Therapeutic Plasma Exchange for Fibrinogen-Associated Hyperviscosity: Results of the COPLEX Randomized Controlled Trial.

Background: Therapeutic plasma exchange (TPE) is the primary intervention for treating symptomatic hyperviscosity from hypergammaglobulinemia, yet its efficacy for treating hyperviscosity related to hyperfibrinogenemia is unclear.

Objective: Define the safety and efficacy of TPE for critically ill COVID-19 patients with elevated blood viscosity from hyperfibrinogenemia.

Method: A prospective, randomized controlled trial in critically ill COVID-19 patients at a single US healthcare system.

How does digital leadership boost competitive performance? The role of digital culture, affective commitment, and strategic agility.

In the age of the digital revolution, businesses are working to become more sustainable. Specifically, when management settings change-which is closely tied to competitive performance-leadership is evolving into digital leadership. Drawing on the resource-based view (RBV) theory, this study focused on finding the interconnection between digital leadership (DL) and competitive performance (CP), as well as the mediating roles of affective commitment (AC) and digital culture (DC), including the moderating effects of strategic agility (SA).

Novel biocomposite of ionic cross-linked chitosan and acid-treated potato (Solanum tuberosum L.) peel agro-waste for highly efficient removal of methylene blue dye from water.

In this study, a biocomposite material (CS-OXA/PP-SA) composed of ionic crosslinked chitosan-oxalate (CS-OXA) and chemically modified lignocellulosic biomass (potato (Solanum tuberosum L.) peel-HSO acid, PP-SA) was synthesized to serve as a bioadsorbent for removing methylene blue (MB) dye from aquatic systems. The research utilized response surface methodology (RSM) to evaluate the effects of three variables: CS-OXA/PP-SA dosage (0.

Effect of the COVID-19 Lockdown on Pediatric Bronchial Asthma Patients in Saudi Arabia: A Comparative Study.

Background: The lockdowns imposed during the COVID-19 pandemic and social distancing measures may have decreased traffic and air pollution, which may contribute to reducing asthma exacerbation. However, there is not enough information about the relationship between asthma and COVID-19 lockdown, especially in children. Therefore, the aim of this study is to identify the effects of the COVID-19 lockdown on pediatric patients with moderate to severe bronchial asthma.

Erysipelothrix rhusiopathiae-associated bloodstream infection in a patient with systemic lupus erythematosus: a case report and literature review.

Systemic human infections caused by have been increasingly reported especially within immunocompromised hosts and those with significant occupational exposure to livestock and aquatic animals. We report a case of bacteraemia in a patient with systemic lupus erythematosus (SLE) and present a literature review on clinical outcomes and microbiologic diagnosis for this organism. A 43-year-old female patient was reporting a 1-month history of intermittent fevers.

Assessing the chemical interactions and biological effects of a petrochemical and bio-based plastic with a common plastic flame retardant and solvent.

Microplastic pollution remains a persistent environmental challenge for aquatic environments. Yet, health impact assessments of microplastics focus largely on the polymers themselves. It is important to understand the chemical behaviour and biological effects of both plastics and chemicals associated with their production, such as additives and solvents.

Preparation and characterizations of chitosan-octanoate nanoparticles for efficient delivery of curcumin into prostate cancer cells.

The goal of the research was to develop a hydrophobic octanoate salt of chitosan (CS-OA) and use the salt as a nanoparticle platform for the delivery of curcumin (CUR) into prostate cancer cells. The nanoprecipitation technique was used to prepare the nanoparticles, which were measured for particle size and encapsulation efficacy relative to CUR-CS nanoparticles. The cytotoxicity of CUR-OA-CS nanoparticles was evaluated in prostate cancerous cells (PC3 and DU145) in comparison with the corresponding blank nanoparticles and hydroalcoholic CUR solution.

Data-driven analysis of the effect of screening and treatment on the spread of HIV in developing and developed countries.

Introduction: In this study, we used a mathematical epidemic model to explore the status of the HIV epidemic in the USA and Pakistan. In addition to studying the dynamics of the model, we fitted the model with recent data to estimate the parameters describing the epidemic in both countries.

Results: Our estimation shows that in the USA, the reproduction number is 0.

A systematic review on reverse-zoonosis: Global impact and changes in transmission patterns.

Reverse zoonosis or zooanthroponosis is the transfer of pathogens from humans to animals. Although less studied than zoonotic diseases, this phenomenon poses significant risks to both animal and public health. The increasing human-animal interactions driven by urbanization, globalization, and environmental changes have exacerbated the occurrence of reverse zoonosis.

Data set for estimating combining abilities for yield and quality attributes in summer tomato using line by tester analysis in Bangladesh.

This article provides a dataset for line × tester analysis in the F1 generation of summer tomatoes using open-source R statistical software and the 'agricolae' package. The dataset includes seven inbred lines as female parents (L) and two testers as male parents (T) with diverse genetic bases and heat tolerance qualities. Fourteen cross combinations were produced through L × T (7 × 2) mating design, involving hybridization between lines () and testers () in a one-to-one fashion.

Heterogeneous virus classification using a functional deep learning model based on transmission electron microscopy images.

Viruses are submicroscopic agents that can infect other lifeforms and use their hosts' cells to replicate themselves. Despite having simplistic genetic structures among all living beings, viruses are highly adaptable, resilient, and capable of causing severe complications in their hosts' bodies. Due to their multiple transmission pathways, high contagion rate, and lethality, viruses pose the biggest biological threat both animal and plant species face.

Dietary Effect of Root Powder on Growth, Hematobiochemical Parameters, Immunity, and Disease Resistance to in .

This study investigates the influence of root powder (WSRP) on different aspects of common carp (), including growth, hematobiochemical parameters, antioxidant status, nonspecific immune response, and resilience to bacterial infections. Over a 60-day period, 180 common carp fingerlings (11.73 ± 0.

Evolving epidemiology, clinical features, and genotyping of dengue outbreaks in Bangladesh, 2000-2024: a systematic review.

Background: The 2023 dengue outbreak has proven that dengue is not only an endemic disease but also an emerging health threat in Bangladesh. Integrated studies on the epidemiology, clinical characteristics, seasonality, and genotype of dengue are limited. This study was conducted to determine recent trends in the molecular epidemiology, clinical features, and seasonality of dengue outbreaks.

The Link Between Metabolic Dysfunction-Associated Steatotic Liver Disease and Gastroesophageal Reflux Disease.

Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly nonalcoholic fatty liver disease (NAFLD), and gastroesophageal reflux disease (GERD) are prevalent chronic conditions with escalating global incidence. This study delves into the intricate interplay between MASLD and GERD. The primary objective is to comprehensively explore the association between MASLD and GERD, investigating how various factors contribute to the coexistence and potential exacerbation of these conditions.

Preoperative Ultrasound-Guided Marking, Mammogram, and Peroperative Use of Image Intensifier: A Cost-Effective Technique in Clipped Non-Palpable Breast Cancer Lesions to Achieve Adequate Surgical Margins.

Objective: To measure the effectiveness of localisation and removal of impalpable target lesions without compromising patient safety in a resource-limited setup using preoperative ultrasound and mammography with peroperative use of C-arm image intensifier.

Study Design: Descriptive study. Place and Duration of the Study: Department of Breast Surgery, Ittefaq Hospital (Trust), Lahore, Pakistan, from 25th October 2011 to 17th February 2023.

Factors affecting the quality of work life for industrial labour force: empirical evidence from a developing country.

The success of any organization requires a skilled, competent, and satisfied workforce. If the workforce can be provided with the necessary components to ensure a high quality of working life, they will become permanent assets. Various factors undoubtedly affect the quality of workers' work lives.

Evaluation of GeneXpert MTB/Rif Ultra assay performance on formalin-fixed paraffin-embedded tissues for detection.

We evaluated the Xpert MTB/Rif Ultra assay performance for (MTB) detection in formalin-fixed paraffin-embedded tissue (FFPET) compared to mycobacterial culture or laboratory-developed MTB PCR test (LDT). FFPET samples with histological features suggestive of tuberculosis from 2018 to 2023 were selected. Five hundred microlitres of tissue lysis buffer was added to FFPET scrolls and incubated at 75 °C for 5 min.

Purine and pyrimidine synthesis differently affect the strength of the inoculum effect for aminoglycoside and β-lactam antibiotics.

Unlabelled: The inoculum effect has been observed for nearly all antibiotics and bacterial species. However, explanations accounting for its occurrence and strength are lacking. Previous work found that the relationship between [ATP] and growth rate can account for the strength and occurrence of the inoculum effect for bactericidal antibiotics.

Pediatric COVID-19 vaccine hesitancy among pregnant and post-partum women: A mixed-method study.

Background: This study aims to understand factors contributing to pediatric COVID-19 vaccine hesitancy among pregnant and postpartum adults.

Method: The study used targeted intercept advertising on Facebook, Twitter, and Instagram to recruit a panel of 3600 pregnant and postpartum US adults. Data were collected between December 2021 and April 2022 (i.

AI-powered VM selection: Amplifying cloud performance with dragonfly algorithm.

The convenience and cost-effectiveness offered by cloud computing have attracted a large customer base. In a cloud environment, the inclusion of the concept of virtualization requires careful management of resource utilization and energy consumption. With a rapidly increasing consumer base of cloud data centers, it faces an overwhelming influx of Virtual Machine (VM) requests.

Sero-evidence of Rickettsia Infection by ELISA in the Northern-Central Area of Bangladesh.

Detection of rickettsia most commonly done by simple, economical Weil-Felix test which detects IgM antibody. This initial investigation provides limited sound guidance to clinical decisions because of its low specificity and sensitivity. An alternative test, enzyme-linked immunosorbent assay (ELISA) is faster, less complicated, can also be automated.

Hidden scars: the persistent multifaceted health and psychosocial consequences for Syrian torture survivors.

The impact on the physical and mental health of those who survived torture and their close circles in the Syrian regime's detention facilities remains under-studied. This qualitative study explored Syrian refugees' narrations of captivity and torture, and the consequences of such extreme traumatic events on their physical and psychosocial health. Thirteen audio-recorded interviews were conducted in Arabic with Syrian refugees.