[Alpha estrogen receptor polymorphisms and their association with breast density].

Background: In the development of breast cancer (BC), estrogen exposure and the increase in breast density (BD) are two determinant factors for BC risk.

Objective: To identify the relationship between the XbaI and PvuII polymorphisms in the estrogen receptor (ER-alpha) with BD.

Material And Methods: Cross-sectional study which included 225 women, aged 40-65 years, without evident cancer data, who underwent routine mammography for early BC diagnosis in a radiology department.

[Inappropriate prescribing in older adults: Critical review of the literature and safety alerts].

Background: Prescribing errors are a risk factor for patients to present adverse events and a strategy that has been incorporated into medical care to reduce them is the use of computer tools. The objective was to obtain the scientific basis for the development of prescribing error alerts for four chronic diseases with a higher prevalence in population ≥ 65 years.

Methods: We reviewed the literature from 2010 to 2015 to obtain information about adverse events and adverse drug reactions associated with the use of drugs for the treatment of diabetes mellitus type 2 (DM2), hypertension, osteoarticular diseases (OD) and depression; the review included these databases: PubMed, OVID, Cochrane Library, LILACS, MEDES, Portal Mayores and SIETES.

[Training of institutional research networks as a strategy of improvement].

The Instituto Mexicano del Seguro Social (IMSS) through the Coordinación de Investigación en Salud (Health Research Council) has promoted a strong link between the generation of scientific knowledge and the clinical care through the program Redes Institucionales de Investigación (Institutional Research Network Program), whose main aim is to promote and generate collaborative research between clinical, basic, epidemiologic, educational, economic and health services researchers, seeking direct benefits for patients, as well as to generate a positive impact on institutional processes. All of these research lines have focused on high-priority health issues in Mexico. The IMSS internal structure, as well as the sufficient health services coverage, allows the integration of researchers at the three levels of health care into these networks.

Hypofibrinolytic State in Subjects with Type 2 Diabetes Mellitus Aggravated by the Metabolic Syndrome before Clinical Manifestations of Atherothrombotic Disease.

. Metabolic and genetic factors induce plasminogen activator inhibitor type-1 (PAI-1) overexpression; higher PAI-1 levels decrease fibrinolysis and promote atherothrombosis. .

[Chronic kidney disease].

Chronic kidney disease has become very important issue in recent years due, among other factors, to its increasing frequency and the high costs that it generates because it is increasingly seen as a major public health problem associated with premature mortality with important social and economic implications. All this has made advisable not only its diagnosis and early detection, but also increase its degree of knowledge and coordination between different levels of care.

[Association of stress hyperglycemia and in-hospital complications].

Background: Stress hyperglycemia is the elevation of serum glucose found in a patient, once he is admitted in the hospital. The objective of this study was to evaluate the impact of admission serum glucose level in the outcome of noncritical hospitalized patients.

Methods: A prospective analytical cohort study was conducted in patients hospitalized in the Internal Medicine service of the Hospital de Especialidades, Centro Médico Nacional Siglo XXI (Instituto Mexicano del Seguro Social), from September 2011 to February 2012.

Proinflammatory and prothrombotic state in subjects with different glucose tolerance status before cardiovascular disease.

Background: Inflammation has been associated with insulin resistance, type 2 diabetes mellitus (T2DM), and atherothrombosis.

Aim: To determine differences in levels of proinflammatory and prothrombotic markers such as high sensitivity C-reactive protein (hs-CRP) and fibrinogen in subjects with normal glucose tolerance (NGT), prediabetes, and T2DM and to establish their relationship with other cardiovascular risk factors before clinical manifestations of cardiovascular disease.

Methods: We conducted a nonrandomized, cross-sectional assay in a hospital at México City.

Drug treatment of hypertension: compliance and adverse reactions in a cohort of hypertensive patients in a primary care setting.

Objectives: The primary was to assess the frequency of therapeutic non-compliance due to ADRs in a cohort of patients with recently diagnosed systemic hypertension. The secondary objectives were to evaluate the blood pressure control during the follow-up in the whole cohort and in patients who received non-steroidal anti-inflammatory drugs (NSAIDs).

Methods: A cohort of 73 recently diagnosed ambulatory hypertensive patients was followed-up for 6 months.

[Cerebral venous thrombosis in systemic lupus erythematosus. Case report and literature review].

We reviewed a case of cerebral venous thrombosis as the manifestation of systemic lupus erythematosus in a 27-year-old woman whose main symptom was headache, and in which subarachnoid hemorrhage was initially suspected. The angiography revealed thrombosis in the superior longitudinal sinus. The treatment with steroids was satisfactory, with complete resolution of symptoms.