Association between mitophagy and inflammasome in uric acid nephropathy.

Objective: This study was recruited to investigate the role of mitophagy in activating NLRP3 inflammasome in the kidney of uric acid (UA) nephropathy (UAN) rats.

Methods: This study developed a uric acid nephropathy (UAN) rat model divided into five groups: Negative control (NC), UAN model (M), UAN + autophagy inhibitor (3-MA), UAN + lysosome inhibitor (CQ), and ROS scavenger (N-acetylcysteine, N). H&E staining assessed renal structure, ROS levels were measured with 2, 7dichlorofluorescin diacetate, and ELISA measured serum markers (, , cystatin , , , ).

The accuracy of DNA methylation detection in endometrial cancer screening: A systematic review and meta-analysis.

Objective: DNA methylation is the hallmark of early endometrial cancer and can be detected through non-invasive methods. The present study systematically reviewed the efficacy of DNA methylation detection for endometrial cancer screening through exfoliative cytology.

Methods: A systematic literature review was performed through the following databases from inception to October 7, 2024: PubMed, Embase, and the Cochrane Library.

Enhanced visible-light-driven photocatalytic degradation via in-situ AIS/ZIS high-low junctions.

The I-III-VI QDs Ag-In-S (AIS) exhibits excellent properties in photocatalysis because of the adjustable band gap, wide light absorption range, and multiple active sites. Introducing homologous or heterogeneous ions not only derives the composition into quaternary/ quinary quantum dots but also generates new sulfide QDs to form composites, which is an effective strategy to promote photoactivity. In this work, we in-situ synthesized the AIS/ZIS (AgInS/ZnInS) composite photocatalyst by introducing Zn and changing the reaction temperature.

Comprehensive Screening and Validation of Stable Internal Reference Genes for Accurate qRT-PCR Analysis in under Diverse Biological Conditions and Environmental Stresses.

is among the world's most destructive pests. For accurate qPCR and gene expression studies, the selection of stable and appropriate reference genes is crucial. However, a thorough evaluation of potential reference genes for use in research is lacking.

Experimental models for preclinical research in kidney disease.

Acute kidney injury (AKI) and chronic kidney disease (CKD) are significant public health issues associated with a long-term increase in mortality risk, resulting from various etiologies including renal ischemia, sepsis, drug toxicity, and diabetes mellitus. Numerous preclinical models have been developed to deepen our understanding of the pathophysiological mechanisms and therapeutic approaches for kidney diseases. Among these, rodent models have proven to be powerful tools in the discovery of novel therapeutics, while the development of kidney organoids has emerged as a promising advancement in the field.

Agrochemical control of gene expression using evolved split RNA polymerase. II.

Agrochemical inducible gene expression system provides cost-effective and orthogonal control of energy and information flow in bacterial cells. However, the previous version of Mandipropamid inducible gene expression system (Mandi-T7) became constitutively active at room temperature. We moved the split site of the eRNAP from position LYS179 to position ILE109.

SNORD3A Regulates STING Transcription to Promote Ferroptosis in Acute Kidney Injury.

Acute kidney injury (AKI) signifies a sudden and prolonged decline in kidney function characterized by tubular cell death and interstitial inflammation. Small nucleolar RNAs (snoRNAs) play pivotal roles in oxidative stress and inflammation, and may play an important role in the AKI process, which remains elusive. an elevated expression of Snord3a is revealed in renal tubules in response to AKI and demonstrates that Snord3a deficiency alleviates renal injury in AKI mouse models.

Tracking moisture contents in the pollution layer on a composite insulator surface using hyperspectral imaging technology.

Electrical insulators used in transmission lines and outdoor substations are exposed to severe environmental pollution, which significantly increases the risk of power system failure, especially when the pollution layer is highly humid due to adverse weather conditions. The focus of this paper is to establish an effective method for assessing the moisture content (MC) in pollution layers as it serves as a crucial indicator for evaluating the risk of failure in insulators. Hyperspectral imaging (HSI) technology with a spectral range of 371.

Alamandine attenuates ovariectomy-induced osteoporosis by promoting osteogenic differentiation via AMPK/eNOS axis.

Background: Alamandine is a newly characterized peptide of renin angiotensin system. Our study aims to investigate the osteo-preservative effects of alamandine, explore underlying mechanism and bring a potential preventive strategy for postmenopausal osteoporosis in the future.

Methods: An ovariectomy (OVX)-induced rat osteoporosis model was established for in vivo experiments.

Tau truncation in the pathogenesis of Alzheimer's disease: a narrative review.

Alzheimer's disease is characterized by two major neuropathological hallmarks-the extracellular β-amyloid plaques and intracellular neurofibrillary tangles consisting of aggregated and hyperphosphorylated Tau protein. Recent studies suggest that dysregulation of the microtubule-associated protein Tau, especially specific proteolysis, could be a driving force for Alzheimer's disease neurodegeneration. Tau physiologically promotes the assembly and stabilization of microtubules, whereas specific truncated fragments are sufficient to induce abnormal hyperphosphorylation and aggregate into toxic oligomers, resulting in them gaining prion-like characteristics.

Identification of Potential Gene Targets for Suppressing Oviposition in Using Comparative Transcriptome Analysis.

is an important plant pest. Comparative feeding experiments showed that the egg production, oviposition duration and survival rate of beetles were significantly higher when they fed on elm leaves than when they fed on willow or purpus privet leaves. RNA sequencing was used to determine transcriptomic changes associated with oviposition.

Effect of Jiawei Tongqiao Huoxue decoction in basilar artery dolichoectasia mice through yes-associated protein/transcriptional co-activator with PDZ-binding motif pathway.

Ethnopharmacological Relevance: The Jiawei Tongqiao Huoxue decoction (JTHD), composed of Acorus calamus var. angustatus Besser, Paeonia lactiflora Pall., Conioselinum anthriscoides 'Chuanxiong', Prunus persica (L.

Passive immunization inhibits tau phosphorylation and improves recognition learning and memory in 3xTg-AD mice.

Tau pathology is essential in the pathogenesis of Alzheimer's disease (AD) and related tauopathies. Tau immunotherapy aimed at reducing the progression of tau pathology provides a potential therapeutic strategy for treating these diseases. By screening monoclonal antibodies 43D, 63B, 39E10, and 77G7 that recognize epitopes ranging from tau's N-terminus to C-terminus, we found the 77G7, which targets the microtubule-binding domain promoted tau clearance in a dose-dependent manner by entering neuronal cells in vitro.

Modular synthesis of the pheromone (2S,7S)-2,7-nonanediyl dibutyrate and its racemate and their field efficacy to control orange wheat blossom midge, Sitodiplosis mosellana (Géhin) (Diptera: Cecidomyiidae).

Background: Sudden outbreaks of the orange wheat blossom midge, Sitodiplosis mosellana (Géhin) cause huge wheat yield losses. Use of sex pheromones is more efficient than laborious egg counting to monitor these hidden-concealed insects. Quick synthesis of the sex pheromones is therefore required to meet the sudden outbreak needs.

A chromosome-level genome assembly of the orange wheat blossom midge, Sitodiplosis mosellana Géhin (Diptera: Cecidomyiidae) provides insights into the evolution of a detoxification system.

The orange wheat blossom midge Sitodiplosis mosellana Géhin (Diptera: Cecidomyiidae), an economically important pest, has caused serious yield losses in most wheat-growing areas worldwide in the past half-century. A high-quality chromosome-level genome for S. mosellana was assembled using PacBio long read, Illumina short read, and Hi-C sequencing technologies.

Agrochemical control of gene expression using evolved split RNA polymerase.

Chemically-inducible gene expression systems are valuable tools for rational control of gene expression both for basic research and biotechnology. However, most chemical inducers are confined to certain groups of organisms. Therefore, dissecting interactions between different organisms could be challenging using existing chemically-inducible systems.

Dimensionality-Controlled Evolution of Charge-Transfer Energy in Digital Nickelates Superlattices.

Fundamental understanding and control of the electronic structure evolution in rare-earth nickelates is a fascinating and meaningful issue, as well as being helpful to understand the mechanism of recently discovered superconductivity. Here the dimensionality effect on the ground electronic state in high-quality (NdNiO ) /(SrTiO ) superlattices is systematically studied through transport and soft X-ray absorption spectroscopy. The metal-to-insulator transition temperature decreases with the thickness of the NdNiO slab decreasing from bulk to 7 unit cells, then increases gradually as m further reduces to 1 unit cell.

Effect of High Temperature and Natural Enemies on the Interspecies Competition Between Two Wheat Aphid Species, Rhopalosiphum padi and Sitobion miscanthi.

Interspecies competition affects the distribution, quantity, and community structure of insects, especially among closely-related (congeners) species. Some ecological factors differentially affect the fitness of co-existing species, thus conferring an advantage on one competitor, and then the structure of communities. The present work evaluated the effects of high temperature and natural enemies on the interspecific competition between the grain aphid Sitobion miscanthi (Takahashi) (Aphididae: Hemiptera) and bird cherry-oat aphid Rhopalosiphum padi (L.

Blocking the Prevalence of Adenoviral Conjunctivitis in Premature Infants by a Combined Disinfection Method.

This study aimed to determine the cause of the outbreak of nosocomial adenoviral conjunctivitis in the Neonatal Intensive Care Unit (NICU) and the impact of infection control measures. The objectives of the present study included investigating the association between hospital-borne infection and adenoviral conjunctivitis, analyzing the possible risk factors, and setting bundled infection control measures, which were adjusted according to the control effect. This study also aimed to observe the effects of different intervention measures on controlling adenoviral conjunctivitis.

Low Barometric Pressure Enhances Tethered-Flight Performance and Reproductive of the Oriental Armyworm, Mythimna separata (Lepidoptera: Noctuidae).

Barometric pressure is an important factor influencing several insect traits. Most studies have been conducted on the behavior of insects in relation to rapid and slight changes in pressure magnitudes or short-term pressure trends, but there is little information on the effect of long-term and large pressure variations on insect traits. Here, we assessed the effects of static low barometric pressure on the tethered flight, lifespan and reproductive performance of Mythimna separata (Walker), a long-distance migratory insect, using an apparatus simulating low barometric pressure at altitudes of 500 m above sea level.

MicroRNA-138 promotes neuroblastoma SH-SY5Y cell apoptosis by directly targeting DEK in Alzheimer's disease cell model.

Background: Alzheimer's disease (AD) is a progressive neuro-degenerative disease with a major manifestation of dementia. MicroRNAs were reported to regulate the transcript expression in patients with Alzheimer's disease (AD). In this study, we investigated the roles of miR-138, a brain-enriched miRNA, in the AD cell model.