Disturbances in cognitive activity and its neuropharmacological correction in structural-functional insufficiency of the head of the caudate nucleus in cats.

The participation of the head of the caudate nucleus in the organization of praxis, perception, gnosis, and "ideational operations" has been demonstrated. The broad spectrum of dysfunctions observed in the presence of caudate insufficiency was eliminated by a specific set of psychotropic preparations acting on classical neuromediator systems of the brain of cats.

The neuropharmacological restoration of cognitive functions of cats following a lesion to the basal nuclei of the forebrain (Meynert's nucleus).

The functions of generalization and abstraction in an experimental model of Alzheimer's disease (the lesion of Meynert's nuclei in cats) were studied against the background of stimulation and inhibition of the cholinergic, GABAergic, and dopaminergic systems of the brain. It was demonstrated that the cholinergic system is a key system for the formation of the function of generalization, the dopaminergic system improves simple forms of learning, while the GABAergic system is actively involved in the establishment of complex types of associations.