LINC01152 upregulates MAML2 expression to modulate the progression of glioblastoma multiforme via Notch signaling pathway.

Glioblastoma multiforme (GBM) brings serious physical and psychological pain to GBM patients, whose survival rate remains not optimistic. Long noncoding RNAs (lncRNAs) have been reported to participate in the progression of many cancers, including GBM. However, the mechanism and function of long intergenic non-protein coding RNA 1152 (LINC01152) in GBM are still unclear.

Adaptively Learning Facial Expression Representation via C-F Labels and Distillation.

Facial expression recognition is of significant importance in criminal investigation and digital entertainment. Under unconstrained conditions, existing expression datasets are highly class-imbalanced, and the similarity between expressions is high. Previous methods tend to improve the performance of facial expression recognition through deeper or wider network structures, resulting in increased storage and computing costs.

Raw cellulose/polyvinyl alcohol blending separators prepared by phase inversion for high-performance supercapacitors.

The development of a biodegradable cellulose-based separator with excellent performance has been of great research significance and application potential for the green development of supercapacitors. Herein, the regenerated porous cellulose/Polyvinyl alcohol films (CP-10, CP-15, CP-20, CP-25) with different mass ratio were successfully fabricated by a simple blending and phase inversion process. Their electrochemical properties as separators in assembled supercapacitor were evaluated.

Direct and Bicarbonate-Induced Iron Deficiency Differently Affect Iron Translocation in Kiwifruit Roots.

Bicarbonate-induced iron (Fe) deficiency (+Bic) is frequently observed in kiwifruit orchards, but more research attention has been paid to direct Fe deficiency (-Fe) in plants, including kiwifruit. Here we compared the differences of kiwifruit plants between -Fe and +Bic in: (1) the traits of Fe uptake and translocation within plants, (2) Fe forms in roots, and (3) some acidic ions and metabolites in roots. The concentration of Fe derived from nutrient solution (Fedfs) in roots was less reduced in +Bic than -Fe treatment, despite similar decrease in shoots of both treatments.

Anxiety of Nurses to support Wuhan in fighting against COVID-19 Epidemic and its Correlation With Work Stress and Self-efficacy.

Aims And Objectives: We aimed to investigate the anxiety of nurses who are supporting Wuhan in fighting against coronavirus disease 2019 (COVID-19) infection and explore relevant influencing factors.

Background: The COVID-19 outbreak poses a major threat to public health worldwide. Nurses play an important role in this epidemic.

Gas-generating mesoporous silica nanoparticles with rapid localized drug release for enhanced chemophotothermal tumor therapy.

Chemophotothermal combination therapy has emerged as a novel and promising strategy to treat cancer. To improve anticancer effectiveness and reduce systemic toxicity, it is essential to trigger drug release at tumor sites or within tumor cells for maximal drug exposure. Herein, we constructed gas-generating mesoporous silica nanoparticles (MSNs) that can load ammonium bicarbonate (ABC) and doxorubicin (DOX) within the pores, encapsulate indocyanine green (ICG) onto the polydopamine (PDA) layer, and modify the RGD peptide on the outer surface [denoted as M(abc)-DOX@PDA-ICG-PEG-RGD] for triggered drug release and targeted chemophotothermal combination therapy.

Recent Advances in Supported Metal Catalysts and Oxide Catalysts for the Reverse Water-Gas Shift Reaction.

The reverse water-gas shift reaction (RWGSR), a crucial stage in the conversion of abundant CO into chemicals or hydrocarbon fuels, has attracted extensive attention as a renewable system to synthesize fuels by non-traditional routes. There have been persistent efforts to synthesize catalysts for industrial applications, with attention given to the catalytic activity, CO selectivity, and thermal stability. In this review, we describe the thermodynamics, kinetics, and atomic-level mechanisms of the RWGSR in relation to efficient RWGSR catalysts consisting of supported catalysts and oxide catalysts.

Knowledge Distillation for Face Photo-Sketch Synthesis.

Significant progress has been made with face photo-sketch synthesis in recent years due to the development of deep convolutional neural networks, particularly generative adversarial networks (GANs). However, the performance of existing methods is still limited because of the lack of training data (photo-sketch pairs). To address this challenge, we investigate the effect of knowledge distillation (KD) on training neural networks for the face photo-sketch synthesis task and propose an effective KD model to improve the performance of synthetic images.

Wavelet-Based Dual Recursive Network for Image Super-Resolution.

Although remarkable progress has been made on single-image super-resolution (SISR), deep learning methods cannot be easily applied to real-world applications due to the requirement of its heavy computation, especially for mobile devices. Focusing on the fewer parameters and faster inference SISR approach, we propose an efficient and time-saving wavelet transform-based network architecture, where the image super-resolution (SR) processing is carried out in the wavelet domain. Different from the existing methods that directly infer high-resolution (HR) image with the input low-resolution (LR) image, our approach first decomposes the LR image into a series of wavelet coefficients (WCs) and the network learns to predict the corresponding series of HR WCs and then reconstructs the HR image.

Rapid Development of an Effective Newcastle Disease Virus Vaccine Candidate by Attenuation of a Genotype VII Velogenic Isolate Using a Simple Infectious Cloning System.

Genotype-matched vaccines provide ideal protection against infection caused by new Newcastle disease virus (NDV) genotypes or variants even in the vaccinated chickens. In this study, we report a protocol for attenuation and rapid development of a velogenic NDV isolate as an effective vaccine candidate, using a simple and reliable infectious cloning platform. Based on DHN3, a genotype VII velogenic NDV isolate, recombinant rDHN3 was rescued by co-transfection of plasmids expressing the genomic RNA, NDV proteins NP, P and L, and the T7 polymerase without using a helper virus.

Current Research of Graphene-Based Nanocomposites and Their Application for Supercapacitors.

This review acmes the latest developments of composites of metal oxides/sulfide comprising of graphene and its analogues as electrode materials in the construction of the next generation of supercapacitors (SCs). SCs have become an indispensable device of energy-storage modes. A prompt increase in the number of scientific accomplishments in this field, including publications, patents, and device fabrication, has evidenced the immense attention they have attracted from scientific communities.

Phase Behavior and Thermo-Mechanical Properties of IF-WS Reinforced PP-PET Blend-Based Nanocomposites.

The industrial advancement of high-performance technologies directly depends on the thermo-mechanical properties of materials. Here we give an account of a facile approach for the bulk production of a polyethylene terephthalate (PET)/polypropylene (PP)-based nanocomposite blend with Inorganic Fullerene Tungsten Sulfide (IF-WS) nanofiller using a single extruder. Nanofiller IF-WS was produced by the rotary chemical vapor deposition (RCVD) method.

Soil mixing with organic matter amendment improves Albic soil physicochemical properties and crop yield in Heilongjiang province, China.

Crop productivity in Albic soil is poor, owing to poor soil physicochemical properties. Mixing of Aw layers, representing Albic soil, with B layers, could improve the physicochemical properties of Albic soil, which is characterized by poor humus on the topsoil and high penetration resistance. The objective of the present study conducted in 2015-2016 in an Albic soil region in Heilongjiang province, China, was to explore the effects of different soil mixing strategies on the physicochemical properties of Albic soil and crop yield.

Calcium dobesilate mediates renal interstitial fibrosis and delay renal peritubular capillary loss through Sirt1/p53 signaling pathway.

Calcium dobesilate (Cad), a protective agent, protects against microvascular damage, and diseases such as diabetic retinopathy and diabetic nephropathy. However, these vascular protective effects have not been demonstrated in chronic kidney disease (CKD). In this study, we aimed to determine the ability of Cad to protect against renal interstitial fibrosis induced by unilateral ureteral obstruction (UUO) and identify the underlying therapeutic mechanisms of Cad during hypoxia/serum deprivation (H/SD) in human umbilical vein endothelial cells (HUVECs).

Emergence and evolution of highly pathogenic porcine epidemic diarrhea virus by natural recombination of a low pathogenic vaccine isolate and a highly pathogenic strain in the gene.

Outbreaks of a new variant of porcine epidemic diarrhea virus (PEDV) at the end of 2010 have raised interest in the mutation and recombination of PEDV. A PEDV strain (CN/Liaoning25/2018) isolated from a clinical outbreak of piglet diarrhea contained a 49-bp deletion in the gene. This deletion is considered a genetic characteristic of low pathogenic attenuated vaccine strains.

Effects of high-quality nursing care on psychological outcomes and quality of life in patients with hepatocellular carcinoma: A protocol of systematic review and meta-analysis.

Background: High quality nursing care (HQNC) has been reported to effectively prevent psychological disorders and improve the quality of life (QoL) in patients with hepatocellular carcinoma (HCC) during the treatment. However, the exact effect of HQNC remains controversial. This systematic review will be aimed to assess the effectiveness of HQNC on psychological disorders and QoL in patients with HCC.

Universal Face Photo-Sketch Style Transfer via Multiview Domain Translation.

Face photo-sketch style transfer aims to convert a representation of a face from the photo (or sketch) domain to the sketch (respectively, photo) domain while preserving the character of the subject. It has wide-ranging applications in law enforcement, forensic investigation and digital entertainment. However, conventional face photo-sketch synthesis methods usually require training images from both the source domain and the target domain, and are limited in that they cannot be applied to universal conditions where collecting training images in the source domain that match the style of the test image is unpractical.

Studies on the role of IS1216E in the formation and dissemination of poxtA-carrying plasmids in an Enterococcus faecium clade A1 isolate.

Objectives: To analyse the role of IS1216E in the dissemination of the phenicol-oxazolidinone-tetracycline resistance gene poxtA in an Enterococcus faecium clade A1 isolate.

Methods: MICs were determined by broth microdilution. The poxtA-positive isolate was typed by MLST.

Dual activatable self-assembled nanotheranostics for bioimaging and photodynamic therapy.

Multifunctional nanosystems that can transport therapeutic and diagnostic agents into tumor sites and activate their respective functions via tumor-microenvironment recognition are highly desirable for clinical applications. We fabricated pH and redox dual-activatable self-assembled nanotheranostics (named as DA-SNs) via coordination-driven self-assembly of chlorin e6 (Ce6) disulfide-linked pH sensitive polymer ligand, poly (isobutylene-alt-maleic anhydride-graft-methoxy-poly (ethyleneglycol)-graft-imidazole-graft-Cystamine-Ce6) [PIMA-mPEG-API-SS-Ce6], and gadolinium ions (Gd). DA-SNs exhibited uniform particle size of ~48 nm, excellent stability, and inherent biosafety.

Haemodynamic mechanism of formation and distribution of coronary atherosclerosis: A lesion-specific model.

Coronary arterial disease, as the most devastated cardiovascular disease, is caused by the atherosclerosis in the coronary arteries, which blocks the blood flow to the heart, resulting in the deficient supply of oxygen and nutrition to the heart, and eventually leading to heart failure. To date, haemodynamic mechanisms for atherosclerosis development are not fully understood although it is believed that the haemodynamic disturbance at the region of the arterial bifurcation, particular, bifurcation angle, plays an important role in the atherosclerosis development. In this study, two types of computational fluid dynamics models, lesion-specific and idealized models, combined with the computer tomography imaging techniques, are used to explore the mechanism of formation and distribution of the atherosclerosis around the bifurcation of left coronary artery and its association with the bifurcation angle.

Regulation of Female Germline Specification via Small RNA Mobility in Arabidopsis.

In the ovules of most sexually reproducing plants, one hypodermal cell differentiates into a megaspore mother cell (MMC), which gives rise to the female germline. -acting small interfering RNAs known as tasiR-ARFs have been suggested to act non-cell-autonomously to prevent the formation of multiple MMCs by repressing () expression in Arabidopsis (), but the underlying mechanisms are unknown. Here, we examined tasiR-ARF-related intercellular regulatory mechanisms.

Overcoming Autocrine FGF Signaling-Induced Heterogeneity in Naive Human ESCs Enables Modeling of Random X Chromosome Inactivation.

Primed and naive human embryonic stem cells (hESCs) do not fully recapitulate the X chromosome status observed in human preimplantation epiblast and fail to initiate random X chromosome inactivation (XCI) upon differentiation. Therefore, an ideal system for studying XCI during early human development is yet to be established. We show that incomplete blocking of autocrine fibroblast growth factor 2 (FGF2) signaling in naive hESCs drives significant heterogeneity in X chromosome and pluripotency status.

Flexible Conductive Cellulose Network-Based Composite Hydrogel for Multifunctional Supercapacitors.

With the continuous development of energy storage devices towards sustainability and versatility, the development of biomass-based multi-functional energy storage devices has become one of the important directions. In this study, a symmetric dual-function supercapacitor was constructed based on a cellulose network/polyacrylamide/polyaniline (CPP) composite hydrogel. The presented supercapacitor, with excellent electrochemical performance and an areal capacitance of 1.

Detecting Cysteine in Bioimaging with a Near-Infrared Probe Based on a Novel Fluorescence Quenching Mechanism.

Near-infrared (NIR) fluorescent probes are very significant for detecting cysteine in biological systems. Herein, we report a highly selective and sensitive NIR turn-on fluorescent probe (BDP-NIR) based on BODIPY with large Stokes shift (105 nm) for detecting Cys. We clarified the sensing mechanism based on the different thiol-induced S Ar substitution/rearrangement reaction of the probe with cysteine and homocysteine/glutathione, which leads to the corresponding amino- and thiol-BODIPY dyes with distinct photophysical properties.

BODIPY-based Fluorescent Probe for the Detection of Cysteine in Living Cells.

Cysteine (Cys), as one of the important amino acids, plays a vital role in various physiological and pathological processes. Hence, it is meaningful to develop a convenient and sensitive detection method. Herein, a novel BODIPY-based fluorescent probe (BDP-DM) was developed, which had a higher selectivity for Cys than other amino acids, including homocysteine (Hcy) and glutathione (GSH).