Publications by authors named "Muskan"

Diabetes mellitus (DM) is a long-term metabolic disorder caused by inadequate production and resistance to insulin. The prevalence of DM is rapidly increasing, with type 2 diabetes (T2D) accounting for more than 90% of cases. Despite new treatments, many patients with T2D do not meet their glycemic targets due to clinical inertia.

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  • - A new trisazo dipyridyl ligand and its copper(I) complex were created and analyzed, with the complex demonstrating a unique five-coordinate geometry and effective redox activity due to its low-lying π* orbital.
  • - The strong π-acceptor nature of the ligand led to an anodic Cu(II)/Cu(I) redox potential of 0.62 V, with various spectroscopic techniques and DFT calculations employed to investigate the redox events of both the ligand and the complex.
  • - The ligand's ability to facilitate multiple reductions allowed for successful Glaser coupling reactions with terminal alkynes, showing that the ligand played a key role in substrate interaction and bond formation, while the metal acted mainly
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Objective: The study was aimed at the synthesis and pharmacological investigation of (4Z)-4-(2-hydroxybenzylidine)-5-methyl-2-(pyridine-3-ylcarbonyl)-2, 4-dihydro-3H-pyrazole-3-one (IIc) in mice model of scopolamine-induced neurodegeneration and cognition impairment.

Methods: The behavioural studies included Y-Maze Test, Water Morris Test, and Novel Object Recognition Test in Albino mice (20-25 g). Scopalamine was used as an inducing agent.

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  • * They utilize biodegradable and environmentally friendly materials, often including cholesterol and common surfactants like Tween 20 and Span 60, to package various medications effectively.
  • * The article discusses the thin film hydration method for creating niosomes, emphasizes the importance of optimal ingredient ratios and production processes, and highlights current research and commercial applications in fields like pharmaceuticals and cosmetics.
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Antimicrobial resistance poses a global health concern and develops a need to discover novel antimicrobial agents or targets to tackle this problem. Fluoroquinolone (FN), a DNA gyrase and topoisomerase IV inhibitor, has helped to conquer antimicrobial resistance as it provides flexibility to researchers to rationally modify its structure to increase potency and efficacy. This review provides insights into the rational modification of FNs, the causes of resistance to FNs, and the mechanism of action of FNs.

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Objective: Despite the historical neurological use of Withania somnifera, limited evidence supports its efficacy for conditions like anxiety and insomnia. Given its known anti-stress properties, this review evaluated its safety and efficacy for anxiety and insomnia.

Methods: We searched Medline, Cochrane Library, and Google Scholar until August 2023 for randomized controlled trials (RCTs) comparing W.

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Introduction: Mucoceles, characterized by cystic lesions with sterile mucus accumulation, mostly occur in the paranasal but rarely affect the temporal-mastoid bone. The pathogenesis involves obstruction of natural drainage or cyst enlargement. Here, the authors present a rare case of temporal-mastoid mucocele with temporal hypertrophy.

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A new, easy-to-prepare, and highly selective fluorescent chemosensor, , 5-aminoisophthalate-based kojic acid-appended bis-1,2,3-triazole, was synthesized from an alkyne of 5-aminoisophthalic acid and azido-kojic acid using Cu(i)-catalyzed click chemistry and then successfully characterized. The alkyne structure of 5-aminoisophthalic acid, 1, was supported by the single-crystal X-ray crystallographic data. The fluorescent probe 3 was found to be highly selective for Cu ions supported by the Job's plot with a stoichiometric ligand : metal ratio of 2 : 1, exhibiting almost a two-fold enhancement in the emission intensity upon the addition of Cu ions (0-25 μM) with a detection limit of 8.

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Public transportation is an important mode of transportation in developing countries like Pakistan since it is accessible and convenient. But there are also serious health hazards associated with it, especially when it comes to the transmission of infectious diseases including COVID-19, TB, and . Worldwide transportation systems are vulnerable, as the COVID-19 pandemic has shown, underscoring the necessity for study and mitigating measures.

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The micellization of choline-based anionic surface-active ionic liquids (SAILs) having lauroyl sarcosinate [Sar], dodecylsulfate [DS], and deoxycholate [Doc] as counter-ions was investigated in an aqueous medium. Density functional theory (DFT) was employed to investigate the net interactional energy (), extent of non-covalent interactions, and band gap of the choline-based SAILs. The critical micelle concentration (cmc) along with various parameters related to the surface adsorption, counter-ion binding (), and polarity of the cores of the micelles were deduced employing surface tension measurements, conductometric titrations and fluorescence spectroscopy, respectively.

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Introduction And Importance: Infantile tremor syndrome (ITS) affects children aged 6-18 months, and is characterized by tremors, pallor, developmental regression, skin pigmentation changes, and sparse hypopigmented hair. This case report highlights an ITS presentation in a 16-month-old exclusively breastfed male, emphasizing the significance of complementary feeding.

Case Presentation: The patient presented with abnormal body movements, loss of developmental milestones, hyperpigmented skin changes, hypopigmented scalp hairs, pallor, and microcephaly.

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Article Synopsis
  • Exosomes are tiny particles released by cells that can carry important molecules, like RNA, proteins, and DNA, from one cell to another.
  • They are useful for new treatments because they protect RNA from being broken down by the body and can help control gene activity, which could help with various diseases.
  • The review talks about how these exosomes are made, how to load them with RNA, and their advantages for delivering medicines, especially for serious conditions like cancer and brain diseases.
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-Alkynylaryl 2-cyanoacrylates have been disclosed as a new synthon for the regioselective synthesis of isoquinolones and naphthyridinones under mild reaction conditions. The attractive feature of this investigation includes carbon-carbon double bond cleavage under metal-free conditions by an intramolecular S2 reaction. Incorporating two distinct C-I bonds in the resulting products provides facile opportunity for structural elaboration.

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Thiazolidinedione has been used successfully by medicinal chemists all over the world in the development of potent antidiabetic derivatives. The few compounds with excellent antidiabetic potency that we have identified in this review could be used as a lead for further research into additional antidiabetic mechanisms. The information provided in this review regarding the design, biological activity, structure-activity relationships, and docking studies may be useful for scientists who wish to further explore this scaffold in order to fully utilize its biological potential and develop antidiabetic agents that would overcome the limitations of currently available medications for the treatment of diabetes.

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Introduction And Importance: Chronic otitis media can lead to dreadful intracranial complications, the most common being meningitis. A concomitant finding of thrombosis in more than one sinus with a cerebral vein is extremely rare. Septic sigmoid sinus thrombosis has an infectious origin and the treatment is debatable between antibiotics and surgery.

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The cleaning solution for the post-chemical mechanical planarization (post-CMP) process of tungsten in neutral-alkaline media requires corrosion inhibitors as an additive, especially for advanced devices where the device node size shrinks below 10 nm. In the present study, the corrosion inhibition performance of benzethonium chloride (BTC) is evaluated in neutral-alkaline conditions. The electrochemical impedance spectroscopy (EIS) analysis showed ∼ 90 % of corrosion inhibition efficiency with an optimum concentration of 0.

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Unlabelled: Guillain-Barré syndrome (GBS) is an immune-mediated disorder of the central nervous system presenting as symmetrical, progressive weakness and areflexia. The incidence of GBS is very low during pregnancy, but the risk increases in the postpartum period. The management is done by intravenous immunoglobulin or conservatively.

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A regioselective tandem approach for annulated napthyridines/isoquinolines embedded with the phosphine oxide group under mild reaction conditions has been achieved in good to excellent yields. The designed strategy involves the triflate-induced formation of new C sp-P and C sp-N bond formation in one pot. This protocol was also well tolerated for the construction of densely functionalized organo-phosphorylated chromenes in good yields.

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Background: Aggressive Angiomyxoma is a benign, slowly growing, locally aggressive and recurrent tumour that occurs in the pelvic-perineal region of females in their reproductive years. It presents as a painless, soft, gelatinous mass and metastasizes rarely. Suspicion can be made based on clinical examination and radiological imaging but final diagnosis is confirmed only after histopathology and immunohistochemistry.

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Humans' great and quick technological breakthroughs in the previous decade have undoubtedly influenced how surgical procedures are executed in the operating room. AI is becoming incredibly influential for surgical decision-making to help surgeons make better projections about the implications of surgical operations by considering different sources of data such as patient health conditions, disease natural history, patient values, and finance. Although the application of artificial intelligence in healthcare settings is rapidly increasing, its mainstream application in clinical practice remains limited.

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A variation in the size of metal nanoparticles leads to a difference in their properties. As the size of metal nanoparticles decreases, the surface area increases which leads to an increase in the reactivity of metal nanoparticles. Metals like Au, Ag, Pd, and Pt have interesting properties when used in nanometric dimensions.

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Road traffic injuries cost countries 3% of their annual GDP. In developing countries like India, every year around 150,000 people die on roads. The type of vehicles involved in a crash contribute majorly to the outcome of casualty (injury/death).

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Article Synopsis
  • * A study of 137 undergraduate females from BP Koirila Institute showed that 94.89% reported menstrual abnormalities, with dysmenorrhea and pre-menstrual syndrome being the most frequent.
  • * Despite the high prevalence and negative effects on academics and social life, only 75.38% of those affected sought medical treatment.
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The NF1 gene encodes for neurofibromin protein, which is ubiquitously expressed, but most highly in the central nervous system. Non-synonymous SNPs (nsSNPs) in the NF1 gene were found to be associated with Neurofibromatosis Type 1 disease, which is characterized by the growth of tumors along nerves in the skin, brain, and other parts of the body. In this study, we used several in silico predictions tools to analyze 16 nsSNPs in the RAS-GAP domain of neurofibromin, the K1444N (K1423N) mutation was predicted as the most pathogenic.

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