Case report and review of the literature.

Introduction And Importance: Lymphangiomas (LG) are a rare type of lesion of the lymphatic vessels. They predominantly occur in young patients, mostly female. Adrenal location represents 0.

Coronary Plaque Characteristics Assessed by Optical Coherence Tomography and Plasma Lipoprotein(a) Levels in Patients With Acute Coronary Syndrome.

Background: Lipoprotein(a) [Lp(a)] is associated with increased cardiovascular risk, but its influence on plaque characteristics at optical coherence tomography (OCT) evaluation is not fully understood.

Aims: This study seeks to explore the impact of Lp(a) levels on plaque morphology as assessed by OCT in a very high-risk subset of patients.

Methods: Consecutive patients admitted for acute coronary syndrome (ACS) and undergoing OCT-guided percutaneous coronary intervention (PCI) at a large tertiary care center between 2019 and 2022 were deemed eligible for the current analysis.

Exploring the relationship among hikikomori tendencies, autistic traits, computer game use and eating disorder symptoms.

Objective: The hikikomori phenomenon has recently gained growing global interest, and evidences of its association with other psychopathological dimensions are slowly but steadily emerging. We aimed to evaluate the presence and correlates of hikikomori tendencies in an Italian University population, focusing on its relationships with autism spectrum, pathological computer gaming, and eating disorders. In particular, to our knowledge, no study has yet systematically evaluated the latter association, using psychometric instruments tailored to assess eating disorder symptoms.

Adaptive remodeling of rat adrenomedullary stimulus-secretion coupling in a chronic hypertensive environment.

Chronic elevated blood pressure impinges on the functioning of multiple organs and therefore harms body homeostasis. Elucidating the protective mechanisms whereby the organism copes with sustained or repetitive blood pressure rises is therefore a topical challenge. Here we address this issue in the adrenal medulla, the master neuroendocrine tissue involved in the secretion of catecholamines, influential hormones in blood pressure regulation.

Correction: Mindfulness-Based Cognitive Therapy for Treatment-Resistant Depression: A protocol for systematic review and meta-analysis.

[This corrects the article DOI: 10.1371/journal.pone.

Integration of clinical outcomes and molecular features in extramedullary disease in multiple myeloma.

Multiple myeloma (MM) remains incurable despite novel therapeutics. A major contributor to the development of relapsed/refractory and resistant MM is extraosseous extramedullary disease (EMD), whose molecular biology is still not fully understood. We analyzed 528 MM patients who presented to our institution between 2014 and 2021 and who had undergone molecular testing.

Environmentally Sustainable Preparation of Oleuropein and Its Dialdehydic Derivatives in a Simple Pharmaceutical Formulation.

In this paper, Krapcho's one-step decarbomethoxylation of oleuropein in DES is reported. Oleuropein used as reagent was extracted with water from olive leaves, widely available and inexpensive waste from the olive oil production chain. The reaction has been carried out in a series of ChCl-based DES of increasing acidity, with or without the addition of an amount of water, under microwave and conventional heating.

Evaluation of Criminal Responsibility in a Patient with Fetal Alcohol Syndrome and Intellectual Disability.

The current study presents the case of a young man with intellectual disability related to fetal alcohol syndrome, referred for forensic psychiatric examination of criminal liability following charges of armed robbery, and who was considered not criminally liable. In such cases, it is crucial to perform early diagnosis and rely on educational and developmental services and a supportive home environment to decrease complications such as substance use and criminal involvement.

Revealing hidden risks: in vitro analysis of PFAS hazards in Mytilus galloprovincialis gills and digestive gland.

Per- and polyfluoroalkyl substances (PFAS) are synthetic chemicals known for their persistence and bioaccumulation, leading to widespread environmental contamination. Despite their recognised environmental risks, particularly to aquatic wildlife, including marine invertebrates, detailed impact studies are limited. PFAS can be categorised according to the length of the compound chain, with short-chain PFAS announced as a safer alternative to the more commonly used long-chain PFAS.

Inter- and intra-molecular charge redistributions in H-bonded Cyanuric Acid*Melamine (CA*M) networks: insight from core level spectroscopy and natural bond orbital analysis.

In this work, we elucidate the electronic charge redistributions that occur within the cyanuric acid (CA) and melamine (M) molecules upon formation of the triple H-bond between the imide group of CA and the diaminopyridine group of M. To achieve this, we investigated 2D H-bonded assemblies of M, CA and CA*M grown on the Au(111) surface, using X-ray photoemission (XPS) and near edge X-ray absorption fine structure (NEXAFS) spectroscopies. Compared to the homomolecular networks, the spectra of the mixed sample reveal core level shifts in opposite directions for CA and M, indicating a nearly complementary charge accumulation on the CA molecule and a charge depletion on the M molecule.

Mitigation of Salt Stress in L. var. Gentile Rossa Using Microalgae as Priming Agents.

Using renewable biomass in agriculture, particularly microalgae as a biostimulant, offers economic and environmental sustainability benefits by reducing costs, improving nutrient cycling, and enhancing water use efficiency. Microalgae contain bioactive compounds that boost crop tolerance to environmental stresses, including salinity. Saline soils, characterized by elevated sodium chloride (NaCl) levels, negatively impact many crops, resulting in low productivity and high remediation costs.

Breaking Down Bone Disease in People Living with HIV: Pathophysiology, Diagnosis, and Treatment.

Bone health in people living with HIV (PLWH) has emerged as a significant concern in the era of effective antiretroviral therapy (ART). While ART has transformed HIV infection into a chronic condition, it has also unmasked long-term health complications, including an increased risk of osteoporosis and fractures. This review aims to elucidate the multifactorial mechanisms contributing to bone health deterioration in PLWH, such as direct viral effects, immune activation, and ART-induced bone metabolism changes.

Heritability, phenotypic, and genetic correlations across dimensional and categorical models of bipolar disorder in a family sample.

Background: Bipolar disorder (BD) presents with a wide range of symptoms that vary among relatives, casting doubt on categorical illness models. To address this uncertainty, we investigated the heritability and genetic relationships between categorical and dimensional models of BD in a family sample.

Methods: This retrospective study included participants (n = 397 Females, n = 329 Males, mean age 47 yr) in the Amish-Mennonite Bipolar Genetics (AMBiGen) study from North and South America that were assigned categorical mood disorder diagnoses ("narrow" or "broad") by structured psychiatric interview and completed the Mood Disorder Questionnaire (MDQ), which assesses lifetime history of manic symptoms and associated impairment.

Outcomes of loop ileostomy after rectal resection for cancer: A prospective observational multicenter snapshot study from Multidisciplinary Italian Study group for STOmas (MISSTO).

Background: Diverting ileostomy is a common procedure in rectal cancer surgery, but it is sometimes associated with a nonnegligible rate of complications. The primary aim of this study was to analyze the incidence and types of stoma-related complications for ileostomy creation after rectal cancer resection. The secondary aims were to report the indications, the technical details, and the efficacy of stoma care provided by ostomy nurses.

Selective Lipophilization of Natural Phenolic Alcohols Induced by Choline Chloride-Based Natural Deep Eutectic Solvents.

In this scientific work, a novel and green method for selective lipophilization of EVOO's bioactive phenolic alcohols (PAs), namely, tyrosol, hydroxytyrosol, and its metabolite homovanillyl alcohol as fatty acid esters, is elucidated. The PAs have been employed as hydrogen bond donors in the formation of natural deep eutectic solvents (NADES) with choline chloride (ChCl). The fast and cheap esterification method by formation of choline chloride-based deep eutectic solvents promotes the derivatization of PAs with various fatty acids as acylating agents in the absence of organic solvents and catalysts.

A checklist of Iranian Aderidae (Coleoptera: Tenebrionoidea).

The fauna of Iranian Aderidae (Coleoptera: Tenebrionoidea) includes five species within four genera, Aderus Stephens, 1829 (one species), Cobososia Collado & Alonso-Zarazaga, 1996 (two), Gompelia Alonso-Zarazaga, 2010 (one) and Phytobaenus R.F. Sahlberg, 1834 (one).

Santiago Ramón y Cajal: Artistic legacy in Science, 90 years later.

Ninety years after his death in 1934, the artistic beauty of the innovative brain images created by physician and histologist Santiago Ramón y Cajal, as well as his revolutionary neuroanatomical theory, remains relevant today. As a scientist who isolated brain nerve cells, he visualized them as physically distinct entities, answering one of the most crucial questions of his time. Prior to his work, the prevailing belief was in the reticular theory, which suggested that nervous tissue was continuous and formed a network of interconnected cells.