Publications by authors named "Ming-Long Yeh"

Introduction: Vascular access (VA) is essential for patients with hemodialysis, and its dysfunction is a major complication that can reduce quality of life or even threaten life. VA patency is not only difficult to predict on an individual basis, but also challenging to predict in real-time. To overcome this challenge, this study aimed to develop a machine learning approach to predict 6-month primary patency (PP) using photoplethysmography (PPG) signals acquired from the tips of both index fingers.

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Biodegradable metals offer significant advantages by reducing the need for additional surgeries following bone fixation. These materials, with their optimal mechanical and degradable properties, also mitigate stress-shielding effects while promoting biological processes essential for healing. This study investigated the in vitro and in vivo biocompatibility of ZK60 magnesium alloy coated with a micro-arc oxidative layer incorporated with cerium oxide nanoparticles in orthopedic implants.

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  • * Research found that Mg levels in wound tissue fluid are significantly lower than in blood serum, leading to the development of a Mg- or Mg-silver (Ag)-based dressing to assess its effects on healing.
  • * The Mg-Ag dressing not only maintains good cell compatibility and releases Mg and Ag effectively, but also enhances antibacterial properties and supports wound repair by promoting blood vessel formation and cell proliferation.
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  • - The study addresses the limitations of traditional mass spectrometry (MS) for intact protein analysis, particularly due to large protein sizes and slow ion flight speeds which lead to low sensitivity and resolution.
  • - A new compact ion trap-mass spectrometry method is proposed to enhance the detection of protein ions, utilizing a specially designed radio frequency waveform to minimize ion motion disturbances and improve spectral quality.
  • - This method successfully measured cytochrome C proteins with a resolution of 20 Da and demonstrated quick scanning capabilities for other proteins, showcasing its potential for high-resolution protein analysis.
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Articular cartilage regeneration is a major challenge in orthopedic medicine. Endothelial progenitor cells (EPCs) are a promising cell source for regenerative medicine applications. However, their roles and functions in cartilage regeneration are not well understood.

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  • Articular cartilage has limited natural healing abilities, making regeneration in osteoarthritis difficult; researchers are exploring scaffolds and bioactive materials for potential solutions.
  • In this study, a combination of decellularized cartilage powder (DCP) and a modified hyaluronic acid hydrogel (AHAMA) was tested in vitro, showing low toxicity and fostering a supportive environment for stem cells.
  • The findings indicated that DCP/AHAMA can enhance cartilage tissue engineering by mimicking natural cartilage properties, promoting cell differentiation, and potentially advancing clinical applications.
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Background: Shoulder disorders, particularly rotator cuff tears, are prevalent musculoskeletal conditions related to aging. Although the widely used suture anchor technique provides strong mechanical support to the tendon, it is associated with a risk of postoperative tendon retearing. The conventionally used titanium alloys can affect the interpretation of magnetic resonance imaging.

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  • The study investigates the effects of different compression durations on spinal cord injury severity using a rat model, revealing a link between longer compression times and more severe deficits.
  • Results indicated significant injuries even with just 1 second of compression, paralleling moderate-to-severe SCI outcomes.
  • The research highlights the need to consider both compression duration and clip deformation in designing SCI experiments, which can influence data interpretation in preclinical studies.
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Background: Cervical spondylotic myelopathy (CSM) may seriously affect quality of life. In the literature, there is scarce evidence of the pros and cons of full endoscopic spine surgery in the treatment of CSM. The main purpose of this study was to conduct a systematic review to elucidate the efficacy of full endoscopic spine surgery in the management of patients with CSM.

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Suitable biomechanical properties, good biocompatibility, and osteoconductivity of a degradable magnesium (Mg) alloy make it a potential material for orthopedic implants. The main limitation of Mg is its high corrosion rate in the human body. Surface modification is necessary to improve the Mg corrosion resistance.

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Background: The intraoperative invisible middle glenohumeral ligament (MGHL) test has been shown to be associated with a subscapularis tendon retraction. However, the preoperative location of the MGHL and its association with subscapularis tear severity has not been evaluated.

Purpose: To determine (1) the interrater reliability for identification and position of the MGHL, (2) any association between the MGHL position and subscapularis tears, and (3) the cutoff point at which MGHL position can predict subscapularis tear severity.

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Background: The Latarjet procedure is a reliable treatment for the management of anterior glenohumeral instability with glenoid bone loss. However, the biomechanical properties of different fixation angles between screw and glenoid surface (α angle) have rarely been studied. The aim of the study was to investigate and compare the fixation stability, failure load, and failure mechanism between different α angles for Latarjet procedures, which were performed on cadaver specimens.

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Cartilage stem/progenitor cells (CSPCs) are cartilage-specific, multipotent progenitor cells residing in articular cartilage. In this study, we investigated the characteristics and potential of human CSPCs combined with poly(lactic-co-glycolic acid) (PLGA) scaffolds to induce osteochondral regeneration in rabbit knees. We isolated CSPCs from human adult articular cartilage undergoing total knee replacement (TKR) surgery.

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Purpose: The aim of this study was to develop a non-cytotoxic, biocompatible innovative acellular porcine cornea (APC) for corneal wound healing and corneal blindness treatment.

Methods: APC was produced by using supercritical carbon dioxide (SCCO2) to decellularize the porcine cornea. Decellularization of the porcine cornea was examined by hematoxylin and eosin staining and 4,6-diamidino-2-phenylindole, dihydrochloride staining.

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Background: Tape-type suture material is well-accepted in arthroscopy surgery.

Purpose: To compare the knot security of a high-tensile strength round suture and high-tensile strength tape with commonly used arthroscopic knots.

Study Design: Controlled laboratory study.

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Introduction: The role of open cerclage wiring in comminuted femoral shaft fracture treatment with intramedullary nails remains unclear. Here, we analyzed the effect of open cerclage wiring and the risk factors for nonunion after interlocking nailing in comminuted femoral shaft fracture treatment. We hypothesized that open cerclage wiring can be applied in patients with severe comminuted femoral shaft fractures without affecting bone healing.

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Case: A 45-year-old woman sustained a unique lateral tibia plateau fracture pattern with a vertically rotated fragment composed of an intact articular surface and subchondral bone. During open reduction and internal fixation (ORIF), a full thickness radial tear of the lateral meniscus was found, which was repaired under direct visualization through arthrotomy. At final follow-up, the patient regained pain-free activity with good meniscus healing, as confirmed with a second-look arthroscopic examination.

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Background: The posterior plating technique could be used as a clinical alternative to parallel plating for treating comminuted distal humerus fractures (DHFs) successfully with good clinical results. However, the biomechanical characteristics for posterior fixation are still unclear. The purpose of this study is to evaluate the biomechanical properties of the posterior fixation and to make comparisons between the parallel and the posterior fixation systems.

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Purpose: To retrospectively assess the clinical outcomes of the patients with large to massive reparable RCTs treated by arthroscopic rotator cuff repair (ARCR) combined with modified superior capsule reconstruction (mSCR) using the long head of biceps tendon (LHBT) as reinforcement with a minimum of 2 years of follow-up.

Methods: We retrospectively evaluated 40 patients with large to massive reparable RCTs who underwent ARCR and mSCR (group I) between February 2017 and June 2018 (18 patients) or underwent ARCR and tenotomy of LHBT performed at the insertion site (group II) between January 2015 and January 2017 (22 patients). The pain visual analog score (VAS) was assessed preoperatively and 1, 3, 6, 12, 24 months postoperatively.

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Absorbable magnesium stents have become alternatives for treating restenosis owing to their better mechanical properties than those of bioabsorbable polymer stents. However, without modification, magnesium alloys cannot provide the proper degradation rate required to match the vascular reform speed. Gallic acid is a phenolic acid with attractive biological functions, including anti-inflammation, promotion of endothelial cell proliferation, and inhibition of smooth muscle cell growth.

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Background: The brisement manipulation is an effective treatment for refractory shoulder stiffness. Rotator cuff tears can sometimes exist in combination with adhesive capsulitis. Arthroscopic capsular release combined with rotator cuff repair has achieved good outcomes in published reports.

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Purpose: To compare the biomechanical properties of a high-tensile strength suture with the high-tensile strength tape for tendon graft fixation.

Methods: A total of 24 porcine tendons were used and were randomly divided into 2 groups. Two kinds of suture materials, a braided nonabsorbable high-strength suture (group S) and a high-tensile strength tape (group T), were used to complete 3 pairs of Krackow stitches on the tendons.

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Purpose: To compare the biomechanical characteristics of the interconnected knotless anchor (IKA) fixation with the double knotless anchor (DKA) and interference screw (IS) fixation in the suprapectoral biceps tenodesis.

Methods: In total, 24 fresh-frozen human cadaveric shoulders (mean age, 67.3 ± 6 years) were used for the study.

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Background: The role of locking plate in lateral malleolar fracture fixation for the elderly remains unclear. The aim of our study is to compare radiological and functional outcomes in older patients (> 50 years) with AO/OTA 44B lateral malleolar fractures after locking plate (PLP) or one-third non-locking tubular plate (TP) lateral fixation.

Methods: We retrospectively reviewed the medical records of 72 patients (PLP group, 34 patients; TP group, 38 patients; mean age, 61.

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