Publications by authors named "Meghana P"
This review offers a comprehensive review of the signals and the paramount role neuroinflammation plays in neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, and amyotrophic lateral sclerosis. The study explores the sophisticated interactions between microglial, astrocytic, and dendritic cells and how neuroinflammation affects long-term neuronal damage and dysfunction. There are specific pathways related to the mentioned inflammatory processes, including Janus kinases/signal transducer and activator of transcriptions, nuclear factor-κB, and mitogen-activated protein kinases pathways.
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- Pancreatic cancer has a very low 5-year survival rate of less than 5%, and the current treatment, gemcitabine, faces challenges due to the development of chemoresistance, especially influenced by nicotine in the tumor microenvironment.
- The study investigates how nicotine contributes to this resistance in pancreatic cancer cells (PANC-1 and MIA PaCa-2) and explores the potential of Embelin, a natural compound, to counteract this resistance by enhancing gemcitabine sensitivity.
- Results showed increased resistance markers in nicotine-treated cells, but Embelin significantly reduced cell viability and caused cell cycle arrests, suggesting its potential role as a chemosensitizer in overcoming nicotine-induced chemoresistance.
A series of new thiophene analogues with acarbonitrile-basedmoiety were designed and synthesized via structural optimization. The conjugates were assessed for their in-vitro cytotoxic activity against a human pancreatic cancer cell line (Mia PaCa-2) and among them compound 5b showed IC value of 13.37 ± 2.
View Article and Find Full Text PDFAlcohol-induced oxidative stress is a key player in the development of liver diseases, and herbal alternatives are important means of ameliorating the hepatotoxic effects. The study aimed to evaluate the hepatoprotective potentiality of Artabotrys odoratissimus, an important medicinal shrub from the family Annonaceae. The phenolic compounds from bark ethanol extract (BEE) were detected using RP-HPLC.
View Article and Find Full Text PDFInflammation is a complex biological response involving immune cells to an infection creating injury to the normal tissues. The anti-inflammatory efficacy of embelin, a benzoquinone from the plant , was screened for antioxidant and anti-inflammatory activity in carrageenan and Freund's adjuvant-induced inflammation models. Embelin exhibited significant dose-dependent antioxidant potential.
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