Regiodivergent formal [4+2] cycloaddition of nitrosoarenes with furanyl cyclopropane derivatives as 4π components.

Cyclopropanes are commonly used as valuable 3-carbon building blocks. Herein, we disclose a different reactivity pattern of furanyl cyclopropanes, which serve as a 4-carbon component in Lewis acid-promoted [4+2] cycloadditions with nitrosoarenes to afford 1,2-oxazine derivatives. Importantly, the regioselectivity of the cycloaddition reaction can be controlled by the appropriate choice of the Lewis acid.

Green walls for greywater treatment: A comprehensive review of operational parameters and climate influence on treatment performance.

Green walls for greywater treatment have emerged as a solution to increase green spaces in densely urbanized areas while providing treated greywater for reuse. Over the past decade, numerous studies have focused on optimizing these systems, though most address specific operational conditions and evaluate a limited set of performance parameters. This review synthesizes the existing literature using a meta-analysis to identify key operational factors and treatment performance metrics.

Brain volumes, cognitive, and adaptive skills in school-age children with Down syndrome.

Background: Down syndrome (DS) is the most common congenital neurodevelopmental disorder, present in about 1 in every 700 live births. Despite its prevalence, literature exploring the neurobiology underlying DS and how this neurobiology is related to behavior is limited. This study fills this gap by examining cortical volumes and behavioral correlates in school-age children with DS.

Elaboration and validity of admission and discharge checklists in Neonatal Intensive Care Units.

Objective: To develop and validate the content of checklists for safe admission and discharge in Neonatal Intensive Care Units.

Methods: A methodological study conducted between 2018 and 2020 in four stages: 1) literature review; 2) checklist construction; 3) content validity by 32 neonatal nursing specialists from different Brazilian states, predominantly from the southeastern region; 4) development of the final version of the instruments. Validity was performed using a Likert-type scale.

Case series of kidney transplantation in two pediatric recipients with rare genetic diseases and intellectual disability.

Background: Kidney transplantation is the gold standard treatment for end-stage kidney disease in children. Rare genetic systemic diseases associated with cystic kidney disease such as COL4A1-related disorder and oral facial digital syndrome type 1 could contribute to end-stage kidney disease in the pediatric population but there is scarce evidence in the literature regarding kidney transplant outcomes in these cases.

Case Presentation: We report a case of a 5-year-old male with COL4A1-related disorder who received a living-related donor kidney transplant from his mother.

Thriving in salty environments: Aspergillus niger's halotolerance and BTEX biodegradation potential.

Benzene, toluene, ethylbenzene, and xylene (BTEX) can be found in marine and estuarine waters due to accidental spills of oil and derivatives, as well as in production water and effluents discharged from petrochemical plants. Addressing the bioremediation of these compounds in saline environments and effluents with elevated salinity levels is imperative. In this study, the halotolerance of Aspergillus niger was assessed by subjecting it to a stepwise increase in salinity, achieved through progressive addition of NaCl from 2 to 30‰ (v/v).

Identification of Predictors of Shift Work Adaptation and Its Association With Immune, Hormonal and Metabolite Biomarkers.

We explored predictors of shift work adaptation and how it relates to disease risk biomarker levels. These analyses included 38 male, rotating shift workers, sampled twice at the end of a 3-week night shift and a 3-week day shift rotation. Participants collected all 24-h urine voids, wore activity sensors, and responded to questionnaires during each shift.

Automatic Segmentation of Sylvian Fissure in Brain Ultrasound Images of Pre-Term Infants Using Deep Learning Models.

Objective: Segmentation of brain sulci in pre-term infants is crucial for monitoring their development. While magnetic resonance imaging has been used for this purpose, cranial ultrasound (cUS) is the primary imaging technique used in clinical practice. Here, we present the first study aiming to automate brain sulci segmentation in pre-term infants using ultrasound images.

Hybrid membranes for wastewater treatment based on polymer-coated barium titanate nanoparticles.

In this work we present a series of hybrid membranes with piezocatalytic properties for wastewater treatment. For this, four types of barium titanate nanoparticles (BTO NPs) with different coatings were synthesized. These NPs were embedded in a polystyrene (PS) matrix to fabricate hybrid, porous membranes using the breath figures (BF) technique.

Drivers and fluxes of dissolved organic carbon along the northern Antarctic Peninsula during late summer.

Dissolved organic carbon (DOC) is a key component of the biogeochemical carbon cycle in the Southern Ocean. However, there are still significant gaps in understanding the role of DOC in polar environments, due to the limitations of spatiotemporal sampling. In this study, we investigated the regional aspects controlling the distribution and diffusive and advective fluxes of DOC along the northern Antarctic Peninsula (NAP) during austral late summers of 1995 and between 2015 and 2019.

Biofabrication and biomanufacturing in Ireland and the UK.

As we navigate the transition from the Fourth to the Fifth Industrial Revolution, the emerging fields of biomanufacturing and biofabrication are transforming life sciences and healthcare. These sectors are benefiting from a synergy of synthetic and engineering biology, sustainable manufacturing, and integrated design principles. Advanced techniques such as 3D bioprinting, tissue engineering, directed assembly, and self-assembly are instrumental in creating biomimetic scaffolds, tissues, organoids, medical devices, and biohybrid systems.

Investigating the role of elastin and extracellular matrix damage in cardiovascular calcification.

Although calcification in the cardiovascular system is highly studied, the mechanisms behind it are not well understood. Current proposed mechanisms focus on cellular processes leading to, or controlling the unwanted mineralization in soft tissues. However, extracellular components such as collagen and elastin fundamentally regulate the mechanical properties of heart tissues.

Corrigendum: Algorithms for predicting COVID outcome using ready-to-use laboratorial and clinical data.

[This corrects the article DOI: 10.3389/fpubh.2024.

A controlled co-assembly approach to tune temperature responsiveness of biomimetic proteins.

The controlled co-assembly of biomacromolecules through tuneable interactions offers a simple and fascinating opportunity to assemble multiple molecules into a single entity with enhanced complexity and unique properties. Herein, our study presents a dynamic co-assembled system using the multistimuli responsive intrinsically disordered protein Rec1-resilin and the adhesive hydrophilic protein silk sericin (SS). We utilized advanced characterization techniques including circular dichroism (CD) spectroscopy, dynamic light scattering (DLS), small-angle X-ray scattering (SAXS), and small/ultra-small angle neutron scattering (SANS/USANS) to elucidate the detailed co-assembly behavior of the system and its evolution over time and temperature.

Crowding effects on the structure and rheology of ultrasoft PNIPAM-PEGMA copolymer microgels.

We investigate the link between the internal microstructure of poly(-isopropylacrylamide)-poly(ethylene glycol) methyl ether methacrylate (PNIPAM-PEGMA) microgels, their bulk moduli and the rheological response and structural arrangement in dense suspensions. The low degree of crosslinking combined with the increased hydrophilicity induced by the presence of PEGMA results in a diffuse, star-like density profile of the particle and very low values of the bulk modulus in dilute conditions, as determined by small angle neutron scattering (SANS). The ultrasoft nature of the particle is reflected in the changes of the structural arrangement in dense suspensions, which evidence a strong deswelling and a sharp rise of the bulk modulus at moderate packing fractions.

Knee Synovial Haemangioma: A Case Report and Imaging Perspective on Diagnosis.

Synovial haemangioma is a rare benign entity, most common in children and adolescents. These tumours can extensively infiltrate joint structures and periarticular soft tissues, making management challenging. Magnetic resonance imaging (MRI) has a key role in diagnosis and therapeutic planning.

Articular cartilage regeneration with a microgel as a support biomaterial. A rabbit knee model.

Articular cartilage has limited regenerative capacity, so focal lesions generate mechanical stress in the joint that induces an aggravation of the damage, which ultimately leads to osteoarthritis. We recently suggested the use of microgels at the site of the cartilage defect, as a support material, to generate a biomechanical environment where pluripotent cells differentiate towards the hyaline cartilage phenotype. Here we propose a chondral regeneration strategy based on subchondral bone injury, and filling the defect site with an agglomerate of two types of microspheres, some rigid made of a biodegradable polyester (40 μm mean diameter), and others with a gel consistency made of platelet-rich plasma obtained from circulating blood (70-110 μm diameter).

Amoebicidal and cysticidal in vitro activity of cationic dendritic molecules against Acanthamoeba polyphaga and Acanthamoeba griffini.

Acanthamoeba species are responsible for serious human infections, including Acanthamoeba keratitis (AK) and granulomatous amoebic encephalitis (GAE). These pathogens have a simple life cycle consisting of an infective trophozoite stage and a resistant cyst stage, with cysts posing significant treatment challenges due to their resilience against harsh conditions and chemical agents. Current treatments for AK often involve combining diamines, such as propamidine, and biguanides, such as chlorhexidine (CLX), which exhibit limited efficacy and significant toxicity.

The landscape of dementia research in Brazil from 2010 to 2021: a Scopus-based bibliometric study.

Background:  Several studies have sought to investigate the trajectory of scholarly publications on dementia. Yet, there has been limited attention to contributions from Latin America.

Objective:  To provide a comprehensive overview of the literature output on dementia in Brazil.

Large language models surpass human experts in predicting neuroscience results.

Scientific discoveries often hinge on synthesizing decades of research, a task that potentially outstrips human information processing capacities. Large language models (LLMs) offer a solution. LLMs trained on the vast scientific literature could potentially integrate noisy yet interrelated findings to forecast novel results better than human experts.

Youth Healthy Eating Index (YHEI) and Diet Adequacy in Relation to Country-Specific National Dietary Recommendations in Children and Adolescents in Five Mediterranean Countries from the DELICIOUS Project.

Background/objectives: The diet quality of younger individuals is decreasing globally, with alarming trends also in the Mediterranean region. The aim of this study was to assess diet quality and adequacy in relation to country-specific dietary recommendations for children and adolescents living in the Mediterranean area.

Methods: A cross-sectional survey was conducted of 2011 parents of the target population participating in the DELICIOUS EU-PRIMA project.