Driving safety risk evaluation for tunnel reinforcement based on matter-element model.

Objective: This study aimed to analyze the influence of different tunnel reinforcement measures on drivers and to evaluate the associated driving safety risks.

Methods: Experimental data of driving behavior and physiological response were collected under different driving simulation scenarios, such as cover arch erection, corrugated steel, grouting, Steel strips, and fire; an evaluation index system was established based on electrocardiographic (ECG), electrodermal activity(EDA), standard deviation of speed (SDSP), Steering Entropy(SE), standard deviation of lateral position (SDLP) and other indices. The classical domain rank standard of each evaluation index was divided using K-Means algorithm, and a synthetic evaluation matter-element model was established to comprehensively evaluate and analyze the safety risks of each scenario.

Bioaccumulation of novel brominated flame retardants in a marine food web: A comprehensive analysis of occurrence, trophic transfer, and interfering factors.

Although the concept of bioaccumulation for novel brominated flame retardants (NBFRs) is clear, the process and interfering factors of bioaccumulation are still not fully understood. The present study comprehensively evaluated the occurrence, transfer and interfering factors of NBFRs in a marine food web to provide new thought and perspective for the bioaccumulation of these compounds. The occurrence of 17 NBFRs were determined from 8 water, 8 sediment and 303 organism samples collected from Dalian Bay, China.

Electrophysiological and Behavioral Responses of (Coleoptera: Curculionidae) to Plant Volatiles.

The flea-weevil Korotyaev (Coleoptera: Curculionidae) is an Eastern Palaearctic Steppe species, and a serious pest of elm trees ( spp., Ulmaceae) by feeding on the leaves (adults) or mining them heavily (larvae) in Xinjiang, China. In order to search for chemical and ecological pest management practices, the olfactory preferences of for leaves of three elm species were investigated.

Scalable Fabrication of Light-Responsive Superhydrophobic Composite Phase Change Materials via Bionic-Engineered Wood for Solar-Thermal Energy Management.

The growing demand for sustainable energy storage solutions has underscored the importance of phase change materials (PCMs) for thermal energy management. However, traditional PCMs are always inherently constrained by issues such as leakage, poor thermal conductivity, and lack of solar energy conversion capacity. Herein, a multifunctional composite phase change material (CPCM) is developed using a balsa-derived morphology genetic scaffold, engineered via bionic catechol surface chemistry.

Identification of the locus controlling leaf rolling and its application in maize breeding.

Unlabelled: Increasing planting density is one of the most important strategies for generating higher maize yields. Moderate leaf rolling decreases mutual shading of leaves and increases the photosynthesis of the population and hence increases the tolerance for high-density planting. Few genes that control leaf rolling in maize have been identified, however, and their applicability for breeding programs remains unclear.

The Role of Lactate in Ischemic Stroke: As an Energy Source and Signaling Molecule.

Stroke is an acute cerebrovascular disease that causes brain tissue damage due to sudden blockage or rupture of blood vessels in the brain. According to the latest data from the Global Burden of Disease Study, the number of stroke patients worldwide is estimated to exceed 100 million, and more than 80% of patients suffer from stroke. Ischemic stroke is a type of stroke due to which two-thirds of the patients are disabled or even die, seriously affecting the patient's quality of life.

Establishing the reference intervals of plasma PLG, FXII activity, and FXIII antigen in healthy adults in Guangzhou.

Objective: To establish the reference intervals of plasma Plasminogen, Factor XII activity, and Factor XIII Antigen in healthy adults in Guangzhou.

Methods: A total of 168 young people (75 males and 93 females, aged 18-65 years) who underwent physical examination in Zhujiang Hospital of Southern Medical University from 2020 to 2022 were recruited. Sysmex CS5100 automatic coagulation analyzer and matching reagents were used to detect Plasminogen.

Global, regional, and national burden of very early-onset colorectal cancer and its risk factors from 1990 to 2019: A systematic analysis for the global burden of disease study 2019.

Aims: Very early-onset colorectal cancer (EOCRC) was defined as CRC diagnosed before the age of 35 proposed by the latest EOCRC management guideline. Until now, the disease burden of very EOCRC has never been reported. This study aimed to explore the burden of very EOCRC across the past three decades.

Does two-level hybrid surgery promote early fusion compared with two-level anterior cervical discectomy and fusion?

Background Context: Hybrid surgery (HS), which involves both anterior cervical discectomy and fusion (ACDF) and cervical disc replacement (ACDR), is increasingly used to treat multilevel cervical disc degenerative disease, yielding satisfactory clinical outcomes. Early fusion is critical after anterior cervical fusion surgeries, but there are no studies comparing the rate of early fusion of HS with that of ACDF.

Purpose: The purpose of this study was to compare the rate of early fusion (3-6 months postoperatively) of two-level HS with that of two-level ACDF surgery.

Genomic Prediction of Semen Traits in Boars Incorporating Biological Interactions.

In the context of modern pig farming, the central role of boars is underscored by large-scale centralized breeding and the widespread application of artificial insemination techniques. However, previous studies and breeding programs have focused mainly on product efficiency traits, such as growth rate, lean meat yield, and litter size, often neglecting boar semen traits. In this study, we estimated the genetic parameters and assessed the genomic prediction accuracy of boar semen traits with phenotypes evaluated from 274,332 ejections in a large population consisting of 2467 Duroc boars.

Chemotherapy combined with immunotherapy in patients with gastric cancer: protocol for a systematic review.

Introduction: The integration of chemotherapy and immunotherapy is continually making new advances in the field of gastric cancer treatment and has already become the new standard of care for the disease. However, few systematic reviews cover a wide array of immune checkpoint inhibitors (ICIs), antibody types and therapeutic modalities (perioperative or systemic) in this domain. Our aim is to incorporate the most recent clinical studies on combination therapy for the treatment of gastric cancer into a systematic review.

The restricted intermittent control for high-speed train movement via the full state dependent event-triggered method.

In this paper, the full state dependent event-triggered aperiodic intermittent control (FE-AIC) strategy based on input constraints is introduced to minimize energy consumption and enhance speed tracking accuracy in the high-speed train (HST) operation. Firstly, a dynamic model based on multi-mass-point (MMP) for HST has been established, transforming the cruise control problem into an error asymptotic convergence problem. Secondly, restricted FE-AIC (RFE-AIC) controller is designed separately in the presence and absence of external disturbances to realize tracking objects.

Mitochondrial transplantation rescues Ca homeostasis imbalance and myocardial hypertrophy in SLC25A3-related hypertrophic cardiomyopathy.

SLC25A3 encodes mitochondrial phosphate carrier (PiC), which is involved in inorganic phosphate transport. Clinical reports have found that most patients with homozygous or complex heterozygous mutations in SLC25A3 exhibit lactic acidosis, cardiac hypertrophy, and premature death. However, the potential molecular mechanisms underlying these associations remain unclear.

Long-term outcomes of induction chemotherapy followed by concurrent chemoradiotherapy and adjuvant chemotherapy for locoregionally advanced nasopharyngeal carcinoma: a retrospective study.

Background: Nasopharyngeal carcinoma (NPC) is a prevalent form of head and neck cancer, particularly in specific regions with a higher incidence. The optimal treatment strategy for locally advanced NPC (stage III and IVA, LA-NPC) involves various combinations of induction chemotherapy (IC), concurrent chemoradiotherapy (CCRT), and adjuvant chemotherapy (AC), each with distinct advantages. This one institutional study aims to retrospectively analysis the efficacy and clinical outcomes of IC with CCRT (IC+CCRT), CCRT with AC (CCRT+AC), and the comprehensive approach of IC followed by CCRT and subsequently AC (IC+CCRT+AC) in the management of LA-NPC.

NTRK-rearranged spindle cell tumor with SPECC1L-NTRK3 fusion in the thoracic spine: a case report.

Neurotrophic Tyrosine Receptor Kinase (NTRK)-rearranged spindle cell tumors are a category of soft tissue tumors characterized by rearrangements of the NTRK gene family (NTRK1, NTRK2, and NTRK3), which leads to distinct molecular genetics, morphological, and immunophenotypic characteristics. The central feature of these tumors is the fusion of NTRK genes with other genes, resulting in abnormal expression and activation of tropomyosin receptor kinase proteins.In this report, we present the first documented case of an NTRK spindle cell tumor with SPECC1L-NTRK3 fusion located in the thoracic spine.

Case report: A rare case of renal tuberculosis combined with bladder cancer.

We report a case of renal tuberculosis combined with bladder cancer. The patient was a 57-year-old man with no history of tuberculosis who presented with hematuria and signs of urinary tract irritation. Computed tomography (CT) showed florid, bowel-filling calcifications at the level of the right renal hilum, multiple hyperdense shadows from the right renal pelvis to the ureter, and left pyelo-ureteral effusion.

Casticin inhibits proliferation of Non-small cell lung cancer cells through regulating reprogramming of glucose metabolism.

Background: Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, with poor prognosis due to its rapid progression and resistance to existing therapies. Metabolic reprogramming, particularly alterations in glucose metabolism, is a key mechanism underlying tumor growth and progression, providing potential targets for novel therapeutic strategies. Casticin (CAS), a bioactive flavonoid, has shown anticancer effects in various cancers, but its specific role in NSCLC metabolism remains unclear.

Cadmium alters the cellular metabolome of human ovarian granulosa cells.

Cadmium (Cd) is a toxic heavy metal that has been extensively implicated in disordered folliculogenesis, but the mechanisms underlying the ovarian toxicity of Cd remain to be explored fully. Granulosa cells are key players in ovarian follicular development and are the primary cells affected by Cd exposure-induced damage and dysfunction. In this study, we investigated how various levels of exposure of Cd (3 and 10 μM) to human granulosa cells (KGN cells) impacted the metabolism of the KGN cells utilizing a non-targeted metabolomics methodology.

Improved mechanical performance and forming accuracy of ZrO fixed partial denture based on the digital light processing technology.

Fixed partial dentures are the primary treatment for dentition defects. Digital light processing (DLP) 3D printing technology is an advanced technique with significant advantages and potential in the field of dental restoration, particularly in cases requiring high precision and personalization. However, challenges persist in printing fixed partial dentures that meet the strength requirements for clinical applications.

The intratumoral landscape of T cell receptor repertoire in esophageal squamous cell carcinoma.

Background: Esophageal squamous cell carcinoma (ESCC) is a malignant neoplasm with detrimental implications for human health. The landscape of ESCC therapy has been revolutionized by the introduction of immunotherapy, specifically involving immune checkpoint inhibitors (ICIs). A number of studies have documented the prognostic significance of T-cell receptor (TCR) repertoire and its association with many tumors.

Transmissibility and control of tuberculosis in school outbreaks: a modeling study based on four outbreaks in China.

Background: The elevated incidence of tuberculosis (TB) outbreaks in schools poses a significant challenge to prevention and control efforts in China. The commonality among most outbreaks is the failure to isolate patients at an early stage. Early isolation of TB cases is crucial for reducing the spread of TB within schools.

The Confinement Behavior and Mechanistic Insights of Organic Phase Change Material Encapsulated in Wood Morphology Genetic Nanostructures for Thermal Energy Storage.

Wood, a renewable and abundant biomass resource, holds substantial promise as an encapsulation matrix for thermal energy storage (TES) applications involving phase change materials (PCMs). However, practical implementations often reveal a disparity between observed and theoretical phase change enthalpy values of wood-derived composite PCMs (CPCMs). This study systematically explores the confinement behavior of organic PCMs encapsulated in a delignified balsa wood matrix with morphology genetic nanostructure, characterized by a specific surface area of 25.