Job burnout and resilience among palliative care professionals in china: a qualitative study.

Background: Medical professionals who are engaged in palliative care commonly experience negative emotions resulting from the pain and grief experienced by patients and family members, which results in enormous psychological pressure for professionals, and the risk related to job burnout is significantly greater.

Objective: We aimed to explore the factors influencing job burnout and resilience among palliative care professionals.

Methods: We conducted a qualitative study using semistructured interviews and purposeful sampling methods.

Factors influencing changes in the quality of life of the Hainan migratory population with hypertension: a survey of the Chengmai mangrove bay community.

Background: Hainan is a tropical island in China with a large migratory population. Study have reported that the blood pressure of Hainan elderly hypertensive migratory population decreased significantly, which may be related to the improvement of environment and quality of life (QoL). Understanding the changes of QoL of these people before and after coming to Hainan and its influencing factors can provide a basis for the prevention and control of hypertension.

A multi-feature dataset of coated end milling cutter tool wear whole life cycle.

Deep learning methods have shown significant potential in tool wear lifecycle analysis. However, there are fewer open source datasets due to the high cost of data collection and equipment time investment. Existing datasets often fail to capture cutting force changes directly.

Integrating Ultra-High-Performance Liquid Chromatography and Orbitrap High-Resolution Mass Spectrometry, Feature-Based Molecular Networking, and Network Medicine to Unlock Harvesting Strategies for Endangered Sinocalycanthus Chinensis.

Evaluating the practical utility of endangered plant species is crucial for their conservation. Nevertheless, numerous endangered plants, including Sinocalycanthus chinensis, lack historical usage data, leading to a paucity of guidance in traditional pharmacological research. This gap impedes their development and potential utilization.

Influence of nutritional guidance during pregnancy on nutritional status and pregnancy outcome of pregnant women.

This study was an original article, mainly aimed to explore the influence of nutritional guidance during pregnancy on nutritional status and pregnancy outcome of pregnant women. Two hundred (200) pregnant women were admitted to the Nanjing General Hospital of Nanjing Military Command from May 2021 to May 2023. They were randomly sub-divided into a control group and an intervention group.

EXPRESS: Fluorouracil enhances the anti-pancreatic cancer effect of anti-PD-L1 antibodies via up-regulating the expression of PD-L1 in cancer cells.

Pancreatic cancer is characterized by occult onset, low early diagnosis rate, rapid progress, and poor prognosis. Due to the low response rate and low PD-L1 expression in pancreatic cancer, the therapeutic application of PL-L1 inhibitors in pancreatic cancer is greatly limited. In vitro studies showed that the expression of PD-L1 increased in pancreatic cancer cells stimulated by fluorouracil (5-FU).

County-Level Integrated Healthcare Practice in China: A Kaiser Permanente-Inspired Approach.

Introduction: China's rapidly aging population and rise in chronic diseases put immense strain on the country's healthcare system. To address these challenges, Yuhuan People's Hospital established County-level Integrated Health Organization (CIHO) as part of the Healthy China 2030 initiative.

Description: Based on the Kaiser Permanente (KP) model, the CIHO takes a multi-disciplinary, collaborative approach to deliver integrated care.

Ocular hypertension after silicone oil filling surgery for high myopia: a case-control study.

Purpose: This study aims to examine the correlation between specific clinical parameters, such as axial eye length, and the onset of ocular hypertension "OH" following the use of silicone oil filling in patients with high myopia.

Method: In this retrospective analysis, we reviewed 214 eyes from 432 patients diagnosed with severe myopia, all of whom underwent vitrectomy and were treated with silicone oil filling. The study aimed to document the incidence and timing of postoperative ocular hypertension "OH" while assessing various factors, including demographic details, medical history, additional surgical interventions, and findings from supplementary examinations (such as axial length, silicone oil emulsification, and anterior chamber penetration).

Molecular characterization of avian pathogenic Escherichia coli strains in Jiangxi Province, China, and development of polyvalent inactivated vaccines.

Avian pathogen Escherichia coli (APEC) poses a significant threat to poultry farming, causing colibacillosis in various hosts, including chickens, ducks, geese, and pigeons. This study aimed to investigate the molecular epidemiology of APEC in Jiangxi Province, China, to inform prevention and control strategies. Between 2020 and 2024, 186 APEC strains were isolated and identified, with 88.

Non-targeted and targeted detection of hydrophilic compounds in fu brick tea: A study on samples from major Chinese production regions and different processing stages.

Systematic research is still lacking on the content of hydrophilic compounds in Fu Brick Tea (FBT) from major Chinese production regions and their variation patterns during the processing of FBT. This study utilized optimized non-targeted (UHPLC-Q-Exactive Orbitrap-MS) and targeted (UHPLC-QqQ-MS) metabolomics to analyze 73 FBT samples from six regions of China and 30 samples from different stages of FBT processing. 573 and 74 hydrophilic compounds were respectively relatively and absolutely quantified for the first time.

Screening for retinopathy of prematurity in China: a five-year cohort study in seven screening centers.

Background: To analyze the demographic characteristics of retinopathy of prematurity (ROP) in China, attempting to propose optimized screening criteria and hopefully providing valuable information for future updates to the ROP guideline.

Methods: A multicenter, retrospective-cohort study was conducted. The study included infants born between January 1, 2018, and July 31, 2023, who underwent ROP screening and were diagnosed with ROP at seven screening centers in China.

Associations between heavy metal exposure and vascular age: a large cross-sectional study.

Background: Heavy metal exposure is an emerging environmental risk factor linked to cardiovascular disease (CVD) through its effects on vascular ageing. However, the relationship between heavy metal exposure and vascular age have not been fully elucidated.

Methods: This cross-sectional study analyzed data from 3,772 participants in the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2016.

Epidemiological Features of Sinonasal Adenocarcinoma and Prognostic Nomogram: A Study Based on the SEER Database.

Objective: Our study aimed to update demographic profiles of sinonasal adenocarcinoma (SNAC) between 2000 and 2020, identify independent prognostic risk factors, and devise a predictive nomogram for overall survival (OS).

Methods: Utilizing the Surveillance, Epidemiology, and End Results (SEER) database, cases of SNAC from 2000 to 2020 were analyzed for incidence trends. Univariate and multivariate Cox regression models helped pinpoint factors impacting patient survival.

[Evodiamine enhances the killing effect of NK cells on small cell lung cancer by regulating BIRC5].

Objective To investigate the effects of evodiamine (EVO) on Natural Killer (NK) cell-mediated killing in small cell lung cancer (SCLC) cells via affecting baculoviral inhibitor of apoptosis repeat containing 5 (BIRC5). Methods H446 cells and NK-92 cells were treated with EVO at different concentrations, and cell proliferation was detected using the MTT (3-(4, 5-Dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide) assay, while cell invasion was assessed using the Transwell assay. NK-92 cells and H446 cells were co-cultured at different effector-to-target ratios to detect the cytotoxicity of NK cells against H446 cells and the level of degranulation in NK-92 cells.

Garlic-Derived Quorum Sensing Inhibitors: A Novel Strategy Against Fungal Resistance.

In recent years, the incidence of fungal infections has been rising annually, especially among immunocompromised populations, posing a significant challenge to public health. Although antifungal medications provide some relief, the escalating problem of resistance sharply curtails their effectiveness, presenting an urgent clinical dilemma that demands immediate attention. Research has shown that fungal resistance is closely related to quorum sensing (QS), and QS inhibitors (QSIs) are considered an effective solution to this issue.

Generation of perthiyl radicals for the synthesis of unsymmetric disulfides.

Unsymmetric disulfides are prevalent in natural products and are essential in medicinal chemistry and materials science, but their robust synthesis poses significant challenges. In this paper, we report an expeditous transition-metal-free methodology for synthesizing unsymmetric disulfides through the addition of perthiyl radicals to alkenes. This study marks the use of generating perthiyl radicals by reacting SO with unactivated alkyl (pseudo)halides (Cl/Br/I/OTs).

Unusual violation of the Wiedemann-Franz law at ultralow temperatures in topological compensated semimetals.

Thermal conductivity and electrical resistivity at ultralow temperatures and high magnetic fields are studied in the topological compensated semimetals TaAs, NbAs, and NdSb. A striking phenomenon is observed where the thermal conductivity shows a T scaling at very low temperatures, while the resistivity shows a T-independent residual term. This indicates a strong violation of the Wiedemann-Franz (WF) law, since the field dependence of κ shows that the low-temperature thermal conductivity is dominated by electronic transport.

Cost-effectiveness analysis of anlotinib plus chemotherapy with or without benmelstobart versus chemotherapy alone for extensive-stage small-cell lung cancer in China.

Objectives: The ETER701 trial demonstrated that benmelstobart combined with anlotinib and etoposide-carboplatin (EC) significantly extends survival in patients with extensive-stage small cell lung cancer (ES-SCLC), setting a new record for median overall survival. In contrast, anlotinib plus EC only significantly prolongs progression-free survival. However, there is currently no evidence evaluating the cost-effectiveness of these regimens as first-line treatments.

Metabolic Reprograming of Macrophages: A New Direction in Traditional Chinese Medicine for Treating Liver Failure.

Acute liver failure (ALF) is a fulminant clinical syndrome that usually leads to multiple organ failure and high mortality. Macrophages play a crucial role in the initiation, development, and recovery of ALF. Targeting macrophages through immunotherapy holds significant promise as a therapeutic strategy.

Comparative transcriptome analysis of albino northern snakehead (Channa argus) reveals its various collagen-related DEGs in caudal fin cells.

The albino northern snakehead (Channa argus) is an aquaculture species characterized by heritable albino body color, in contrast to the typical coloration. Additionally, there are gray- and golden-finned individuals, which exhibit distinct coloration in their caudal fins. We performed RNA-seq to profile the transcriptome of caudal fin tissues in albino gray-finned and golden-finned C.

Electron Transport Chains Promote Selective Photocatalytic Conversion of CO to Methanol.

The photocatalytic conversion of carbon dioxide (CO) into "liquid sunshine" methanol (CHOH) using semiconductor catalysts has garnered significant attention. Increasing the number of effective electrons and regulating reaction pathways is the key to improving the activity and selectivity of CHOH. Due to the electron transport properties of semiconductor heterojunctions and reduced graphene oxide (rGO), a CoS/CoS-rGO nanocomposite was constructed and applied to the photocatalytic reduction of CO to CHOH.

Sliding ferroelectric memories and synapses based on rhombohedral-stacked bilayer MoS.

Recent advances have uncovered an exotic sliding ferroelectric mechanism, which endows to design atomically thin ferroelectrics from non-ferroelectric parent monolayers. Although notable progress has been witnessed in understanding the fundamental properties, functional devices based on sliding ferroelectrics remain elusive. Here, we demonstrate the rewritable, non-volatile memories at room-temperature with a two-dimensional (2D) sliding ferroelectric semiconductor of rhombohedral-stacked bilayer MoS.

Medium-scale flexible integrated circuits based on 2D semiconductors.

Two-dimensional (2D) semiconductors, combining remarkable electrical properties and mechanical flexibility, offer fascinating opportunities for flexible integrated circuits (ICs). Despite notable progress, so far the showcased 2D flexible ICs have been constrained to basic logic gates and ring oscillators with a maximum integration scale of a few thin film transistors (TFTs), creating a significant disparity in terms of circuit scale and functionality. Here, we demonstrate medium-scale flexible ICs integrating both combinational and sequential elements based on 2D molybdenum disulfide (MoS).

Multicopy subtelomeric genes underlie animal infectivity of divergent Cryptosporidium hominis subtypes.

The anthroponotic Cryptosporidium hominis differs from the zoonotic C. parvum in its lack of infectivity to animals, but several divergent subtypes have recently been found in nonhuman primates and equines. Here, we sequence 17 animal C.