Publications by authors named "Manoj"

The Crabtree effect in yeast, where cells prefer fermentation over respiration in high -glucose environments, is associated with mitochondrial repression, but the molecular mechanisms were previously unclear. Recently, Vengayil et al. revealed that knocking out the ubp3 gene, encoding a deubiquitinase enzyme, mitigates the Crabtree effect by increasing mitochondrial phosphate levels.

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Neutrophils, as essential component of the innate immune response, form a crucial part in the defence mechanisms through the release of extracellular traps (NETs). These web-like structures, composed of chromatin and antimicrobial proteins, are essential for the entrapment and inactivation of pathogens. However, either constitutive formation or inefficient clearance of NETs leads to adverse effects such as fibrosis, thrombosis, delayed wound healing and tissue damage in multiple diseases associated with sterile inflammation.

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Purpose: We set out to develop a publicly available tool that could accurately diagnose spinal muscular atrophy (SMA) in exome, genome or panel sequencing datasets aligned to a GRCh37, GRCh38, or T2T reference genome.

Methods: The SMA Finder algorithm detects the most common genetic causes of SMA by evaluating reads that overlap the c.840 position of the SMN1 and SMN2 paralogs.

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Background: Dental caries remains a significant oral health concern, particularly in young children. With an increasing interest in preventive strategies, pediatric and preventive dentistry research is now more focused on developing newer materials and techniques to coat the primary teeth to prevent the onset of new carious lesions. While traditional preventive measures such as fluoride application and sealants have been effective in reducing caries incidence, there is still a need for innovative approaches.

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Heat acclimation is an adaptive process that improves physiological performance and supports survival in the face of increasing environmental temperatures, but the underlying mechanisms are not well understood. Here we identified a discrete group of neurons in the mouse hypothalamic preoptic area (POA) that rheostatically increase their activity over the course of heat acclimation, a property required for mice to become heat tolerant. In non-acclimated mice, peripheral thermoafferent pathways via the parabrachial nucleus activate POA neurons and mediate acute heat-defense mechanisms.

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Brucellosis and Q-fever are two highly contagious bacterial diseases with significant zoonotic potential and economic threats, yet they often remain underreported and neglected in low- and middle-income countries. The present study aimed to determine the seroprevalence of Brucellosis and Q-fever in water buffaloes in the Haryana state of India to implement effective preventive measures for disease control. The study covered all 22 districts of Haryana and involved 400 serum samples collected from female buffaloes belonging to two age groups and three distinct agro-climatic zones.

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Background: Cashew (Anacardium occidentale L.) is a widely cultivated tree with great economic significance. In cashew, several elite cultivars have been developed for commercial cultivation, which form the underpinning for the cashew-based industries and the several billion-dollar world trade.

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Article Synopsis
  • - The study focuses on synthesizing a series of 4,6-diarylpyrimidin-2-amine derivatives that exhibit adjustable optical properties depending on the aryl groups attached to them, both in solid and solution states.
  • - The synthesized compounds showed significant variability in their optical characteristics, including absorption and emission rates, with quantum yields ranging from 8.11% to 71.00% in DMF and specific fluorescence lifetimes.
  • - The results suggest that these derivatives have potential applications in optoelectronics due to their unique dual-state emission properties and the ability to modify energy levels through different substituents.
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This study aimed to investigate the potential protective effects of riociguat, a soluble guanylyl cyclase (sGC) stimulator, on kidney function and structure in rats with acute kidney injury (AKI) induced by the chemotherapeutic drug doxorubicin (DX). Rats were subjected to a single intraperitoneal injection of DX (13.5 mg/kg) on the 5th day, either alone or in combination with low-dose riociguat (3 mg/kg/day), or high-dose riociguat (10 mg/kg/day) for 8 consecutive days.

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: Effective management of acute pancreatitis (AP) hinges on prompt volume resuscitation and is adversely affected by delays in diagnosis. Given diverse clinical settings (tertiary care vs. community hospitals), further investigation is needed to understand the impact of the initial setting to which patients presented on clinical outcomes and quality of care.

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Lower Back Pain (LBP) is a global health issue, with increasing prevalence, partly attributed to vehicular vibrations experienced by motorcyclists. The L4 lumbar vertebra is responsible for greater mobility and flexibility of the body, but also is the most crucial body element affected by vehicular vibrations. Anthropometric properties, types of speed humps, and vehicle types are the critical variables that impact bone health during riding, need to be studied.

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Objective: Giant cell arteritis (GCA) is a chronic inflammatory condition associated with a significantly increased risk of various cardiovascular and thromboembolic events. Existing studies suggest an increased risk of cardiovascular disease in GCA, but results vary. This meta-analysis aims to quantify the association between GCA and the risk of various cardiovascular outcomes, providing a comprehensive evaluation of the cardiovascular burden in patients with GCA.

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Background & objectives Overcoming the challenge of early diagnosis of prostate cancer (PCa) by exploring molecular biomarkers is urgently needed. With this objective, this study was designed to explore the biomarker and therapeutic potential of miRNA (miR)-363-3p in PCa pathogenesis. Methods Total participants (n=188) were enrolled, and blood and tissue samples were collected from individuals categorized into the control group (n=55), benign prostate hyperplasia (BPH) group (n=60), PCa group (n=48), and castration-resistant PCa (CRPC) group (n=25).

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Presence of extended-spectrum β-lactamases (ESBL)-producing in the dairy farm environment and food chain could be a possible interface for the exchange of antimicrobial resistance genes between humans and animals. A total of 600 samples comprised of raw bovine milk, faeces, feed, environmental swabs and water samples from 20 different bovine dairy farms in and around Hisar city, Haryana, India were analysed for presence of ESBL encoding genes. Out of 240 isolates of obtained, 74 isolates were found to be ESBL producers.

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Background: While cochlear implantation (CI) and electric acoustic stimulation (EAS) have a positive outcome in most cases, their effectiveness varies depending on the etiology of the hearing loss. Among the various etiologies, genetic factors are the leading cause of hearing loss and may impact CI and EAS outcomes.

Aims/objectives: To reveal the genetic background of the hearing loss in CI/EAS patients in each ethnic population, we undertook a multi-center study involving the genetic testing of hearing loss in CI/EAS patients from 10 centers.

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Photosynthesis is an essential process in plants that synthesizes sugars used for growth and development, highlighting the importance of establishing robust methods to monitor photosynthetic activity. Infrared gas analysis (IRGA) can be used to track photosynthetic rates by measuring plant CO assimilation and release. Although much progress has been made in the development of IRGA technologies, challenges remain when using this technique on small herbaceous plants such as Arabidopsis thaliana.

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We study the influence of tyrosine phosphorylation on PTP-PEST, a cytosolic protein tyrosine phosphatase. Utilizing a combination of experimental data and computational modeling, specific tyrosine sites, notably, Y64 and Y88, are identified for potential phosphorylation. Phosphorylation at these sites affects loop dynamics near the catalytic site, altering interactions among key residues and modifying the size of the binding pocket.

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Article Synopsis
  • A study was conducted to examine the link between whole blood viscosity (WBV) and sensorineural hearing loss (SNHL) in Indian patients with type 2 diabetes mellitus (T2DM), as diabetes may alter blood viscosity.
  • Among 60 participants, a significant 73.3% had SNHL, primarily moderate and bilateral, with results showing a clear correlation between poorer glycemic control and increased severity of SNHL.
  • However, the study found no significant relationship between WBV and SNHL, microangiopathies (like retinopathy and neuropathy), or glycemic control indicators, suggesting that while SNHL is common in diabetics, blood viscosity might not play a crucial role in its development.
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Background: The efficacy and safety of the ultrathin BioMime sirolimus-eluting coronary stent (SES) system in treating single or multiple native coronary lesions, in-stent restenosis, and bifurcation lesions have been evidenced at 1 year.

Aims: We sought to investigate the long-term safety and efficacy of the BioMime SES in a real-world population with obstructive coronary artery disease (CAD).

Methods: The prospective, single-arm, multicentre meriT-2 trial enrolled 250 patients from 11 sites across India.

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Objectives: The purpose of this study was to assess, in a tertiary care context, the significance of C-reactive protein (CRP) in salivary gland illness.

Methods: This prospective research included 100 consecutive individuals with symptoms indicative of illness of the salivary glands. Demographic information, clinical information, and presenting symptoms were noted.

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Article Synopsis
  • Patients with small-cell lung cancer (SCLC) usually have a hard time and don't get great results from current treatments.
  • A new study shows that blocking a protein called ATR can help destroy cancer cells and improve the immune system's response against tumors.
  • When ATR is blocked along with another treatment called PD-L1, it works better than PD-L1 alone, offering hope for new ways to help people with SCLC.
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  • Kyrle disease is an acquired perforating disorder linked to conditions like type 2 diabetes and chronic kidney disease, characterized by skin lesions that show transepidermal elimination of dermal contents upon histopathological examination.
  • In the reported case, the patient exhibited only hyperuricemia as an abnormal lab finding, with no typical associated conditions present, making the cause of the disease unclear.
  • Treatment focused on addressing the underlying issues; however, the patient saw improvement with medications like acitretin, dapsone, and topical corticosteroids, highlighting the need for more research on factors like hyperuricemia in cases lacking classic associations.
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Article Synopsis
  • Infections resistant to antibiotics, especially carbapenem-resistant ones, are a serious global health issue, particularly in cases of hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP).
  • The review explores sulbactam-durlobactam therapy (SUL-DUR), assessing its approval process, how it works, and its potential in treating these bacterial infections.
  • SUL-DUR, known as Xacduro, has shown safety and effectiveness in clinical trials, making it a promising treatment alternative compared to traditional options like colistin for VAP, HAP, and related infections.
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